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K

Karen E. Swales

The Institute of Cancer Research
H指数:24
被引数:1,973

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Tumor control and immune activation through palliative irradiation and ATR inhibition, PATRIOT Part C: a phase Ib trial

通过姑息性放疗和ATR抑制实现肿瘤控制和免疫激活，PATRIOT Part C：一项 Ib 期临床试验

Nature Communications
IF15.7
2025-08-010
OAAI
Magnus T. Dillon; Emmanuel C. Patin; Kabir Mohammed; Jeane Guevara; Simon A. Smith; Emma Dean; Heba Soliman; Pablo Nenclares; Motoko Ryugenji; Davina Northcote; Neel Shah; Lorna Grove; Christopher J. Lord; Stephen Pettit; Matt Tall; Karen E. Swales; Udai Banerji; Alan A. Melcher; Mark Saunders; Martin D. Forster; Kevin J. Harrington
Defactinib with avutometinib in patients with solid tumors: the phase 1 FRAME trial

德法替尼联合阿瓦替尼治疗实体瘤患者: 1期框架试验

Nature Medicine
IF50
2025-06-270
OAAI
Susana Banerjee; Matthew G. Krebs; Alastair Greystoke; Alvaro Ingles Garces; Vicky Sanchez Perez; Angelika Terbuch; Rajiv Shinde; Reece Caldwell; Rafael Grochot; Mahtab Rouhifard; Ruth Ruddle; Bora Gurel; Karen Swales; Nina Tunariu; Toby Prout; Mona Parmar; Stefan Symeonides; Jan Rekowski; Christina Yap; Adam Sharp; Alec Paschalis; Juanita Lopez; Anna Minchom; Johann Sebastian de Bono; Udai Banerji
Proof-of-concept and preliminary efficacy of triple IAP blockade to maximize immunogenic cell death and induce efficient adaptive immune response: First report on the ASTEROID phase 1 trial
CANCER RESEARCH
IF16.6
2024-04-050
PRE
Tiu, Crescens; Yau, Wing; Sanchez-Perez, Victoria; Codacci-Pisanelli, Giovanni; Leung, Ching; Andrews, Eden S.; Basu, Bristi; Zachariou, Anna; Prout, Toby; Parmar, Mona; Turner, Alison; Lai, Xiaoran; Yin, Zhulin; Swales, Karen E.; Haider, Syed; Lund, Thomas; Dos Reis, Diego C.; Silveira, Tatiany L.; Dunlop, Alan S.; Baker, Ann-Marie; Gurel, Bora; Ferreira, Ana; Bertan, Claudia; Tunariu, Nina; Johnston, Edward W.; Ring, Alistair; Tenev, Tencho; Smyth, Tomoko; Jueliger, Simone; Banerji, Udai; de Bono, Johann S.; Paschalis, Alec; Sharp, Adam; Minchom, Anna; Yap, Christina; Meier, Pascal; Lopez, Juanita S.
Durable responses to ATR inhibition with ceralasertib in tumors with genomic defects and high inflammation
JOURNAL OF CLINICAL INVESTIGATION
IF13.6
2024-01-168
OAAI
Dillon, Magnus T.; Guevara, Jeane; Mohammed, Kabir; Patin, Emmanuel C.; Smith, Simon A.; Dean, Emma; Jones, Gemma N.; Willis, Sophie E.; Petrone, Marcella; Silva, Carlos; Thway, Khin; Bunce, Catey; Roxanis, Ioannis; Nenclares, Pablo; Wilkins, Anna; Mclaughlin, Martin; Jayme-Laiche, Adoracion; Benafif, Sarah; Nintos, Georgios; Kwatra, Vineet; Grove, Lorna; Mansfield, David; Proszek, Paula; Martin, Philip; Moore, Luiza; Swales, Karen E.; Banerji, Udai; Saunders, Mark P.; Spicer, James; Forster, Martin D.; Harrington, Kevin J.
Results of a phase 1 dose escalation clinical trial of NXP800, a novel GCN2 activator, in patients with advanced or metastatic solid tumors
MOLECULAR CANCER THERAPEUTICS
IF5.5
2023-12-010
PRE
Banerji, Udai; Pacey, Simon; Finkelstein, Karen; Rodney, Simon; DosReis, Ana Filipa Palma; Codaccipisanelli, Giovanni; Sloan, Mark; Raynaud, Florence I.; Ruddle, Ruth; Swales, Karen; Tall, Matthew; Shemesh, Shay; Marsolini, Diane; Sardone, Megan; Hay, Justin; Bliss, Robin; Poradosu, Enrique; Workman, Paul
Targeting myeloid chemotaxis to reverse prostate cancer therapy resistance

