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D

Douglas M. Fowler

university of washington

45H-index
193Paper Count
9.5KCitation Count
Published Papers 72
Publication Date
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An integrated, scaled approach to resolve TSC2 variants of uncertain significance
errNature Communications
IF15.7
err2026-07-09
err0
errOAAI
errCarina G. Biar; Ziyu R. Wang; Nathan D. Camp; Daniel L. Holmes; Melinda K. Wheelock; Sriram Pendyala; Abby V. McGee; Pankhuri Gupta; Abbye E. McEwen; Malvika Tejura; Marcy E. Richardson; Jamie D. Weyandt; Taylor Coleman; Alan F. Rubin; Nick Moore; Ross Stewart; Daniel Zeiberg; Allyssa J. Vandi; Samantha Dawson; Predrag Radivojac; Lea M. Starita; Gemma L. Carvill; Richard G. James; Douglas M. Fowler; Jeffrey D. Calhoun
errShare
errSave
A near-complete map of human cytosolic degrons and their relevance for disease
errScience Advances
IF12.5
err2026-02-06
err0
errOAAI
errVasileios Voutsinos; Kristoffer E. Johansson; Fia B. Larsen; Martin Grønbæk-Thygesen; Nicolas Jonsson; Emma Holm-Olesen; Giulio Tesei; Amelie Stein; Douglas M. Fowler; Kresten Lindorff-Larsen; Rasmus Hartmann-Petersen
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errSave
The IGVF catalog-from genetic variation to function
errNUCLEIC ACIDS RESEARCH
IF13.1
err2025-12-01
err1
PREAI
errLi, Daofeng; Liu, Shane; Assis, Pedro R.; Li, Mingjie; Dong, Shengcheng; Whaling, Ian; Jolanki, Otto; Kagda, Meenakshi; Zhang, Wenjin; Macias-Velasco, Juan F.; Liu, Tianjie; Cody, Sarah; Antonacci-Fulton, Lucinda; Huang, Yuanhao; Liu, Jie; Montgomery, Michael T.; Zeiberg, Daniel; Jain, Shantanu; Pejaver, Vikas; Bergquist, Timothy; Chen, Yile; Radivojac, Predrag; Gersbach, Charles A.; Sherpa, Rintsen N.; Castro, Christopher P.; Boyle, Alan P.; Starita, Lea M.; Fowler, Douglas M.; Ahituv, Nadav; Dey, Kushal K.; Majoros, William H.; Reddy, Timothy E.; Craven, Mark; Sinha, Riya; Sverchkov, Yuriy; Cai, Xiangmeng; Nzima, Mpathi Z.; Calderwood, Michael A.; Rozowsky, Joel; Gerstein, Mark; Ma, Jian; Yue, Feng; Cherry, J. Michael; Love, Michael, I; Engreitz, Jesse M.; Hitz, Benjamin C.; Wang, Ting
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errSave
Identification of affinity-optimized peptide binders of a viral protease for chemical genetic applications
errBioorganic & Medicinal Chemistry Letters
IF2.2
err2025-11-05
err0
PREAI
errFernando Banales-Mejia; Emily M. Dieter; Kyler J. Radmall; Glenna W. Foight; Douglas M. Fowler; Dustin J. Maly
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errSave
The functional landscape of coding variation in the familial hypercholesterolemia gene LDLR
errScience
IF45.8
err2025-10-30
err0
PREAI
errDaniel R. Tabet; Atina G. Coté; Megan C. Lancaster; Jochen Weile; Ashyad Rayhan; Iosifina Fotiadou; Nishka Kishore; Roujia Li; Da Kuang; Jennifer J. Knapp; Carmela S. Carrero; Olivia Taverniti; Anna Axakova; Jack M. P. Castelli; Mohammad M. Islam; Shahin Sowlati-Hashjin; Aanshi Gandhi; Ranim Maaieh; Michael Garton; Kenneth Matreyek; Douglas M. Fowler; Mafalda Bourbon; Simon G. Pfisterer; Andrew M. Glazer; Brett M. Kroncke; Victoria N. Parikh; Euan A. Ashley; Joshua W. Knowles; Melina Claussnitzer; Elizabeth T. Cirulli; Robert A. Hegele; Dan M. Roden; Calum A. MacRae; Frederick P. Roth
