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H

Holger Stark

Heinrich Heine University Düsseldorf

57H指数
527论文数
1.3W被引数
收录论文 204
发表时间
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Virtual Screening, Synthesis and In Vitro Characterization of Histamine H4 Receptor Ligands Based on Pyrimidine Scaffolds基于嘧啶骨架的组胺H4受体配体的虚拟筛选、合成及体外表征
errInternational Journal of Molecular Sciences
IF4.9
err2026-08-02
err0
errOAAI
errOlga Michalak; Marcin Cybulski; Piotr Krzeczyński; Oliwia Zegrocka-Stendel; Małgorzata Dutkiewicz; Dorota Dymkowska; Agnieszka Olejarz-Maciej; Tadeusz Karcz; Mariam Dubiel; Pakhuri Mehta; Marek Kubiszewski; Marcin Lorkowski; Jakub Jakowiecki; Paweł Pasznik; Przemysław Miszta; Holger Stark; Katarzyna Koziak; Sławomir Filipek
err分享
err收藏
Multitargeted Aza-Arylcarboxamides for Neurodegenerative Diseases: Potent Histamine H3 Receptor Ligands with Anticholinesterase and Metal-Chelating Activities多靶点氮杂-芳基甲酰胺类化合物用于神经退行性疾病：具有抗胆碱酯酶和金属螯合活性的强效组胺H3受体配体
errACS Chemical Neuroscience
IF3.9
err2026-01-29
err0
errOAAI
errFlavia B. Lopes; Tobias Werner; Izilda A. Bagatin; Holger Stark; João Paulo S. Fernandes
err分享
err收藏
Sclareol and cinnarizine are non-selective inhibitors of voltage-gated Cav1.3 L-type Ca2+ channelsSclareol和cinnarizine是电压门控Cav1.3 L型Ca2+通道的非选择性抑制剂。
errCHANNELS
IF3.2
err2025-12-31
err0
PREAI
errZanetti, Lucia; Torok, Ferenc; Leitzbach, Luisa; Stark, Holger; Striessnig, Jorg
err分享
err收藏
The impact of secondary site interactions on the binding specificity of bitopic dopamine D2/D3 receptor ligands次级位点相互作用对双拓扑多巴胺D2/D3受体配体结合特异性的影响
errEuropean Journal of Medicinal Chemistry Reports
IF4.1
err2025-10-20
err0
errOAAI
errAttila Egyed; Dóra Judit Kiss; Zsófia Pável; Keve Rajna; Supriya A. Gaitonde; Mariam Dubiel; María Isabel Loza; Edina Szűcs; Éva Borbély; Zsófia Hajna; Grzegorz Satala; Márton Vass; Pál Szabó; Katalin Jósvay; Andrzej J. Bojarski; Holger Stark; Zsuzsanna Helyes; Erika Pintér; Michel Bouvier; György M. Keserű
err分享
err收藏
Design, Synthesis, and Biological Evaluation of Novel Multitarget 7-Alcoxyamino-3-(1,2,3-triazole)-coumarins as Potent Acetylcholinesterase Inhibitors设计、合成及新型多靶点7-羟氨基-3-(1,2,3-三唑基)-香豆素的生物活性评价：作为强效乙酰胆碱酯酶抑制剂
errPharmaceuticals 2025, Vol. 18, Page 1398
IF4.8
err2025-09-21
err0
errOAAI
errNathalia F. Nadur; Larissa de A. P. Ferreira; Daiana P. Franco; Luciana L. de Azevedo; Lucas Caruso; Thiago da S. Honório; Priscila de S. Furtado; Alice Simon; Lucio M. Cabral; Tobias Werner; Holger Stark; Arthur E. Kümmerle
err分享
err收藏
Targeting Histone H3K9 Methyltransferase G9a as a Potential Therapeutic Strategy for Neuropsychiatric Disorders以组蛋白H3K9甲基转移酶G9a为靶向治疗精神神经疾病的潜在策略
errMedicinal Research Reviews
IF11.6
err2025-05-19
err0
errOAAI
errMalak Hajar; Tobias Werner; Mihajlo Gajic; Holger Stark; Bassem Sadek
err分享
err收藏
Positive allosteric modulation of AMPA receptors via PF4778574 leads to reduced demyelination and clinical disability in experimental models of multiple sclerosisPF4778574对AMPA受体的正向变构调节可减轻实验性多发性硬化模型中的脱髓鞘和临床残疾。
errFRONTIERS IN IMMUNOLOGY
IF5.9
err2025-03-05
err0
errOAAI
errSindi, Mustafa; Dietrich, Michael; Klees, Diana; Gruchot, Joel; Hecker, Christina; Silbereis, John; Issberner, Andrea; Hartung, Hans-Peter; Ruck, Tobias; Stark, Holger; Kurz, Thomas; Kuery, Patrick; Meuth, Sven G.; Albrecht, Philipp