靶向髓系趋化逆转前列腺癌治疗耐药

Nature
IF48.5
2023-10-160
OAAI
Christina Guo; Adam Sharp; Bora Gurel; Mateus Crespo; Ines Figueiredo; Suneil Jain; Ursula Vogl; Jan Rekowski; Mahtab Rouhifard; Lewis Gallagher; Wei Yuan; Suzanne Carreira; Khobe Chandran; Alec Paschalis; Ilaria Colombo; Anastasios Stathis; Claudia Bertan; George Seed; Jane Goodall; Florence Raynaud; Ruth Ruddle; Karen E. Swales; Jason Malia; Denisa Bogdan; Crescens Tiu; Reece Caldwell; Caterina Aversa; Ana Ferreira; Antje Neeb; Nina Tunariu; Daniel Westaby; Juliet Carmichael; Maria Dolores Fenor de la Maza; Christina Yap; Ruth Matthews; Hannah Badham; Toby Prout; Alison Turner; Mona Parmar; Holly Tovey; Ruth Riisnaes; Penny Flohr; Jesus Gil; David Waugh; Shaun Decordova; Anna Schlag; Bianca Calì; Andrea Alimonti; Johann S. de Bono
Preliminary evidence of antitumor activity of Ipatasertib (Ipat) and Atezolizumab (A) in glioblastoma (GBM) patients (pts) with PTEN loss in the Phase 1 Ice-CAP trial (NCT03673787)
CANCER RESEARCH
IF16.6
2023-04-142
PRE
Tiu, Crescens; Yau, Wing Hing; Welsh, Liam C.; Jones, Timothy L.; Zachariou, Anna; Prout, Toby; Parmar, Mona; Turner, Alison J.; Daly, Robert W.; Yap, Christina; Crespo, Mateus; Gurel, Bora; Riisnaes, Ruth M.; DeCordova, Shaun A.; Swales, Karen E.; Banerji, Udai; Minchom, Anna R.; Sharp, Adam; de Bono, Johann S.; Lopez, Juanita S.
Triplet Therapy with Palbociclib, Taselisib, and fulvestrant in PIK3CA-Mutant Breast Cancer and Doublet Palbociclib and Taselisib in Pathway-Mutant Solid Cancers
CANCER DISCOVERY
IF33.3
2021-01-0645
OAAI
Pascual, Javier; Lim, Joline S. J.; Macpherson, Iain R.; Armstrong, Anne C.; Ring, Alistair; Okines, Alicia F. C.; Cutts, Rosalind J.; Herrera-Abreu, Maria Teresa; Garcia-Murillas, Isaac; Pearson, Alex; Hrebien, Sarah; Gevensleben, Heidrun; Proszek, Paula Z.; Hubank, Michael; Hills, Margaret; King, Jenny; Parmar, Mona; Prout, Toby; Finneran, Laura; Malia, Jason; Swales, Karen E.; Ruddle, Ruth; Raynaud, Florence, I; Turner, Alison; Hall, Emma; Yap, Timothy A.; Lopez, Juanita S.; Turner, Nicholas C.
Phase I Trial of the PARP Inhibitor Olaparib and AKT Inhibitor Capivasertib in Patients with BRCA1/2- and Non-BRCA1/2-Mutant Cancers

PARP抑制剂Olaparib和AKT抑制剂Capivasertib在BRCA1/2和Non-BRCA1/2突变型癌症患者中的I期试验

CANCER DISCOVERY
IF33.3
2020-10-0192
OAAI
Yap, Timothy A.; Kristeleit, Rebecca; Michalarea, Vasiliki; Pettitt, Stephen J.; Lim, Joline S. J.; Carreira, Suzanne; Roda, Desamparados; Miller, Rowan; Riisnaes, Ruth; Miranda, Susana; Figueiredo, Ines; Rodrigues, Daniel Nava; Ward, Sarah; Matthews, Ruth; Parmar, Mona; Turner, Alison; Tunariu, Nina; Chopra, Neha; Gevensleben, Heidrun; Turner, Nicholas C.; Ruddle, Ruth; Raynaud, Florence, I; Decordova, Shaun; Swales, Karen E.; Finneran, Laura; Hall, Emma; Rugman, Paul; Lindemann, Justin P. O.; Foxley, Andrew; Lord, Christopher J.; Banerji, Udai; Plummer, Ruth; Basu, Bristi; Lopez, Juanita S.; Drew, Yvette; de Bono, Johann S.
A phase I dose-escalation study of enzalutamide in combination with the AKT inhibitor AZD5363 (capivasertib) in patients with metastatic castration-resistant prostate cancer

