Xiaolin Tu - Publications, H-index & Citations

涂

涂小林 (Xiaolin Tu)

Chongqing Medical University

25H指数

67论文数

4.6K被引数

收录论文 26

发表时间

LF3 exerts anti-osteosarcoma effects through Wnt signaling inhibition-coupled ferroptosis induction via HO-1/ACSL4 axis LF3通过抑制Wnt信号通路并耦合诱导铁死亡（通过HO-1/ACSL4轴）发挥抗骨肉瘤作用

Frontiers in Oncology

IF3.3

2026-05-12

OAAI

MY Mengfan Yang †; PL Pei Liu †; HZ Hongjun Zhang †; XT Xun Tang; XH Xiang Hong; YL Yujiao Liu; MD Meichao Deng; XT Xiaolin Tu; GS Gaohai Shao

Engineering a Wnt-activated osteomimetic microenvironment with iPSC-derived MSCs for synergistic bone regeneration, angiogenesis, and neurogenesis 利用iPSC来源的MSCs构建Wnt激活的骨拟态微环境，以协同促进骨再生、血管生成和神经发生。

Biomaterials

IF12.9

2026-01-03

PREAI

Qiqi Bu; Hao Bai; Minjie Ruan; Lu Gao; Liuqing Wang; Mao Nie; Mingming Zhao; Xiaolin Tu; Chengzhu Zhao

Inhibition of ferroptosis rescues BMP osteogenic differentiation impaired by iron overload in the osteoporotic microenvironment 抑制铁死亡可挽救骨质疏松微环境中铁过载所损害的BMP成骨分化

Cellular Signalling

IF3.7

2025-09-08

PREAI

Xun Tang; Mengfan Yang; Yujiao Liu; Hongjun Zhang; Xiang Hong; Meichao Deng; Pei Liu; Qing Sun; Xiaolin Tu; Gaohai Shao

BMP9 attenuates microgravity-related disuse osteoporosis by modulating TGFβ and BMP signaling BMP9通过调节TGFβ和BMP信号通路来减轻微重力相关的废用性骨质疏松。

npj Microgravity

IF4.1

2025-08-01

OAAI

Haoyang Zhao; Mengfan Yang; Yujiao Liu; Xiaolin Tu; Gaohai Shao

The potential key genes within focal adhesion that regulate mesenchymal stem cells osteogenesis or adipogenesis in microgravity related disuse osteoporosis: an integrated analysis

FRONTIERS IN ENDOCRINOLOGY

IF4.6

2025-03-10

OAAI

Zhao, Haoyang; Tu, Xiaolin

Establishing stable and highly osteogenic hiPSC-derived MSCs for 3D-printed bone graft through microenvironment modulation by CHIR99021-treated osteocytes

MATERIALS TODAY BIO

IF10.2

2024-06-01

OAAI

Guo, Qiuling; Chen, Jingjing; Bu, Qiqi; Zhang, Jinling; Ruan, Minjie; Chen, Xiaoyu; Zhao, Mingming; Tu, Xiaolin; Zhao, Chengzhu

A novel decellularized matrix of Wnt signaling-activated osteocytes accelerates the repair of critical-sized parietal bone defects with osteoclastogenesis, angiogenesis, and neurogenesis

BIOACTIVE MATERIALS

IF20.3

2023-03-01

OAAI

Wang, Xiaofang; Ma, Yufei; Chen, Jie; Liu, Yujiao; Liu, Guangliang; Wang, Pengtao; Wang, Bo; Taketo, Makoto M.; Bellido, Teresita; Tu, Xiaolin

Canonical Wnt signaling works downstream of iron overload to prevent ferroptosis from damaging osteoblast differentiation

FREE RADICAL BIOLOGY AND MEDICINE

IF8.2

2022-08-01

PREAI

Luo, Cen; Xu, Wenjuan; Tang, Xun; Liu, Xinyu; Cheng, Yu; Wu, Yixun; Xie, Zhengsong; Wu, Xiaohong; He, Xin; Wang, Qian; Xiao, Yao; Qiu, Xueting; Tang, Zhurong; Shao, Gaohai; Tu, Xiaolin

A Highly Selective GSK-3β Inhibitor CHIR99021 Promotes Osteogenesis by Activating Canonical and Autophagy-Mediated Wnt Signaling

FRONTIERS IN ENDOCRINOLOGY

IF4.6

2022-07-18

OAAI

Wang, Bo; Khan, Saima; Wang, Pengtao; Wang, Xiaofang; Liu, Yangxi; Chen, Jingjing; Tu, Xiaolin

3D printing of osteocytic Dll4 integrated with PCL for cell fate determination towards osteoblasts in vitro

BIO-DESIGN AND MANUFACTURING

IF7.6

2022-04-18

OAAI

Wang, Pengtao; Wang, Xiaofang; Wang, Bo; Li, Xian; Xie, Zhengsong; Chen, Jie; Honjo, Tasuku; Tu, Xiaolin

The Osteocyte Stimulated by Wnt Agonist SKL2001 Is a Safe Osteogenic Niche Improving Bioactivities in a Polycaprolactone and Cell Integrated 3D Module

CELLS

IF5.2

2022-02-28

OAAI

Liu, Yangxi; Ruan, Xiaojie; Li, Jun; Wang, Bo; Chen, Jie; Wang, Xiaofang; Wang, Pengtao; Tu, Xiaolin