err分享
err收藏
First in class pyrrolo[2,3-d]pyrimidine derivatives fused to fluorobenzylpiperidines as dual ligands of acetylcholinesterase and histamine H3 receptor作为乙酰胆碱酯酶和组胺H3受体双靶点的第一类吡咯并[2,3-d]嘧啶衍生物，其与氟苄基哌啶并环。
errARCHIV DER PHARMAZIE
IF3.6
err2025-03-04
err0
PREAI
errAnazco, Tito; Werner, Tobias; Torres, Maria Jose; Hornos-Carneiro, Maria Fernanda; Fernandez, Joaquin; Zivkovic, Aleksandra; Salas, Cristian O.; Castro-Alvarez, Alejandro; Gutierrez, Margarita; Stark, Holger; Espinosa-Bustos, Christian
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err收藏
Virtual Screening Approaches to Identify Promising Multitarget-Directed Ligands for the Treatment of Autism Spectrum Disorder
errMOLECULES
IF4.6
err2024-11-07
err0
errOAAI
errJonczyk, Jakub; Przybylska, Klaudia; Staszewski, Marek; Godyn, Justyna; Werner, Tobias; Stefaniak-Napieralska, Monika; Stark, Holger; Walczynski, Krzysztof; Bajda, Marek
err分享
err收藏
First Report on Cationic Triphenylphosphonium Compounds as Mitochondriotropic H3R Ligands with Antioxidant Properties
errANTIOXIDANTS
IF6.6
err2024-11-01
err0
errOAAI
errWerner, Tobias; Anazco, Tito; Osses-Mendoza, Paula; Castro-alvarez, Alejandro; Salas, Cristian O.; Bridi, Raquel; Stark, Holger; Espinosa-Bustos, Christian
err分享
err收藏
Histamine H3 receptor antagonist/nitric oxide donors as novel promising therapeutic hybrid-tools for glaucoma and retinal neuroprotection
errBIOMEDICINE & PHARMACOTHERAPY
IF7.5
err2024-11-01
err0
errOAAI
errSgambellone, Silvia; Khanfar, Mohammad A.; Marri, Silvia; Villano, Serafina; Nardini, Patrizia; Frank, Annika; Reiner-Link, David; Stark, Holger; Lucarini, Laura
err分享
err收藏
Progress on the development of Class A GPCR-biased ligandsA类GPCR偏向性配体的研究进展
errBRITISH JOURNAL OF PHARMACOLOGY
IF7.7
err2024-09-11
err0
errOAAI
errMorales, Paula; Scharf, Magdalena M.; Bermudez, Marcel; Egyed, Attila; Franco, Rafael; Hansen, Olivia K.; Jagerovic, Nadine; Jakubik, Jan; Keseru, Gyorgy M.; Kiss, Dora Judit; Kozielewicz, Pawel; Larsen, Olav; Majellaro, Maria; Mallo-Abreu, Ana; Navarro, Gemma; Prieto-Diaz, Ruben; Rosenkilde, Mette M.; Sotelo, Eddy; Stark, Holger; Werner, Tobias; Wingler, Laura M.
err分享
err收藏
The stimulation of TH2 cells results in increased IL-5 and IL-13 production via the H4 receptorTH2细胞的刺激导致通过H4受体增加IL-5和IL-13的产生
errALLERGY
IF12
err2024-06-10
err0
errOAAI
errNikolouli, Eirini; Mommert, Susanne; Dawodu, Damilola Modupe; Schaper-Gerhardt, Katrin; Stark, Holger; Dittrich-Breiholz, Oliver; Gutzmer, Ralf; Werfel, Thomas
err分享
err收藏
4-Oxypiperidine Ethers as Multiple Targeting Ligands at Histamine H3 Receptors and Cholinesterases
errACS CHEMICAL NEUROSCIENCE
IF3.9
err2024-03-05
err2
errOAAI
errMichalska, Beata; Dziegielewski, Marek; Godyn, Justyna; Werner, Tobias; Bajda, Marek; Karcz, Tadeusz; Szczepanska, Katarzyna; Stark, Holger; Wieckowska, Anna; Walczynski, Krzysztof; Staszewski, Marek
err分享
err收藏
Discovery of a Small Molecule Activator of Slack (Kcnt1) Potassium Channels That Significantly Reduces Scratching in Mouse Models of Histamine-Independent and Chronic Itch
errADVANCED SCIENCE
IF14.1
err2024-02-13
err2
errOAAI
