Leon Aarons - Publications, H-index & Citations

Leon Aarons

University of Manchester

44H指数

333论文数

8.0K被引数

收录论文 85

发表时间

Simultaneous Estimation of fm and FG Values Directly from Clinical Drug-Drug Interaction Study Data (vol 27, 83, 2025)直接从临床药物相互作用研究数据中同时估计fm和FG值（卷27，83，2025）

AAPS JOURNAL

IF3.7

2025-05-16

OAAI

Cleary, Y; Milani, N; Ogungbenro, K; Aarons, L; Galetin, A; Gertz, M

Simultaneous Estimation of fm and FG Values Directly from Clinical Drug-Drug Interaction Study Data 直接从临床药物相互作用研究数据中同时估计fm和FG值

AAPS JOURNAL

IF3.7

2025-04-29

OAAI

Cleary, Y; Milani, N; Ogungbenro, K; Aarons, L; Galetin, A; Gertz, M

Hierarchical cluster analysis and nonlinear mixed-effects modelling for candidate biomarker detection in preclinical models of cancer.

EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES

IF4.7

2024-06-01

OAAI

Hodson, David; Mistry, Hitesh; Yates, James; Guzzetti, Sofia; Davies, Michael; Aarons, Leon; Ogungbenro, Kayode

Constrained numerical deconvolution using orthogonal polynomials

HELIYON

IF3.6

2024-02-01

OAAI

Maestre, J. M.; Chanfreut, P.; Aarons, L.

Radiation in Combination with Immune Checkpoint Blockade and DNA Damage Response Inhibitors in Mice: Dosage Optimization in MC38 Syngeneic Tumors via Modelling and Simulation

JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

IF3.8

2023-10-01

OAAI

Hodson, David; Mistry, Hitesh; Yates, James; Farrington, Paul; Staniszewska, Anna; Guzzetti, Sofia; Davies, Michael; Aarons, Leon; Ogungbenro, Kayode

Mixed effects modeling of radiotherapy in combination with immune checkpoint blockade or inhibitors of the DNA damage response pathway

CPT-PHARMACOMETRICS & SYSTEMS PHARMACOLOGY

IF3

2023-09-18

OAAI

Hodson, David; Mistry, Hitesh; Guzzetti, Sofia; Davies, Michael; Staniszewska, Anna; Farrington, Paul; Cadogan, Elaine; Yates, James; Aarons, Leon; Ogungbenro, Kayode

Investigation of simplified physiologically-based pharmacokinetic models in rat and human

CPT-PHARMACOMETRICS & SYSTEMS PHARMACOLOGY

IF3

2023-02-08

OAAI

Yau, Estelle; Olivares-Morales, Andres; Ogungbenro, Kayode; Aarons, Leon; Gertz, Michael

A middle-out approach for the prediction of human drug disposition from preclinical data using simplified physiologically based pharmacokinetic (PBPK) models

CPT-PHARMACOMETRICS & SYSTEMS PHARMACOLOGY

IF3

2023-01-31

OAAI

Yau, Estelle; Gertz, Michael; Ogungbenro, Kayode; Aarons, Leon; Olivares-Morales, Andres

Model-Based Drug-Drug Interaction Extrapolation Strategy From Adults to Children: Risdiplam in Pediatric Patients With Spinal Muscular Atrophy

CLINICAL PHARMACOLOGY & THERAPEUTICS

IF5.5

2021-09-01

OAAI

Cleary, Yumi; Gertz, Michael; Grimsey, Paul; Gunther, Andreas; Heinig, Katja; Ogungbenro, Kayode; Aarons, Leon; Galetin, Aleksandra; Kletzl, Heidemarie

Evaluation of area under the concentration curve adjusted by the terminal-phase as a metric to reduce the impact of variability in bioequivalence testing

