David J. Tweardy - Publications, H-index & Citations

David J. Tweardy

the university of texas md anderson cancer center

60H指数

339论文数

1.3W被引数

收录论文 87

发表时间

STAT3 Inhibition to Treat Ulcerative Colitis-Associated Colorectal Cancer STAT3 抑制治疗溃疡性结肠炎相关结直肠癌

International Journal of Molecular Sciences

IF4.9

2026-03-03

OAAI

Prema Robinson; Zal Italia; Zara Italia; Tan Hoang; Emma Rodriguez; T. Kris Eckols; Moses Kasembeli; Leticia Hamana Zorrilla; Luisa Maren Solis Soto; Rajasekaran Mahalingam; David J. Tweardy

Update on Structure and Function of SH2 Domains: Mechanisms and Emerging Targeting Strategies SH2结构域的结构与功能研究进展：机制及新兴靶向策略

International Journal of Molecular Sciences 2025, Vol. 26, Page 9060

IF4.9

2025-09-21

OAAI

Moses M. Kasembeli; Jorge Rodas; David J. Tweardy

IL-6 predicts CDK4/6 inhibitor resistance, identifying STAT3 as a target in HR + /HER2-negative metastatic breast cancer IL-6预测CDK4/6抑制剂耐药性，确定STAT3为HR + /HER2阴性转移性乳腺癌的靶点

npj Precision Oncology

IF8

2025-07-25

OAAI

Nicole M. Kettner; Tuyen N. Bui; Juliana Navarro-Yepes; Sanaz Ghotbaldini; Bethanie Quintela; Catherine K. Luo; Nghi Lam; Xiayu Rao; Akshara Singareeka Raghavendra; Yan Wang; Nancy Azizian; T. Kris Eckols; Moses Makokha Kasembeli; Kurt Evans; Min Yi; Hannah Wingate; Jing Wang; Aysegul A. Sahin; Funda Meric-Bernstam; Kelly K. Hunt; Senthil Damodaran; David J. Tweardy; Debu Tripathy; Khandan Keyomarsi

Selective inhibition of canonical STAT3 signaling suppresses K-ras mutant lung tumorigenesis and reinvigorates anti-tumor immunity 选择性抑制经典STAT3信号通路可抑制K-ras突变型肺癌发生并增强抗肿瘤免疫。

FRONTIERS IN IMMUNOLOGY

IF5.9

2025-04-28

OAAI

Clowers, Michael J.; Rahal, Zahraa; Cho, Sung-Nam; Krishna, Avantika; Yuan, Bo; Zorrilla, Leticia G. Hamana; Eckols, T. Kris; Kasembeli, Moses M.; Liu, Samuel; Peng, Stephen; Ramos-Castaneda, Marco; Thompson, Annamarie L.; Reyna, Carlos Ignacio Rodriguez; Larsen, Katherine E.; Grimaldo, Maria T.; Deng, Shanshan; Karimi, Nastaran; Chou, Cody; Velasco, Walter V.; Zarghooni, Melody; Alekseev, Sayan; Soto, Luisa M. Solis; Ostrin, Edwin J.; Kadara, Humam; Ekmekcioglu, Suhendan; Tweardy, David J.; Moghaddam, Seyed Javad

Reduced intranuclear mobility of APL fusion proteins accompanies their mislocalization and results in sequestration and decreased mobility of retinoid X receptor α

MOLECULAR AND CELLULAR BIOLOGY

IF2.7

2023-03-27

OAAI

Dong, S; Stenoien, DL; Qiu, JH; Mancini, MA; Tweardy, DJ

Spatial molecular and cellular determinants of STAT3 activation in liver fibrosis progression in non-alcoholic fatty liver disease

JHEP REPORTS

IF7.5

2023-02-01

OAAI

Jiao, Jingjin; Sanchez, Jessica I.; Saldarriaga, Omar A.; Solis, Luisa M.; Tweardy, David J.; Maru, Dipen M.; Stevenson, Heather L.; Beretta, Laura

Genetic and Small-Molecule Modulation of Stat3 in a Mouse Model of Crohn's Disease 克罗恩病小鼠模型中Stat3的遗传和小分子调节

JOURNAL OF CLINICAL MEDICINE

IF2.9

2022-11-28

OAAI

Robinson, Prema; Magness, Emily; Montoya, Kelsey; Engineer, Nikita; Eckols, Thomas K.; Rodriguez, Emma; Tweardy, David J.

