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王杰 (Jie Wang)
H指数:39
被引数:8,144
个人简介
"2000-2005年，天津医科大学医学检验学系，医学学士；2005-2008年，北京大学基础医学院病原生物学系，医学硕士；2008-2010年，美国田纳西大学医学院分子科学系，访问学者；2012-2015年，北京大学基础医学院病原生物学系，医学博士；2015年至今，北京大学基础医学院病原生物学系，讲师、副研究员。目前已发表中英文文章90余篇，其中以第一或通讯作者（含并列）在Gut、Journal of Hepatology、Advanced Science、Autophagy、Small、Cell Death & Disease、Oncogene、Journal of Virology、Emerging Microbes & Infections等杂志上发表30余篇SCI论文，获得国家授权发明专利10余项。主持国家自然科学基金原创探索项目、面上项目、北京市自然科学基金、部委融合重点项目（子课题）、科技部“传染病防治”重大专项（任务）等多项科研课题。现任中华医学会肝病学分会青年学组委员及肝炎学组、肝癌学组和肝病基础医学与实验诊断协作组委员，北京医学会肝病学分会常务委员，中华预防医学会促进消除病毒性肝炎工作委员会委员，中国研究型医院学会病毒肿瘤学专业委员会委员等。\n代表性论文（#第一作者，*通讯作者）\n1.Yang X#, Sun H, Luo Z, Zhang Q, Song Y, Li J, Liu X, Wang J*. Anticodon engineered transfer RNA (tRNASUAG) inhibits hepatitis B virus replication by promoting the degradation of core protein. Advanced Science. 2025; e03534.\n2.Li Z#, Song Y#, Huang H#, Chen R, Liu M, Yang X, Luo Z, Liu BM, Wang J*. Highly stable Cas9 promotesHBV genome destruction by antagonizing HSC70-mediated degradation. Emerging Microbes & Infections. 2025, Sep 4:2556728. doi: 10.1080/22221751.2025.2556728. Online ahead of print.\n3.Song Y#, Feng Y#, Jiang Feng#, Xu X#, Yang P#, Liu M, Li L, Du C, Li H, Li Q, Qiao J, Shi J, Yang L, Yao T, Zhang G, Wang J*, Li J*. The HBV seroprevalence and immune responses to hepatitis B vaccination among college students from four universities in China. Vaccine. 2025; 61:127408.\n4.Huang H#, Shi W#, Yan H#, Fan L, Lu J, Long Z, Li X, Li J, Wang J*, Liu L*, Qian J*. Dual roles of CXCR4 (C-X-C motif chemokine receptor 4) in promoting entry of ebolavirus and targeting excessive glycoprotein of reticulophagic degradation to facilitate viral fitness. Autophagy. 2025;Apr 20:1-20. doi: 10.1080/15548627.2025.2492877. Online ahead of print.\n5.Li Y#, Song Y, Xiao Y, Wang T, Li L, Liu M, Li J*, Wang J*. The characteristic of HBV quasispecies is related to occult HBV infection of infants born to highly viremic mothers. Viruses. 2024; 16(7): 1104.\n6.Zheng H#, Liu M#, Shi S#, Huang H, Yang X, Luo Z, Song Y, Xu Q, Li T, Xue L, Lu F, Wang J*. MAP4K4 and WT1 mediate SOX6-induced cellular senescence by synergistically activating the ATF2–TGFb2–Smad2/3 signaling pathway in cervical cancer. Mol Oncol. 2024; 18(5):1327-1346.\n7.Liu M#, Song Y#, Li Y, Yang X, Zhuang H, Li J*, Wang J*.C2729T mutation associated with HBV mother-to-child transmission reduces HBV production via suppressing LHBs expression. Virulence. 2023; 14(1):2189676.\n8.Song Y#, Lu Y, Li Y, Liu M, Zhuang H, Li J*, Wang J*. HBx 128-133 deletion affecting HBV mother-to-child transmission weakens HBV replication via reducing HBx level and CP/ENII transcriptional activity. Viruses. 2022; 14(9):1887.\n9.Huang H#, Han Q#, Zheng H, Liu M, Shi S, Zhang T, Yang X, Li Z, Xu Q, Guo H*,Lu F, Wang J*. MAP4K4 mediates the SOX6-induced autophagy and reduces the chemosensitivity of cervical cancer. Cell Death & Disease. 2022; 13(1):13.\n10.Yu G#, Chen R, Zheng S, Liu Y, Zou J, Gu Z, Jiang B, Gao Q, Dai L*, Peng J*, Wang J*, Lu F*. A standardized assay for the quantitative detection of serum HBV RNA in chronic hepatitis B patients. Emerging Microbes & Infections. 2022; 11(1):775-785.\n11.Li Y#, Xiao Y, Li L, Song Y, Zhai X, Liu J, Duan Z, Yan L, Ding F, Liu J, Zhu L, Jiang J, Zou H, Li L, Liang C, Wang J*, Li J*.The dynamic changes of HBV quasispecies diversity in infancy after immunoprophylaxis failure: a prospective cohort study. Virology Journal. 