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Synthesis, in vitro and in vivo biological evaluation of novel dual compounds targeting both acetylcholinesterase and serotonergic 5-HT4 receptors with potential interest in the treatment of Alzheimer's disease Rochais, Christophe; Lecoutey, Cedric; Lalut, Julien; Davis, Audrey; Duval, Emilie; Gaven, Florence; Largilliere, Stacy; Nee, Gerald; Corvaisier, Sophie; Santos, Jana Sopkova de Oliveira; Since, Marc; Freret, Thomas; Legrand, Romain; Callizot, Noelle; Claeysen, Sylvie; Boulouard, Michel; Dallemagne, Patrick Share Save
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Development of Pleiotropic TrkB and 5-HT4 Receptor Ligands as Neuroprotective Agents Antonijevic, Mirjana; Charou, Despoina; Davis, Audrey; Curel, Thomas; Valcarcel, Maria; Ramos, Isbaal; Villace, Patricia; Claeysen, Sylvie; Dallemagne, Patrick; Gravanis, Achille; Charalampopoulos, Ioannis; Rochais, Christophe Share Save
Biginelli Reaction Synthesis of Novel Multitarget-Directed Ligands with Ca2+ Channel Blocking Ability, Cholinesterase Inhibition, Antioxidant Capacity, and Nrf2 Activation Malek, Rim; Simakov, Alexey; Davis, Audrey; Maj, Maciej; Bernard, Paul J.; Wnorowski, Artur; Martin, Helene; Marco-Contelles, Jose; Chabchoub, Fakher; Dallemagne, Patrick; Rochais, Christophe; Jozwiak, Krzysztof; Ismaili, Lhassane Share Save
Active Targeted Nanoemulsions for Repurposing of Tegaserod in Alzheimer's Disease Treatment Seguy, Line; Guyon, Lena; Maurel, Manon; Verdie, Pascal; Davis, Audrey; Corvaisier, Sophie; Lisowski, Vincent; Dallemagne, Patrick; Groo, Anne-Claire; Malzert-Freon, Aurelie Share Save
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Pleiotropic prodrugs: Design of a dual butyrylcholinesterase inhibitor and 5-HT6 receptor antagonist with therapeutic interest in Alzheimer's disease Toublet, Francois-Xavier; Lalut, Julien; Hatat, Berenice; Lecoutey, Cedric; Davis, Audrey; Since, Marc; Corvaisier, Sophie; Freret, Thomas; Santos, Jana Sopkova-de Oliveira; Claeysen, Sylvie; Boulouard, Michel; Dallemagne, Patrick; Rochais, Christophe Share Save
First Synthesis of Racemic Trans Propargylamino-Donepezil, a Pleiotrope Agent Able to Both Inhibit AChE and MAO-B, with Potential Interest against Alzheimer's Disease Guieu, Benjamin; Lecoutey, Cedric; Legay, Remi; Davis, Audrey; Sopkova de Oliveira Santos, Jana; Altomare, Cosimo Damiano; Catto, Marco; Rochais, Christophe; Dallemagne, Patrick Share Save
Disproportionality analysis in VigiBase as a drug repositioning method for the discovery of potentially useful drugs in Alzheimer's disease Chretien, Basile; Jourdan, Jean-Pierre; Davis, Audrey; Fedrizzi, Sophie; Bureau, Ronan; Sassier, Marion; Rochais, Christophe; Alexandre, Joachim; Lelong-Boulouard, Veronique; Dolladille, Charles; Dallemagne, Patrick Share Save
Pharmacotechnical Development of a Nasal Drug Delivery Composite Nanosystem Intended for Alzheimer's Disease Treatment Adnet, Thomas; Groo, Anne-Claire; Picard, Celine; Davis, Audrey; Corvaisier, Sophie; Since, Marc; Bounoure, Frederic; Rochais, Christophe; Le Pluart, Loic; Dallemagne, Patrick; Malzert-Freon, Aurelie Share Save
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Novel multi target-directed ligands targeting 5-HT4 receptors with in cellulo antioxidant properties as promising leads in Alzheimer's disease Lanthier, Caroline; Payan, Hugo; Liparulo, Irene; Hatat, Berenice; Lecoutey, Cedric; Since, Marc; Davis, Audrey; Bergamini, Christian; Claeysen, Sylvie; Dallemagne, Patrick; Bolognesi, Maria-Laura; Rochais, Christophe Share Save
Inhibiting Acetylcholinesterase to Activate Pleiotropic Prodrugs with Therapeutic Interest in Alzheimer's Disease Toublet, Francois-Xavier; Lecoutey, Cedric; Lalut, Julien; Hatat, Berenice; Davis, Audrey; Since, Marc; Corvaisier, Sophie; Freret, Thomas; Santos, Jana Sopkova de Oliveira; Claeysen, Sylvie; Boulouard, Michel; Dallemagne, Patrick; Rochais, Christophe Share Save
A Novel in vivo Anti-amnesic Agent, Specially Designed to Express Both Acetylcholinesterase (AChE) Inhibitory, Serotonergic Subtype 4 Receptor (5-HT4R) Agonist and Serotonergic Subtype 6 Receptor (5-HT6R) Inverse Agonist Activities, With a Potential Interest Against Alzheimer's Disease Hatat, Berenice; Yahiaoui, Samir; Lecoutey, Cedric; Davis, Audrey; Freret, Thomas; Boulouard, Michel; Claeysen, Sylvie; Rochais, Christophe; Dallemagne, Patrick Share Save
Novel multitarget-directed ligands targeting acetylcholinesterase and σ1 receptors as lead compounds for treatment of Alzheimer's disease: Synthesis, evaluation, and structural characterization of their complexes with acetylcholinesterase Lalut, Julien; Santoni, Gianluca; Karila, Delphine; Lecoutey, Cedric; Davis, Audrey; Nachon, Florian; Silman, Israel; Sussman, Joel; Weik, Martin; Maurice, Tangui; Dallemagne, Patrick; Rochais, Christophe Share Save
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