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H

Hassan H. Fakih

university of massachusetts chan medical school

15H-index
25Paper Count
590Citation Count
Published Papers 22
Publication Date
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Single-dose administration of therapeutic divalent siRNA targeting MECP2 prevents lethality in an MECP2 duplication mouse model
errNature Communications
IF15.7
err2026-07-21
err0
errOAAI
errVignesh N. Hariharan; Ashley Summers; Amy E. Clipperton-Allen; Jillian Caiazzi; Samuel R. Hildebrand; Daniel O’ Reilly; Qi Tang; Zachary Kennedy; Dimas Echeverria; Nicholas McHugh; David Cooper; Jacquelyn Sousa; Chantal Ferguson; Hassan H. Fakih; Laurent Bogdanik; Monica Coenraads; Anastasia Khvorova
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errSave
Intradermal delivery of lipophilic siRNAs enables prolonged skin retention and sustained gene silencing in a porcine model
errNature Communications
IF15.7
err2026-02-03
err0
errOAAI
errHassan H. Fakih; Mohammad Zain UI Abideen; Mohamad Omar Rachid; Katherine Y. Gross; Thomas J. R. Ormsby; Vella M. Ross; Rosemary Gagnon; Christopher Dahlke; Raymond C. Furgal; Clemens Lochmann; Ashley Summers; Hanadi F. Sleiman; Sylvia M. Fürst; Shanté N. Jackson; Juliana O. Gordilho; Claire Bouix-Peter; Thibaud Portal; Qi Tang; John E. Harris; Anastasia Khvorova; Carine Blanchard; Julia F. Alterman
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errSave
Albumin-binding dendritic siRNA improves delivery and efficacy to solid tumors in a melanoma model
errMolecular Therapy Nucleic Acids
IF6.1
err2025-05-24
err0
errOAAI
errHassan H. Fakih; Qi Tang; Ashley Summers; Katherine Y. Gross; Mohamad Omar Rachid; Ken Okamura; Nuria Martinez; Hanadi F. Sleiman; John E. Harris; Anastasia Khvorova
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errSave
A Therapeutic Small-Interfering RNA Potentiates Janus Kinase 1 Modulation for the Treatment of Dog Inflammatory Diseases
errACS PHARMACOLOGY & TRANSLATIONAL SCIENCE
IF3.7
err2025-03-24
err0
PREAI
errTang, Q; Fakih, HH; Gross, KY; Winter, SJ; Bramato, BM; Yildiz-Altay, U; Chang, BK; Echeverria, D; Jackson, SO; Mchugh, N; Srnka, A; Alterman, JF; Almela, RM; Kudej, RK; London, CA; Richmond, JM; Harris, JE; Khvorova, A
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errSave
Sequence-Defined DNA Polymers: New Tools for DNA Nanotechnology and Nucleic Acid Therapy
errACCOUNTS OF CHEMICAL RESEARCH
IF17.7
err2025-01-08
err1
PREAI
errRafique, MG; Laurent, Q; Dore, MD; Fakih, HH; Trinh, T; Rizzuto, FJ; Sleiman, HF
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errSave
Enhancing siRNA efficacy in vivo with extended nucleic acid backbones
errNATURE BIOTECHNOLOGY
IF41.7
err2024-08-01
err1
PREAI
errYamada, Ken; Hariharan, Vignesh N.; Caiazzi, Jillian; Miller, Rachael; Ferguson, Chantal M.; Sapp, Ellen; Fakih, Hassan H.; Tang, Qi; Yamada, Nozomi; Furgal, Raymond C.; Paquette, Joseph D.; Biscans, Annabelle; Bramato, Brianna M.; Mchugh, Nicholas; Summers, Ashley; Lochmann, Clemens; Godinho, Bruno M. D. C.; Hildebrand, Samuel; Jackson, Samuel O.; Echeverria, Dimas; Hassler, Matthew R.; Alterman, Julia F.; Difiglia, Marian; Aronin, Neil; Khvorova, Anastasia
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errSave
Quantifying the activity profile of ASO and siRNA conjugates in glioblastoma xenograft tumors in vivo
errNUCLEIC ACIDS RESEARCH
IF13.1
err2024-04-13
err2
errOAAI
errSarli, Samantha L.; Fakih, Hassan H.; Kelly, Karen; Devi, Gitali; Rembetsy-Brown, Julia M.; McEachern, Holly R.; Ferguson, Chantal M.; Echeverria, Dimas; Lee, Jonathan; Sousa, Jacquelyn; Sleiman, Hanadi F.; Khvorova, Anastasia; Watts, Jonathan K.
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errSave
Nucleic Acid Therapeutics: Successes, Milestones, and Upcoming Innovation
errNUCLEIC ACID THERAPEUTICS
IF4.7
err2024-04-01
err25
PREAI
errBelgrad, Jillian; Fakih, Hassan H.; Khvorova, Anastasia
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errSave
Multispecies-targeting siRNAs for the modulation of JAK1 in the skin
errMOLECULAR THERAPY NUCLEIC ACIDS
IF6.1
err2024-03-01
err10
errOAAI
errTang, Qi; Gross, Katherine Y.; Fakih, Hassan H.; Jackson, Samuel O.; Abideen, Mohammad Zain U. I.; Monopoli, Kathryn R.; Blanchard, Carine; Bouix-Peter, Claire; Portal, Thibaud; Harris, John E.; Khvorova, Anastasia; Alterman, Julia F.
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errSave
Control of the Assembly and Disassembly of Spherical Nucleic Acids Is Critical for Enhanced Gene Silencing
