.png){kind=icon}
返回
Multiple-laboratory comparison of microarray platforms
.png){kind=icon}
PRE
AI
DOI：10.1038/nmeth756.png)
.png){kind=icon}
原文求助.png){kind=icon}
分享.png){kind=icon}
收藏
摘要
En 中文
Microarray technology is a powerful tool for measuring RNA expression for thousands of genes at once. Various studies have been published comparing competing platforms with mixed results: some find agreement, others do not. As the number of researchers starting to use microarrays and the number of cross-platform meta-analysis studies rapidly increases, appropriate platform assessments become more important. Here we present results from a comparison study that offers important improvements over those previously described in the literature. In particular, we noticed that none of the previously published papers consider differences between tabs. For this study, a consortium of ten laboratories from the Washington, DC-Baltimore, USA, area was formed to compare data obtained from three widely used platforms using identical RNA samples. We used appropriate statistical analysis to demonstrate that there are relatively large differences in data obtained in tabs using the same platform, but that the results from the best-performing tabs agree rather well.
Keyword:
OLIGONUCLEOTIDE
AI总结
对已上传原文的论文进行重点信息的提取，主要内容包括：简要概述、研究摘要、背景介绍、关键亮点、图文解析、展望与总结。
期刊
IF:
32.1
论文数:
7.2K
被引数:
12.7W
机构
暂无机构信息
引用论文
Assessing unmodified 70-mer oligonucleotide probe performance on glass-slide microarrays.png)
GENOME BIOLOGY
OAAI
GENOME BIOLOGYIF9.4
OAAI分享收藏Using Support Vector Machines with Multiple Indices of Diffusion for Automated Classification of Mild Cognitive Impairment使用具有多个扩散指标的支持向量机对轻度认知障碍进行自动分类PLoS ONEOAAI
PLoS ONEIF0
OAAI分享收藏Assessment of the sensitivity and specificity of oligonucleotide (50mer) microarraysNUCLEIC ACIDS RESEARCHOAAI
NUCLEIC ACIDS RESEARCHIF13.1
OAAI分享收藏Evaluation of gene expression measurements from commercial microarray platformsNUCLEIC ACIDS RESEARCHOAAI
NUCLEIC ACIDS RESEARCHIF13.1
OAAI分享收藏Normalization for cDNA microarray data: a robust composite method addressing single and multiple slide systematic variationNUCLEIC ACIDS RESEARCHOAAI
NUCLEIC ACIDS RESEARCHIF13.1
OAAI分享收藏Bioconductor: open software development for computational biology and bioinformaticsGENOME BIOLOGYOAAI
GENOME BIOLOGYIF9.4
OAAI分享收藏
查看更多内容