Not logged in Share Save
Share Save
Discovery of AVI-6451, a Potent and Selective Inhibitor of the SARS-CoV-2 ADP-Ribosylhydrolase Mac1 with Oral Efficacy In Vivo Jaishankar, Priyadarshini; Correy, Galen J.; Matsui, Yusuke; Togo, Takaya; Rachman, Moira M.; Stevens, Maisie G. V.; Hantz, Eric R.; Zheng, Jeffrey; Diolaiti, Morgan E.; Montano, Mauricio; Taha, Taha Y.; Rosecrans, Julia; Pampel, Julius; Krogan, Nevan J.; Shoichet, Brian K.; Ashworth, Alan; Ott, Melanie; Fraser, James S.; Renslo, Adam R. Share Save
The Mac1 ADP-ribosylhydrolase is a therapeutic target for SARS-CoV-2 Suryawanshi, Rahul K.; Jaishankar, Priyadarshini; Correy, Galen J.; Rachman, Moira M.; O'leary, Patrick C.; Taha, Taha Y.; Matsui, Yusuke; Zapatero-Belinchon, Francisco J.; Mccavitt-Malvido, Maria; Doruk, Yagmur U.; Stevens, Maisie Gv; Diolaiti, Morgan E.; Jogalekar, Manasi P.; Chen, Huadong; Richards, Alicia L.; Kongpracha, Pornparn; Bali, Sofia; Montano, Mauricio; Rosecrans, Julia; Matthay, Michael; Togo, Takaya; Gonciarz, Ryan L.; Gopalkrishnan, Saumya; Neitz, R. Jeffrey; Krogan, Nevan J.; Swaney, Danielle L.; Shoichet, Brian K.; Ott, Melanie; Renslo, Adam R.; Ashworth, Alan; Fraser, James S. Share Save
Identifying Artifacts from Large Library Docking (vol 67 , pg16796-16806 , 2024) Wu, Yujin; Liu, Fangyu; Glenn, Isabella; Fonseca-Valencia, Karla; Paris, Lu; Xiong, Yeyue; Mailhot, Olivier; Jerome, Steven V.; Brooks III, Charles L.; Shoichet, Brian K. Share Save
Share Save
Share Save
Docking 14 Million Virtual Isoquinuclidines against the μ and κ Opioid Receptors Reveals Dual Antagonists-Inverse Agonists with Reduced Withdrawal Effects Vigneron, SF; Ohno, S; Braz, J; Kim, JY; Kweon, OS; Webb, C; Billesbolle, CB; Srinivasan, K; Bhardwaj, K; Irwin, JJ; Manglik, A; Basbaum, AI; Ellman, JA; Shoichet, BK Share Save
Structure-based discovery of highly bioavailable, covalent, broad-spectrum coronavirus MPro inhibitors with potent in vivo efficacy Detomasi, Tyler C.; Degotte, Gilles; Huang, Sijie; Suryawanshi, Rahul K.; Diallo, Amy; Lizzadro, Luca; Zaptero-Belinchon, Francisco J.; Taha, Taha Y.; Li, Jiapeng; Richards, Alicia L.; Hantz, Eric R.; Alam, Zain; Montano, Mauricio; McCavitt-Malvido, Maria; Gumpena, Rajesh; Partridge, James R.; Correy, Galen J.; Matsui, Yusuke; Charvat, Annemarie F.; Glenn, Isabella S.; Rosecrans, Julia; Revalde, Jezrael L.; Anderson, Dashiell; Hultquist, Judd F.; Arkin, Michelle R.; Neitz, R. Jeffrey; Swaney, Danielle L.; Krogan, Nevan J.; Shoichet, Brian K.; Verba, Kliment A.; Ott, Melanie; Renslo, Adam R.; Craik, Charles S. Share Save
Share Save
Characterization of quinazolinone calcilytic therapy for autosomal dominant hypocalcemia type 1 (ADH1) Hannan, Fadil M.; Kooblall, Kreepa G.; Stevenson, Mark; Elajnaf, Taha; Liu, Fangyu; Lines, Kate E.; Meng, Xin; Stewart, Michelle; Wells, Sara; Nemeth, Edward F.; Shoichet, Brian K.; Kneissel, Michaela; Gasser, Juerg A.; Thakker, Rajesh, V Share Save