errACS NANO
IF16
err2024-01-24
err3
PREAI
errAsohan, Jathavan; Fakih, Hassan H.; Das, Trishalina; Sleiman, Hanadi F.
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errSave
Dendritic amphiphilic siRNA: Selective albumin binding, in vivo efficacy, and low toxicity
errMOLECULAR THERAPY NUCLEIC ACIDS
IF6.1
err2023-12-01
err6
errOAAI
errFakih, Hassan H.; Tang, Qi; Summers, Ashley; Shin, Minwook; Buchwald, Julianna E.; Gagnon, Rosemary; Hariharan, Vignesh N.; Echeverria, Dimas; Cooper, David A.; Watts, Jonathan K.; Khvorova, Anastasia; Sleiman, Hanadi F.
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errSave
Editorial: Nucleic Acids Research virtual issue dedicated to nucleic acid therapeutics, 2018-2023
errNUCLEIC ACIDS RESEARCH
IF13.1
err2023-11-30
err0
errOAAI
errBelgrad, Jillian; Fakih, Hassan H.; Johnson, Krystal C.; Corey, David R.
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errSave
Rational design of a JAK1-selective siRNA inhibitor for the modulation of autoimmunity in the skin
errNATURE COMMUNICATIONS
IF15.7
err2023-11-04
err16
errOAAI
errTang, Qi; Fakih, Hassan H.; Ul Abideen, Mohammad Zain; Hildebrand, Samuel R.; Afshari, Khashayar; Gross, Katherine Y.; Sousa, Jacquelyn; Maebius, Allison S.; Bartholdy, Christina; Sogaard, Pia Pernille; Jackerott, Malene; Hariharan, Vignesh; Summers, Ashley; Fan, Xueli; Okamura, Ken; Monopoli, Kathryn R.; Cooper, David A.; Echeverria, Dimas; Bramato, Brianna; Mchugh, Nicholas; Furgal, Raymond C.; Dresser, Karen; Winter, Sarah J.; Biscans, Annabelle; Chuprin, Jane; Haddadi, Nazgol-Sadat; Sherman, Shany; Yildiz-Altay, Ummugulsum; Rashighi, Mehdi; Richmond, Jillian M.; Bouix-Peter, Claire; Blanchard, Carine; Clauss, Adam; Alterman, Julia F.; Khvorova, Anastasia; Harris, John E.
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errSave
Sequence-Controlled Spherical Nucleic Acids: Gene Silencing, Encapsulation, and Cellular Uptake
errNUCLEIC ACID THERAPEUTICS
IF4.7
err2023-08-01
err10
PREAI
errKaviani, Sepideh; Fakih, Hassan H. H.; Asohan, Jathavan; Katolik, Adam; Damha, Masad J. J.; Sleiman, Hanadi F. F.
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errSave
Stabilization of Functional DNA Structures with Mild Photochemical Methods
errJOURNAL OF THE AMERICAN CHEMICAL SOCIETY
IF15.6
err2023-01-18
err10
PREAI
errBrown, Tyler M.; Fakih, Hassan H.; Saliba, Daniel; Asohan, Jathavan; Sleiman, Hanadi F.
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errSave
Design and enhanced gene silencing activity of spherical 2′-fluoroarabinose nucleic acids (FANA-SNAs)
errCHEMICAL SCIENCE
IF7.4
err2021-01-01
err27
errOAAI
errFakih, Hassan H.; Katolik, Adam; Malek-Adamian, Elise; Fakhoury, Johans J.; Kaviani, Sepideh; Damha, Masad J.; Sleiman, Hanadi F.
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errSave
Detailed cellular assessment of albumin-bound oligonucleotides: Increased stability and lower non-specific cell uptake
errJOURNAL OF CONTROLLED RELEASE
IF11.5
err2020-08-01
err24
PREAI
errLacroix, Aurelie; Fakih, Hassan H.; Sleiman, Hanadi F.
errShare
errSave
Effect of 2′-5′/3′-5′ phosphodiester linkage heterogeneity on RNA interference
errNUCLEIC ACIDS RESEARCH
IF13.1
err2020-04-13
err20
errOAAI
errHabibian, Maryam; Harikrishna, S.; Fakhoury, Johans; Barton, Maria; Ageely, Eman A.; Cencic, Regina; Fakih, Hassan H.; Katolik, Adam; Takahashi, Mayumi; Rossi, John; Pelletier, Jerry; Gagnon, Keith T.; Pradeepkumar, P., I; Damha, Masad J.
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Minimalist Design of a Stimuli-Responsive Spherical Nucleic Acid for Conditional Delivery of Oligonucleotide Therapeutics
errACS APPLIED MATERIALS & INTERFACES
IF8.2
err2019-02-05
err32
PREAI
errFakih, Hassan H.; Fakhoury, Johans J.; Bousmail, Danny; Sleiman, Hanadi F.
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errSave
Amplified Detection of a Unique Genomic Viral Marker Using Fluorescently Labeled Liposomes
errADVANCED MATERIALS INTERFACES
IF4.4
err2018-03-15
err7
PREAI
errAbou Shaheen, Samir; Fakih, Hassan H.; Kobeissi, Jana M.; Karam, Pierre
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errSave

Research Directions

No research directions
Co-authors
Cooperation Journals
J
John J. Rossi
H-index: 95 · Papers: 646
J
Jerry Pelletier
H-index: 90 · Papers: 481
M
Marian DiFiglia
H-index: 76 · Papers: 200
N
Neil Aronin
H-index: 74 · Papers: 230
K
Karen Kelly
H-index: 70 · Papers: 694
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