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Identification of a novel potent CDK inhibitor degrading cyclinK with a superb activity to reverse trastuzumab-resistance in HER2-positive breast cancer in vivo Kuchukulla, Ratnakar Reddy; Hwang, Injeoung; Kim, Suhn Hyung; Kye, Younghyeon; Park, Narae; Cha, Heary; Moon, Sojeong; Chung, Hwan Won; Lee, Cheolju; Kong, Gu; Hur, Wooyoung 分享 收藏
Identification of novel class inhibitors of NSD3 methyltransferase showing a unique, bivalent binding mode in the SET domain Kim, Sumin; Hwang, Injeoung; Kim, Suhn Hyung; Chung, Hwan Won; Ji, Mi-Jung; Moon, Sojeong; Park, Hyun-Mee; Kong, Gu; Hur, Wooyoung 分享 收藏
Novel 2,6,9-Trisubstituted Purines as Potent CDK Inhibitors Alleviating Trastuzumab-Resistance of HER2-Positive Breast Cancers Kuchukulla, Ratnakar Reddy; Hwang, Injeoung; Park, Sang Won; Moon, Sojeong; Kim, Suhn Hyung; Kim, Sumin; Chung, Hwan Won; Ji, Mi-Jung; Park, Hyun-Mee; Kong, Gu; Hur, Wooyoung 分享 收藏
NSD3-Induced Methylation of H3K36 Activates NOTCH Signaling to Drive Breast Tumor Initiation and Metastatic Progression Jeong, Ga-Young; Park, Mi Kyung; Choi, Hee-Joo; An, Hee Woon; Park, Young-Un; Choi, Hyung-Jun; Park, Jin; Kim, Hyung-Yong; Son, Taekwon; Lee, Ho; Min, Kyueng-Whan; Oh, Young-Ha; Lee, Jeong-Yeon; Kong, Gu 分享 收藏
Epigenetic priming by Dot1l in lymphatic endothelial progenitors ensures normal lymphatic development and function Yoo, Hyunjin; Lee, Young Jae; Park, Chanhyeok; Son, Dabin; Choi, Dong Yoon; Park, Ji-Hyun; Choi, Hee-Jin; La, Hyun Woo; Choi, Yun-Jung; Moon, Eun-Hye; Saur, Dieter; Chung, Hyung Min; Song, Hyuk; Do, Jeong Tae; Jang, Hoon; Lee, Dong Ryul; Park, Chankyu; Lee, Ok-Hee; Cho, Ssang-Goo; Hong, Seok-Ho; Kong, Gu; Kim, Jin-Hoi; Choi, Youngsok; Hong, Kwonho 分享 收藏
CDK12 drives breast tumor initiation and trastuzumab resistance via WNT and IRS1-ErbB-PI3K signaling CDK12通过WNT和IRS1-ErbB-PI3K信号驱动乳腺肿瘤启动和曲妥珠单抗耐药 Choi, Hee-Joo; Jin, Sora; Cho, Hani; Won, Hee-Young; An, Hee Woon; Jeong, Ga-Young; Park, Young-Un; Kim, Hyung-Yong; Park, Mi Kyung; Son, Taekwon; Min, Kyueng-Whan; Jang, Ki-Seok; Oh, Young-Ha; Lee, Jeong-Yeon; Kong, Gu 分享 收藏
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Role of MEL-18 Amplification in Anti-HER2 Therapy of Breast Cancer Lee, Jeong-Yeon; Joo, Hyeong-Seok; Choi, Hee-Joo; Jin, Sora; Kim, Hyung-Yong; Jeong, Ga-Young; An, Hee Woon; Park, Mi Kyung; Lee, Seung Eun; Kim, Wan-Seop; Son, Taekwon; Min, Kyueng-Whan; Oh, Young-Ha; Kong, Gu 分享 收藏
A somatic-mutational process recurrently duplicates germline susceptibility loci and tissue-specific super-enhancers in breast cancers (vol 49, pg 341, 2017) Glodzik, Dominik; Morganella, Sandro; Davies, Helen; Simpson, Peter T.; Li, Yilong; Zou, Xueqing; Diez-Perez, Javier; Staaf, Johan; Alexandrov, Ludmil B.; Smid, Marcel; Brinkman, Arie B.; Rye, Inga Hansine; Russnes, Hege; Raine, Keiran; Purdie, Colin A.; Lakhani, Sunil R.; Thompson, Alastair M.; Birney, Ewan; Stunnenberg, Hendrik G.; van de Vijver, Marc J.; Martens, John W. M.; Borresen-Dale, Anne-Lise; Richardson, Andrea L.; Kong, Gu; Viari, Alain; Easton, Douglas; Evan, Gerard; Campbell, Peter J.; Stratton, Michael R.; Nik-Zainal, Serena 分享 收藏
