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Y

Yong Cheng

St. Jude Children's Research Hospital

41H-index
128Paper Count
1.9WCitation Count
Published Papers 48
Publication Date
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The H3K4 methyltransferase KMT2D is an essential cofactor for GATA1 at erythroid gene enhancers
errNature Communications
IF15.7
err2026-07-06
err0
errOAAI
errJianxiang Zhang; Ye Xin; Li Cheng; Yuan Xing; Yuxin Ouyang; Mengli Zhang; Yubin Chen; Ruopeng Feng; Xiaohui Qiu; Beisi Xu; Yong Cheng; Chunliang Li; Hans-Martin Herz; Mitchell J. Weiss; Peng Xu
errShare
errSave
Single-cell transcriptomics reveals heterocellular γ-globin gene expression in Aγδβ-thalassemia
errBlood Advances
IF7.1
err2025-12-06
err0
errOAAI
errPhillip A. Doerfle; Yichao Li; Yu Yao; Ruopeng Feng; Thiyagaraj Mayuranathan; Jingjing Zhang; Emilia Kooienga; David L. Cullins; Rohith Jesudas; Dillon C. Williams; Jane S. Hankins; Yong Cheng; David K. Wood; Mitchell J. Weiss
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errSave
Silencing of BCL11A by Disrupting Enhancer-Dependent Epigenetic Insulation
errBlood
IF23.1
err2025-11-07
err0
errOAAI
errKaili Wang; Juan Wang; Ruopeng Feng; Kseniia Dudnyk; Yoon Jung Kim; Jun Yi Stanley Lim; Michael Lee; Yuannyu Zhang; Xiaofei Gao; Yong Cheng; Stuart H. Orkin; Jian Zhou; Mitchell J. Weiss; Feng Yue; Jian Xu
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errSave
The correlation of DPM1 overexpression with immune infiltration and poor prognosis in hepatocellular carcinoma
errDiscover Oncology
IF2.9
err2025-10-27
err0
errOAAI
errLaiwei You; Yang Zhou; Yong Cheng; Huan Wang; Hao Li; Jianrong Guo
errShare
errSave
Enhancing lipase activity in Aspergillus niger through CRISPR/Cas9-mediated protease gene knockout and fermentation optimization
errBIOTECHNOLOGY LETTERS
IF2.1
err2025-09-25
err0
PREAI
errNie, Hongmei; Wang, Zebin; Lin, Zhenkai; Gao, Yan; Zhang, Yinjun; Zheng, Jianyong; Cheng, Yong
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errSave
Murine hematopoietic progenitor cell lines with erythroid and megakaryocyte potential
errNature Communications
IF15.7
err2025-08-07
err0
errOAAI
errRuiqiong Wu; Faraz Salehi; Vanessa Redecke; Zhijun Ma; Marco Marchetti; David Finkelstein; Peng Xu; Yong Cheng; Kimberly A. Queisser; Aaron C. Petrey; Conroy O. Field; Hyun Sook Ahn; Mortimer Poncz; Mitchell J. Weiss; Hans Häcker
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errSave
Removal of promoter CpG methylation by epigenome editing reverses HBG silencing
errNature Communications
IF15.7
err2025-07-27
err0
errOAAI
errHenry W. Bell; Ruopeng Feng; Manan Shah; Yu Yao; James Douglas; Phillip A. Doerfler; Thiyagaraj Mayuranathan; Michael F. O’Dea; Yichao Li; Yong-Dong Wang; Jingjing Zhang; Joel P. Mackay; Yong Cheng; Kate G. R. Quinlan; Mitchell J. Weiss; Merlin Crossley
errShare
errSave
Preclinical development of lentiviral vector gene therapy for Diamond-Blackfan anemia syndrome
errMolecular Therapy
IF12
err2024-12-12
err0
errOAAI
errSenthil Velan Bhoopalan; Thiyagaraj Mayuranathan; Nana Liu; Kalin Mayberry; Yu Yao; Jingjing Zhang; Jean-Yves Métais; Koon-Kiu Yan; Robert E. Throm; Steven R. Ellis; Yan Ju; Lei Han; Shruthi Suryaprakash; Lance E. Palmer; Sheng Zhou; Jiyang Yu; Yong Cheng; Jonathan S. Yen; Stephen Gottschalk; Mitchell J. Weiss
