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Amylovis-201 is a new dual-target ligand, acting as an anti-amyloidogenic compound and a potent agonist of the σ1 chaperone protein Garcia-Pupo, Laura; Crouzier, Lucie; Bencomo-Martinez, Alberto; Meunier, Johann; Morilleau, Axelle; Delprat, Benjamin; Carrazana, Marquiza Sablon; del Valle, Roberto Menendez Soto; Maurice, Tangui; Rodriguez-Tanty, Chryslaine Share Save
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The Wolfram-like variant WFS1E864K destabilizes MAM and compromises autophagy and mitophagy in human and mice Patergnani, Simone; Bataillard, Meghane S.; Danese, Alberto; Alves, Stacy; Cazevieille, Chantal; Valero, Rene; Tranebjaerg, Lisbeth; Maurice, Tangui; Pinton, Paolo; Delprat, Benjamin; Richard, Elodie M. Share Save
Convolamine, a tropane alkaloid extracted from Convolvulus plauricalis, is a potent sigma-1 receptor-positive modulator with cognitive and neuroprotective properties Crouzier, Lucie; Meunier, Johann; Carles, Allison; Morilleau, Axelle; Vrigneau, Cassandre; Schmitt, Martine; Bourguignon, Jean-Jacques; Delprat, Benjamin; Maurice, Tangui Share Save
Wfs1E864K knock-in mice illuminate the fundamental role of Wfs1 in endocochlear potential production Richard, Elodie M.; Brun, Emilie; Korchagina, Julia; Crouzier, Lucie; Affortit, Corentin; Alves, Stacy; Cazevieille, Chantal; Mausset-Bonnefont, Anne-Laure; Lenoir, Marc; Puel, Jean-Luc; Maurice, Tangui; Thiry, Marc; Wang, Jing; Delprat, Benjamin Share Save
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Dual-Acting Small Molecules: Subtype-Selective Cannabinoid Receptor 2 Agonist/Butyrylcholinesterase Inhibitor Hybrids Show Neuroprotection in an Alzheimer?s Disease Mouse Model Spatz, Philipp; Steinmueller, Sophie A. M.; Tutov, Anna; Poeta, Eleonora; Morilleau, Axelle; Carles, Allison; Deventer, Marie H.; Hofmann, Julian; Stove, Christophe P.; Monti, Barbara; Maurice, Tangui; Decker, Michael Share Save
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Sigma-1 receptor agonist PRE-084 confers protection against TAR DNA-binding protein-43 toxicity through NRF2 signalling Lasbleiz, Christelle; Peyrel, Amandine; Tarot, Pauline; Sarniguet, Jerome; Crouzier, Lucie; Cubedo, Nicolas; Delprat, Benjamin; Rossel, Mireille; Maurice, Tangui; Lievens, Jean-Charles Share Save
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Morphological, behavioral and cellular analyses revealed different phenotypes in Wolfram syndrome wfs1a and wfs1b zebrafish mutant lines Crouzier, Lucie; Richard, Elodie M.; Diez, Camille; Alzaeem, Hala; Denus, Morgane; Cubedo, Nicolas; Delaunay, Thomas; Glendenning, Emily; Baxendale, Sarah; Lievens, Jean-Charles; Whitfield, Tanya T.; Maurice, Tangui; Delprat, Benjamin Share Save
Activation of the sigma-1 receptor chaperone alleviates symptoms of Wolfram syndrome in preclinical models Crouzier, Lucie; Danese, Alberto; Yasui, Yuko; Richard, Elodie M.; Lievens, Jean-Charles; Patergnani, Simone; Couly, Simon; Diez, Camille; Denus, Morgane; Cubedo, Nicolas; Rossel, Mireille; Thiry, Marc; Su, Tsung-Ping; Pinton, Paolo; Maurice, Tangui; Delprat, Benjamin Share Save
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Development of novel phenoxyalkylpiperidines as high-affinity Sigma-1 (σ1) receptor ligands with potent anti-amnesic effect Abatematteo, Francesca S.; Mosier, Philip D.; Niso, Mauro; Brunetti, Leonardo; Berardi, Francesco; Loiodice, Fulvio; Contino, Marialessandra; Delprat, Benjamin; Maurice, Tangui; Laghezza, Antonio; Abate, Carmen Share Save
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