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Whole-Genome Sequencing Reveals Breast Cancers with Mismatch Repair Deficiency Davies, Helen; Morganella, Sandro; Purdie, Colin A.; Jang, Se Jin; Borgen, Elin; Russnes, Hege; Glodzik, Dominik; Zou, Xueqing; Viari, Alain; Richardson, Andrea L.; Borresen-Dale, Anne-Lise; Thompson, Alastair; Eyfjord, Jorunn E.; Kong, Gu; Stratton, Michael R.; Nik-Zainal, Serena 分享 收藏
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LSD1 demethylates HIF1α to inhibit hydroxylation and ubiquitin-mediated degradation in tumor angiogenesis Lee, J-Y; Park, J-H; Choi, H-J; Won, H-Y; Joo, H-s; Shin, D-H; Park, M. K.; Han, B.; Kim, K. P.; Lee, T. J.; Croce, C. M.; Kong, G. 分享 收藏
HRDetect is a predictor of BRCA1 and BRCA2 deficiency based on mutational signatures HRDetect是基于突变特征的BRCA1和BRCA2缺陷的预测因子 Davies, Helen; Glodzik, Dominik; Morganella, Sandro; Yates, Lucy R.; Staaf, Johan; Zou, Xueqing; Ramakrishna, Manasa; Martin, Sancha; Boyault, Sandrine; Sieuwerts, Anieta M.; Simpson, Peter T.; King, Tari A.; Raine, Keiran; Eyfjord, Jorunn E.; Kong, Gu; Borg, Ake; Birney, Ewan; Stunnenberg, Hendrik G.; van de Vijver, Marc J.; Borresen-Dale, Anne-Lise; Martens, John W. M.; Span, Paul N.; Lakhani, Sunil R.; Vincent-Salomon, Anne; Sotiriou, Christos; Tutt, Andrew; Thompson, Alastair M.; Van Laere, Steven; Richardson, Andrea L.; Viari, Alain; Campbell, Peter J.; Stratton, Michael R.; Nik-Zainal, Serena 分享 收藏
A somatic-mutational process recurrently duplicates germline susceptibility loci and tissue-specific super-enhancers in breast cancers Glodzik, Dominik; Morganella, Sandro; Davies, Helen; Simpson, Peter T.; Li, Yilong; Zou, Xueqing; Diez-Perez, Javier; Staaf, Johan; Alexandrov, Ludmil B.; Smid, Marcel; Brinkman, Arie B.; Rye, Inga Hansine; Russnes, Hege; Raine, Keiran; Purdie, Colin A.; Lakhani, Sunil R.; Thompson, Alastair M.; Birney, Ewan; Stunnenberg, Hendrik G.; van de Vijver, Marc J.; Martens, John W. M.; Borresen-Dale, Anne-Lise; Richardson, Andrea L.; Kong, Gu; Viari, Alain; Easton, Douglas; Evan, Gerard; Campbell, Peter J.; Stratton, Michael R.; Nik-Zainal, Serena 分享 收藏
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The topography of mutational processes in breast cancer genomes Morganella, Sandro; Alexandrov, Ludmil B.; Glodzik, Dominik; Zou, Xueqing; Davies, Helen; Staaf, Johan; Sieuwerts, Anieta M.; Brinkman, Arie B.; Martin, Sancha; Ramakrishna, Manasa; Butler, Adam; Kim, Hyung-Yong; Borg, Ake; Sotiriou, Christos; Futreal, P. Andrew; Campbell, Peter J.; Span, Paul N.; Van Laere, Steven; Lakhani, Sunil R.; Eyfjord, Jorunn E.; Thompson, Alastair M.; Stunnenberg, Hendrik G.; de Vijver, Marc J. van; Martens, John W. M.; Borresen-Dale, Anne-Lise; Richardson, Andrea L.; Kong, Gu; Thomas, Gilles; Sale, Julian; Rada, Cristina; Stratton, Michael R.; Birney, Ewan; Nik-Zainal, Serena 分享 收藏
Clonal dynamics in a single AML case tracked for 9 years reveals the complexity of leukemia progression Kim, T.; Yoshida, K.; Kim, Y. K.; Tyndel, M. S.; Park, H. J.; Choi, S. H.; Ahn, J-S; Jung, S-H; Yang, D-H; Lee, J-J; Kim, H. J.; Kong, G.; Ogawa, S.; Zhang, Z.; Kim, H. J.; Kim, D. D. 分享 收藏
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