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errSave
Development and IND-enabling studies of a novel Cas9 genome-edited autologous CD34+cell therapy to induce fetal hemoglobin for sickle cell disease
errMOLECULAR THERAPY
IF12
err2024-10-01
err0
errOAAI
errKatta, Varun; O'Keefe, Kiera; Li, Yichao; Mayuranathan, Thiyagaraj; Lazzarotto, Cicera R.; Wood, Rachael K.; Levine, Rachel M.; Powers, Alicia; Mayberry, Kalin; Manquen, Garret; Yao, Yu; Zhang, Jingjing; Jang, Yoonjeong; Nimmagadda, Nikitha; Dempsey, Erin A.; Lee, GaHyun; Uchida, Naoya; Cheng, Yong; Fazio, Frank; Lockey, Tim; Meagher, Mike; Sharma, Akshay; Tisdale, John F.; Zhou, Sheng; Yen, Jonathan S.; Weiss, Mitchell J.; Tsai, Shengdar Q.
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errSave
Transcription factor 4 is a key mediator of oncogenesis in neuroblastoma by promoting MYC activity
errMOLECULAR ONCOLOGY
IF4.5
err2024-08-09
err0
errOAAI
errAljouda, Nour A.; Shrestha, Dewan; Devaux, Chelsea; Olsen, Rachelle R.; Alleboina, Satyanarayana; Walker, Megan; Cheng, Yong; Freeman, Kevin W.
errShare
errSave
Interspecies regulatory landscapes and elements revealed by novel joint systematic integration of human and mouse blood cell epigenomes
errGENOME RESEARCH
IF5.5
err2024-07-01
err0
errOAAI
errXiang, Guanjue; He, Xi; Giardine, Belinda M.; Isaac, Kathryn J.; Taylor, Dylan J.; Mccoy, Rajiv C.; Jansen, Camden; Keller, Cheryl A.; Wixom, Alexander Q.; Cockburn, April; Miller, Amber; Qi, Qian; He, Yanghua; Li, Yichao; Lichtenberg, Jens; Heuston, Elisabeth F.; Anderson, Stacie M.; Luan, Jing; Vermunt, Marit W.; Yue, Feng; Sauria, Michael E. G.; Schatz, Michael C.; Taylor, James; Goettgens, Berthold; Hughes, Jim R.; Higgs, Douglas R.; Weiss, Mitchell J.; Cheng, Yong; Blobel, Gerd A.; Bodine, David M.; Zhang, Yu; Li, Qunhua; Mahony, Shaun; Hardison, Ross C.
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errSave
An NFIX-mediated regulatory network governs the balance of hematopoietic stem and progenitor cells during hematopoiesis
errBLOOD ADVANCES
IF7.1
err2023-08-23
err6
errOAAI
errWalker, Megan; Li, Yichao; Morales-Hernandez, Antonio; Qi, Qian; Parupalli, Chaithanyarani; Brown, Scott; Christian, Claiborne; Clements, Wilson K.; Cheng, Yong; McKinney-Freeman, Shannon
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errSave
Potent and uniform fetal hemoglobin induction via base editing
errNATURE GENETICS
IF31.8
err2023-07-03
err25
errOAAI
errMayuranathan, Thiyagaraj; Newby, Gregory A.; Feng, Ruopeng; Yao, Yu; Mayberry, Kalin D.; Lazzarotto, Cicera R.; Li, Yichao; Levine, Rachel M.; Nimmagadda, Nikitha; Dempsey, Erin; Kang, Guolian; Porter, Shaina N.; Doerfler, Phillip A.; Zhang, Jingjing; Jang, Yoonjeong; Chen, Jingjing; Bell, Henry W.; Crossley, Merlin; Bhoopalan, Senthil Velan; Sharma, Akshay; Tisdale, John F.; Pruett-Miller, Shondra M.; Cheng, Yong; Tsai, Shengdar Q.; Liu, David R.; Weiss, Mitchell J.; Yen, Jonathan S.
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errSave
Ex vivo prime editing of patient haematopoietic stem cells rescues sickle-cell disease phenotypes after engraftment in mice
errNATURE BIOMEDICAL ENGINEERING