2021; 18:236.\n12.Lu Y#, Song Y#, Zhai X, Zhu F, Liu J, Chang Z, Li Y, Xiao Y, Li L, Liu M, Liu J, Duan Z, Zou H, Zhuang H, Wang J*, Li J*. Maternal Hepatitis B e Antigen can be an Indicator for Antiviral Prophylaxis of Perinatal Transmission of Hepatitis B Virus. Emerging Microbes & Infections. 2021; 10(1):555-564.\n13.Xiao Y#, Sun K#, Duan Z, Liu Z, Li Y, Yan L, Song Y, Zou H, Liu J, Zhuang H*, Wang J*, Li J*. Quasispecies characteristic in “a” determinant region is a potential predictor for the risk of immunoprophylaxis failure of mother-to-child-transmission of sub-genotype C2 hepatitis B virus: a prospective nested case-control study.Gut. 2020; 69(5):933-941.\n14.Li Y#, Liu Z#, Song Y, Xiao Y, Jiang J, Li L, Zhai X, Liu J, Duan Z, Ding F, Liu J, Zhuang H, Zhu L, Jiang J, Zou H, Wang J*, Li J*. Reduction of the occurrence of occult HBV infection in infants by increasing the dose of hepatitis B vaccine: A large prospective cohort study. Emerging Microbes & Infections. 2020; 9(1):1881-1891.\n15.Shi S#, Liu M, Xi J, Liu H, Guan G, Shen C, Guo Z, Zhang T, Xu Q, Kudereti D, Chen X, Wang J*, Lu F*. Sex-determining region Y box 4 (SOX4) suppresses hepatitis B virus replication by inhibiting hepatocyte nuclear factor 4α expression. Antiviral Research. 2020; 176: 104745.\n16.Chen R#, Huang H#, Liu H, Xi J, Ning J, Zeng W, Shen C, Zhang T, Yu G, Xu Q, Chen X, Wang J*, Lu F*. Friend or Foe? Evidences Indicate Endogenous Exosomes Can Deliver Functional gRNA and Cas9 Protein. Small. 2019;15(38): e1902686.\n17.Wang J#, Chen R#, Zhang R#, Ding S, Zhang T, Yuan Q, Guan G, Chen X, Zhang T, Zhuang H, Nunes F, Block T, Liu S, Duan Z, Xia N*, Xu Z*, Lu F*. The gRNA-miRNA-gRNA ternary cassette combining CRISPR/Cas9 with RNAi approach strongly inhibits hepatitis B virus replication. Theranostics. 2017; 7(12):3090-3105.\n18.Wang J#, Shen T#, Huang X#, Kumar GR#,Chen X,Zeng Z,Zhang R,Chen R,Li T,Zhang T,Yuan Q,Li PC,Huang Q,Colonno R,Jia J,Hou J,McCrae MA,Gao Z*,Ren H*,Xia N*,Zhuang H,Lu F*. Serum hepatitis B virus RNA is encapsidated pregenome RNA that may be associated with persistence of viral infection and rebound. Journal of Hepatology. 2016; 65(4):700-710.\n19.Wang J, Ding S, Duan Z, Xie Q, Zhang T, Zhang X, Wang Y, Chen X*, Zhuang H, Lu F*. The role of p14ARF-HDM2-p53 in SOX6-mediated tumor suppression. Oncogene. 2016; 35(13):1692-1702.\n20.Wang J, Liu B, Wang N, Lee YM, Liu C, Li K*. TRIM 56 is a virus- and interferon-inducible E3 ubiquitin ligase that restricts pestivirus infection. Journal of Virology. 2011; 85(8):3733-3745."
教育背景
2012.01 – 2015.12
北京大学基础医学院病原生物学系 医学博士
2005.01 – 2008.12
北京大学基础医学院病原生物学系 医学硕士
2000.01 – 2005.12
天津医科大学医学检验学系 医学学士
工作经历
2015.01 – 至今
北京大学基础医学院病原生物学系
讲师、副研究员
2008.01 – 2010.12
美国田纳西大学医学院分子科学系
访问学者
荣誉奖项
暂无内容
增加新生儿疫苗剂量或加强免疫接种可预防来自HBsAg和HBeAg阳性母亲的儿童突破性乙型肝炎病毒感染。
npj Vaccines
IF6.5
免疫学特征及其在儿童传染性单核细胞增多症中的临床意义
反密码子工程化转移RNA (tRNASUAG) 通过促进核心蛋白降解抑制乙型肝炎病毒复制
Advanced Science
IF14.1
单细胞和组织中体内RNA-蛋白质相互作用与转录组的共分析
Nature Methods
IF32.1
新型2-(2-噻吩基)-噻唑并[4;5-d]嘧啶-7(6H)-酮类化合物与GABAAR的β+/α–亚基界面结合，作为治疗小鼠癫痫持续状态的正向别构调节剂。
中国四所大学中学生的乙型肝炎病毒（HBV）血清流行率及对乙肝疫苗接种的免疫应答
Vaccine
IF3.5
CXCR4（C-X-C基序趋化因子受体4）在促进埃博拉病毒进入和靶向过量糖蛋白以进行网状自噬降解，从而促进病毒适应性方面具有双重作用。
AUTOPHAGY
IF14.3
Wnt/β-Catenin与Hedgehog之间的串扰支持颅缝中Gli1+谱系成骨。
内吞作用通过去除异位定位的分支配体来限制树突分支。
NATURE COMMUNICATIONS
IF15.7
中国杭州新型冠状病毒肺炎大流行之前和期间住院儿童呼吸道合胞病毒的流行病学和病毒载量
PHARMACOLOGICAL RESEARCH
IF10.5
VIRUSES-BASEL
IF3.5
HELIYON
IF3.6
MOLECULAR ONCOLOGY
IF4.5
RhtA转运体体内进化的靶向c-t-a-g双诱变系统
