Dorothee Kern - Publications, H-index & Citations

Dorothee Kern

scripps research and howard hughes medical institute

46H指数

168论文数

1.4W被引数

收录论文 39

发表时间

Learning millisecond protein dynamics from what is missing in NMR spectra 从NMR谱中缺失的信息学习毫秒级蛋白质动力学

Nature

IF48.5

2026-08-10

PREAI

Hannah K. Wayment-Steele; Gina El Nesr; Ramith Hettiarachchi; Adedolapo M. Ojoawo; Hasindu Kariyawasam; Sergey Ovchinnikov; Dorothee Kern

Does sequence clustering confound AlphaFold2?序列聚类是否会影响AlphaFold2？

Journal of Molecular Biology

IF4.5

2025-08-06

OAAI

Hannah K. Wayment-Steele; Sergey Ovchinnikov; Lucy Colwell; Dorothee Kern

Mechanism and application of thiol-disul fide redox biosensors with a fluorescence- lifetime readout 巯基-二硫键氧化还原生物传感器的机制与应用：基于荧光寿命读出

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

IF9.1

2025-05-06

OAAI

Rosen, Paul C.; Glaser, Andrew; Martinez-Francois, Juan R.; Lim, Daniel C.; Brooks, Daniel J.; Fu, Panhui; Kim, Erica; Kern, Dorothee; Yellen, Gary

Dual- action kinase inhibitors influence p38α MAP kinase dephosphorylation 双功能激酶抑制剂影响p38α MAP激酶的去磷酸化

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

IF9.1

2024-12-31

OAAI

Stadnicki, Emily J.; Ludewig, Hannes; Kumar, Ramasamy P.; Wang, Xicong; Qiao, Youwei; Kern, Dorothee; Bradshaw, Niels

The conformational landscape of fold- switcher KaiB is tuned to the circadian rhythm timescale

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

IF9.1

2024-10-30

OAAI

Wayment-Steele, Hannah K.; Otten, Renee; Pitsawong, Warintra; Ojoawo, Adedolapo M.; Glaser, Andrew; Calderone, Logan A.; Kern, Dorothee

A biophysical framework for double- drugging kinases 双药物激酶的生物物理框架

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

IF9.1

2023-08-17

OAAI

Kim, Chansik; Ludewig, Hannes; Hadzipasic, Adelajda; Kutter, Steffen; Nguyen, Vy; Kern, Dorothee

From structure to mechanism: skiing the energy landscape

NATURE METHODS

IF32.1

2021-05-07

PREAI

Kern, Dorothee

Response to Comment on Ancient origins of allosteric activation in a Ser-Thr kinase

SCIENCE

IF45.8

2020-11-20

OAAI

Wilson, Christopher; Kern, Dorothee

Cumulative mechanism of several major imatinib-resistant mutations in Abl kinase

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

IF9.1

2020-07-27

OAAI

Hoemberger, Marc; Pitsawong, Warintra; Kern, Dorothee

Allosteric modulation of a human protein kinase with monobodies 用单体对人类蛋白激酶的变构调节

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

IF9.1

2019-06-25

OAAI

Zorba, Adelajda; Nguyen, Vy; Koide, Akiko; Hoemberger, Marc; Zheng, Yuejiao; Kutter, Steffen; Kim, Chansik; Koide, Shohei; Kern, Dorothee

Mechanism of activating mutations and allosteric drug inhibition of the phosphatase SHP2

NATURE COMMUNICATIONS

IF15.7

2018-10-30

OAAI

Padua, Ricardo A. P.; Sun, Yizhi; Marko, Ingrid; Pitsawong, Warintra; Stiller, John B.; Otten, Renee; Kern, Dorothee

Dynamics of human protein kinase Aurora A linked to drug selectivity

ELIFE

IF0

2018-06-14

OAAI

Pitsawong, Warintra; Buosi, Vanessa; Otten, Renee; Agafonov, Roman, V; Zorba, Adelajda; Kern, Nadja; Kutter, Steffen; Kern, Gunther; Padua, Ricardo A. P.; Meniche, Xavier; Kern, Dorothee

Rescue of conformational dynamics in enzyme catalysis by directed evolution

NATURE COMMUNICATIONS

IF15.7

2018-04-03

102

OAAI

Otten, Renee; Liu, Lin; Kenner, Lillian R.; Clarkson, Michael W.; Mavor, David; Tawfik, Dan S.; Kern, Dorothee; Fraser, James S.

Second Harmonic Generation as a Method to Identify and Screen for Allosteric Modulators of Protein Targets

BIOPHYSICAL JOURNAL

IF3.1

2017-02-01

OAAI

Salafsky, Joshua; Agafonov, Roman; Vo, Elizabeth Donohue; Connell, Katelyn; Mercado, Gabriel; George, Tad; McCormick, Frank; Kern, Dorothee

Conformational Selection in a Protein-Protein Interaction Revealed by Dynamic Pathway Analysis

CELL REPORTS

IF6.9

2016-01-01

OAAI

Chakrabarti, Kalyan S.; Agafonov, Roman V.; Pontiggia, Francesco; Otten, Renee; Higgins, Matthew K.; Schertler, Gebhard F. X.; Oprian, Daniel D.; Kern, Dorothee

Free energy landscape of activation in a signalling protein at atomic resolution

NATURE COMMUNICATIONS

IF15.7

2015-06-15

OAAI

Pontiggia, F.; Pachov, D. V.; Clarkson, M. W.; Villali, J.; Hagan, M. F.; Pande, V. S.; Kern, D.

Evolution and intelligent design in drug development

FRONTIERS IN MOLECULAR BIOSCIENCES

IF4

2015-05-21

OAAI

Agafonov, Roman V.; Wilson, Christopher; Kern, Dorothee

The energy landscape of adenylate kinase during catalysis

NATURE STRUCTURAL & MOLECULAR BIOLOGY

IF10.1

2015-01-12

152

OAAI

Kerns, S. Jordan; Agafonov, Roman V.; Cho, Young-Jin; Pontiggia, Francesco; Otten, Renee; Pachov, Dimitar V.; Kutter, Steffen; Phung, Lien A.; Murphy, Padraig N.; Vu Thai; Alber, Tom; Hagan, Michael F.; Kern, Dorothee

Regulation of Kinases: 1 Billion Years of Evolution

BIOPHYSICAL JOURNAL

IF3.1

2015-01-01

OAAI

Agafonov, Roman; Wilson, Chris; Biswas, Sarita; Kern, Dorothee

Activation Mechanism of a Signaling Protein at Atomic Resolution

BIOPHYSICAL JOURNAL

IF3.1

2015-01-01

OAAI

Pontiggia, Francesco; Pachov, Dimitar V.; Clarkson, Michael W.; Villali, Janice; Hagan, Michael F.; Pande, Vijay S.; Kern, Dorothee

研究方向