Not logged in Thoughts for the future Alkhalaf, Lona M.; Arrowsmith, Cheryl; Balskus, Emily P.; Bergamini, Giovanna; Bhandari, Rashna; Chang, Christopher J.; Chen, Peng; Chen, Xing; Ciulli, Alessio; Cricco, Julia A.; Davis, Benjamin G.; Delbianco, Martina; Dudareva, Natalia; Dueber, Erin; Ferguson, Fleur; de Giuseppe, Priscila Oliveira; Hamachi, Itaru; Hammond, Ming Chen; Hatzios, Stavroula K.; Do Heo, Won; Janet, Jon Paul; Kamat, Siddhesh S.; Knapp, Stefan; Krishnan, Yamuna; Lang, Kathrin; Laraia, Luca; Leveson-Gower, Reuben B.; Li, Xiang David; Liu, David R.; Liu, Mo-Fang; London, Nir; Mahanta, Nilkamal; Mayor-Ruiz, Cristina; Muir, Tom; Murakami, Mario Tyago; Rhee, Hyun-Woo; Robers, Matt; Satz, Alex; Schulman, Brenda A.; Shen, Ben; Shoichet, Brian; Strauss, Erick; Suzuki, Tsutomu; Tiwary, Pratyush; Waldmann, Herbert; Ward, Thomas R.; Weeks, Amy; Weerapana, Eranthie; Winter, Georg Share Save
Maintaining the tumor microenvironment: Serum-free cell culture for an advanced 3D in vitro tissue model Siebenmorgen, Alina; Wohle, Christian; Lamfried, Katharina; Carrera, Lilian Martinez; Heller, Bianca; Lupar, Katharina; Bergamini, Giovanna; Poeckel, Daniel; Hardt, Olaf; Theek, Benjamin Share Save
Network integration of thermal proteome profiling with multi-omics data decodes PARP inhibition Burtscher, Mira L.; Gade, Stephan; Garrido-Rodriguez, Martin; Rutkowska, Anna; Werner, Thilo; Eberl, H. Christian; Petretich, Massimo; Knopf, Natascha; Zirngibl, Katharina; Grandi, Paola; Bergamini, Giovanna; Bantscheff, Marcus; Faelth-Savitski, Maria; Saez-Rodriguez, Julio Share Save
Dostarlimab shows dose-dependent immune activation of the tumor microenvironment in a patient-derived NSCLC explant model similar to pembrolizumab Perrin, Jessica; Wippich, Frank; Sherina, Valeriia; Dvornikov, Dmytro; Lupar, Katharina; Melhem, Murad M.; Hanafin, Patrick; Waight, Jeremy; Yu, Jong; Yadavilli, Sapna; Poeckel, Daniel; Bergamini, Giovanna Share Save
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amTCO, a new trans-cyclooctene derivative to study drug-target interactions in cells Echalier, Cecile; Rutkowska, Anna; Kojic, Ana; Thomson, Douglas W.; Edwards, Lee J.; McKay, Blandine S. J.; Muelbaier, Marcel; Schultz, Carsten; Bergamini, Giovanna Share Save
An integrated multiomic and quantitative label-free microscopy-based approach to study pro-fibrotic signalling in ex vivo human precision-cut lung slices Khan, Muzamil Majid; Poeckel, Daniel; Halavatyi, Aliaksandr; Zukowska-Kasprzyk, Joanna; Stein, Frank; Vappiani, Johanna; Sevin, Daniel C.; Tischer, Christian; Zinn, Nico; Eley, Jessica D.; Gudmann, Natasja Staehr; Muley, Thomas; Winter, Hauke; Fisher, Andrew J.; Nanthakumar, Carmel B.; Bergamini, Giovanna; Pepperkok, Rainer Share Save
