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Discovery of dual-active ethionamide boosters inhibiting the Mycobacterium tuberculosis ESX-1 secretion system Gries, Raphael; Chhen, Jason; van Gumpel, Edeltraud; Theobald, Sebastian J.; Sonnenkalb, Lindsay; Utpatel, Christian; Metzen, Fabian; Koch, Manuel; Dallenga, Tobias; Djaout, Kamel; Baulard, Alain; Molin, Michael Dal; Rybniker, Jan 分享 收藏
Loss-of-function mutations in ndh do not confer delamanid, ethionamide, isoniazid, or pretomanid resistance in Mycobacterium tuberculosis Pandey, Sushil; Vilcheze, Catherine; Werngren, Jim; Bainomugisa, Arnold; Mansjo, Mikael; Groenheit, Ramona; Miotto, Paolo; Cirillo, Daniela M.; Coulter, Christopher; Baulard, Alain R.; Schon, Thomas; Jacobs Jr, William R.; Djaout, Kamel; Koser, Claudio U. 分享 收藏
Both Nitro Groups Are Essential for High Antitubercular Activity of 3,5-Dinitrobenzylsulfanyl Tetrazoles and 1,3,4-Oxadiazoles through the Deazaflavin-Dependent Nitroreductase Activation Pathway Karabanovich, Galina; Fabianova, Viktoria; Vocat, Anthony; Dusek, Jan; Valaskova, Lenka; Stolarikova, Jirina; Kitson, Russell R. A.; Pavek, Petr; Vavrova, Katerina; Djaout, Kamel; Mikusova, Katarina; Baulard, Alain R.; Cole, Stewart T.; Kordulakova, Jana; Roh, Jaroslav 分享 收藏
Exploring the Antitubercular Activity of Anthranilic Acid Derivatives: From MabA (FabG1) Inhibition to Intrabacterial Acidification Faion, Leo; Djaout, Kamel; Pintiala, Catalin; Piveteau, Catherine; Leroux, Florence; Biela, Alexandre; Slupek, Stephanie; Antoine, Rudy; Zahorszka, Monika; Cantrelle, Francois-Xavier; Hanoulle, Xavier; Kordulakova, Jana; Deprez, Benoit; Willand, Nicolas; Baulard, Alain R.; Flipo, Marion 分享 收藏
The small-molecule SMARt751 reverses Mycobacterium tuberculosis resistance to ethionamide in acute and chronic mouse models of tuberculosis 小分子SMARt751在急性和慢性结核病小鼠模型中逆转结核分枝杆菌对乙硫酰胺的耐药性 Flipo, Marion; Frita, Rosangela; Bourotte, Marilyne; Martinez-Martinez, Maria S.; Boesche, Markus; Boyle, Gary W.; Derimanov, Geo; Drewes, Gerard; Gamallo, Pablo; Ghidelli-Disse, Sonja; Gresham, Stephanie; Jimenez, Elena; de Mercado, Jaime; Perez-Herran, Esther; Porras-De Francisco, Esther; Rullas, Joaquin; Casado, Patricia; Leroux, Florence; Piveteau, Catherine; Kiass, Mehdi; Mathys, Vanessa; Soetaert, Karine; Megalizzi, Veronique; Tanina, Abdalkarim; Wintjens, Rene; Antoine, Rudy; Brodin, Priscille; Delorme, Vincent; Moune, Martin; Djaout, Kamel; Slupek, Stephanie; Kemmer, Christian; Gitzinger, Marc; Ballell, Lluis; Mendoza-Losana, Alfonso; Lociuro, Sergio; Deprez, Benoit; Barros-Aguirre, David; Remuinan, Modesto J.; Willand, Nicolas; Baulard, Alain R. 分享 收藏
On the Hunt for Next-Generation Antimicrobial Agents: An Online Symposium Organized Jointly by the French Society for Medicinal Chemistry (Societe de Chimie Therapeutique) and the French Microbiology Society (Societe Francaise de Microbiologie) on 9-10 December 2021 Antraygues, Kevin; Compagne, Nina; Ruggieri, Francesca; Djaout, Kamel; Edoo, Zainab; Eveque, Maxime; Faion, Leo; Gioia, Bruna; Tangara, Salia; Da Cruz, Anais Vieira; Villemagne, Baptiste; Flipo, Marion; Baulard, Alain; Willand, Nicolas 分享 收藏
Discovery of the first Mycobacterium tuberculosis MabA (FabG1) inhibitors through a fragment-based screening 通过基于片段的筛选发现第一个结核分枝杆菌MabA (FabG1) 抑制剂 Faion, Leo; Djaout, Kamel; Frita, Rosangela; Pintiala, Catalin; Cantrelle, Francois-Xavier; Moune, Martin; Vandeputte, Alexandre; Bourbiaux, Kevin; Piveteau, Catherine; Herledan, Adrien; Biela, Alexandre; Leroux, Florence; Kremer, Laurent; Blaise, Mickael; Tanina, Abdalkarim; Wintjens, Rene; Hanoulle, Xavier; Deprez, Benoit; Willand, Nicolas; Baulard, Alain R.; Flipo, Marion 分享 收藏