errShare
errSave
Multiplexed assays of variant effect for clinical variant interpretation
errNature Reviews Genetics
IF52
err2025-07-21
err0
PREAI
errAbbye E. McEwen; Malvika Tejura; Shawn Fayer; Lea M. Starita; Douglas M. Fowler
errShare
errSave
Imprecision medicine: Systematic gaps in reporting variants of uncertain significance (VUS) and their reclassifications
errGenetics in Medicine
IF6.2
err2025-06-18
err0
PREAI
errAndrew Folta; Adriana E. Sedeño Cortés; Pankhuri Gupta; Abbye E. McEwen; Eric Y. Kao; Martha Horike-Pyne; Jeremy Stone; Brian H. Shirts; Marianne E. Dubard-Gault; Douglas M. Fowler; Lea M. Starita; Fuki M. Hisama; Andrew B. Stergachis
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errSave
A missense variant effect map for the human tumor-suppressor protein CHK2
errAMERICAN JOURNAL OF HUMAN GENETICS
IF8.1
err2024-12-01
err0
PREAI
errGebbia, Marinella; Zimmerman, Daniel; Jiang, Rosanna; Nguyen, Maria; Weile, Jochen; Li, Roujia; Gavac, Michelle; Kishore, Nishka; Sun, Song; Boonen, Rick A.; Hamilton, Rayna; Dines, Jennifer N.; Wahl, Alexander; Reuter, Jason; Johnson, Britt; Fowler, Douglas M.; Couch, Fergus J.; van Attikum, Haico; Roth, Frederick P.
errShare
errSave
Multiplexed profiling of intracellular protein abundance, activity, interactions and druggability with LABEL-seq
errNATURE METHODS
IF32.1
err2024-10-21
err0
PREAI
errSimon, Jessica J.; Fowler, Douglas M.; Maly, Dustin J.
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errSave
Deep mutational scanning of CYP2C19 in human cells reveals a substrate specificity-abundance tradeoff
errGENETICS
IF5.1
err2024-09-25
err0
PREAI
errBoyle, Gabriel E.; Sitko, Katherine A.; Galloway, Jared G.; Haddox, Hugh K.; Bianchi, Aisha Haley; Dixon, Ajeya; Wheelock, Melinda K.; Vandi, Allyssa J.; Wang, Ziyu R.; Thomson, Raine E. S.; Garge, Riddhiman K.; Rettie, Allan E.; Rubin, Alan F.; Geck, Renee C.; Gillam, Elizabeth M. J.; Dewitt, William S.; Matsen, Frederick A.; Fowler, Douglas M.
errShare
errSave
Calibration of variant effect predictors on genome-wide data masks heterogeneous performance across genes
errAMERICAN JOURNAL OF HUMAN GENETICS
IF8.1
err2024-09-01
err2
PREAI
errTejura, Malvika; Fayer, Shawn; McEwen, Abbye E.; Flynn, Jake; Starita, Lea M.; Fowler, Douglas M.
errShare
errSave
Retinoic acid induces human gastruloids with posterior embryo-like structures
errNATURE CELL BIOLOGY
IF19.1
err2024-08-20
err2
errOAAI
errHamazaki, Nobuhiko; Yang, Wei; Kubo, Connor A.; Qiu, Chengxiang; Martin, Beth K.; Garge, Riddhiman K.; Regalado, Samuel G.; Nichols, Eva K.; Pendyala, Sriram; Bradley, Nicholas; Fowler, Douglas M.; Lee, Choli; Daza, Riza M.; Srivatsan, Sanjay; Shendure, Jay
errShare
errSave
