Charles P. Emerson - Publications, H-index & Citations

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Charles P. Emerson

University of Massachusetts Chan Medical School

67H-index

250Paper Count

1.3WCitation Count

Published Papers 33

Publication Date

A systemically deliverable lipid-conjugated siRNA targeting DUX4 as an facioscapulohumeral muscular dystrophy therapeutic

Molecular Therapy Methods & Clinical Development

IF4.7

2025-06-16

OAAI

Katelyn Daman; Jing Yan; Annabelle Biscans; Dimas Echeverria; Taisia Shmushkovich; Alexey Wolfson; Julia F. Alterman; Anastasia Khvorova; Charles P. Emerson

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Increasing intracellular dNTP levels improves prime editing efficiency

NATURE BIOTECHNOLOGY

IF41.7

2024-09-25

PREAI

Liu, Pengpeng; Ponnienselvan, Karthikeyan; Nyalile, Thomas; Oikemus, Sarah; Joynt, Anya T.; Iyer, Sukanya; Kelly, Karen; Guo, Dongsheng; Kyawe, Pyae P.; Vanderleeden, Emma; Redick, Sambra D.; Huang, Lei; Chen, Zexiang; Lee, Jeong Min; Schiffer, Celia A.; Harlan, David M.; Wang, Jennifer P.; Emerson Jr, Charles P.; Lawson, Nathan D.; Watts, Jonathan K.; Sontheimer, Erik J.; Luban, Jeremy; Wolfe, Scot A.

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SMCHD1 activates the expression of genes required for the expansion of human myoblasts

NUCLEIC ACIDS RESEARCH

IF13.1

2024-07-12

OAAI

Wong, Matthew Man-Kin; Hachmer, Sarah; Gardner, Ed; Runfola, Valeria; Arezza, Eric; Megeney, Lynn A.; Emerson Jr, Charles P.; Gabellini, Davide; Dilworth, F. Jeffrey

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Flavones provide resistance to DUX4-induced toxicity via an mTor-independent mechanism

CELL DEATH & DISEASE

IF9.6

2023-11-16

OAAI

Cohen, Justin; Huang, Shushu; Koczwara, Katherine E.; Woods, Kristen T.; Ho, Vincent; Woodman, Keryn G.; Arbiser, Jack L.; Daman, Katelyn; Lek, Monkol; Emerson Jr, Charles P.; Desimone, Alec M.

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Post-Translational Modifications of the DUX4 Protein Impact Toxic Function in FSHD Cell Models

ANNALS OF NEUROLOGY

IF7.7

2023-05-19

OAAI

Knox, Renatta N.; Eidahl, Jocelyn O.; Wallace, Lindsay M.; Choudury, Sarah G.; Rashnonejad, Afrooz; Daman, Katelyn; Guggenbiller, Matthew J.; Saad, Nizar Y.; Hoover, Michael E.; Zhang, Liwen; Branson, Owen E.; Emerson, Charles P.; Freitas, Michael A.; Harper, Scott Q.

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Impaired mitochondrial oxidative metabolism in skeletal progenitor cells leads to musculoskeletal disintegration

NATURE COMMUNICATIONS

IF15.7

2022-11-11

OAAI

Lin, Chujiao; Yang, Qiyuan; Guo, Dongsheng; Xie, Jun; Yang, Yeon-Suk; Chaugule, Sachin; DeSouza, Ngoc; Oh, Won-Taek; Li, Rui; Chen, Zhihao; John, Aijaz A.; Qiu, Qiang; Zhu, Lihua Julie; Greenblatt, Matthew B.; Ghosh, Sankar; Li, Shaoguang; Gao, Guangping; Haynes, Cole; Emerson, Charles P.; Shim, Jae-Hyuck

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DUX4 expression activates JNK and p38 MAP kinases in myoblasts

DISEASE MODELS & MECHANISMS

IF3.3

2022-10-31

OAAI

Brennan, Christopher M.; Hill, Abby S.; St Andre, Michael; Li, Xianfeng; Madeti, Vijaya; Breitkopf, Susanne; Garren, Seth; Xue, Liang; Gilbert, Tamara; Hadjipanayis, Angela; Monetti, Mara; Emerson Jr, Charles P.; Moccia, Robert; Owens, Jane; Christoforou, Nicolas

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Efficient Homology-Directed Repair with Circular Single-Stranded DNA Donors

CRISPR JOURNAL

IF4

2022-10-01

OAAI

Iyer, Sukanya; Mir, Aamir; Vega-Badillo, Joel; Roscoe, Benjamin P.; Ibraheim, Raed; Zhu, Lihua Julie; Lee, Jooyoung; Liu, Pengpeng; Luk, Kevin; Mintzer, Esther; Guo, Dongsheng; Soares de Brito, Josias; Emerson Jr, Charles P.; Zamore, Phillip D.; Sontheimer, Erik J.; Wolfe, Scot A.

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Outcome Measures in Facioscapulohumeral Muscular Dystrophy Clinical Trials

CELLS

IF5.2

2022-02-16

OAAI

Ghasemi, Mehdi; Emerson, Charles P., Jr.; Hayward, Lawrence J.

