未登录 Real World Efficacy and Safety of Momelotinib for Myelofibrosis: Evaluation of a UK-Wide Study Confirms 40% Anaemia Response Rate in a Non-Clinical Trial Cohort 真实世界中Momelotinib治疗骨髓纤维化的疗效与安全性：一项英国全国性研究的评估证实了在非临床试验队列中40%的贫血缓解率 Rampotas, Alexandros; Torre, Elena; Carter-Brzezinski, Luke; Duminuco, Andrea; Cadman-Davies, Llywelyn; Chee, Ashlyn; Panitsas, Fotios; Alimam, Samah; Milojkovic, Dragana; Kaczmarski, Richard; Fraser, Louise; Frewin, Rebecca; Foley, Kate; Hockings, Catherine; Khan, Alesia; Williams, Rhys; Ryan, Jennifer; Yip, Kawai; Thaw, Kyaw Htin; Sheikh, Amna; Wadelin, Frances; Godfrey, Anna L.; Teh, Chun Huat; Wilson, Andrew J.; Lambert, Jonathan; Mead, Adam J.; Mclornan, Donal P.; Innes, Andrew J.; Mcgregor, Andrew; Somervaille, Tim; Harrison, Claire; Harrington, Patrick; Psaila, Bethan 分享 收藏
Iadademstat in combination with azacitidine in patients with newly diagnosed acute myeloid leukaemia (ALICE) :an open-label, phase 2a dose-finding study Salamero, Olga; Molero, Antonieta; Perez-Simon, Jose Antonio; Arnan, Montserrat; Coll, Rosa; Garcia-Avila, Sara; Acuna-Cruz, Evelyn; Cano, Isabel; Somervaille, Tim C. P.; Gutierrez, Sonia; Arevalo, Maria Isabel; Xaus, Jordi; Buesa, Carlos; Limon, Ana; Faller, Douglas, V; Bosch, Francesc; Montesinos, Pau 分享 收藏
A TIAM1-TRIM28 complex mediates epigenetic silencing of protocadherins to promote migration of lung cancer cells TIAM1-TRIM28复合物介导原钙黏蛋白的表观遗传沉默促进肺癌细胞迁移 Ginn, Lucy; Maltas, Joe; Baker, Martin J.; Chaturvedi, Anshuman; Wilson, Leah; Guilbert, Ryan; Amaral, Fabio M. R.; Priest, Lynsey; Mole, Holly; Blackhall, Fiona; Diamantopoulou, Zoi; Somervaille, Tim C. P.; Hurlstone, Adam; Malliri, Angeliki 分享 收藏
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HMG20B stabilizes association of LSD1 with GFI1 on chromatin to confer transcription repression and leukemia cell differentiation block Maiques-Diaz, Alba; Nicosia, Luciano; Basma, Naseer J.; Romero-Camarero, Isabel; Camera, Francesco; Spencer, Gary J.; Amaral, Fabio M. R.; Simeoni, Fabrizio; Wingelhofer, Bettina; Williamson, Andrew J. K.; Pierce, Andrew; Whetton, Anthony D.; Somervaille, Tim C. P. 分享 收藏
A retrospective real-world study of the current treatment pathways for myelofibrosis in the United Kingdom: the REALISM UK study Mead, Adam J.; Butt, Nauman M.; Nagi, Waseem; Whiteway, Alastair; Kirkpatrick, Suriya; Rinaldi, Ciro; Roughley, Catherine; Ackroyd, Sam; Ewing, Joanne; Neelakantan, Pratap; Garg, Mamta; Tucker, David; Murphy, John; Patel, Hitesh; Bains, Rozinder; Chiu, Gavin; Hickey, Joe; Harrison, Claire; Somervaille, Tim C. P. 分享 收藏
Pharmacological inhibition of LSD1 triggers myeloid differentiation by targeting GSE1 oncogenic functions in AML LSD1的药理学抑制通过靶向AML中的GSE1致癌功能触发髓样分化 Nicosia, Luciano; Boffo, Francesca Ludovica; Ceccacci, Elena; Conforti, Fabio; Pallavicini, Isabella; Bedin, Fabio; Ravasio, Roberto; Massignani, Enrico; Somervaille, Tim C. P.; Minucci, Saverio; Bonaldi, Tiziana 分享 收藏
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Enhancer recruitment of transcription repressors RUNX1 and TLE3 by mis-expressed FOXC1 blocks differentiation in acute myeloid leukemia Simeoni, Fabrizio; Romero-Camarero, Isabel; Camera, Francesco; Amaral, Fabio M. R.; Sinclair, Oliver J.; Papachristou, Evangelia K.; Spencer, Gary J.; Lie-A-Ling, Michael; Lacaud, Georges; Wiseman, Daniel H.; Carroll, Jason S.; Somervaille, Tim C. P. 分享 收藏