恩扎鲁他胺联合AKT抑制剂AZD5363 (capivasertib) 在转移性去势抵抗性前列腺癌患者中的I期剂量递增研究

ANNALS OF ONCOLOGY
IF65.4
2020-05-0163
OAAI
Kolinsky, M. P.; Rescigno, P.; Bianchini, D.; Zafeirio, Z.; Mehra, N.; Mateo, J.; Michalarea, V.; Riisnaes, R.; Crespo, M.; Figueiredo, I.; Miranda, S.; Rodrigues, D. Nava; Flohr, P.; Tunariu, N.; Banerji, U.; Ruddle, R.; Sharp, A.; Welti, J.; Lambros, M.; Carreira, S.; Raynaud, F. I.; Swales, K. E.; Plymate, S.; Luo, J.; Tovey, H.; Porta, N.; Slade, R.; Leonard, L.; Hall, E.; de Bono, J. S.
Vistusertib (dual m-TORC1/2 inhibitor) in combination with paclitaxel in patients with high-grade serous ovarian and squamous non-small-cell lung cancer
ANNALS OF ONCOLOGY
IF65.4
2018-09-0125
OAAI
Basu, B.; Krebs, M. G.; Sundar, R.; Wilson, R. H.; Spicer, J.; Jones, R.; Brada, M.; Talbot, D. C.; Steele, N.; Garces, A. H. Ingles; Brugger, W.; Harrington, E. A.; Evans, J.; Hall, E.; Tovey, H.; de Oliveira, F. M.; Carreira, S.; Swales, K.; Ruddle, R.; Raynaud, F. I.; Purchase, B.; Dawes, J. C.; Parmar, M.; Turner, A. J.; Tunariu, N.; Banerjee, S.; de Bono, J. S.; Banerji, U.
A phase I pharmacokinetic and pharmacodynamic study of the oral mitogen-activated protein kinase kinase (MEK) inhibitor, WX-554, in patients with advanced solid tumours
EUROPEAN JOURNAL OF CANCER
IF7.1
2016-11-0113
OAAI
Jamieson, David; Griffin, Melanie J.; Sludden, Julieann; Drew, Yvette; Cresti, Nicola; Swales, Karen; Merriman, Mark; Allen, Rodger; Bevan, Paul; Buerkle, Markus; Mala, Carola; Coyle, Vicky; Rodgers, Lisa; Dean, Emma; Greystoke, Alastair; Banerji, Udai; Wilson, Richard H.; Evans, T. R. Jeffery; Anthoney, Alan; Ranson, Malcolm; Boddy, Alan V.; Plummer, Ruth
Accelerated phase I trial of two schedules of the combination of the PARP inhibitor olaparib and AKT inhibitor AZD5363 using a novel intrapatient dose escalation design in advanced cancer patients
CANCER RESEARCH
IF16.6
2015-08-016
PRE
Michalarea, Vasiliki; Lorente, David; Lopez, Juanita; Carreira, Suzanne; Hassam, Hasina; Parmar, Mona; Sathiyayogan, Nitharsan; Turner, Alison; Hall, Emma; Fandos, Sonia Serrano; Seeramreddi, Satyanarayana; Decordova, Shaun; Swales, Karen; Ruddle, Ruth; Raynaud, Florence; Tunariu, Nina; Attard, Gerhardt; Molife, L. Rhoda; Banerji, Udai; Plummer, Ruth; de Bono, Johann S.; Yap, Timothy A.
Exploratory genetic analysis of tumors from a phase I/II dose escalation study of GSK2636771 in patients (pts) with PTEN deficient advanced tumors
CANCER RESEARCH
IF16.6
2015-08-010
PRE
de Bono, Johann; Arkenau, Hendrik-Tobias; Mateo, Joaquin; Infante, Jeffrey R.; Burris, Howard A.; Bang, Yung-Jue; Eder, Joseph; Sharma, Sunil; Chung, Hyun C.; Decordova, Shaun; Swales, Karen E.; Garrett, Michelle D.; Roda-Perezi, Desamaparados; Ding, Meichun; Russo, Mark; Yang, Li; Suttle, Ben; Tolson, Jerry M.; Halsey, Wendy S.; Gopi, Ganji; Van Der Keyl, Harjeet K.; Kalyana-Sundaram, Shanker; Sathe, Ganesh M.; Motwani, Monica; Kumar, Rakesh

研究方向

暂未获取到该数据
U
Udai Banerji
H 指数:52论文数:647被引数:1.2万
R
Ruth Ruddle
H 指数:21论文数:182被引数:1,772
J
Johann S. de Bono
H 指数:160论文数:2,491被引数:13.5万
F
Florence I. Raynaud
H 指数:75论文数:775被引数:1.9万
M
Mona Parmar
H 指数:13论文数:81被引数:690
N
Nina Tunariu
H 指数:50论文数:440被引数:1.8万
E
Emma Hall
H 指数:69论文数:502被引数:2.5万
S
Suzanne Carreira
H 指数:49论文数:437被引数:1.5万
S
Shaun Decordova
H 指数:11论文数:62被引数:703
A
Alison Turner
H 指数:13论文数:60被引数:834