TTI-101: A competitive inhibitor of STAT3 that spares oxidative phosphorylation and reverses mechanical allodynia in mouse models of neuropathic pain (vol 192, 114688, 2021)

BIOCHEMICAL PHARMACOLOGY

IF5.6

2022-01-01

OAAI

Kasembeli, Moses M.; Singhmar, Pooja; Ma, Jiacheng; Edralin, Jules; Tang, Yongfu; Adams, Clydell, III; Heijnen, Cobi J.; Kavelaars, Annemieke; Tweardy, David J.

TTI-101: A competitive inhibitor of STAT3 that spares oxidative phosphorylation and reverses mechanical allodynia in mouse models of neuropathic pain

BIOCHEMICAL PHARMACOLOGY

IF5.6

2021-10-01

OAAI

Kasembeli, Moses M.; Singhmar, Pooja; Ma, Jiacheng; Edralin, Jules; Tang, Yongfu; Adams, Clydell, III; Heijnen, Cobi J.; Kavelaars, Annemieke; Tweardy, David J.

Novel STAT3 small-molecule inhibitors identified by structure-based virtual ligand screening incorporating SH2 domain flexibility

PHARMACOLOGICAL RESEARCH

IF10.5

2021-07-01

OAAI

Kong, Ren; Bharadwaj, Uddalak; Eckols, T. Kris; Kolosov, Mikhail; Wu, Haoyi; Cruz-Pavlovich, Francisco J. Santa; Shaw, Alison; Ifelayo, Oluwatomilona I.; Zhao, Hong; Kasembeli, Moses M.; Wong, Stephen T. C.; Tweardy, David J.

Pharmacokinetics and pharmacodynamics of TTI-101, a STAT3 inhibitor that blocks muscle proteolysis in rats with chronic kidney disease

AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY

IF3.4

2020-07-01

OAAI

Zhang, Liping; Wang, Ying; Dong, Yanlan; Chen, Zihong; Eckols, Thomas K.; Kasembeli, Moses M.; Tweardy, David J.; Mitch, William E.

Targeting Janus Kinases and Signal Transducer and Activator of Transcription 3 to Treat Inflammation, Fibrosis, and Cancer: Rationale, Progress, and Caution

PHARMACOLOGICAL REVIEWS

IF17.3

2020-04-01

203

OAAI

Bharadwaj, Uddalak; Kasembeli, Moses M.; Robinson, Prema; Tweardy, David J.

STAT3 as a therapeutic target in estrogen receptor positive breast cancer patients refractory to CDK4/6 inhibition

CANCER RESEARCH

IF16.6

2020-02-15

PREAI

Kettner, Nicole M.; Bui, Tuyen; Ha, Min Jin; Eckols, T. Kris; Tweardy, David J.; Meric-Bernstam, Funda; Hunt, Kelly K.; Tripathy, Debu; Keyomarsi, Khandan

Bempegaldesleukin selectively depletes intratumoral Tregs and potentiates T cell-mediated cancer therapy

NATURE COMMUNICATIONS

IF15.7

2020-01-31

128

OAAI

Sharma, Meenu; Hiep Khong; Fa'ak, Faisal; Bentebibel, Salah-Eddine; Janssen, Louise M. E.; Chesson, Brent C.; Creasy, Caitlin A.; Forget, Marie-Andree; Kahn, Laura Maria S.; Pazdrak, Barbara; Karki, Binisha; Hailemichael, Yared; Singh, Manisha; Vianden, Christina; Vennam, Srinivas; Bharadwaj, Uddalak; Tweardy, David J.; Haymaker, Cara; Bernatchez, Chantale; Huang, Shixia; Rajapakshe, Kimal; Coarfa, Cristian; Hurwitz, Michael E.; Sznol, Mario; Hwu, Patrick; Hoch, Ute; Addepalli, Murali; Charych, Deborah H.; Zalevsky, Jonathan; Diab, Adi; Overwijk, Willem W.