Divergent clonal evolution of blastic plasmacytoid dendritic cell neoplasm and chronic myelomonocytic leukemia from a shared TET2-mutated origin Batta, Kiran; Bossenbroek, Hasse M.; Pemmaraju, Naveen; Wilks, Deepti P.; Chasty, Richard; Dennis, Mike; Milne, Paul; Collin, Matthew; Beird, Hannah C.; Taylor, Justin; Patnaik, Mrinal M.; Cargo, Catherine A.; Somervaille, Tim C. P.; Wiseman, Daniel H. 分享 收藏
Results of a national UK physician reported survey of COVID-19 infection in patients with a myeloproliferative neoplasm Salisbury, Richard A.; Curto-Garcia, Natalia; O'Sullivan, Jennifer; Chen, Frederick; Polzella, Paolo; Godfrey, Anna L.; Russell, James; Knapper, Steven; Willan, John; Frewin, Rebecca; Joshi, Shivani; Arami, Siamak; Burns, Sarah; Teh, Chun Huat; Wadelin, Frances; Dhanapal, Jaymathi; Neelakantan, Pratap; Milojkovic, Dragana; Psaila, Beth; Szydlo, Richard; Francis, Sebastian; Cargo, Catherine; Jain, Manish; McGregor, Andrew; Wallis, Louise; Duncombe, Andrew; Hussein, Hayder; Dyer, Peter; Munro, Laura; Bond, Lee; McMullin, Mary Frances; Somervaille, Tim C. P.; Garg, Mamta; Sekhar, Mallika; Harrison, Claire; Mead, Adam J.; Innes, Andrew J. 分享 收藏
Targeted nanopore sequencing for the identification of ABCB1 promoter translocations in cancer Williams, Mark S.; Basma, Naseer J.; Amaral, Fabio M. R.; Williams, Gillian; Weightman, John P.; Breitwieser, Wolfgang; Nelson, Louisa; Taylor, Stephen S.; Wiseman, Daniel H.; Somervaille, Tim C. P. 分享 收藏
EVI1 phosphorylation at S436 regulates interactions with CtBP1 and DNMT3A and promotes self-renewal Paredes, Roberto; Kelly, James R.; Geary, Bethany; Almarzouq, Batool; Schneider, Marion; Pearson, Stella; Narayanan, Prakrithi; Williamson, Andrew; Lovell, Simon C.; Wiseman, Daniel H.; Chadwick, John A.; Jones, Nigel J.; Kustikova, Olga; Schambach, Axel; Garner, Terence; Amaral, Fabio M. R.; Pierce, Andrew; Stevens, Adam; Somervaille, Tim C. P.; Whetton, Anthony D.; Meyer, Stefan 分享 收藏
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Response to tyrosine kinase inhibitors in myeloid neoplasms associated with PCM1-JAK2, BCR-JAK2 and ETV6-ABL1 fusion genes Schwaab, Juliana; Naumann, Nicole; Luebke, Johannes; Jawhar, Mohamad; Somervaille, Tim C. P.; Williams, Mark S.; Frewin, Rebecca; Jost, Philipp J.; Lichtenegger, Felix S.; La Rosee, Paul; Storch, Nicola; Haferlach, Torsten; Horny, Hans-Peter; Fabarius, Alice; Haferlach, Claudia; Burchert, Andreas; Hofmann, Wolf-Karsten; Cross, Nicholas C. P.; Hochhaus, Andreas; Reiter, Andreas; Metzgeroth, Georgia 分享 收藏
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Pre-clinical activity of combined LSD1 and mTORC1 inhibition in MLL-translocated acute myeloid leukaemia Deb, Gauri; Wingelhofer, Bettina; Amaral, Fabio M. R.; Maiques-Diaz, Alba; Chadwick, John A.; Spencer, Gary J.; Williams, Emma L.; Leong, Hui-Sun; Maes, Tamara; Somervaille, Tim C. P. 分享 收藏
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Targeting the RNA m6A Reader YTHDF2 Selectively Compromises Cancer Stem Cells in Acute Myeloid Leukemia Paris, Jasmin; Morgan, Marcos; Campos, Joana; Spencer, Gary J.; Shmakova, Alena; Ivanova, Ivayla; Mapperley, Christopher; Lawson, Hannah; Wotherspoon, David A.; Sepulveda, Catarina; Vukovic, Milica; Allen, Lewis; Sarapuu, Annika; Tavosanis, Andrea; Guitart, Amelie V.; Villacreces, Arnaud; Much, Christian; Choe, Junho; Azar, Ali; van de Lagemaat, Louie N.; Vernimmen, Douglas; Nehme, Ali; Mazurier, Frederic; Somervaille, Tim C. P.; Gregory, Richard I.; O'Carroll, Donal; Kranc, Kamil R. 分享 收藏
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