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Modeling colorectal cancer: A bio-resource of 50 patient-derived organoid lines 模拟结直肠癌: 50个患者衍生的类器官系的生物资源 Engel, Rebekah M.; Jarde, Thierry; Oliva, Karen; Kerr, Genevieve; Chan, Wing Hei; Hlavca, Sara; Nickless, David; Archer, Stuart K.; Yap, Raymond; Ranchod, Pravin; Bell, Stephen; Niap, Ann; Koulis, Christine; Chong, Ashley; Wilkins, Simon; Dale, Trevor C.; Hollins, Andrew J.; McMurrick, Paul J.; Abud, Helen E. 分享 收藏
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Assessing the mechanism and therapeutic potential of modulators of the human mediator complex-associated protein kinases CDK8 and CDK19 Clarke, Paul A.; Ortiz-Ruiz, Maria-Jesus; Te Poele, Robert; Adeniji-Popoola, Olajumoke; Box, Gary; Esdar, Christina; Ewan, Kenneth; Gowan, Sharon; Brandon, Alexis De Haven; Hewitt, Phllip; Kaufmann, Wolfgang; Mallinger, Aurelie; Raynaud, Florence; Rohdich, Felix; Schiemann, Kai; Simon, Stephanie; Schneider, Richard; Valenti, Melanie; Blagg, Julian; Dale, Trevor; Eccles, Suzanne; Workman, Paul; Wienke, Dirk 分享 收藏
Assessing the mechanism and therapeutic potential of modulators of the human Mediator complex-associated protein kinases Clarke, Paul A.; Ortiz-Ruiz, Maria-Jesus; TePoele, Robert; Adeniji-Popoola, Olajumoke; Box, Gary; Court, Will; Czasch, Stephanie; El Bawab, Samer; Esdar, Christina; Ewan, Ken; Gowan, Sharon; Brandon, Alexis De Haven; Hewitt, Phillip; Hobbs, Stephen M.; Kaufmann, Wolfgang; Mallinger, Aurelie; Raynaud, Florence; Roe, Toby; Rohdich, Felix; Schiemann, Kai; Simon, Stephanie; Schneider, Richard; Valenti, Melanie; Weigt, Stefan; Blagg, Julian; Blaukat, Andree; Dale, Trevor C.; Eccles, Suzanne A.; Hecht, Stefan; Urbahns, Klaus; Workman, Paul; Wienke, Dirk 分享 收藏
Wnt and Neuregulin1/ErbB signalling extends 3D culture of hormone responsive mammary organoids Jarde, Thierry; Lloyd-Lewis, Bethan; Thomas, Mairian; Kendrick, Howard; Melchor, Lorenzo; Bougaret, Lauriane; Watson, Peter D.; Ewan, Kenneth; Smalley, Matthew J.; Dale, Trevor C. 分享 收藏
Structure-Based Optimization of Potent, Selective, and Orally Bioavailable CDK8 Inhibitors Discovered by High-Throughput Screening 通过高通量筛选发现的有效，选择性和口服生物利用度CDK8抑制剂的基于结构的优化 Czodrowski, Paul; Mallinger, Aurelie; Wienke, Dirk; Esdar, Christina; Poeschke, Oliver; Busch, Michael; Rohdich, Felix; Eccles, Suzanne A.; Ortiz-Ruiz, Maria-Jesus; Schneider, Richard; Raynaud, Florence I.; Clarke, Paul A.; Musil, Djordje; Schwarz, Daniel; Dale, Trevor; Urbahns, Klaus; Blagg, Julian; Schiemann, Kai 分享 收藏
Discovery of preclinical development candidate inhibitors of the mediator complex-associated kinases CDK8 and CDK19 and evaluation of their therapeutic potential Clarke, Paul; Esdar, Christina; Mallinger, Aurelie; Schiemann, Kai; Waalboer, Dennis; Crumpler, Simon; Rink, Christian; Stieber, Frank; Calderini, Michel; Adeniji-Popoola, Olajumoke; Ortiz-Ruiz, Maria-Jesus; Samant, Rahul S.; Czodrowski, Paul; Musil, Djordje; Schwarz, Daniel; Schneider, Klaus; Busch, Michael; Stubbs, Mark; Burke, Rosemary; TePoele, Robert; Gowan, Sharon; Rohdich, Felix; Raynaud, Florence; Schneider, Richard; Poeschke, Oliver; Blaukat, Andree; Urbahns, Klaus; Workman, Paul; Kaufmann, Wolfgang; Simon, Stephanie; Eccles, Suzanne A.; Dale, Trevor; Wienke, Dirk; Blagg, Julian 分享 收藏
