未登录 A Cardiac-Specific Humanized Mouse Model to Evaluate the Disposition of OCT3 Substrates 用于评估OCT3底物分布的心脏特异性人源化小鼠模型 Boeckman, Mike; Bohnert, Regina; Ahmed, Bagdad; Talebi, Zahra; Ahmed, Eman; Zahedimaram, Pegah; Lemen, Lisa; Wang, Xiangning; Hertlein, Erin; Baker, Sharyn; Addison, Daniel; Schaeffeler, Elke; Schwab, Matthias; Nies, Anne T.; Sparreboom, Alex; Huang, Kevin M. 分享 收藏
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Metabolic activation of WHO-congeners PCB28, 52, and 101 by human CYP2A6: evidence from in vitro and in vivo experiments Randerath, Isabella; Schettgen, Thomas; Mueller, Julian Peter; Rengelshausen, Jens; Ziegler, Susanne; Quinete, Nathalia; Bertram, Jens; Laieb, Salah; Schaeffeler, Elke; Kaifie, Andrea; Just, Katja S.; Voigt, Aaron; Tremmel, Roman; Schwab, Matthias; Stingl, Julia C.; Kraus, Thomas; Ziegler, Patrick 分享 收藏
In silico and biological analyses of missense variants of the human biliary efflux transporter ABCC2: effects of novel rare missense variants 人类胆汁外流转运蛋白ABCC2的错义变体的计算机和生物学分析: 新型罕见错义变体的作用 Koelz, Charlotte; Gaugaz, Fabienne Z.; Handin, Niklas; Schaeffeler, Elke; Tremmel, Roman; Winter, Stefan; Klein, Kathrin; Zanger, Ulrich M.; Artursson, Per; Schwab, Matthias; Nies, Anne T. 分享 收藏
Genetic associations of cardiovascular risk genes in European patients with coronary artery spasm Tremmel, Roman; Pereyra, Valeria Martinez; Broders, Incifer; Schaeffeler, Elke; Hoffmann, Per; Noethen, Markus M.; Bekeredjian, Raffi; Sechtem, Udo; Schwab, Matthias; Ong, Peter 分享 收藏
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Nutrimetric Validation of Solanidine as Dietary-Derived CYP2D6 Activity Marker In Vivo Mueller, Julian Peter; Saroemba, Jens; Ziegler, Patrick; Tremmel, Roman; Rengelshausen, Jens; Schaeffeler, Elke; Just, Katja S.; Schwab, Matthias; Kraus, Thomas; Stingl, Julia C. 分享 收藏
Novel drug transporter substrates identification: An innovative approach based on metabolomic profiling, in silico ligand screening and biological validation Nies, Anne T.; Koenig, Jorg; Leuthold, Patrick; Damme, Katja; Winter, Stefan; Haag, Mathias; Masuda, Satohiro; Kruck, Stephan; Daniel, Hannelore; Spanier, Britta; Fromm, Martin F.; Bedke, Jens; Inui, Ken-Ichi; Schwab, Matthias; Schaeffeler, Elke 分享 收藏
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An in vivo platform of pre-characterized renal cell carcinoma (RCC) patient- derived xenograft models allows the preclinical evaluation of patient-tailored intervention strategies Kobelt, Dennis; Gurgen, Dennis; Becker, Michael; Dahlmann, Mathias; Flechsig, Susanne; Schaeffeler, Elke; Buttner, Florian A.; Schmees, Christian; Bohnert, Regina; Bedke, Jens; Schwab, Matthias; Wendler, Johann J.; Schostak, Martin; Jandrig, Burkhard; Walther, Wolfgang; Hoffmann, Jens 分享 收藏