The mTORC1/4E-BP1 axis represents a critical signaling node during fibrogenesis (vol 10, 6, 2019) Woodcock, Hannah V.; Eley, Jessica D.; Guillotin, Delphine; Plate, Manuela; Nanthakumar, Carmel B.; Martufi, Matteo; Peace, Simon; Joberty, Gerard; Poeckel, Daniel; Good, Robert B.; Taylor, Adam R.; Zinn, Nico; Redding, Matthew; Forty, Ellen J.; Hynds, Robert E.; Swanton, Charles; Karsdal, Morten; Maher, Toby M.; Fisher, Andrew; Bergamini, Giovanna; Marshall, Richard P.; Blanchard, Andy D.; Mercer, Paul F.; Chambers, Rachel C. Share Save
Identifying drug targets in tissues and whole blood with thermal-shift profiling Perrin, Jessica; Werner, Thilo; Kurzawa, Nils; Rutkowska, Anna; Childs, Dorothee D.; Kalxdorf, Mathias; Poeckel, Daniel; Stonehouse, Eugenia; Strohmer, Katrin; Heller, Bianca; Thomson, Douglas W.; Krause, Jana; Becher, Isabelle; Eberl, H. Christian; Vappiani, Johanna; Sevin, Daniel C.; Rau, Christina E.; Franken, Holger; Huber, Wolfgang; Faelth-Savitski, Maria; Savitski, Mikhail M.; Bantscheff, Marcus; Bergamini, Giovanna Share Save
Optimization of Orally Bioavailable PI3Kδ Inhibitors and Identification of Vps34 as a Key Selectivity Target Henley, Zoe A.; Amour, Augustin; Barton, Nick; Bantscheff, Marcus; Bergamini, Giovanna; Bertrand, Sophie M.; Convery, Maire; Down, Kenneth; Duempelfeld, Birgit; Edwards, Chris D.; Grandi, Paola; Gore, Paul M.; Keeling, Steve; Livia, Stefano; Mallett, David; Maxwell, Aoife; Price, Mark; Rau, Christina; Reinhard, Friedrich B. M.; Rowedder, James; Rowland, Paul; Taylor, Jonathan A.; Thomas, Daniel A.; Hessel, Edith M.; Hamblin, J. Nicole Share Save
Discovery of GSK8612, a Highly Selective and Potent TBK1 Inhibitor Thomson, Douglas W.; Poeckel, Daniel; Zinn, Nico; Rau, Christina; Strohmer, Katrin; Wagner, Anne J.; Graves, Alan P.; Perrin, Jessica; Bantscheff, Marcus; Duempelfeld, Birgit; Kasparcova, Viera; Ramanjulu, Joshi M.; Pesiridis, G. Scott; Muelbaier, Marcel; Bergamini, Giovanna Share Save
The mTORC1/4E-BP1 axis represents a critical signaling node during fibrogenesis Woodcock, Hannah V.; Eley, Jessica D.; Guillotin, Delphine; Plate, Manuela; Nanthakumar, Carmel B.; Martufi, Matteo; Peace, Simon; Joberty, Gerard; Poeckel, Daniel; Good, Robert B.; Taylor, Adam R.; Zinn, Nico; Redding, Matthew; Forty, Ellen J.; Hynds, Robert E.; Swanton, Charles; Karsdal, Morten; Maher, Toby M.; Bergamini, Giovanna; Marshall, Richard P.; Blanchard, Andy D.; Mercer, Paul F.; Chambers, Rachel C. Share Save
Systematic analysis of protein turnover in primary cells Mathieson, Toby; Franken, Holger; Kosinski, Jan; Kurzawa, Nils; Zinn, Nico; Sweetman, Gavain; Poeckel, Daniel; Ratnu, Vikram S.; Schramm, Maike; Becher, Isabelle; Steidel, Michael; Noh, Kyung-Min; Bergamini, Giovanna; Beck, Martin; Bantscheff, Marcus; Savitski, Mikhail M. Share Save
