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SpaDiff denoises sequence-based spatial transcriptomics via diffusion process
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DOI：10.1016/j.crmeth.2026.101530.png)
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Abstract
En 中文
• SpaDiff denoises spatial transcriptomics via mass-conserving reverse diffusion • Score-based ODE corrects spot-swapping while preserving total UMI counts exactly • Outperforms five state-of-the-art denoisers on simulated and three real datasets • Sharpens spatial domains without erasing within-region tumor heterogeneity
Keywords:
sequence-based spatial transcriptomics
spatial transcriptomics
data denoising
diffusion process
score-based diffusion
spot swapping
CP: computational biology
CP: systems biology
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