BRITISH JOURNAL OF CLINICAL PHARMACOLOGY

IF3

2021-08-24

OAAI

Lucas, Adam J.; Ogungbenro, Kayode; Yang, Shuying; Aarons, Leon; Chen, Chao

Investigating the impact of target lesion selection on drug effect evaluation and tumour growth rate determination using tumour growth inhibition models: Example of malignant pleural mesothelioma patients treated with cisplatin alone or in combination with pemetrexed

EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES

IF4.7

2021-06-01

OAAI

Lombard, Aurelie; Mistry, Hitesh; Chapman, Sonya C.; Gueorguieva, Ivelina; Aarons, Leon; Ogungbenro, Kayode

Dose individualisation in oncology using chemotherapy-induced neutropenia: Example of docetaxel in non-small cell lung cancer patients

BRITISH JOURNAL OF CLINICAL PHARMACOLOGY

IF3

2020-12-19

OAAI

Lombard, Aurelie; Mistry, Hitesh; Aarons, Leon; Ogungbenro, Kayode

Global Sensitivity Analysis of the Rodgers and Rowland Model for Prediction of Tissue: Plasma Partitioning Coefficients: Assessment of the Key Physiological and Physicochemical Factors That Determine Small-Molecule Tissue Distribution

AAPS JOURNAL

IF3.7

2020-02-03

OAAI

Yau, Estelle; Olivares-Morales, Andres; Gertz, Michael; Parrott, Neil; Darwich, Adam S.; Aarons, Leon; Ogungbenro, Kayode

Ratifying the dosage and duration of levo-bupivacaine infusion by the caudal-epidural route in infants aged three to six months

BRITISH JOURNAL OF ANAESTHESIA

IF9.2

2018-05-01

OAAI

Vashisht, R.; Bendon, A.; Okonkwo, I.; Darwich, A.; Aarons, L.

Whole body physiologically based modelling of β-blockers in the rat: events in tissues and plasma following an i.v. bolus dose

BRITISH JOURNAL OF PHARMACOLOGY

IF7.7

2017-12-01

OAAI

Cheung, S. Y. A.; Rodgers, T.; Aarons, L.; Gueorguieva, I.; Dickinson, G. L.; Murby, S.; Brown, C.; Collins, B.; Rowland, M.

Population pharmacokinetics of the MEK inhibitor selumetinib and its active N-desmethyl metabolite: data from 10 phase I trials

BRITISH JOURNAL OF CLINICAL PHARMACOLOGY

IF3

2017-09-22

OAAI

Patel, Parul; Howgate, Eleanor; Martin, Paul; Carlile, David J.; Aarons, Leon; Zhou, Diansong

Why has model-informed precision dosing not yet become common clinical reality? lessons from the past and a roadmap for the future

CLINICAL PHARMACOLOGY & THERAPEUTICS

IF5.5

2017-04-04

181

OAAI

Darwich, A. S.; Ogungbenro, K.; Vinks, A. A.; Powell, J. R.; Reny, J-L; Marsousi, N.; Daali, Y.; Fairman, D.; Cook, J.; Lesko, L. J.; McCune, J. S.; Knibbe, C. A. J.; de Wildt, S. N.; Leeder, J. S.; Neely, M.; Zuppa, A. F.; Vicini, P.; Aarons, L.; Johnson, T. N.; Boiani, J.; Rostami-Hodjegan, A.

IMI - oral biopharmaceutics tools project - evaluation of bottom-up PBPK prediction success part 1: Characterisation of the OrBiTo database of compounds

EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES

IF4.7

2017-01-01

OAAI

Margolskee, Alison; Darwich, Adam S.; Pepin, Xavier; Pathak, Shriram M.; Bolger, Michael B.; Aarons, Leon; Rostami-Hodjegan, Amin; Angstenberger, Jonas; Graf, Franziska; Laplanche, Loic; Mueller, Thomas; Carlert, Sara; Daga, Pankaj; Murphy, Donal; Tannergren, Christer; Yasin, Mohammed; Greschat-Schade, Susanne; Mueck, Wolfgang; Muenster, Uwe; van der Mey, Dorina; Frank, Kerstin Julia; Lloyd, Richard; Adriaenssen, Lieve; Bevernage, Jan; De Zwart, Loeckie; Swerts, Dominique; Tistaert, Christophe; Van Den Bergh, An; Van Peer, Achiel; Beato, Stefania; Anh-Thu Nguyen-Trung; Bennett, Joanne; McAllister, Mark; Wong, Mei; Zane, Patricia; Ollier, Celine; Vicat, Pascale; Kolhmann, Markus; Marker, Alexander; Brun, Priscilla; Mazuir, Florent; Beilles, Stephane; Venczel, Marta; Boulenc, Xavier; Loos, Petra; Lennernas, Hans; Abrahamsson, Bertil