Activation of the Amino Acid Response Pathway Blunts the Effects of Cardiac Stress Qin, Pu; Arabacilar, Pelin; Bernard, Roberta E.; Bao, Weike; Olzinski, Alan R.; Guo, Yuanjun; Lal, Hind; Eisennagel, Stephen H.; Platchek, Michael C.; Xie, Wensheng; del Rosario, Julius; Nayal, Mohamad; Lu, Quinn; Roethke, Theresa; Schnackenberg, Christine G.; Wright, Fe; Quaile, Michael P.; Halsey, Wendy S.; Hughes, Ashley M.; Sathe, Ganesh M.; Livi, George P.; Kirkpatrick, Robert B.; Qu, Xiaoyan A.; Rajpal, Deepak K.; Savitski, Maria Faelth; Bantscheff, Marcus; Joberty, Gerard; Bergamini, Giovanna; Force, Thomas L.; Gatto, Gregory J., Jr.; Hu, Erding; Willette, Robert N. Share Save
A Modular Probe Strategy for Drug Localization, Target Identification and Target Occupancy Measurement on Single Cell Level Rutkowska, Anna; Thomson, Douglas W.; Vappiani, Johanna; Werner, Thilo; Mueller, Katrin M.; Dittus, Lars; Krause, Jana; Muelbaier, Marcel; Bergamini, Giovanna; Bantscheff, Marcus Share Save
CZ415, a Highly Selective mTOR Inhibitor Showing in Vivo Efficacy in a Collagen Induced Arthritis Model Cansfield, Andrew D.; Ladduwahetty, Tammy; Sunose, Mihiro; Ellard, Katie; Lynch, Rosemary; Newton, Anthea L.; Lewis, Ann; Bennett, Gavin; Zinn, Nico; Thomson, Douglas W.; Rueger, Anne J.; Feutrill, John T.; Rausch, Oliver; Watt, Alan P.; Bergamini, Giovanna Share Save
Catalytic in vivo protein knockdown by small-molecule PROTACs Bondeson, Daniel P.; Mares, Alina; Smith, Ian E. D.; Ko, Eunhwa; Campos, Sebastien; Miah, Afjal H.; Mulholland, Katie E.; Routly, Natasha; Buckley, Dennis L.; Gustafson, Jeffrey L.; Zinn, Nico; Grandi, Paola; Shimamura, Satoko; Bergamini, Giovanna; Faelth-Savitski, Maria; Bantscheff, Marcus; Cox, Carly; Gordon, Deborah A.; Willard, Ryan R.; Flanagan, John J.; Casillas, Linda N.; Votta, Bartholomew J.; den Besten, Willem; Famm, Kristoffer; Kruidenier, Laurens; Carter, Paul S.; Harling, John D.; Churcher, Ian; Crews, Craig M. Share Save
A selective inhibitor reveals PI3Kγ dependence of TH17 cell differentiation (vol 8, pg 576, 2012) Bergamini, Giovanna; Bell, Kathryn; Shimamura, Satoko; Werner, Thilo; Cansfield, Andrew; Mueller, Katrin; Perrin, Jessica; Rau, Christina; Ellard, Katie; Hopf, Carsten; Doce, Carola; Leggate, Daniel; Mangano, Raffaella; Mathieson, Toby; O'Mahony, Alison; Plavec, Ivan; Rharbaoui, Faiza; Reinhard, Friedrich; Savitski, Mikhail M.; Ramsden, Nigel; Hirsch, Emilio; Drewes, Gerard; Rausch, Oliver; Bantscheff, Marcus; Neubauer, Gitte Share Save
A selective inhibitor reveals PI3Kγ dependence of TH17 cell differentiation Bergamini, Giovanna; Bell, Kathryn; Shimamura, Satoko; Werner, Thilo; Cansfield, Andrew; Mueller, Katrin; Perrin, Jessica; Rau, Christina; Ellard, Katie; Hopf, Carsten; Doce, Carola; Leggate, Daniel; Mangano, Raffaella; Mathieson, Toby; O'Mahony, Alison; Plavec, Ivan; Rharbaoui, Faiza; Reinhard, Friedrich; Savitski, Mikhail M.; Ramsden, Nigel; Hirsch, Emilio; Drewes, Gerard; Rausch, Oliver; Bantscheff, Marcus; Neubauer, Gitte Share Save
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