Does sequence clustering confound AlphaFold2?

Hannah K. Wayment-Steele

doi:10.1016/j.jmb.2025.169376

2025-08-06

Hannah K. Wayment-Steele *

Sergey Ovchinnikov

Lucy J. Colwell

Dorothee Kern *

DOI：10.1016/j.jmb.2025.169376

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摘要

En 中文

• 澄清关于AF-Cluster预期用途的误解。 • 描述了消融研究，以直接测试进化耦合在神经网络中的作用。 • 驳斥进化耦合未被AF-Cluster使用的说法。

Keyword:

AlphaFold2

conformational ensembles

evolutionary couplings

clustering

metamorphic proteins

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期刊

Journal of Molecular Biology

IF:

4.5

论文数:

667

被引数:

5.4W

机构

Howard Hughes Medical Institute

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1.2W

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被引数: 6.0W

Massachusetts Institute of Technology

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2.4K

论文数: 1.1K

被引数: 8

google research

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210

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被引数: 0

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