Discovery of Potent, Selective, and Orally Bioavailable Small-Molecule Modulators of the Mediator Complex-Associated Kinases CDK8 and CDK19 发现介质复合物相关激酶CDK8和CDK19的有效，选择性和口服生物可利用的小分子调节剂 Mallinger, Aurelie; Schiemann, Kai; Rink, Christian; Stieber, Frank; Calderini, Michel; Crumpler, Simon; Stubbs, Mark; Adeniji-Popoola, Olajumoke; Poeschke, Oliver; Busch, Michael; Czodrowski, Paul; Musil, Djordje; Schwarz, Daniel; Ortiz-Ruiz, Maria-Jesus; Schneider, Richard; Thai, Ching; Valenti, Melanie; Brandon, Alexis de Haven; Burke, Rosemary; Workman, Paul; Dale, Trevor; Wienke, Dirk; Clarke, Paul A.; Esdar, Christina; Raynaud, Florence I.; Eccles, Suzanne A.; Rohdich, Felix; Blagg, Julian 分享 收藏
A functional connectome: regulation of Wnt/TCF-dependent transcription by pairs of pathway activators Freeman, Jamie; Smith, David; Latinkic, Branko; Ewan, Ken; Samuel, Lee; Zollo, Massimo; Marino, Natascia; Tyas, Lorraine; Jones, Nick; Dale, Trevor C. 分享 收藏
A selective chemical probe for exploring the role of CDK8 and CDK19 in human disease 用于探索CDK8和CDK19在人类疾病中的作用的选择性化学探针 Dale, Trevor; Clarke, Paul A.; Esdar, Christina; Waalboer, Dennis; Adeniji-Popoola, Olajumoke; Ortiz-Ruiz, Maria-Jesus; Mallinger, Aurelie; Samant, Rahul S.; Czodrowski, Paul; Musil, Djordje; Schwarz, Daniel; Schneider, Klaus; Stubbs, Mark; Ewan, Ken; Fraser, Elizabeth; TePoele, Robert; Court, Will; Box, Gary; Valenti, Melanie; Brandon, Alexis de Haven; Gowan, Sharon; Rohdich, Felix; Raynaud, Florence; Schneider, Richard; Poeschke, Oliver; Blaukat, Andree; Workman, Paul; Schiemann, Kai; Eccles, Suzanne A.; Wienke, Dirk; Blagg, Julian 分享 收藏
THE LONG NON CODING RNA UC.158 MODULATES GROWTH OF Wnt/β;-CATENIN DRIVEN HEPATOCELLULAR CARCINOMA (HCC) Cheong, I. H.; Lampis, A.; Fassan, M.; Paulus-Hock, V.; Vicentini, C.; Hahne, J.; Cascione, L.; Quagliata, L.; Jamieson, T.; Athineos, D.; Veronese, A.; Visone, R.; Murgia, C.; Ferrari, G.; Evans, T. R.; Feng, G. J.; Dale, T.; Boulter, L.; Guest, R.; Forbes, S.; Negrini, M.; Terracciano, L.; Scarpa, A.; Patel, T.; Workman, P.; Sansom, O.; Valeri, N.; Braconi, C. 分享 收藏
WNT-3A Regulates an Axin1/NRF2 Complex That Regulates Antioxidant Metabolism in Hepatocytes Rada, Patricia; Rojo, Ana I.; Offergeld, Anika; Feng, Gui Jie; Velasco-Martin, Juan P.; Manuel Gonzalez-Sancho, Jose; Valverde, Angela M.; Dale, Trevor; Regadera, Javier; Cuadrado, Antonio 分享 收藏
Discovery of Potent, Orally Bioavailable, Small-Molecule Inhibitors of WNT Signaling from a Cell-Based Pathway Screen Mallinger, Aurelie; Crumpler, Simon; Pichowicz, Mark; Waalboer, Dennis; Stubbs, Mark; Adeniji-Popoola, Olajumoke; Wood, Bozena; Smith, Elizabeth; Thai, Ching; Henley, Alan T.; Georgi, Katrin; Court, William; Hobbs, Steve; Box, Gary; Ortiz-Ruiz, Maria-Jesus; Valenti, Melanie; Brandon, Alexis De Haven; TePoele, Robert; Leuthner, Birgitta; Workman, Paul; Aherne, Wynne; Poeschke, Oliver; Dale, Trevor; Wienke, Dirk; Esdar, Christina; Rohdich, Felix; Raynaud, Florence; Clarke, Paul A.; Eccles, Suzanne A.; Stieber, Frank; Schiemann, Kai; Blagg, Julian 分享 收藏
THE ULTRACONSERVED NON CODING RNA UC.158 IS DOWNSTREAM OF THE WNT/β-CATENIN PATHWAY IN LIVER CANCERS Paulus-Hock, V.; Lampis, A.; Ferrari, G.; Boulton, L.; Guest, R.; Athineos, D.; Jamieson, T.; Veronese, A.; Visone, R.; Evans, R.; Feng, G. J.; Dale, T.; Negrini, M.; Forbes, S.; Patel, T.; Sansom, O.; Valeri, N.; Braconi, C. 分享 收藏
Huwe1-Mediated Ubiquitylation of Dishevelled Defines a Negative Feedback Loop in the Wnt Signaling Pathway de Groot, Reinoud E. A.; Ganji, Ranjani S.; Bernatik, Ondrej; Lloyd-Lewis, Bethan; Seipel, Katja; Sedova, Katerina; Zdrahal, Zbynek; Dhople, Vishnu M.; Dale, Trevor C.; Korswagen, Hendrik C.; Bryja, Vitezslav 分享 收藏
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