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D

D. Lorne Tyrrell

university of alberta

52H-index
273Paper Count
1.0WCitation Count
Published Papers 106
Publication Date
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Hepatitis C virus infection dynamics; treatment; and lipid nanoparticle–mediated infection in humanized liver chimeric mouse models
errScience Advances
IF12.5
err2026-05-29
err0
errOAAI
errSeung Bum Park; Jaime Sánchez-Meza; Regina Umarova; Justin Shields; Laura Collignon; Xhuliana Sula; Kenn Holmbeck; Ji Hoon Oh; Patrizia Farci; D. Lorne Tyrrell; Jordan J. Feld; Jens Bukh; Charles M. Rice; T. Jake Liang
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errSave
Quantification of avian influenza A virus (H5N1) via enzymatic reactions and glucometer test strips
errsens. diagn.
IF0
err2026-04-11
err0
errOAAI
errMd Reazul Islam; Faisal Hossain; Michael A. Joyce; Mohamed Elaish; D. Lorne Tyrrell; Tom C. Hobman; Michael J. Serpe
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errSave
Angiostatin—a novel SARS-CoV-2 inhibitor and biomarker underlying COVID-19 pathophysiology
errJournal of Thrombosis and Haemostasis
IF5
err2025-04-06
err0
errOAAI
errAleksandra Franczak; Michael Joyce; Joaquin Lopez–Orozco; Holly A. Saffran; Max Saito; Amir Asgari; Subha Kalyaanamoorthy; Khaled Barakat; Tom C. Hobman; D. Lorne Tyrrell; Paul Jurasz
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errSave
Recombinant H77C gpE1/gpE2 heterodimer elicits superior HCV cross-neutralisation than H77C gpE2 alone
errJOURNAL OF HEPATOLOGY
IF33
err2024-12-01
err1
errOAAI
errKundu, Juthika; Le, Hoa T.; Logan, Michael; Hockman, Darren; Landi, Abdolamir; Crawford, Kevin; Wininger, Mark; Johnson, Janelle; Kundu, Joydeb K.; Tiffney, E. Alana; Urbanowicz, Richard A.; Ball, Jonathan K.; Bailey, Justin R.; Bukh, Jens; Law, Mansun; Foung, Steven; Tyrrell, D. Lorne; Houghton, Michael; Law, John Lokman
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Peptide Aldehydes Incorporating Thiazol-4-yl Alanine Are Potent In Vitro Inhibitors of SARS-CoV-2 Main Protease
errACS MEDICINAL CHEMISTRY LETTERS
IF4
err2024-11-03
err0
PREAI
errFeys, Jenson R.; Edwards, Kyle; Joyce, Michael A.; Saffran, Holly A.; Shields, Justin A.; Garcia, Kassandra; Tyrrell, D. Lorne; Fischer, Conrad
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errSave
Small molecules targeting GRP78 mitigate anti-GRP78 autoantibody-mediated tissue factor procoagulant activity in cultured endothelial cells
errJOURNAL OF THROMBOSIS AND HAEMOSTASIS
IF5
err2024-11-01
err0
errOAAI
errChen, Jack; Lynn, Edward G.; Sharma, Hitesh; Byun, Jae H.; Kenyon, Victor A.; Sahu, Kamlesh K.; Tyrrell, D. Lorne; Houghton, Michael; Gross, Peter L.; Trigatti, Bernardo L.; Shayegan, Bobby; Austin, Richard C.
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The Effect of Deuteration and Homologation of the Lactam Ring of Nirmatrelvir on Its Biochemical Properties and Oxidative Metabolism
errACS BIO & MED CHEM AU
IF4.3
err2023-11-15
err5
errOAAI
errArutyunova, Elena; Belovodskiy, Alexandr; Chen, Pu; Khan, Muhammad Bashir; Joyce, Michael; Saffran, Holly; Lu, Jimmy; Turner, Zoe; Bai, Bing; Lamer, Tess; Young, Howard S.; Vederas, John C.; Tyrrell, D. Lorne; Lemieux, M. Joanne; Nieman, James A.