IMI - Oral biopharmaceutics tools project - Evaluation of bottom-up PBPK prediction success part 3: Identifying gaps in system parameters by analysing In Silico performance across different compound classes

EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES

IF4.7

2017-01-01

OAAI

Darwich, Adam S.; Margolskee, Alison; Pepin, Xavier; Aarons, Leon; Galetin, Aleksandra; Rostami-Hodjegan, Amin; Carlert, Sara; Hammarberg, Maria; Hilgendorf, Constanze; Johansson, Pernilla; Karlsson, Eva; Murphy, Donal; Tannergren, Christer; Thorn, Helena; Yasin, Mohammed; Mazuir, Florent; Nicolas, Olivier; Ramusovic, Sergej; Xu, Christine; Pathak, Shriram M.; Korjamo, Timo; Laru, Johanna; Malkki, Jussi; Pappinen, Sari; Tuunainen, Johanna; Dressman, Jennifer; Hansmann, Simone; Kostewicz, Edmund; He, Handan; Heimbach, Tycho; Wu, Fan; Hoft, Carolin; Pang, Yan; Bolger, Michael B.; Huehn, Eva; Lukacova, Viera; Mullin, James M.; Szeto, Ke X.; Costales, Chester; Lin, Jian; McAllister, Mark; Modi, Sweta; Rotter, Charles; Varma, Manthena; Wong, Mei; Mitra, Amitava; Bevernage, Jan; Biewenga, Jeike; Van Peer, Achiel; Lloyd, Richard; Shardlow, Carole; Langguth, Peter; Mishenzon, Irina; Mai Anh Nguyen; Brown, Jonathan; Lennernas, Hans; Abrahamsson, Bertil

IMI - Oral biopharmaceutics tools project - Evaluation of bottom-up PBPK prediction success part 2: An introduction to the simulation exercise and overview of results

EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES

IF4.7

2017-01-01

OAAI

Margolskee, Alison; Darwich, Adam S.; Pepin, Xavier; Aarons, Leon; Galetin, Aleksandra; Rostami-Hodjegan, Amin; Carlert, Sara; Hammarberg, Maria; Hilgendorf, Constanze; Johansson, Pernilla; Karlsson, Eva; Murphy, Donal; Tannergren, Christer; Thorn, Helena; Yasin, Mohammed; Mazuir, Florent; Nicolas, Olivier; Ramusovic, Sergej; Xu, Christine; Pathak, Shriram M.; Korjamo, Timo; Laru, Johanna; Malkki, Jussi; Pappinen, Sari; Tuunainen, Johanna; Dressman, Jennifer; Hansmanni, Simone; Kostewicz, Edmund; He, Handan; Heimbach, Tycho; Wu, Fan; Hoft, Carolin; Laplanche, Loic; Pang, Yan; Bolger, Michael B.; Huehn, Eva; Lukacova, Viera; Mullin, James M.; Szeto, Ke X.; Costales, Chester; Lin, Jian; McAllister, Mark; Modi, Sweta; Rotter, Charles; Varma, Manthena; Wong, Mei; Mitra, Amitava; Bevernage, Jan; Biewenga, Jeike; Van Peer, Achiel; Lloyd, Richard; Shardlow, Carole; Langguth, Peter; Mishenzon, Irina; Mai Anh Nguyen; Brown, Jonathan; Lennernas, Hans; Abrahamsson, Bertil

研究方向