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S

Sydney M. Shaffer

university of pennsylvania

19H-index
90Paper Count
3.7KCitation Count
Published Papers 33
Publication Date
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Pre-existing cell states predict resistance to multiple treatments
errCell Genomics
IF9
err2026-03-30
err0
errOAAI
errDylan L. Schaff; Phoebe E. White; Christopher J. Cote; Grace E. Watterson; Kevin Z. Lin; Aria J. Fasse; Nancy R. Zhang; Sydney M. Shaffer
errShare
errSave
SpaceBar enables single-cell-resolution clone tracing with imaging-based spatial transcriptomics
errNature Methods
IF32.1
err2025-12-18
err0
PREAI
errGrant Kinsler; Caitlin Fagan; Haiyin Li; Jessica Kaster; Maggie Dunne; Robert J. Vander Velde; Ryan H. Boe; Sydney Shaffer; Meenhard Herlyn; Arjun Raj; Yael Heyman
errShare
errSave
Clonal cell states link gastroesophageal junction tissues with metaplasia and cancer
errNature Communications
IF15.7
err2025-12-08
err0
errOAAI
errRodrigo A. Gier; Sydney A. Bracht; Jiazhen Rong; Raúl A. Reyes Hueros; Madison L. Wahlsten; Christopher Cote; Maureen DeMarshall; Tatiana A. Karakasheva; Alexandra Strauss Starling; Amanda B. Muir; Gary W. Falk; Nancy R. Zhang; Sydney M. Shaffer
errShare
errSave
Unveiling heterogeneity in rare cells by combining RNA-based sorting and scRNA-seq
errNATURE GENETICS
IF0
err2025-02-07
err0
PREAI
errWahlsten, Madison; Shaffer, Sydney M.
errShare
errSave
Cancer-associated fibroblasts maintain critical pancreatic cancer cell lipid homeostasis in the tumor microenvironment
errCELL REPORTS
IF6.9
err2024-11-01
err0
errOAAI
errHan, Xu; Burrows, Michelle; Kim, Laura C.; Xu, Jimmy P.; Vostrejs, Will; Le, Tran Ngoc Van; Poltorack, Carson; Jiang, Yanqing; Cukierman, Edna; Stanger, Ben Z.; Reiss, Kim A.; Shaffer, Sydney M.; Mesaros, Clementina; Keith, Brian; Simon, M. Celeste
errShare
errSave
Spatial and single cell transcriptomics uncovers metabolic reprogramming and NETosis of neutrophils in human pancreatic cancer
errCANCER RESEARCH
IF16.6
err2024-09-15
err0
PREAI
errPoltorack, Carson D.; Shaffer, Sydney M.; Simon, M. Celeste
errShare
errSave
Development of a functional beige fat cell line uncovers independent subclasses of cells expressing UCP1 and the futile creatine cycle
errCELL METABOLISM
IF30.9
err2024-09-01
err1
PREAI
errVargas-Castillo, Ariana; Sun, Yizhi; Smythers, Amanda L.; Grauvogel, Louisa; Dumesic, Phillip A.; Emont, Margo P.; Tsai, Linus T.; Rosen, Evan D.; Zammit, Nathan W.; Shaffer, Sydney M.; Ordonez, Martha; Chouchani, Edward T.; Gygi, Steven P.; Wang, Tongtong; Sharma, Anand K.; Balaz, Miroslav; Wolfrum, Christian; Spiegelman, Bruce M.
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errSave
Disrupting cellular memory to overcome drug resistance (vol 14, 7130, 2023)
errNATURE COMMUNICATIONS
IF15.7
err2024-05-20
err0
errOAAI
errHarmange, Guillaume; Hueros, Raul A. Reyes; Schaff, Dylan L.; Emert, Benjamin; Saint-Antoine, Michael; Kim, Laura C.; Niu, Zijian; Nellore, Shivani; Fane, Mitchell E.; Alicea, Gretchen M.; Weeraratna, Ashani T.; Simon, M. Celeste; Singh, Abhyudai; Shaffer, Sydney M.
errShare
errSave
Clonal differences underlie variable responses to sequential and prolonged treatment
errCELL SYSTEMS
IF7.7
err2024-03-01
err1
errOAAI
errSchaff, Dylan L.; Fasse, Aria J.; White, Phoebe E.; Vander Velde, Robert J.; Shaffer, Sydney M.
errShare
errSave
EGF/EGFR signaling in priming for resistance to BRAF/MEK inhibitors in melanoma
errCANCER RESEARCH