Thoughts for the future Alkhalaf, Lona M.; Arrowsmith, Cheryl; Balskus, Emily P.; Bergamini, Giovanna; Bhandari, Rashna; Chang, Christopher J.; Chen, Peng; Chen, Xing; Ciulli, Alessio; Cricco, Julia A.; Davis, Benjamin G.; Delbianco, Martina; Dudareva, Natalia; Dueber, Erin; Ferguson, Fleur; de Giuseppe, Priscila Oliveira; Hamachi, Itaru; Hammond, Ming Chen; Hatzios, Stavroula K.; Do Heo, Won; Janet, Jon Paul; Kamat, Siddhesh S.; Knapp, Stefan; Krishnan, Yamuna; Lang, Kathrin; Laraia, Luca; Leveson-Gower, Reuben B.; Li, Xiang David; Liu, David R.; Liu, Mo-Fang; London, Nir; Mahanta, Nilkamal; Mayor-Ruiz, Cristina; Muir, Tom; Murakami, Mario Tyago; Rhee, Hyun-Woo; Robers, Matt; Satz, Alex; Schulman, Brenda A.; Shen, Ben; Shoichet, Brian; Strauss, Erick; Suzuki, Tsutomu; Tiwary, Pratyush; Waldmann, Herbert; Ward, Thomas R.; Weeks, Amy; Weerapana, Eranthie; Winter, Georg Share Save
High-affinity agonists reveal recognition motifs for the MRGPRD GPCR Wang, Chunyu; Liu, Yongfeng; Lanier, Marion; Yeager, Adam; Singh, Isha; Gumpper, Ryan H.; Krumm, Brian E.; Deleon, Chelsea; Zhang, Shicheng; Boehm, Marcus; Pittner, Richard; Baron, Alain; Dvorak, Lisa; Bacon, Corinne; Shoichet, Brain K.; Martinborough, Esther; Fay, Jonathan F.; Cao, Can; Roth, Bryan L. Share Save
Cryo-EM structure of Alzheimer's disease tau filaments with PET ligand MK-6240 Kunach, Peter; Vaquer-Alicea, Jaime; Smith, Matthew S.; Monistrol, Jim; Hopewell, Robert; Moquin, Luc; Therriault, Joseph; Tissot, Cecile; Rahmouni, Nesrine; Massarweh, Gassan; Soucy, Jean-Paul; Guiot, Marie-Christine; Shoichet, Brian K.; Rosa-Neto, Pedro; Diamond, Marc I.; Shahmoradian, Sarah H. Share Save
Identifying Artifacts from Large Library Docking Wu, Yujin; Liu, Fangyu; Glenn, Isabella; Fonseca-Valencia, Karla; Paris, Lu; Xiong, Yuyue; Jerome, Steven V.; Brooks, Charles L., III; Shoichet, Brian K. Share Save
Share Save
Share Save
Profiling the proximal proteome of the activated μ-opioid receptor Polacco, Benjamin J.; Lobingier, Braden T.; Blythe, Emily E.; Abreu, Nohely; Khare, Prachi; Howard, Matthew K.; Gonzalez-Hernandez, Alberto J.; Xu, Jiewei; Li, Qiongyu; Novy, Brandon; Naing, Zun Zar Chi; Shoichet, Brian K.; Coyote-Maestas, Willow; Levitz, Joshua; Krogan, Nevan J.; Von Zastrow, Mark; Huttenhain, Ruth Share Save
Docking for Molecules That Bind in a Symmetric Stack with SymDOCK Smith, Matthew S.; Knight, Ian S.; Kormos, Rian C.; Pepe, Joseph G.; Kunach, Peter; Diamond, Marc I.; Shahmoradian, Sarah H.; Irwin, John J.; Degrado, William F.; Shoichet, Brian K. Share Save
Docking for EP4R antagonists active against inflammatory pain Gahbauer, Stefan; DeLeon, Chelsea; Braz, Joao M.; Craik, Veronica; Kang, Hye Jin; Wan, Xiaobo; Huang, Xi-Ping; Billesbolle, Christian B.; Liu, Yongfeng; Che, Tao; Deshpande, Ishan; Jewell, Madison; Fink, Elissa A.; Kondratov, Ivan S.; Moroz, Yurii S.; Irwin, John J.; Basbaum, Allan I.; Roth, Bryan L.; Shoichet, Brian K. Share Save
.png){kind=icon}
.png){kind=icon}
.png){kind=icon}
.png){kind=icon}
.png){kind=icon}
Share.png){kind=icon}
Save
Not logged in.png){kind=icon}