Combined inhibition of STAT-3 & DNA repair in palbociclib resistant breast cancer

CANCER RESEARCH

IF16.6

2019-07-01

PREAI

Kettner, Nicole M.; Vijayaraghavan, Smruthi; Durak, Merih Guray; Bui, Tuyen; Kohansal, Mehrnoosh; Ha, Min Jin; Liu, Bin; Rao, Xiayu; Yang, Jing; Yi, Min; Carey, Jason P.; Chen, Xian; Eckols, T. Kris; Raghavendra, Akshara S.; Ibrahim, Nuhad K.; Karuturi, Meghan; Watowich, Stephanie S.; Sahin, Aysegul A.; Tweardy, David J.; Hunt, Kelly K.; Tripathy, Debu; Keyomarsi, Khandan

Novel STAT3 inhibitors identified by Structure-Based Virtual Ligand Screening incorporating SH2 domain flexibility

CANCER RESEARCH

IF16.6

2019-07-01

PREAI

Kong, Ren; Bharadwaj, Uddalak; Eckols, Thomas Kris; Kasembeli, Moses; Kolosov, Mikhail; Anh Tran; Ifelayo, Oluwatomilona I.; Zhao, Hong; Wong, Stephen T.; Tweardy, David J.

Intratumoral CD40 activation and checkpoint blockade induces T cell-mediated eradication of melanoma in the brain

NATURE COMMUNICATIONS

IF15.7

2017-11-13

OAAI

Singh, Manisha; Vianden, Christina; Cantwell, Mark J.; Dai, Zhimin; Xiao, Zhilan; Sharma, Meenu; Khong, Hiep; Jaiswal, Ashvin R.; Faak, Faisal; Hailemichael, Yared; Janssen, L. M. E.; Bharadwaj, Uddalak; Curran, Michael A.; Diab, Adi; Bassett, Roland L.; Tweardy, David J.; Hwu, Patrick; Overwijk, Willem W.

Estrogen Replacement Reduces Risk and Increases Survival Times of Women With Hepatocellular Carcinoma

CLINICAL GASTROENTEROLOGY AND HEPATOLOGY

IF12

2017-11-01

OAAI

Hassan, Manal M.; Botrus, Gehan; Abdel-Wahab, Reham; Wolff, Robert A.; Li, Donghui; Tweardy, David; Phan, Alexandria T.; Hawk, Ernest; Javle, Milind; Lee, Ju-Seog; Torres, Harrys A.; Rashid, Asif; Lenzi, Renato; Hassabo, Hesham M.; Abaza, Yasmin; Shalaby, Ahmed S.; Lacin, Sahin; Morris, Jeffrey; Patt, Yehuda Z.; Amos, Christopher I.; Khaderi, Saira A.; Goss, John A.; Jalal, Prasun K.; Kaseb, Ahmed O.

Diminution of signal transducer and activator of transcription 3 signaling inhibits vascular permeability and anaphylaxis

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

IF11.2

2016-07-01

OAAI

Hox, Valerie; O'Connell, Michael P.; Lyons, Jonathan J.; Sackstein, Paul; Dimaggio, Thomas; Jones, Nina; Nelson, Celeste; Boehm, Manfred; Holland, Steven M.; Freeman, Alexandra F.; Tweardy, David J.; Olivera, Ana; Metcalfe, Dean D.; Milner, Joshua D.

STAT3 inhibition prevents lung inflammation, remodeling, and accumulation of Th2 and Th17 cells in a murine asthma model

ALLERGY

IF12

2016-06-23

106

PREAI

Gavino, A. C.; Nahmod, K.; Bharadwaj, U.; Makedonas, G.; Tweardy, D. J.

研究方向