IF16.6
err2024-02-01
err0
PREAI
errVander Velde, Robert J.; Shaffer, Sydney M.
errShare
errSave
The role of tumor transcriptional variability in evading acute CD8+T cell exposure in melanoma
errCANCER RESEARCH
IF16.6
err2024-02-01
err0
PREAI
errNg, Raymond W. S.; Shaffer, Sydney M.
errShare
errSave
IGF2BP1/IMP1 Deletion Enhances a Facultative Stem Cell State via Regulation of MAP1LC3B
errCELLULAR AND MOLECULAR GASTROENTEROLOGY AND HEPATOLOGY
IF7.4
err2024-01-01
err1
errOAAI
errParham, Louis R.; Williams, Patrick A.; Katada, Kay; Nettleford, Shaneice K.; Chatterji, Priya; Acheampong, Kofi K.; Danan, Charles H.; Ma, Xianghui; Simon, Lauren A.; Naughton, Kaitlyn E.; Mizuno, Rei; Karakasheva, Tatiana; McMillan, Emily A.; Whelan, Kelly A.; Brady, Donita C.; Shaffer, Sydney M.; Hamilton, Kathryn E.
errShare
errSave
Disrupting cellular memory to overcome drug resistance
errNATURE COMMUNICATIONS
IF15.7
err2023-11-06
err10
errOAAI
errHarmange, Guillaume; Hueros, Raul A. Reyes; Schaff, Dylan L.; Emert, Benjamin; Saint-Antoine, Michael; Kim, Laura C.; Niu, Zijian; Nellore, Shivani; Fane, Mitchell E.; Alicea, Gretchen M.; Weeraratna, Ashani T.; Simon, M. Celeste; Singh, Abhyudai; Shaffer, Sydney M.
errShare
errSave
Detection of blood-brain barrier disruption in brains of patients with COVID-19, but no evidence of brain penetration by SARS-CoV-2
errACTA NEUROPATHOLOGICA
IF9.3
err2023-08-25
err8
PREAI
errSong, Hailong; Tomasevich, Alexandra; Acheampong, Kofi K.; Schaff, Dylan L.; Shaffer, Sydney M.; Dolle, Jean-Pierre; Johnson, Victoria E.; Mikytuck, Bailey; Lee, Edward B.; Nolan, Amber; Keene, C. Dirk; Weiss, Susan R.; Stewart, William; Smith, Douglas H.
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errSave
A Curious Case of Cocaine-Induced Hypokalemic Periodic Paralysis Mimicking Guillain-Barre Syndrome
errNEUROLOGY
IF8.5
err2023-04-25
err0
PREAI
errBaumann, Elizabeth; Rizvi, Hassnain; Alayon, Amaris; Kendall, Tyler; Shaffer, Sydney; Mouhanna, Stephan; Kenniff, Sean
errShare
errSave
Integrating mutational and nonmutational mechanisms of acquired therapy resistance within the Darwinian paradigm
errTRENDS IN CANCER
IF17.5
err2022-06-01
err5
errOAAI
errVelde, Robert Vander; Shaffer, Sydney; Marusyk, Andriy
errShare
errSave
Selection and reprogramming contribute to the evolution of targeted therapy resistance
errCANCER RESEARCH
IF16.6
err2022-05-15
err0
PREAI
errVander Velde, Robert; Shaffer, Sydney
errShare
errSave
Overcoming resistance by driving melanoma cells into drug-susceptible states
errCANCER RESEARCH
IF16.6
err2022-05-15
err0
PREAI
errHarmange, Guillaume; Emert, Ben; Schaff, Dylan; Reyes-Hueros, Raul; Shaffer, Sydney
errShare
errSave
Does order matter? Dissecting the single-cell differences underlying resistance to sequential drug treatment
errCANCER RESEARCH
IF16.6
err2022-05-15
err0
PREAI
errFasse, Aria J.; Schaff, Dylan L.; Shaffer, Sydney M.
errShare
errSave
Rare cell variability and drug resistance in cancer Sydney Shaffer
errCANCER RESEARCH
IF16.6
err2022-05-15
err0
PREAI
errShaffer, Sydney
errShare
errSave

Research Directions

No research directions
Co-authors
Cooperation Journals
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Steven P. Gygi
H-index: 195 · Papers: 1.0K
B
Bruce M. Spiegelman
H-index: 186 · Papers: 471
M
Meenhard Herlyn
H-index: 136 · Papers: 1.7K
M
M. Celeste Simon
H-index: 118 · Papers: 609
D
Douglas H. Smith
H-index: 102 · Papers: 352
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