The Classification and Evolution of Enzyme Function

doi:10.1016/j.bpj.2015.04.020

2015-09-01

Sergio Martínez Cuesta

Syed Asad Rahman

Nicholas Furnham

Janet M. Thornton *

DOI：10.1016/j.bpj.2015.04.020

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摘要

En 中文

Enzymes are the proteins responsible for the catalysis of life. Enzymes sharing a common ancestor as defined by sequence and structure similarity are grouped into families and superfamilies. The molecular function of enzymes is defined as their ability to catalyze biochemical reactions; it is manually classified by the Enzyme Commission and robust approaches to quantitatively compare catalytic reactions are just beginning to appear. Here, we present an overview of studies at the interface of the evolution and function of enzymes.

Keyword:

LARGE-SCALE

PROMISCUITY

SEQUENCE

MUTATION

SITES

TOOL

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期刊

Biophysical Journal

IF:

3.1

论文数:

5.1W

被引数:

4.4W

机构

European Bioinformatics Institute

学者数:

1.2K

论文数: 605

被引数: 1.4W

european molecular biology laboratory (embl)

学者数:

8.3K

论文数: 5.1K

被引数: 31

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