Pharmacogenetic Implementation Studies—Lessons Learned From the PREPARE Study

Henk‐Jan Guchelaar

doi:10.1002/cpt.3749

2025-06-24

Henk‐Jan Guchelaar *

Cathelijne H. van der Wouden

Candace Joefield‐Roka

Christina Mitropoulou

Cristina Lucía Dávila-Fajardo

Vita Dolžan

George P. Patrinos

Munir Pirmohamed

Gere Sunder‐Plassmann

Giuseppe Toffoli

Jesse J. Swen

Ubiquitous Pharmacogenomics Consortium

DOI：10.1002/cpt.3749

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摘要

En 中文

无处不在的药物基因组学联盟（www.upgx.eu）最近完成了关于实施基于基因组的药物遗传学检测的“预防性药物基因组学检测以预防不良药物反应（PREPARE）”研究，并已发布。PREPARE为未来临床实施研究的设计、执行和解释提供了有趣的启示。本文中，我们分享了从PREPARE研究中获得的经验和教训，以用于未来的药物遗传学实施研究。所涉及的问题包括研究人群、干预措施、终点、随机化、盲法、交叉、伦理、研究期间的现实变化，以及数据分析和报告。

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