The Notch pathway regulates the bone gain induced by PTH anabolic signaling Notch通路调控PTH合成代谢信号诱导的骨增量

FASEB JOURNAL

IF4.2

2022-02-09

OAAI

Delgado-Calle, Jesus; McAndrews, Kevin; Wu, Gerald; Orr, Ashley L.; Ferrari, Adam; Tu, Xiaolin; Srinivasan, Venkatesan; Roodman, G. David; Ebetino, Frank H.; Boeckman, Robert K.; Bellido, Teresita

In vivo evaluation of porous nanohydroxyapatite/polyamide 66 struts in a goat cervical fusion model

SCIENTIFIC REPORTS

IF3.9

2020-06-26

OAAI

Liang, Xi; Li, Feilong; Gong, Xuan; Li, Junchao; Yin, Shijie; Li, Qi; Liu, Ziming; Zhao, Zenghui; Tu, Xiaolin; Huang, Wei; Hu, Ning

Control of Bone Anabolism in Response to Mechanical Loading and PTH by Distinct Mechanisms Downstream of the PTH Receptor

JOURNAL OF BONE AND MINERAL RESEARCH

IF5.9

2016-10-05

OAAI

Delgado-Calle, Jesus; Tu, Xiaolin; Pacheco-Costa, Rafael; McAndrews, Kevin; Edwards, Rachel; Pellegrini, Gretel G.; Kuhlenschmidt, Kali; Olivos, Naomie; Robling, Alexander; Peacock, Munro; Plotkin, Lilian I.; Bellido, Teresita

In vitro and in vivo biocompatibility and osteogenesis of graphene-reinforced nanohydroxyapatite polyamide66 ternary biocomposite as orthopedic implant material

INTERNATIONAL JOURNAL OF NANOMEDICINE

IF6.5

2016-07-01

OAAI

Zhang, Shiyang; Yang, Qiming; Zhao, Weikang; Qiao, Bo; Cui, Hongwang; Fan, Jianjun; Li, Hong; Tu, Xiaolin; Jiang, Dianming

Osteocytes mediate the anabolic actions of canonical Wnt/β-catenin signaling in bone 骨细胞介导经典Wnt/β-catenin信号在骨中的合成代谢作用

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

IF9.1

2015-01-20

248

OAAI

Tu, Xiaolin; Delgado-Calle, Jesus; Condon, Keith W.; Maycas, Marta; Zhang, Huajia; Carlesso, Nadia; Taketo, Makoto M.; Burr, David B.; Plotkin, Lilian I.; Bellido, Teresita

Parathyroid Hormone Receptor Signaling Induces Bone Resorption in the Adult Skeleton by Directly Regulating the RANKL Gene in Osteocytes

ENDOCRINOLOGY

IF3.3

2014-08-01

OAAI

Ben-awadh, Abdullah N.; Delgado-Calle, Jesus; Tu, Xiaolin; Kuhlenschmidt, Kali; Allen, Matthew R.; Plotkin, Lilian I.; Bellido, Teresita

Notch-Dependent Repression of miR-155 in the Bone Marrow Niche Regulates Hematopoiesis in an NF-κB-Dependent Manner

CELL STEM CELL

IF20.4

2014-07-01

180

OAAI

Wang, Lin; Zhang, Huajia; Rodriguez, Sonia; Cao, Liyun; Parish, Jonathan; Mumaw, Christen; Zollman, Amy; Kamoka, Malgorzata M.; Mu, Jian; Chen, Danny Z.; Srour, Edward F.; Chitteti, Brahmananda R.; HogenEsch, Harm; Tu, Xiaolin; Bellido, Teresita M.; Boswell, H. Scott; Manshouri, Taghi; Verstovsek, Srdan; Yoder, Mervin C.; Kapur, Reuben; Cardoso, Angelo A.; Carlesso, Nadia

WNT7B Promotes Bone Formation in part through mTORC1

PLOS GENETICS

IF3.7

2014-01-30

100

OAAI

Chen, Jianquan; Tu, Xiaolin; Esen, Emel; Joeng, Kyu Sang; Lin, Congxin; Arbeit, Jeffrey M.; Rueegg, Markus A.; Hall, Michael N.; Ma, Liang; Long, Fanxin

Physiological Notch Signaling Maintains Bone Homeostasis via RBPjk and Hey Upstream of NFATc1

PLOS GENETICS

IF3.7

2012-03-22

OAAI

Tu, Xiaolin; Chen, Jianquan; Lim, Joohyun; Karner, Courtney M.; Lee, Seung-Yon; Heisig, Julia; Wiese, Cornelia; Surendran, Kameswaran; Kopan, Raphael; Gessler, Manfred; Long, Fanxin

研究方向

干细胞与骨发育3D打印与再生医学骨发育与稳态维持分子机制骨折不愈合与骨不连基础研究与防治对策失重骨流失基础研究与防治对策骨退行性病变与铁死亡3D生物打印与骨类器官和工程化仿真骨构建生物墨水与可降解骨修复材料研发干细胞/iPSC细胞定向分化、谱系转变与成骨分化的时空调控成骨药物筛选与应用骨与衰老生物力学与骨

合作学者

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