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Deciphering Combinatorial Genetics

delete2016-11-23
delete12
PRE
AI
A
Alan S.L. Wong
G
Gigi C.G. Choi
T
Timothy K. Lu *
DOI：10.1146/annurev-genet-120215-034902delete
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摘要

摘要

En 中文
High-order interactions among components of interconnected genetic networks regulate complex functions in biological systems, but deciphering these interactions is challenging. New strategies are emerging to decode these combinatorial genetic interactions across a wide range of organisms. Here, we review advances in multiplexed and combinatorial genetic perturbation technologies and high-throughput profiling platforms that are enabling the systematic dissection of complex genetic networks. These rapidly evolving technologies are being harnessed to probe combinatorial gene functions in functional genomics studies and have the potential to advance our understanding of how genetic networks regulate sophisticated biological phenotypes, to generate novel therapeutic strategies, and to enable the engineering of complex artificial gene networks.
Keyword:
multiplexed genetic perturbations
combinatorial assembly
high-throughput screening
functional genomics
synthetic biology
systems biology
combinatorial genetics en masse
CombiGEM
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对已上传原文的论文进行重点信息的提取，主要内容包括：简要概述、研究摘要、背景介绍、关键亮点、图文解析、展望与总结。

期刊

Annual Review of Genetics 封面图
Annual Review of Genetics
IF:
8.6
论文数:
912
被引数:
7.7K

机构

U
University of Hong Kong
学者数:
4.1W
论文数: 3.9W
被引数: 10.1W
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