Fragment-Based Optimized EthR Inhibitors with in Vivo Ethionamide Boosting Activity 基于片段的优化的EthR抑制剂，具有体内乙硫酰胺增强活性 Villemagne, Baptiste; Machelart, Arnaud; Ngoc Chau Tran; Flipo, Marion; Moune, Martin; Leroux, Florence; Piveteau, Catherine; Wohlkonig, Alexandre; Wintjens, Rene; Li, Xue; Gref, Ruxandra; Brodin, Priscille; Deprez, Benoit; Baulard, Alain R.; Willand, Nicolas 分享 收藏
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A fragment-based approach towards the discovery of N-substituted tropinones as inhibitors of Mycobacterium tuberculosis transcriptional regulator EthR2 一种基于片段的方法，用于发现N-取代的tropinones作为结核分枝杆菌转录调节剂EthR2的抑制剂 Prevet, Hugues; Moune, Martin; Tanina, Abdalkarim; Kemmer, Christian; Herledan, Adrien; Frita, Rosangela; Wohlkonig, Alexandre; Bourotte, Marilyne; Villemagne, Baptiste; Leroux, Florence; Gitzinger, Marc; Baulard, Alain R.; Deprez, Benoit; Wintjens, Rene; Willand, Nicolas; Flipo, Marion 分享 收藏
Intrinsic Antibacterial Activity of Nanoparticles Made of β-Cyclodextrins Potentiates Their Effect as Drug Nanocarriers against Tuberculosis Machelart, Arnaud; Salzano, Giuseppina; Li, Xue; Demars, Aurore; Debrie, Anne-Sophie; Menendez-Miranda, Mario; Pancani, Elisabetta; Jouny, Samuel; Hoffmann, Eik; Deboosere, Nathalie; Belhaouane, Imene; Rouanet, Carine; Simar, Sophie; Talahari, Smail; Giannini, Valerie; Villemagne, Baptiste; Flipo, Marion; Brosch, Roland; Nesslany, Fabrice; Deprez, Benoit; Muraille, Eric; Locht, Camille; Baulard, Alain R.; Willand, Nicolas; Majlessi, Laleh; Gref, Ruxandra; Brodin, Priscille 分享 收藏
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Combination therapy for tuberculosis treatment: pulmonary administration of ethionamide and booster co-loaded nanoparticles (vol 7, 5390, 2017) Costa-Gouveia, Joana; Pancani, Elisabetta; Jouny, Samuel; Machelart, Arnaud; Delorme, Vincent; Salzano, Giuseppina; Iantomasi, Raffaella; Piveteau, Catherine; Queval, Christophe J.; Song, Ok-Ryul; Flipo, Marion; Deprez, Benoit; Saint-Andre, Jean-Paul; Hureaux, Jose; Majlessi, Laleh; Willand, Nicolas; Baulard, Alain; Brodin, Priscille; Gref, Ruxandra 分享 收藏
ArfGAP1 restricts Mycobacterium tuberculosis entry by controlling the actin cytoskeleton Song, Ok-Ryul; Queval, Christophe J.; Iantomasi, Raffaella; Delorme, Vincent; Marion, Sabrina; Veyron-Churlet, Romain; Werkmeister, Elisabeth; Popoff, Michka; Ricard, Isabelle; Jouny, Samuel; Deboosere, Nathalie; Lafont, Frank; Baulard, Alain; Yeramian, Edouard; Marsollier, Laurent; Hoffmann, Eik; Brodin, Priscille 分享 收藏
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Combination therapy for tuberculosis treatment: pulmonary administration of ethionamide and booster co-loaded nanoparticles Costa-Gouveia, Joana; Pancani, Elisabetta; Jouny, Samuel; Machelart, Arnaud; Delorme, Vincent; Salzano, Giuseppina; Iantomasi, Raffaella; Piveteau, Catherine; Queval, Christophe J.; Song, Ok-Ryul; Flipo, Marion; Deprez, Benoit; Saint-Andre, Jean-Paul; Hureaux, Jose; Majlessi, Laleh; Willand, Nicolas; Baulard, Alain; Brodin, Priscille; Gref, Ruxandra 分享 收藏
Fragment-Sized EthR Inhibitors Exhibit Exceptionally Strong Ethionamide Boosting Effect in Whole-Cell Mycobacterium tuberculosis Assays Nikiforov, Petar O.; Blaszczyk, Michal; Surade, Sachin; Boshoff, Helena I.; Sajid, Andaleeb; Delorme, Vincent; Deboosere, Nathalie; Brodin, Priscille; Baulard, Alain R.; Barry, Clifton E., III; Blundell, Tom L.; Abell, Chris 分享 收藏
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