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R

Reinhard Büttner

University of Cologne
H指数:87
被引数:2.9万

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Rationale and Study Design of the GUIDANCE trial: A Multicenter Phase II Trial of Maintenance Durvalumab and Olaparib After Standard Fist Line Treatment (Carboplatin/Cisplatin, Etoposide, and Durvalumab) in HRD Positive Extensive Disease (ED) Small-cell Lung Cancer (SCLC) (AIO-TRK-0124/ass)

GUIDANCE试验的原理与设计方案：一项多中心II期临床试验，旨在评估标准一线治疗（卡铂/顺铂、依托泊苷和度伐利尤单抗）后，对HRD阳性广泛期（ED）小细胞肺癌（SCLC）患者进行度伐利尤单抗和奥拉帕利维持治疗的疗效（AIO-TRK-0124/ass）

Clinical Lung Cancer
IF3.3
2026-09-010
PRE
Riedel, Richard; Verheyen, Malte; Michels, Sebastian; Ruge, Lea; Stilianakis, Sofia; Jakob, Carolin; Scharpenseel, Heather; Scheffler, Matthias; Nogova, Lucia; Schulmann, Karsten; Bozorgmehr, Farastuk; Grohe, Christian; Griesinger, Frank; Welter, Vanessa; Fassunke, Jana; Siemanowski-Hrach, Janna; Tolkach, Yuri; Siebolts, Udo; Merkelbach-Bruse, Sabine; Buettner, Reinhard; Wolf, Jurgen; John, Felix
Pitfalls in detecting MET exon 14 skipping variants by DNA- and RNA- based next generation sequencing technologies in a large real-world cohort and results of the first multinational EQA schemes

在大型真实世界队列中，通过基于DNA和RNA的下一代测序技术检测MET外显子14跳跃变异的陷阱及首个跨国EQA方案的初步结果

the journal of molecular diagnostics
IF0
2026-06-040
PRE
Carina Heydt; Michaela Angelika Ihle; Katharina Ilm; Jan Rehker; Peony Poon; Janna Siemanowski-Hrach; Roberto Pappesch; Svenja Wagener-Ryczek; Christoph Jonas; Jana Fassunke; Richard Riedel; Anne Maria Schultheis; Reinhard Buettner; Sabine Merkelbach-Bruse; Udo Siebolts
An agentic framework for autonomous scientific discovery in cancer pathology

面向癌症病理自主科学发现的智能框架

Nature Medicine
IF50
2026-04-290
OAAI
Florian Trost; Bide Zhang; Ines Aring; Marcus Bauer; Lennert Glamann; Michael Wessolly; Kyra Johnson; Heike Göbel; Tristan Lerbs; Taban Sangenne; Peter Herrmann; Fabian Mairinger; Christopher Kopp; Sebastian Michels; Anna Rasokat; Matthias Heldwein; Steffen Wagner; Birgid Schömig-Markiefka; Jürgen Wolf; Sylvia Hartmann; Claudia Wickenhauser; Andrey Bychkov; Jens Peter Klussmann; Alexander Quaas; Reinhard Buettner; Yuri Tolkach
Expression of cFLIP in B cells is essential for diffuse large B-cell lymphoma pathogenesis

B细胞中cFLIP的表达对弥漫大B细胞淋巴瘤的发病机制至关重要

Blood
IF23.1
2026-04-250
OAAI
Kristie T. Bariboloka; Santiago Serrano-Saenz; Deniz Pinar Savcigil; Sarah Spöck; Rebecca E. Poss; Luca D. Schreurs; Jens Löber; Nazli Serin; Justinas Valiulis; Kalvin Nugraha; Giulia Gangarossa; Anna Lütz; Moritz Reese; Sebastian Klein; Julius C Enssle; Reinhard Buettner; Hamid Kashkar; Martin Peifer; Björn Chapuy; Gero Knittel
ERBB2 signaling drives immune cell evasion and resistance against immunotherapy in small cell lung cancer

ERBB2信号驱动小细胞肺癌中的免疫细胞逃逸以及对免疫治疗的抵抗

Nature Communications
IF15.7
2025-12-090
OA
Lydia Meder; Charlotte I. Orschel; Cyrielle L. Bouchez; Rahil Gholamipoorfard; Claudia V. Orschel; David Stahl; Christoph Kreer; Mirjam Koker; Marieke Nill; Ilayda G. Kocak; Ka-Won Noh; Xinlei Zhao; Leon Ullrich; Björn Häupl; Josefine Jakob; Marie-Lisa Eich; Alexandra Florin; Holger Grüll; Jürgen Wolf; Filippo Beleggia; Reinhard Büttner; Thomas Oellerich; Florian Klein; Johannes Brägelmann; H. Christian Reinhardt; Nima Abedpour; Roland T. Ullrich
AI-powered spatial cell phenomics enhances risk stratification in non-small cell lung cancer