IF26.6
err2023-04-17
err56
errOAAI
errEverette, Kelcee A.; Newby, Gregory A.; Levine, Rachel M.; Mayberry, Kalin; Jang, Yoonjeong; Mayuranathan, Thiyagaraj; Nimmagadda, Nikitha; Dempsey, Erin; Li, Yichao; Bhoopalan, Senthil Velan; Liu, Xiong; Davis, Jessie R.; Nelson, Andrew T.; Chen, Peter J.; Sousa, Alexander A.; Cheng, Yong; Tisdale, John F.; Weiss, Mitchell J.; Yen, Jonathan S.; Liu, David R.
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errSave
Abnormal sperm in mice lacking the Taf7l gene
errMOLECULAR AND CELLULAR BIOLOGY
IF2.7
err2023-03-27
err115
errOAAI
errCheng, Yong; Buffone, Mariano G.; Kouadio, Martin; Goodheart, Mary; Page, David C.; Gerton, George L.; Davidson, Irwin; Wang, Peijing Jeremy
errShare
errSave
Genomics and epigenetics guided identification of tissue-specific genomic safe harbors
errGENOME BIOLOGY
IF9.4
err2022-09-21
err8
errOAAI
errShrestha, Dewan; Bag, Aishee; Wu, Ruiqiong; Zhang, Yeting; Tang, Xing; Qi, Qian; Xing, Jinchuan; Cheng, Yong
errShare
errSave
Easy-Prime: a machine learning-based prime editor design tool
errGENOME BIOLOGY
IF9.4
err2021-08-19
err41
errOAAI
errLi, Yichao; Chen, Jingjing; Tsai, Shengdar Q.; Cheng, Yong
errShare
errSave
Activation of γ-globin gene expression by GATA1 and NF-Y in hereditary persistence of fetal hemoglobin
errNATURE GENETICS
IF31.8
err2021-08-02
err32
errOAAI
errDoerfler, Phillip A.; Peng, Ruopeng; Li, Yichao; Palmer, Lance E.; Porter, Shaina N.; Bell, Henry W.; Crossley, Merlin; Pruett-Miller, Shondra M.; Cheng, Yong; Weiss, Mitchell J.
errShare
errSave
A polygenic score for acute vaso-occlusive pain in pediatric sickle cell disease
errBLOOD ADVANCES
IF7.1
err2021-07-20
err16
errOAAI
errRampersaud, Evadnie; Kang, Guolian; Palmer, Lance E.; Rashkin, Sara R.; Wang, Shuoguo; Bi, Wenjian; Alberts, Nicole M.; Anghelescu, Doralina; Barton, Martha; Birch, Kirby; Boulos, Nidal; Brandow, Amanda M.; Brooke, Russell John; Chang, Ti-Cheng; Chen, Wenan; Cheng, Yong; Ding, Juan; Easton, John; Hodges, Jason R.; Kanne, Celeste K.; Levy, Shawn; Mulder, Heather; Patel, Ashwin P.; Puri, Latika; Rosencrance, Celeste; Rusch, Michael; Sapkota, Yadav; Sioson, Edgar; Sharma, Akshay; Tang, Xing; Thrasher, Andrew; Wang, Winfred; Yao, Yu; Yasui, Yutaka; Yergeau, Donald; Hankins, Jane S.; Sheehan, Vivien A.; Downing, James R.; Estepp, Jeremie H.; Zhang, Jinghui; DeBaun, Michael; Wu, Gang; Weiss, Mitchell J.
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errSave
Single-nucleotide-level mapping of DNA regulatory elements that control fetal hemoglobin expression
errNATURE GENETICS
IF31.8
err2021-05-06
err36
errOAAI
errCheng, Li; Li, Yichao; Qi, Qian; Xu, Peng; Feng, Ruopeng; Palmer, Lance; Chen, Jingjing; Wu, Ruiqiong; Yee, Tiffany; Zhang, Jingjing; Yao, Yu; Sharma, Akshay; Hardison, Ross C.; Weiss, Mitchell J.; Cheng, Yong
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errSave

Research Directions

No research directions
Co-authors
Cooperation Journals
M
M Snyder
H-index: 210 · Papers: 3.3K
R
Ruedi Aebersold
H-index: 198 · Papers: 1.2K
S
Stuart H. Orkin
H-index: 179 · Papers: 795
H
Huanming Yang
H-index: 171 · Papers: 1.1K
L
Leslie L. Robison
H-index: 154 · Papers: 1.6K
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