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errSave
Analysis of SARS-CoV-2 isolates, namely the Wuhan strain, Delta variant, and Omicron variant, identifies differential immune profiles
errMICROBIOLOGY SPECTRUM
IF3.8
err2023-10-17
err14
errOAAI
errShahbaz, Shima; Bozorgmehr, Najmeh; Lu, Julia; Osman, Mohammed; Sligl, Wendy; Tyrrell, D. Lorne; Elahi, Shokrollah
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errSave
Challenge Inoculum for Hepatitis C Virus Controlled Human Infection Model
errCLINICAL INFECTIOUS DISEASES
IF7.3
err2023-08-14
err4
errOAAI
errLiang, T. Jake; Law, John L. M.; Pietschmann, Thomas; Ray, Stuart C.; Bukh, Jens; Bull, Rowena; Chung, Raymond T.; Tyrrell, D. Lorne; Houghton, Michael; Rice, Charles M.
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errSave
Bovine Serum Albumin-Protected Gold Nanoclusters for Sensing of SARS-CoV-2 Antibodies and Virus
errACS APPLIED MATERIALS & INTERFACES
IF8.2
err2023-06-14
err7
PREAI
errShen, Qiming; Hossain, Faisal; Fang, Changhao; Shu, Tong; Zhang, Xueji; Law, John Lok Man; Logan, Michael; Houghton, Michael; Tyrrell, D. Lorne; Joyce, Michael A.; Serpe, Michael J.
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errSave
Utilization of a Glucometer Test Strip and Enzymatic Reactions to Quantify Anti-SARS-CoV-2 Spike RBD IgG Antibody and SARS-CoV-2 Virus in Saliva and Serum
errANALYTICAL CHEMISTRY
IF6.7
err2023-05-08
err6
PREAI
errHossain, Faisal; Shen, Qinling; Balasuriya, Nicholas; Law, John Lok Man; Logan, Michael; Houghton, Michael; Tyrrell, D. Lorne; Joyce, Michael A.; Serpe, Michael J.
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errSave
Interferon regulatory factor 3 mediates effective antiviral responses to human coronavirus 229E and OC43 infection
errFRONTIERS IN IMMUNOLOGY
IF5.9
err2023-05-01
err8
errOAAI
errDuncan, Joseph K. Sampson; Xu, Danyang; Licursi, Maria; Joyce, Michael A.; Saffran, Holly A.; Liu, Kaiwen; Gohda, Jin; Tyrrell, D. Lorne; Kawaguchi, Yasushi; Hirasawa, Kensuke
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errSave
Interferon-λ treatment accelerates SARS-CoV-2 clearance despite age-related delays in the induction of T cell immunity
errNATURE COMMUNICATIONS
IF15.7
err2022-11-16
err21
errOAAI
errSanter, Deanna M.; Li, Daniel; Ghosheh, Yanal; Zahoor, Muhammad Atif; Prajapati, Dhanvi; Hansen, Bettina E.; Tyrrell, D. Lorne J.; Feld, Jordan J.; Gehring, Adam J.
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errSave
Differential Impact of SARS-CoV-2 Isolates, Namely, the Wuhan Strain, Delta, and Omicron Variants on Erythropoiesis
errMICROBIOLOGY SPECTRUM
IF3.8
err2022-08-31
err22
errOAAI
errSaito, Suguru; Shahbaz, Shima; Sligl, Wendy; Osman, Mohammed; Tyrrell, D. Lorne; Elahi, Shokrollah
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errSave
Two DNA vaccines protect against severe disease and pathology due to SARS-CoV-2 in Syrian hamsters
errNPJ VACCINES
IF6.5
err2022-04-26
err11
errOAAI
errBabuadze, George Giorgi; Fausther-Bovendo, Hugues; deLaVega, Marc-Antoine; Lillie, Brandon; Naghibosadat, Maedeh; Shahhosseini, Nariman; Joyce, Michael A.; Saffran, Holly A.; Lorne Tyrrell, D.; Falzarano, Darryl; Senthilkumaran, Chandrika; Christie-Holmes, Natasha; Ahn, Steven; Gray-Owen, Scott D.; Banerjee, Arinjay; Mubareka, Samira; Mossman, Karen; Dupont, Chanel; Pedersen, Jannie; Lafrance, Mark-Alexandre; Kobinger, Gary P.; Kozak, Robert
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Improved SARS-CoV-2 Mpro inhibitors based on feline antiviral drug GC376: Structural enhancements, increased solubility, and micellar studies
errEUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
IF5.9
err2021-10-01
err71
errOAAI
errVuong, Wayne; Fischer, Conrad; Khan, Muhammad Bashir; van Belkum, Marco J.; Lamer, Tess; Willoughby, Kurtis D.; Lu, Jimmy; Arutyunova, Elena; Joyce, Michael A.; Saffran, Holly A.; Shields, Justin A.; Young, Howard S.; Nieman, James A.; Tyrrell, D. Lorne; Lemieux, M. Joanne; Vederas, John C.