人工智能驱动的空间细胞表型学增强非小细胞肺癌的风险分层

Nature Communications
IF15.7
2025-11-030
OAAI
Simon Schallenberg; Gabriel Dernbach; Sharon Ruane; Philipp Jurmeister; Cornelius Böhm; Kai Standvoss; Sandip Ghosh; Marco Frentsch; Mihnea P. Dragomir; Philipp G. Keyl; Corinna Friedrich; Il-Kang Na; Sabine Merkelbach-Bruse; Alexander Quaas; Nikolaj Frost; Kyrill Boschung; Winfried Randerath; Georg Schlachtenberger; Matthias Heldwein; Ulrich Keilholz; Khosro Hekmat; Jens-Carsten Rückert; Reinhard Büttner; Angela Vasaturo; David Horst; Lukas Ruff; Maximilian Alber; Klaus-Robert Müller; Frederick Klauschen
Comparison of glass-based and whole-slide image-based grade assignment for clear-cell and papillary renal cell carcinoma: a multi-cohort, international reproducibility study

基于玻璃和全切片图像的分级分配比较：透明细胞和乳头状肾细胞癌的多队列、国际可重复性研究

Histopathology
IF4.1
2025-10-310
PRE
Julian Westerdorf; Maria Tretiakova; Richard Weiten; Alexey Pryalukhin; Alexander Quaas; Henning Reis; Nadine Therese Gaisa; Ibrahim Fahoum; Hoa Pham; Tarek A Bismar; Joema Felipe Lima; Marie-Lisa Eich; Nina A Lasnitschka; Wolfgang Hulla; Axel Heidenreich; George J Netto; Reinhard Büttner; Pia Paffenholz; Yuri Tolkach
Ubiquitin precursor with C-terminal extension promotes proteostasis and longevity

泛素前体具有C末端延伸可促进蛋白质稳态和长寿

Molecular Cell
IF16.6
2025-09-230
PREAI
Selver Altin; Tânia Simões; Christina Behrendt; Vincent Anton; Dennis Domke; Kai Mayor Völtzke; Rajesh Kumar; Hendrik Nolte; Thomas Hermanns; Nahal Brocke-Ahmadinejad; Katja Bendrin; Marcel Zimmermann; Reinhard Büttner; Natascia Ventura; Marcus Krüger; R. Jürgen Dohmen; Kay Hofmann; Thorsten Hoppe; Andreas S. Reichert; Mafalda Escobar-Henriques
Publisher Correction: Functional synapses between neurons and small cell lung cancer

出版更正：神经元和小细胞肺癌之间的功能性突触

Nature
IF48.5
2025-09-190
OAAI
Vignesh Sakthivelu; Anna Schmitt; Franka Odenthal; Kristiano Ndoci; Marian Touet; Ali H. Shaib; Abdulla Chihab; Gulzar A. Wani; Pascal Nieper; Griffin G. Hartmann; Isabel Pintelon; Ilmars Kisis; Maike Boecker; Naja M. Eckert; Manoela Iannicelli Caiaffa; Olta Ibruli; Julia Weber; Roman Maresch; Christina M. Bebber; Ali Chitsaz; Anna Lütz; Mira Kim Alves Carpinteiro; Kaylee M. Morris; Camilla A. Franchino; Jonas Benz; Laura Pérez-Revuelta; Jorge A. Soriano-Campos; Maxim A. Huetzen; Jonas Goergens; Milica Jevtic; Hannah M. Jahn-Kelleter; Hans Zempel; Aleksandra Placzek; Alexandru A. Hennrich; Karl-Klaus Conzelmann; Hannah L. Tumbrink; Pascal Hunold; Joerg Isensee; Lisa Werr; Felix Gaedke; Astrid Schauss; Marielle Minère; Marie Müller; Henning Fenselau; Yin Liu; Alena Heimsoeth; Gülce S. Gülcüler Balta; Henning Walczak; Christian Frezza; Ron D. Jachimowicz; Julie George; Marcel Schmiel; Johannes Brägelmann; Tim Hucho; Silvia von Karstedt; Martin Peifer; Alessandro Annibaldi; Robert Hänsel-Hertsch; Thorsten Persigehl; Holger Grüll; Martin L. Sos; Guido Reifenberger; Matthias Fischer; Dirk Adriaensen; Reinhard Büttner; Julien Sage; Inge Brouns; Roland Rad; Roman K. Thomas; Max Anstötz; Silvio O. Rizzoli; Matteo Bergami; Elisa Motori; Hans Christian Reinhardt; Filippo Beleggia
Functional synapses between neurons and small cell lung cancer

