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S

Simon J. Dovedi

b oncology r&d, astrazeneca, cambridge, ukcorrespondencesimon.dovedi@astrazeneca.com view further author information
H指数:29
被引数:4,629

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IL-2-armored peptide-major histocompatibility class I bispecific antibodies redirect antiviral effector memory CD8+T cells to induce potent anti-cancer cytotoxic activity with limited cytokine release

IL-2-armored肽-主要组织相容性I类双特异性抗体重定向抗病毒效应记忆CD8 T细胞以诱导有效的抗癌细胞毒活性和有限的细胞因子释放

MABS
IF7.3
2024-08-280
OAAI
Schardt, John S.; Walseng, Even; Le, Kim; Yang, Chunning; Shah, Pooja; Fu, Ying; Alam, Kausar; Kelton, Cathryn R.; Gu, Yu; Huang, Fengying; Lin, Jia; Liu, Wenhai; Dippel, Andrew; Zhang, Hanzhi; Mulgrew, Kathy; Pryts, Stacy; Chennupati, Vijaykumar; Chen, Hung-Chang; Denham, Jessica; Chen, Xiaoru; Pradhan, Pallab; Wu, Yuling; Hardman, Colin; Zhao, Chihao; Kierny, Michael; Song, Yang; Dovedi, Simon J.; Cemerski, Saso; Mazor, Yariv
Rapid functional impairment of natural killer cells following tumor entry limits anti-tumor immunity
NATURE COMMUNICATIONS
IF15.7
2024-01-2423
OAAI
Dean, Isaac; Lee, Colin Y. C.; Tuong, Zewen K.; Li, Zhi; Tibbitt, Christopher A.; Willis, Claire; Gaspal, Fabrina; Kennedy, Bethany C.; Matei-Rascu, Veronika; Fiancette, Remi; Nordenvall, Caroline; Lindforss, Ulrik; Baker, Syed Murtuza; Stockmann, Christian; Sexl, Veronika; Hammond, Scott A.; Dovedi, Simon J.; Mjoesberg, Jenny; Hepworth, Matthew R.; Carlesso, Gianluca; Clatworthy, Menna R.; Withers, David R.
Efficacy and pharmacodynamic effect of anti-CD73 and anti-PD-L1 monoclonal antibodies in combination with cytotoxic therapy: observations from mouse tumor models
CANCER BIOLOGY & THERAPY
IF4.6
2024-01-112
OAAI
Kaistha, Brajesh P.; Kar, Gozde; Dannhorn, Andreas; Watkins, Amanda; Opoku-Ansah, Grace; Ilieva, Kristina; Mullins, Stefanie; Anderton, Judith; Galvani, Elena; Garcon, Fabien; Lapointe, Jean-Martin; Brown, Lee; Hair, James; Slidel, Tim; Luheshi, Nadia; Ryan, Kelli; Hardaker, Elizabeth; Dovedi, Simon; Kumar, Rakesh; Wilkinson, Robert W.; Hammond, Scott A.; Eyles, Jim
Targeting DNA damage response components induces enhanced STING-dependent type-I IFN response in ATM deficient cancer cells and drives dendritic cell activation

靶向DNA损伤反应成分可在ATM缺陷的癌细胞中诱导STING依赖性I型IFN反应增强，并驱动树突状细胞活化

ONCOIMMUNOLOGY
IF6.3
2022-09-1320
OA
Lopez-Pelaez, Marta; Young, Lucy; Vazquez-Chantada, Mercedes; Nelson, Nadine; Durant, Steve; Wilkinson, Robert W.; Poon, Edmund; Gaspar, Miguel; Valge-Archer, Viia; Smith, Paul; Dovedi, Simon J.
A LAT-Based Signaling Complex in the Immunological Synapse as Determined with Live Cell Imaging Is Less Stable in T Cells with Regulatory Capability

通过活细胞成像确定的免疫突触中基于LAT的信号传导复合物在具有调节能力的T细胞中不太稳定

CELLS
IF5.2
2021-02-171
OAAI
Li, Yikui; Tunbridge, Helen M.; Britton, Graham J.; Hill, Elaine V.; Sinai, Parisa; Cirillo, Silvia; Thompson, Clare; Fallah-Arani, Farnaz; Dovedi, Simon J.; Wraith, David C.; Wulfing, Christoph
Design and Efficacy of a Monovalent Bispecific PD-1/CTLA4 Antibody That Enhances CTLA4 Blockade on PD-1+ Activated T Cells

增强PD-1活化T细胞CTLA4阻断的单价双特异性PD-1/CTLA4抗体的设计和功效

CANCER DISCOVERY
IF33.3
2021-01-08123
PRE
Dovedi, Simon J.; Elder, Matthew J.; Yang, Chunning; Sitnikova, Suzanne, I; Irving, Lorraine; Hansen, Anna; Hair, James; Jones, Des C.; Hasani, Sumati; Wang, Bo; Im, Seock-Ah; Tran, Ben; Subramaniam, Deepa S.; Gainer, Shelby D.; Vashisht, Kapil; Lewis, Arthur; Jin, Xiaofang; Kentner, Stacy; Mulgrew, Kathy; Wang, Yaya; Overstreet, Michael G.; Dodgson, James; Wu, Yanli; Palazon, Asis; Morrow, Michelle; Rainey, Godfrey J.; Browne, Gareth J.; Neal, Frances; Murray, Thomas, V; Toloczko, Aleksandra D.; Dall'Acqua, William; Achour, Ikbel; Freeman, Daniel J.; Wilkinson, Robert W.; Mazor, Yariv
CALIBRATION: Can early changes in circulating tumour DNA (ctDNA) predict durable tumour responses in patients (pts) with advanced esophageal adenocarcinoma (EAC) receiving anti PD-L1 antibody durvalumab (D)?
ANNALS OF ONCOLOGY
IF65.4
2020-09-010
OAAI
Linossi, C.; Funingana, I. G.; Petruzzelli, M.; de Paula, B. H. Rala; O'Donovan, M.; Andrea, M.; Hewitt, S.; Williams, A. L.; Grehan, N.; Redmond, A.; Smyth, E. C.; Baird, R. D.; Godfrey, E. M.; Di Pietro, M.; Faull, I.; Dovedi, S.; Fitzgerald, R. C.; Pacey, S.

研究方向

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R
Robert W. Wilkinson
H 指数:57论文数:624被引数:1.3万
M
Michelle Morrow
H 指数:19论文数:179被引数:3,835
T
Tim Illidge
H 指数:64论文数:410被引数:2.0万
E
Edmund Poon
H 指数:11论文数:88被引数:2,595
J
Jamie Honeychurch
H 指数:24论文数:107被引数:4,691
R
Ronald Herbst
H 指数:50论文数:329被引数:1.1万
S
Scott A. Hammond
H 指数:41论文数:246被引数:6,231
B
Barry R. Davies
H 指数:43论文数:374被引数:6,913
M
Matthew J. Elder
H 指数:11论文数:34被引数:968
S
Suzanne I. Sitnikova
H 指数:4论文数:15被引数:218