Srinivasan Yegnasubramanian

johns hopkins university

63H指数

575论文数

1.6W被引数

收录论文 148

发表时间

A transition zone enriched WIF1⁺ basal cell subtype is associated with benign prostatic hyperplasia 富集WIF1⁺基底细胞亚型的过渡区与良性前列腺增生相关

Journal of Pathology

IF5.2

2026-09-10

OAAI

Rulin Wang; Qizhi Zheng; Mindy K Graham; Ajay Vaghasia; Jianyong Liu; Jordan Gregg; Tracy Jones; Anuj Gupta; Nicole Castagna; Yan Zhang; Kornel Schuebel; Jennifer Meyers; Alyza Skaist; Dixie Hoyle; Jasmine Kung; Jessica Hicks; Alok Mishra; Yuhan Yang; William G Nelson; Angelo M De Marzo; Srinivasan Yegnasubramanian

Triptolide sensitizes cancer cells to nucleoside DNA methyltransferase inhibitors through inhibition of DCTPP1-mediated cell-intrinsic resistance 雷公藤内酯醇通过抑制DCTPP1介导的细胞固有耐药性，增强癌细胞对核苷类DNA甲基转移酶抑制剂的敏感性

Nature Communications

IF15.7

2026-08-26

OAAI

Jianyong Liu; Qing-Li He; Jianya Zhou; Ajay M. Vaghasia; Roshan Chikarmane; Glenn Hauk; Archana Rachakonda; Nicole Castagna; Ruchama C. Steinberg; Minh-Tam Pham; Jordan M. Gregg; Alok Mishra; Yuhan Yang; Talha Anwar; Roy Elias; Pengshan Li; Jasmine Yun-Tong Kung; Anthony C. O’Donnell; Nicole M. Anders; Teresia M. Wanjiku; Philipp Nuhn; Joong Sup Shim; Hugh Giovinazzo; David M. Esopi; Kunhwa Kim; Jonathan Coulter; Rulin Wang; Jianying Zhou; Michelle A. Rudek; Kathleen Gabrielson; Angelo M. De Marzo; James M. Berger; Jun O. Liu; William G. Nelson; Srinivasan Yegnasubramanian

Somatic mutations reveal hyperactive Notch signaling in prurigo nodularis 体细胞突变揭示结节性痒疹中Notch信号通路的过度活化

JCI Insight

IF6.1

2026-04-22

PREAI

Rajeh, Ahmad; Shahsavari, Shahin; Cornman, Hannah; Kollhoff, Alexander; Gupta, Anuj; Szeto, Mindy D.; Kambala, Anusha; Oladipo, Olusola O.; Parthasarathy, Varsha; Deng, Junwen; Marani, Melika; Shahsavari, Shirin; Yossef, Selina M.; Vaddaraju, Vedha; Adawi, Waleed; Akiska, Yagiz M.; Gage, Davies M.; Wheelan, Sarah; Pritchard, Thomas; Kwatra, Madan M.; Semenov, Yevgeniy R.; Gusev, Alexander; Ho, Won Jin; Yegnasubramanian, Srinivasan; Kwatra, Shawn G.

RRM1 inhibition sensitizes lung adenocarcinoma to decitabine treatment RRM1抑制增强肺腺癌对地西他滨治疗的敏感性

Cell Death & Disease

IF9.6

2026-02-26

OAAI

Nan Jiang; Jianyong Liu; Ajay Vaghasia; Nicole Anders; Michelle Rudek; William G. Nelson; Srinivasan Yegnasubramanian; Jianya Zhou

Cellular senescence in precancer lesions and early-stage cancers 癌前病变和早期癌症中的细胞衰老

Cancer Cell

IF44.5

2025-11-06

PREAI

Xen Ping Hoi; Mary M. Stangis; Sarah E. Glass; Jin-Hee Kim; Seung Woo Kang; W. Nathaniel Brennen; Ziyi Li; William M. Grady; Srinivasan Yegnasubramanian; Peter Kuhn; Costas A. Lyssiotis; Akiko Sagara; Martha J. Shrubsole; Humam Kadara; Ying Yuan; Robert J. Coffey; Ken S. Lau; Angelo M. De Marzo; Anirban Maitra; Jimin Min; Ming Yu; Keith S. Chan

Ossifying Spindled and Epithelioid Tumor: A Novel Soft Tissue Tumor 骨化性梭形细胞和上皮样肿瘤：一种新型软组织肿瘤

Modern Pathology

IF5.5

2025-07-16

PREAI

John M. Gross; Ying S. Zou; Michael Michal; Abbas Agaimy; Roberto A. Garcia; Christopher Hysell; Karen J. Fritchie; Josephine K. Dermawan; Brian P. Rubin; Melanie Klausner; Laura Morsberger; Jonathan Dudley; Alyza Skaist; Yan Zhang; Kornel Schuebel; Jennifer Meyers; Srinivasan Yegnasubramanian; Leslie Cope; Nasir Ud Din; Ali Alani; David I. Suster; Lisa Rooper; Pedram Argani; Ezra G. Baraban; Daniel Baumhoer; Baptiste Ameline; Gregory W. Charville; Andrew E. Rosenberg

