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Sensitive, specific polymorphism discovery in bacteria using massively parallel sequencing
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DOI：10.1038/NMETH.1286.png)
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摘要
En 中文
Our variant ascertainment algorithm, VAAL, uses massively parallel DNA sequence data to identify differences between bacterial genomes with high sensitivity and specificity. VAAL detected similar to 98% of differences (including large insertion-deletions) between pairs of strains from three species while calling no false positives. VAAL also pinpointed a single mutation between Vibrio cholerae genomes, identifying an antibiotic's site of action by identifying sequence differences between drug-sensitive strains and drug-resistant derivatives.
Keyword:
HELICOBACTER-PYLORI
GENOME
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32.1
论文数:
7.2K
被引数:
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