Deep mutational scanning reveals a correlation between degradation and toxicity of thousands of aspartoacylase variants
errNATURE COMMUNICATIONS
IF15.7
err2024-05-13
err1
errOAAI
errGronbaek-Thygesen, Martin; Voutsinos, Vasileios; Johansson, Kristoffer E.; Schulze, Thea K.; Cagiada, Matteo; Pedersen, Line; Clausen, Lene; Nariya, Snehal; Powell, Rachel L.; Stein, Amelie; Fowler, Douglas M.; Lindorff-Larsen, Kresten; Hartmann-Petersen, Rasmus
errShare
errSave
Multiplexed Functional Assessments of MYH7 Variants in Human Cardiomyocytes
errCIRCULATION-GENOMIC AND PRECISION MEDICINE
IF5.5
err2024-04-01
err0
PREAI
errFriedman, Clayton E.; Fayer, Shawn; Pendyala, Sriram; Chien, Wei-Ming; Loiben, Alexander; Tran, Linda; Chao, Leslie S.; McKinstry, Ashley; Ahmed, Dania; Farris, Stephen D.; Stempien-Otero, April; Jonlin, Erica C.; Murry, Charles E.; Starita, Lea M.; Fowler, Douglas M.; Yang, Kai-Chun
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errSave
A mutational atlas for Parkin proteostasis
errNATURE COMMUNICATIONS
IF15.7
err2024-02-20
err6
errOAAI
errClausen, Lene; Voutsinos, Vasileios; Cagiada, Matteo; Johansson, Kristoffer E.; Gronbaek-Thygesen, Martin; Nariya, Snehal; Powell, Rachel L.; Have, Magnus K. N.; Oestergaard, Vibe H.; Stein, Amelie; Fowler, Douglas M.; Lindorff-Larsen, Kresten; Hartmann-Petersen, Rasmus
errShare
errSave
Profiling of drug resistance in Src kinase at scale uncovers a regulatory network coupling autoinhibition and catalytic domain dynamics
errCELL CHEMICAL BIOLOGY
IF7.2
err2024-02-01
err7
PREAI
errChakraborty, Sujata; Ahler, Ethan; Simon, Jessica J.; Fang, Linglan; Potter, Zachary E.; Sitko, Katherine A.; Stephany, Jason J.; Guttman, Miklos; Fowler, Douglas M.; Maly, Dustin J.
errShare
errSave
Will variants of uncertain significance still exist in 2030?
errAMERICAN JOURNAL OF HUMAN GENETICS
IF8.1
err2024-01-01
err26
errOAAI
errFowler, Douglas M.; Rehm, Heidi L.
errShare
errSave
Antigen perception in T cells by long-term Erk and NFAT signaling dynamics
errPROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
IF9.1
err2023-12-19
err4
errOAAI
errWither, Matthew J.; White, William L.; Pendyala, Sriram; Leanza, Paul J.; Fowler, Douglas M.; Kueh, Hao Yuan
errShare
errSave
Highlighting rare disease research with a GENETICS and G3 series on genetic models of rare diseases
errGENETICS
IF5.1
err2023-08-09
err0
errOAAI
errHieter, Philip; Andrews, Brenda; Fowler, Douglas; Bellen, Hugo
errShare
errSave
High-throughput Generation And Functional Characterization Of Myosin Heavy Chain 7 Variants In Genome-edited Cardiomyocytes
errCIRCULATION RESEARCH
IF16.2
err2023-08-04
err0
PREAI
errYang, Kai-Chun; Friedman, Clayton; Fayer, Shawn; Pendyala, Sriram; Chien, Wei-Ming; Loiben, Alexander; Chao, Leslie; Ahmed, Dania; Karbassi, Elaheh; Murry, Charles; Starita, Lea; Fowler, Douglas
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errSave

Research Directions

No research directions
Co-authors
Cooperation Journals
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