A Combined Multiplex IHC and Machine Learning Based Approach to PSMA Protein Quantification

LABORATORY INVESTIGATION

IF4.2

2025-03-01

PREAI

Gomes-Alexandre, Carolina; Jones, Tracy; Graham, Mindy; Hicks, Jessica; Yegnasubramanian, Srinivasan; Anabaraonye, Nancy; Pavlovich, Christian; Deweese, Theodore; Pomper, Martin; Mosallaie, Seyed Ali; Deville, Curtland; De Marzo, Angelo

Distinct single-cell transcriptional profile in CD4+T-lymphocytes among obese children with asthma 肥胖哮喘儿童CD4+T淋巴细胞中独特的单细胞转录谱

AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

IF3.5

2025-03-01

PREAI

Tejwani, V; Wang, RL; Villabona-Rueda, A; Suresh, K; Wu, TD; Adcock, IM; Kermani, NZ; Zein, J; Hansel, NN; Yegnasubramanian, S; Mccormack, MC; D'Alessio, FR

Overexpression of fibroblast activation protein (FAP) in the stroma of proliferative inflammatory atrophy (PIA) and primary adenocarcinoma of the prostate 前列腺增生性炎症性萎缩（PIA）和原发性前列腺腺癌基质中纤维细胞活化蛋白（FAP）的过表达

Pathology

IF3

2025-03-01

OAAI

Fernanda Caramella-Pereira; Qizhi Zheng; Jessica L. Hicks; Sujayita Roy; Tracy Jones; Martin Pomper; Lizamma Antony; Alan K. Meeker; Srinivasan Yegnasubramanian; Angelo M. De Marzo; W. Nathaniel Brennen

CD137 agonism enhances anti-PD1 induced activation of expanded CD8+ T cell clones in a neoadjuvant pancreatic cancer clinical trial CD137激动作用增强了新辅助性胰腺癌临床试验中抗PD-1诱导的扩增CD8+ T细胞克隆的激活。

ISCIENCE

IF4.1

2025-01-01

PREAI

Montagne, Janelle M.; Mitchell, Jacob T.; Tandurella, Joseph A.; Christenson, Eric S.; Danilova, Ludmila, V; Deshpande, Atul; Loth, Melanie; Sidiropoulos, Dimitrios N.; Davis-Marcisak, Emily; Bergman, Daniel R.; Zhu, Qingfeng; Wang, Hao; Kagohara, Luciane T.; Engle, Logan L.; Green, Benjamin F.; Favorov, Alexander, V; Ho, Won Jin; Lim, Su Jin; Zhang, Rui; Li, Pan; Gai, Jessica; Mo, Guanglan; Mitchell, Sarah; Wang, Rulin; Vaghasia, Ajay; Hou, Wenpin; Xu, Yao; Zimmerman, Jacquelyn W.; Elisseeff, Jennifer H.; Yegnasubramanian, Srinivasan; Anders, Robert A.; Jaffee, Elizabeth M.; Zheng, Lei; Fertig, Elana J.

Convergent alterations in the tumor microenvironment of MYC-driven human and murine prostate cancer

NATURE COMMUNICATIONS

IF15.7

2024-08-28

OAAI

Graham, Mindy K.; Wang, Rulin; Chikarmane, Roshan; Abel, Bulouere; Vaghasia, Ajay; Gupta, Anuj; Zheng, Qizhi; Hicks, Jessica; Sysa-Shah, Polina; Pan, Xin; Castagna, Nicole; Liu, Jianyong; Meyers, Jennifer; Skaist, Alyza; Zhang, Yan; Rubenstein, Michael; Schuebel, Kornel; Simons, Brian W.; Bieberich, Charles J.; Nelson, William G.; Lupold, Shawn E.; Deweese, Theodore L.; De Marzo, Angelo M.; Yegnasubramanian, Srinivasan

Immunomodulation of the tumor microenvironment of pancreatic ductal adenocarcinoma with histone deacetylase inhibition: Results of a phase 2 clinical trial of entinostat in combination with nivolumab

CANCER RESEARCH

IF16.6

2024-04-05

PREAI

Baretti, Marina; Danilova, Ludmila; Durham, Jennifer N.; Betts, Courtney B.; Cope, Leslie; Sidiropoulos, Dimitrios N.; Tandurella, Joseph A.; Charmsaz, Soren; Gross, Nicole; Hernandez, Alexei; Ho, Won J.; Thoburn, Chris; Walker, Rosalind; Leatherman, James Leatherman; Mitchell, Sarah; Christmas, Brian; Gaykalova, Daria A.; Yegnasubramanian, Srinivasan; Fertig, Elana J.; Coussens, Lisa M.; Yarchoan, Mark; Jaffee, Elizabeth; Azad, Nilofer S.

