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Rules were made to be broken
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DOI：10.1038/s41570-022-00451-0.png)
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Twenty five years ago, Christopher Lipinski and colleagues published arguably the most influential sentence in small-molecule drug discovery. Their cleverly crafted 'rule of 5' (Ro5) mnemonic was adopted into everyday medicinal chemistry practice and has influenced a generation of small-molecule drug discovery scientists. Five times five years later, we consider the impact of the Ro5 and ask to what extent it should still guide today's medicinal chemistry efforts.
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Experimental and computational approaches to estimate solubility and permeability in drug discovery and development settings在药物发现和开发环境中估算溶解度和渗透性的实验和计算方法
PREAI
分享收藏Two Decades under the Influence of the Rule of Five and the Changing Properties of Approved Oral Drugs五法则影响下的二十年和已批准的口服药物性质的变化
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分享收藏A selective and orally bioavailable VHL-recruiting PROTAC achieves SMARCA2 degradation in vivo.png)
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