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p38 MAPKs - roles in skeletal muscle physiology, disease mechanisms, and as potential therapeutic targets

JCI INSIGHT

IF6.1

2021-06-22

OAAI

Brennan, Christopher M.; Emerson, Charles P., Jr.; Owens, Jane; Christoforou, Nicolas

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Identification of the hyaluronic acid pathway as a therapeutic target for facioscapulohumeral muscular dystrophy

SCIENCE ADVANCES

IF12.5

2019-12-06

OAAI

DeSimone, Alec M.; Leszyk, John; Wagner, Kathryn; Emerson, Charles P., Jr.

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Facioscapulohumeral Muscular Dystrophy

COMPREHENSIVE PHYSIOLOGY

IF5.2

2017-09-12

PREAI

DeSimone, Alec M.; Pakula, Anna; Lek, Angela; Emerson, Charles P., Jr.

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CRISPR/Cas9-mediated genome editing induces exon skipping by alternative splicing or exon deletion

GENOME BIOLOGY

IF9.4

2017-06-14

139

OAAI

Mou, Haiwei; Smith, Jordan L.; Peng, Lingtao; Yin, Hao; Moore, Jill; Zhang, Xiao-Ou; Song, Chun-Qing; Sheel, Ankur; Wu, Qiongqiong; Ozata, Deniz M.; Li, Yingxiang; Anderson, Daniel G.; Emerson, Charles P.; Sontheimer, Erik J.; Moore, Melissa J.; Weng, Zhiping; Xue, Wen

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Morpholino-mediated Knockdown of DUX4 Toward Facioscapulohumeral Muscular Dystrophy Therapeutics

MOLECULAR THERAPY

IF12

2016-08-01

OAAI

Chen, Jennifer C. J.; King, Oliver D.; Zhang, Yuanfan; Clayton, Nicholas P.; Spencer, Carrie; Wentworth, Bruce M.; Emerson, Charles P., Jr.; Wagner, Kathryn R.

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Individual epigenetic status of the pathogenic D4Z4 macrosatellite correlates with disease in facioscapulohumeral muscular dystrophy

CLINICAL EPIGENETICS

IF4.4

2015-03-29

OAAI

Jones, Takako I.; King, Oliver D.; Himeda, Charis L.; Homma, Sachiko; Chen, Jennifer C. J.; Beermann, Mary Lou; Yan, Chi; Emerson, Charles P., Jr.; Miller, Jeffrey B.; Wagner, Kathryn R.; Jones, Peter L.

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Human skeletal muscle xenograft as a new preclinical model for muscle disorders

HUMAN MOLECULAR GENETICS

IF3.2

2014-01-22

OAAI

Zhang, Yuanfan; King, Oliver D.; Rahimov, Fedik; Jones, Takako I.; Ward, Christopher W.; Kerr, Jaclyn P.; Liu, Naili; Emerson, Charles P., Jr.; Kunkel, Louis M.; Partridge, Terence A.; Wagner, Kathryn R.

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Telomere position effect regulates DUX4 in human facioscapulohumeral muscular dystrophy

NATURE STRUCTURAL & MOLECULAR BIOLOGY

IF10.1

2013-05-05

OAAI

Stadler, Guido; Rahimov, Fedik; King, Oliver D.; Chen, Jennifer C. J.; Robin, Jerome D.; Wagner, Kathryn R.; Shay, Jerry W.; Emerson, Charles P., Jr.; Wright, Woodring E.

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Transcriptional profiling in facioscapulohumeral muscular dystrophy to identify candidate biomarkers

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

IF9.1

2012-09-17

OAAI

Rahimov, Fedik; King, Oliver D.; Leung, Doris G.; Bibat, Genila M.; Emerson, Charles P., Jr.; Kunkel, Louis M.; Wagner, Kathryn R.

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Facioscapulohumeral muscular dystrophy family studies of DUX4 expression: evidence for disease modifiers and a quantitative model of pathogenesis

HUMAN MOLECULAR GENETICS

IF3.2

2012-07-13

155

OAAI

Jones, Takako Iida; Chen, Jennifer C. J.; Rahimov, Fedik; Homma, Sachiko; Arashiro, Patricia; Beermann, Mary Lou; King, Oliver D.; Miller, Jeffrey B.; Kunkel, Louis M.; Emerson, Charles P., Jr.; Wagner, Kathryn R.; Jones, Peter L.

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A unique library of myogenic cells from facioscapulohumeral muscular dystrophy subjects and unaffected relatives: family, disease and cell function

EUROPEAN JOURNAL OF HUMAN GENETICS

IF4.6

2011-11-23

OAAI

Homma, Sachiko; Chen, Jennifer C. J.; Rahimov, Fedik; Beermann, Mary Lou; Hanger, Kendal; Bibat, Genila M.; Wagner, Kathryn R.; Kunkel, Louis M.; Emerson, Charles P., Jr.; Miller, Jeffrey Boone

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Research Directions