A 12-gene pharmacogenetic panel to prevent adverse drug reactions: an open-label, multicentre, controlled, cluster-randomised crossover implementation study 预防药物不良反应的12基因药物遗传学小组: 一项开放标签，多中心，对照，集群随机交叉实施研究 Swen, Jesse J.; van der Wouden, Cathelijne H.; Manson, Lisanne E. N.; Abdullah-Koolmees, Heshu; Blagec, Kathrin; Blagus, Tanja; Boehringer, Stefan; Cambon-Thomsen, Anne; Cecchin, Erika; Cheung, Ka-Chun; Deneer, Vera H. M.; Dupui, Mathilde; Ingelman-Sundberg, Magnus; Jonsson, Siv; Joefield-Roka, Candace; Just, Katja S.; Karlsson, Mats O.; Konta, Lidija; Koopmann, Rudolf; Kriek, Marjolein; Lehr, Thorsten; Mitropoulou, Christina; Rial-Sebbag, Emmanuelle; Rollinson, Victoria; Roncato, Rossana; Samwald, Matthias; Schaeffeler, Elke; Skokou, Maria; Schwab, Matthias; Steinberger, Daniela; Stingl, Julia C.; Tremmel, Roman; Turner, Richard M.; van Rhenen, Mandy H.; Fajardo, Cristina L. Davila; Dolzan, Vita; Patrinos, George P.; Pirmohamed, Munir; Sunder-Plassmann, Gere; Toffoli, Giuseppe; Guchelaar, Henk-Jan 分享 收藏
Cross-Ancestry Genome-Wide Association Study Defines the Extended CYP2D6 Locus as the Principal Genetic Determinant of Endoxifen Plasma Concentrations Khor, Chiea Chuen; Winter, Stefan; Sutiman, Natalia; Muerdter, Thomas E.; Chen, Sylvia; Lim, Joanne Siok Liu; Li, Zheng; Li, Jingmei; Sim, Kar Seng; Ganchev, Boian; Eccles, Diana; Eccles, Bryony; Tapper, William; Zgheib, Nathalie K. K.; Tfayli, Arafat; Ng, Raymond Chee Hui; Yap, Yoon Sim; Lim, Elaine; Wong, Mabel; Wong, Nan Soon; Ang, Peter Cher Siang; Dent, Rebecca; Tremmel, Roman; Klein, Kathrin; Schaeffeler, Elke; Zhou, Yitian; Lauschke, Volker M. M.; Eichelbaum, Michel; Schwab, Matthias; Brauch, Hiltrud B. B.; Chowbay, Balram; Schroth, Werner 分享 收藏
Chemotherapy-related hyperbilirubinemia in pediatric acute lymphoblastic leukemia: a genome-wide association study from the AIEOP-BFM ALL study group 小儿急性淋巴细胞白血病的化疗相关高胆红素血症: aieop-bfm ALL研究组的全基因组关联研究 Junk, Stefanie V. V.; Schaeffeler, Elke; Zimmermann, Martin; Moericke, Anja; Beier, Rita; Schuette, Peter; Fedders, Birthe; Alten, Julia; Hinze, Laura; Klein, Norman; Kulozik, Andreas; Muckenthaler, Martina U. U.; Koehler, Rolf; Borkhardt, Arndt; Vijayakrishnan, Jayaram; Ellinghaus, David; Forster, Michael; Franke, Andre; Wintering, Astrid; Kratz, Christian P. P.; Schrappe, Martin; Schwab, Matthias; Houlston, Richard S. S.; Cario, Gunnar; Stanulla, Martin 分享 收藏
Prediction of Drug-Drug-Gene Interaction Scenarios of (E)-Clomiphene and Its Metabolites Using Physiologically Based Pharmacokinetic Modeling Kovar, Christina; Kovar, Lukas; Ruedesheim, Simeon; Selzer, Dominik; Ganchev, Boian; Kroener, Patrick; Igel, Svitlana; Kerb, Reinhold; Schaeffeler, Elke; Muerdter, Thomas E.; Schwab, Matthias; Lehr, Thorsten 分享 收藏
Dendritic Cells or Macrophages? The Microenvironment of Human Clear Cell Renal Cell Carcinoma Imprints a Mosaic Myeloid Subtype Associated with Patient Survival Brech, Dorothee; Herbstritt, Anna S.; Diederich, Sarah; Straub, Tobias; Kokolakis, Evangelos; Irmler, Martin; Beckers, Johannes; Buettner, Florian A.; Schaeffeler, Elke; Winter, Stefan; Schwab, Matthias; Nelson, Peter J.; Noessner, Elfriede 分享 收藏
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