神经元与小细胞肺癌之间的功能性突触

Nature
IF48.5
2025-09-100
OA
Vignesh Sakthivelu; Anna Schmitt; Franka Odenthal; Kristiano Ndoci; Marian Touet; Ali H. Shaib; Abdulla Chihab; Gulzar A. Wani; Pascal Nieper; Griffin G. Hartmann; Isabel Pintelon; Ilmars Kisis; Maike Boecker; Naja M. Eckert; Manoela Ianicelli Caiaffa; Olta Ibruli; Julia Weber; Roman Maresch; Christina M. Bebber; Ali Chitsaz; Anna Lütz; Mira Kim Alves Carpinteiro; Kaylee M. Morris; Camilla A. Franchino; Jonas Benz; Laura Pérez-Revuelta; Jorge A. Soriano-Campos; Maxim A. Huetzen; Jonas Goergens; Milica Jevtic; Hannah M. Jahn-Kelleter; Hans Zempel; Aleksandra Placzek; Alexandru A. Hennrich; Karl-Klaus Conzelmann; Hannah L. Tumbrink; Pascal Hunold; Joerg Isensee; Lisa Werr; Felix Gaedke; Astrid Schauss; Marielle Minère; Marie Müller; Henning Fenselau; Yin Liu; Alena Heimsoeth; Gülce S. Gülcüler Balta; Henning Walczak; Christian Frezza; Ron D. Jachimowicz; Julie George; Marcel Schmiel; Johannes Brägelmann; Tim Hucho; Silvia von Karstedt; Martin Peifer; Alessandro Annibaldi; Robert Hänsel-Hertsch; Thorsten Persigehl; Holger Grüll; Martin L. Sos; Guido Reifenberger; Matthias Fischer; Dirk Adriaensen; Reinhard Büttner; Julien Sage; Inge Brouns; Roland Rad; Roman K. Thomas; Max Anstötz; Silvio O. Rizzoli; Matteo Bergami; Elisa Motori; Hans Christian Reinhardt; Filippo Beleggia
Imaging mass cytometry dataset of small-cell lung cancer tumors and tumor microenvironments

小细胞肺癌肿瘤及肿瘤微环境的成像质谱 cytometry 数据集

BMC RESEARCH NOTES
IF1.7
2025-09-080
OAAI
Rose, France; Ibruli, Olta; Lichius, Luca; Kiljan, Martha; Gozum, Gokcen; Caiaffa, Manoela Iannicelli; Cai, Jiali; Niu, Li-na; Herter, Jan M.; Grull, Holger; Buttner, Reinhard; Beleggia, Filippo; Bosco, Graziella; George, Julie; Herter-Sprie, Grit S.; Reinhardt, Hans Christian; Bozek, Katarzyna
AI Algorithm for Lung Adenocarcinoma Pattern Quantification (PATQUANT): International Validation and Advanced Risk Stratification Superior to Conventional Grading

肺癌腺癌模式量化（PATQUANT）的AI算法：国际验证及优于传统分级的先进风险分层

MedComm
IF10.7
2025-09-080
OAAI
Yuan Wang; Kris Lami; Waleed Ahmad; Simon Schallenberg; Andrey Bychkov; Yuanzi Ye; Danny Jonigk; Xiaoya Zhu; Sofia Campelos; Anne Schultheis; Matthias Heldwein; Alexander Quaas; Ales Ryska; Andre L. Moreira; Junya Fukuoka; Reinhard Büttner; Yuri Tolkach

研究方向

暂未获取到该数据
S
Sabine Merkelbach‐Bruse
H 指数:55论文数:373被引数:9,624
H
Hans Christian Reinhardt
H 指数:49论文数:547被引数:9,507
M
Martin Peifer
H 指数:73论文数:477被引数:3.3万
A
Alexander Quaas
H 指数:48论文数:491被引数:7,790
R
Roman K. Thomas
H 指数:76论文数:488被引数:3.6万
C
Christoph Engel
H 指数:92论文数:691被引数:3.6万
C
Carina Heydt
H 指数:26论文数:108被引数:2,652
T
Thorsten Persigehl
H 指数:38论文数:390被引数:7,228
E
Eva Wardelmann
H 指数:70论文数:689被引数:2.2万
L
Lukas C. Heukamp
H 指数:65论文数:442被引数:1.7万