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scGAMNN: Graph Antoencoder-Based Single-Cell RNA Sequencing Data Integration Algorithm Using Mutual Nearest Neighbors
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DOI：10.1109/JBHI.2023.3311340.png)
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摘要
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It is critical to correctly assemble high-dimensional single-cell RNA sequencing (scRNA-seq) datasets and downscale them for downstream analysis. However, given the complex relationships between cells, it remains a challenge to simultaneously eliminate batch effects between datasets and maintain the topology between cells within each dataset. Here, we propose scGAMNN, a deep learning model based on graph autoencoder, to simultaneously achieve batch correction and topology-preserving dimensionality reduction. The low-dimensional integrated data obtained by scGAMNN can be used for visualization, clustering and trajectory inference.By comparing it with the other five methods, multiple tasks show that scGAMNN consistently has comparable data integration performance in clustering and trajectory conservation.
Keyword:
Batch correction
deep learning
graph autoencoder
mutual nearest neighbor
scRNA-seq data integration
期刊
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6.8
论文数:
4.6K
被引数:
2.0W
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