errBalzulat, Annika; Zhu, W. Felix; Flauaus, Cathrin; Hernandez-Olmos, Victor; Heering, Jan; Sethumadhavan, Sunesh; Dubiel, Mariam; Frank, Annika; Menge, Amelie; Hebchen, Maureen; Metzner, Katharina; Lu, Ruirui; Lukowski, Robert; Ruth, Peter; Knapp, Stefan; Mueller, Susanne; Steinhilber, Dieter; Haenelt, Inga; Stark, Holger; Proschak, Ewgenij; Schmidtko, Achim
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err收藏
An orally available Cav2.2 calcium channel inhibitor for the treatment of neuropathic pain
errBRITISH JOURNAL OF PHARMACOLOGY
IF7.7
err2024-02-07
err1
errOAAI
errKutzsche, Janine; Guzman, Gustavo A.; Willuweit, Antje; Kletke, Olaf; Wollert, Esther; Gering, Ian; Juergens, Dagmar; Breitkreutz, Joerg; Stark, Holger; Beck-Sickinger, Annette G.; Kloecker, Nikolaj; Hidalgo, Patricia; Willbold, Dieter
err分享
err收藏
Dual Piperidine-Based Histamine H3 and Sigma-1 Receptor Ligands in the Treatment of Nociceptive and Neuropathic Pain
errJOURNAL OF MEDICINAL CHEMISTRY
IF6.8
err2023-07-07
err7
errOAAI
errSzczepanska, Katarzyna; Karcz, Tadeusz; Dichiara, Maria; Mogilski, Szczepan; Kalinowska-Tluscik, Justyna; Pilarski, Boguslaw; Leniak, Arkadiusz; Pietrus, Wojciech; Podlewska, Sabina; Popiolek-Barczyk, Katarzyna; Humphrys, Laura J.; Ruiz-Cantero, M. Carmen; Reiner-Link, David; Leitzbach, Luisa; Lazewska, Dorota; Pockes, Steffen; Gorka, Michal; Zmyslowski, Adam; Calmels, Thierry; Cobos, Enrique J.; Marrazzo, Agostino; Stark, Holger; Bojarski, Andrzej J.; Amata, Emanuele; Kiec-Kononowicz, Katarzyna
err分享
err收藏
Trisubstituted 1,3,5-Triazines as Histamine H4 Receptor Antagonists with Promising Activity In Vivo
errMOLECULES
IF4.6
err2023-05-19
err3
errOAAI
errOlejarz-Maciej, Agnieszka; Mogilski, Szczepan; Karcz, Tadeusz; Werner, Tobias; Kaminska, Katarzyna; Kupczyk, Jaroslaw; Honkisz-Orzechowska, Ewelina; Latacz, Gniewomir; Stark, Holger; Kiec-Kononowicz, Katarzyna; Lazewska, Dorota
err分享
err收藏
Guanidines: Synthesis of Novel Histamine H3R Antagonists with Additional Breast Anticancer Activity and Cholinesterases Inhibitory Effect
errPHARMACEUTICALS
IF4.8
err2023-04-30
err4
errOAAI
errStaszewski, Marek; Iwan, Magdalena; Werner, Tobias; Bajda, Marek; Godyn, Justyna; Latacz, Gniewomir; Korga-Plewko, Agnieszka; Kubik, Joanna; Szalaj, Natalia; Stark, Holger; Malawska, Barbara; Wieckowska, Anna; Walczynski, Krzysztof
err分享
err收藏
Adriforant is a functional antagonist of histamine receptor 4 and attenuates itch and skin inflammation in mice
errEUROPEAN JOURNAL OF PHARMACOLOGY
IF4.7
err2023-04-01
err5
PREAI
errUluckan, Ozge; Bruno, Sandro; Wang, Yichen; Wack, Nathalie; Wilzopolski, Jenny; Goetschy, Jean-Francois; Delucis-Bronn, Corinne; Urban, Beatrice; Fehlmann, Dominique; Stark, Holger; Hauchard, Alice; Roussel, Elsa; Kempf, Dominique; Kaupmann, Klemens; Raulf, Friedrich; Baeumer, Wolfgang; Rohn, Till A.; Zerwes, Hans Gunter
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err收藏

研究方向

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合作学者
合作期刊
N
Nicholas G. Martin
H 指数: 221 · 论文数: 2.8K
S
Stephen S. Rich
H 指数: 160 · 论文数: 1.9K
K
Kjell Fuxé
H 指数: 141 · 论文数: 1.7K
A
Andrew P. Morris
H 指数: 139 · 论文数: 765
E
Erik Ingelsson
H 指数: 137 · 论文数: 675
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