.png){kind=icon}
返回
The BioGRID interaction database: 2019 update
.png){kind=icon}
OA
AI
DOI：10.1093/nar/gky1079.png)
.png){kind=icon}
.png){kind=icon}
分享.png){kind=icon}
收藏
摘要
En 中文
The Biological General Repository for Interaction Datasets (BioGRID: https://thebiogrid.org) is an open access database dedicated to the curation and archival storage of protein, genetic and chemical interactions for all major model organism species and humans. As of September 2018 (build 3.4.164), BioGRID contains records for 1 598 688 biological interactions manually annotated from 55 809 publications for 71 species, as classified by an updated set of controlled vocabularies for experimental detection methods. BioGRID also houses records for >700 000 post-translational modification sites. BioGRID now captures chemical interaction data, including chemical-protein interactions for human drug targets drawn from the DrugBank database and manually curated bioactive compounds reported in the literature. A new dedicated aspect of BioGRID annotates genome-wide CRISPR/Cas9-based screens that report gene-phenotype and gene-gene relationships. An extension of the BioGRID resource called the Open Repository for CRISPR Screens (ORCS) database (https://orcs.thebiogrid.org) currently contains over 500 genome-wide screens carried out in human or mouse cell lines. All data in BioGRID is made freely available without restriction, is directly downloadable in standard formats and can be readily incorporated into existing applications via our web service platforms. BioGRID data are also freely distributed through partner model organism databases and meta-databases.
Keyword:
INTERACTION NETWORKS
CRISPR/CAS9 LIBRARY
FUNCTIONAL GENOMICS
SYSTEMS BIOLOGY
CANCER
SCREENS
LANDSCAPE
RESOURCE
ONTOLOGY
COMMON
AI总结
对已上传原文的论文进行重点信息的提取，主要内容包括：简要概述、研究摘要、背景介绍、关键亮点、图文解析、展望与总结。
期刊
IF:
13.1
论文数:
3.6W
被引数:
29.0W
机构
引用论文
Effect of Food and Ranitidine on Saquinavir Pharmacokinetics and Gastric pH in Healthy Volunteers
PREAI
分享收藏
Analyzing and interpreting genome data at the network level with ConsensusPathDB.png)
NATURE PROTOCOLSOAAI
NATURE PROTOCOLSIF16
OAAI分享收藏A Network of Conserved Synthetic Lethal Interactions for Exploration of Precision Cancer TherapyMOLECULAR CELLOAAI
MOLECULAR CELLIF16.6
OAAI分享收藏分享收藏
查看更多内容