STING protein expression is increased in intermediate luminal cells in proliferative inflammatory atrophy of the prostate (PIA) and is absent in the majority of primary prostatic adenocarcinomas

CANCER RESEARCH

IF16.6

2024-04-05

PREAI

Steele, Thomas M.; Meeker, Alan K.; Graham, Mindy K.; Wang, Rulin; Gomes-Alexandre, Carolina; Nelson, William G.; Pereiria, Fernanda Caramella; Kachhap, Sushant; Yegnasubramanian, Srinivasan; De Marzo, Angelo Michael

The Hallmarks of Precancer 癌前病变的标志

CANCER DISCOVERY

IF33.3

2024-04-04

OAAI

Stangis, Mary M.; Chen, Zhengyi; Min, Jimin; Glass, Sarah E.; Jackson, Jordan O.; Radyk, Megan D.; Hoi, Xen Ping; Brennen, W. Nathaniel; Yu, Ming; Dinh, Huy Q.; Coffey, Robert J.; Shrubsole, Martha J.; Chan, Keith S.; Grady, William M.; Yegnasubramanian, Srinivasan; Lyssiotis, Costas A.; Maitra, Anirban; Halberg, Richard B.; Dey, Neelendu; Lau, Ken S.

MYC activation and PTEN loss synergistically activate proliferation in a mouse model of lethal prostate cancer

CANCER RESEARCH

IF16.6

2024-03-22

PREAI

Rubenstein, Michael; Jones, Tracy; Hicks, Jessica; Rege, Apurv; Zheng, Qizhi; Gomes-Alexandre, Carolina; Hubbard, Gretchen; Yegnasubramanian, Srinivasan; Bieberich, Charles; DeMarzo, Angelo

Tertiary lymphoid structures and T-cell aggregates signal a robust antitumor immune response in a subset of leiomyosarcoma patients

CANCER RESEARCH

IF16.6

2024-03-22

PREAI

Suru, Aditya; Maalouf, Alexandre; Chen, Lingling; Tam, Ada; Villasi, William; Sharma, Kaushal; Zhang, Lindy; Meyer, Christian; Greer, Jonathan; Johnston, Fabian; Morris, Carol; Strike, Sophia; Levin, Adam; Rhee, Daniel; Ladle, Brian; Schuebel, Kornel; Zhang, Yan; Wang, Rulin; Yegnasubramanian, Srinivasan; Gross, John; Anders, Robert; Pardoll, Andrew; Llosa, Nicolas

Bipolar androgen therapy plus nivolumab for patients with metastatic castration-resistant prostate cancer: the COMBAT phase II trial

NATURE COMMUNICATIONS

IF15.7

2024-01-02

OAAI

Markowski, Mark C.; Taplin, Mary-Ellen; Aggarwal, Rahul; Sena, Laura A.; Wang, Hao; Qi, Hanfei; Lalji, Aliya; Sinibaldi, Victoria; Carducci, Michael A.; Paller, Channing J.; Marshall, Catherine H.; Eisenberger, Mario A.; Sanin, David E.; Yegnasubramanian, Srinivasan; Gomes-Alexandre, Carolina; Ozbek, Busra; Jones, Tracy; De Marzo, Angelo M.; Denmeade, Samuel R.; Antonarakis, Emmanuel S.

MYC-driven increases in mitochondrial DNA copy number occur early and persist throughout prostatic cancer progression MYC驱动的线粒体DNA拷贝数增加发生在早期，并在整个前列腺癌进展中持续存在

JCI INSIGHT

IF6.1

2023-12-22

OAAI

Chen, Jiayu; Zheng, Qizhi; Hicks, Jessica L.; Trabzonlu, Levent; Ozbek, Busra; Jones, Tracy; Vaghasia, Ajay M.; Larman, Tatianna C.; Wang, Rulin; Markowski, Mark C.; Denmeade, Sam R.; Pienta, Kenneth J.; Hruban, Ralph H.; Antonarakis, Emmanuel S.; Gupta, Anuj; Dang, Chi V.; Yegnasubramanian, Srinivasan; De Marzo, Angelo M.

CD4 T cell-activating neoantigens enhance personalized cancer vaccine efficacy

JCI INSIGHT

IF6.1

2023-12-08

OAAI

Huff, Amanda L.; Longway, Gabriella; Mitchell, Jacob T.; Andaloori, Lalitya; Davis-Marcisak, Emily; Chen, Fangluo; Lyman, Melissa R.; Wang, Rulin; Mathew, Jocelyn; Barrett, Benjamin; Rahman, Sabahat; Leatherman, James; Yarchoan, Mark; Azad, Nilofer S.; Yegnasubramanian, Srinivasan; Kagohara, Luciane T.; Fertig, Elana J.; Jaffee, Elizabeth M.; Armstrong, Todd D.; Zaidi, Neeha

Prognostic and therapeutic potential of senescent stromal fibroblasts in prostate cancer

NATURE REVIEWS UROLOGY

IF14.6

2023-10-31

PREAI

Mori, Joakin O.; Elhussin, Isra; Brennen, W. Nathaniel; Graham, Mindy K.; Lotan, Tamara L.; Yates, Clayton C.; De Marzo, Angelo M.; Denmeade, Samuel R.; Yegnasubramanian, Srinivasan; Nelson, William G.; Denis, Gerald V.; Platz, Elizabeth A.; Meeker, Alan K.; Heaphy, Christopher M.

研究方向