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errSave
Integrating Reverse Transcription Recombinase Polymerase Amplification with CRISPR Technology for the One-Tube Assay of RNA
errANALYTICAL CHEMISTRY
IF6.7
err2021-09-10
err75
errOAAI
errFeng, Wei; Peng, Hanyong; Xu, Jingyang; Liu, Yanming; Pabbaraju, Kanti; Tipples, Graham; Joyce, Michael A.; Saffran, Holly A.; Tyrrell, D. Lorne; Babiuk, Shawn; Zhang, Hongquan; Le, X. Chris
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errSave
CRISPR Technique Incorporated with Single-Cell RNA Sequencing for Studying Hepatitis B Infection
errANALYTICAL CHEMISTRY
IF6.7
err2021-07-30
err10
errOAAI
errLe, Connie; Liu, Yanming; Lopez-Orozco, Joaquin; Joyce, Michael A.; Le, X. Chris; Tyrrell, D. Lorne
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errSave
Peptidomimetic α-Acyloxymethylketone Warheads with Six-Membered Lactam P1 Glutamine Mimic: SARS-CoV-2 3CL Protease Inhibition, Coronavirus Antiviral Activity, and in Vitro Biological Stability
errJOURNAL OF MEDICINAL CHEMISTRY
IF6.8
err2021-07-09
err75
PREAI
errBai, Bing; Belovodskiy, Alexandr; Hena, Mostofa; Kandadai, Appan Srinivas; Joyce, Michael A.; Saffran, Holly A.; Shields, Justin A.; Khan, Muhammad Bashir; Arutyunova, Elena; Lu, Jimmy; Bajwa, Sardeev K.; Hockman, Darren; Fischer, Conrad; Lamer, Tess; Vuong, Wayne; van Belkum, Marco J.; Gu, Zhengxian; Lin, Fusen; Du, Yanhua; Xu, Jia; Rahim, Mohammad; Young, Howard S.; Vederas, John C.; Tyrrell, D. Lorne; Lemieux, M. Joanne; Nieman, James A.
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errSave
Peginterferon lambda for the treatment of outpatients with COVID-19: a phase 2, placebo-controlled randomised trial
errLANCET RESPIRATORY MEDICINE
IF32.8
err2021-05-01
err169
errOAAI
errFeld, Jordan J.; Kandel, Christopher; Biondi, Mia J.; Kozak, Robert A.; Zahoor, Muhammad Atif; Lemieux, Camille; Borgia, Sergio M.; Boggild, Andrea K.; Powis, Jeff; McCready, Janine; Tan, Darrell H. S.; Chan, Tiffany; Coburn, Bryan; Kumar, Deepali; Humar, Atul; Chan, Adrienne; O'Neil, Braden; Noureldin, Seham; Booth, Joshua; Hong, Rachel; Smookler, David; Aleyadeh, Wesam; Patel, Anjali; Barber, Bethany; Casey, Julia; Hiebert, Ryan; Mistry, Henna; Choong, Ingrid; Hislop, Colin; Santer, Deanna M.; Tyrrell, D. Lorne; Glenn, Jeffrey S.; Gehring, Adam J.; Janssen, Harry L. A.; Hansen, Bettina E.
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Research Directions

No research directions
Co-authors
Cooperation Journals
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Raymond A. Dwek
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A
Antoní Torres
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