Not logged in Predicting compound activity from phenotypic profiles and chemical structures Moshkov, Nikita; Becker, Tim; Yang, Kevin; Horvath, Peter; Dancik, Vlado; Wagner, Bridget K.; Clemons, Paul A.; Singh, Shantanu; Carpenter, Anne E.; Caicedo, Juan C. Share Save
Progress toward a universal biomedical data translator Fecho, Karamarie; Thessen, Anne E.; Baranzini, Sergio E.; Bizon, Chris; Hadlock, Jennifer J.; Huang, Sui; Roper, Ryan T.; Southall, Noel; Ta, Casey; Watkins, Paul B.; Williams, Mark D.; Xu, Hao; Byrd, William; Dancik, Vlado; Duby, Marc P.; Dumontier, Michel; Glusman, Gustavo; Harris, Nomi L.; Hinderer, Eugene W.; Hyde, Greg; Johs, Adam; Su, Andrew, I; Qin, Guangrong; Zhu, Qian Share Save
Biolink Model: A universal schema for knowledge graphs in clinical, biomedical, and translational science Unni, Deepak R.; Moxon, Sierra A. T.; Bada, Michael; Brush, Matthew; Bruskiewich, Richard; Caufield, J. Harry; Clemons, Paul A.; Dancik, Vlado; Dumontier, Michel; Fecho, Karamarie; Glusman, Gustavo; Hadlock, Jennifer J.; Harris, Nomi L.; Joshi, Arpita; Putman, Tim; Qin, Guangrong; Ramsey, Stephen A.; Shefchek, Kent A.; Solbrig, Harold; Soman, Karthik; Thessen, Anne E.; Haendel, Melissa A.; Bizon, Chris; Mungall, Christopher J. Share Save
Phenotypic Screening for Small Molecules that Protect ?-Cells from Glucolipotoxicity Small, Jonnell C.; Joblin-Mills, Aidan; Carbone, Kaycee; Kost-Alimova, Maria; Ayukawa, Kumiko; Khodier, Carol; Dancik, Vlado; Clemons, Paul A.; Munkacsi, Andrew B.; Wagner, Bridget K. Share Save
High-resolution specificity profiling and off-target prediction for site-specific DNA recombinases (vol 10, 1937, 2019) Bessen, Jeffrey L.; Afeyan, Lena K.; Dancik, Vlado; Koblan, Luke W.; Thompson, David B.; Leichner, Chas; Clemons, Paul A.; Liu, David R. Share Save
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A GPX4-dependent cancer cell state underlies the clear-cell morphology and confers sensitivity to ferroptosis Zou, Yilong; Palte, Michael J.; Deik, Amy A.; Li, Haoxin; Eaton, John K.; Wang, Wenyu; Tseng, Yuen-Yi; Deasy, Rebecca; Kost-Alimova, Maria; Dancik, Vlado; Leshchiner, Elizaveta S.; Viswanathan, Vasanthi S.; Signoretti, Sabina; Choueiri, Toni K.; Boehm, Jesse S.; Wagner, Bridget K.; Doench, John G.; Clish, Clary B.; Clemons, Paul A.; Schreiber, Stuart L. Share Save
Small-molecule inhibitors directly target CARD9 and mimic its protective variant in inflammatory bowel disease Leshchiner, Elizaveta S.; Rush, Jason S.; Durney, Michael A.; Cao, Zhifang; Dancik, Vlado; Chittick, Benjamin; Wu, Huixian; Petrone, Adam; Bittker, Joshua A.; Phillips, Andrew; Perez, Jose R.; Shamji, Alykhan F.; Kaushik, Virendar K.; Daly, Mark J.; Graham, Daniel B.; Schreiber, Stuart L.; Xavier, Ramnik J. Share Save
CTD2 Dashboard: a searchable web interface to connect validated results from the Cancer Target Discovery and Development Network Aksoy, Bulent Arman; Dancik, Vlado; Smith, Kenneth; Mazerik, Jessica N.; Ji, Zhou; Gross, Benjamin; Nikolova, Olga; Jaber, Nadia; Califano, Andrea; Schreiber, Stuart L.; Gerhard, Daniela S.; Hermida, Leandro C.; Jagu, Subhashini; Sander, Chris; Floratos, Aris; Clemons, Paul A. Share Save
A dataset of images and morphological profiles of 30 000 small-molecule treatments using the Cell Painting assay Bray, Mark-Anthony; Gustafsdottir, Sigrun M.; Rohban, Mohammad H.; Singh, Shantanu; Ljosa, Vebjorn; Sokolnicki, Katherine L.; Bittker, Joshua A.; Bodycombe, Nicole E.; Dancik, Vlado; Hasaka, Thomas P.; Hon, Cindy S.; Kemp, Melissa M.; Li, Kejie; Walpita, Deepika; Wawer, Mathias J.; Golub, Todd R.; Schreiber, Stuart L.; Clemons, Paul A.; Shamji, Alykhan F.; Carpenter, Anne E. Share Save
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DiSCoVERing innovative therapies for rare tumors: Combining genetically accurate disease models with advanced in silico analysis to identify novel therapeutic targets Hanaford, Allison Rose; Archer, Tenley C.; Price, Antoinette; Kahlert, Ulf; Maciaczyk, Jarek; Guido, Nikkhah; Kim, Wiliam; Ehrenberger, Tobias; Clemons, Paul; Dancik, Vlado; Seashore-Ludlow, Brinton; Viswanathan, Vasanthi; Stewart, Michelle; Rees, Matthew; Shamji, Alykahn; Hahn, William; Schreiber, Stuart; Fraenkel, Ernest; Pomeroy, Scott; Mesirov, Jill; Tamayo, Pablo; Eberhart, Charles G.; Raabe, Eric H. Share Save
Inhibition of DYRK1A Stimulates Human β-Cell Proliferation Dirice, Ercument; Walpita, Deepika; Vetere, Amedeo; Meier, Bennett C.; Kahraman, Sevim; Hu, Jiang; Dancik, Vlado; Burns, Sean M.; Gilbert, Tamara J.; Olson, David E.; Clemons, Paul A.; Kulkarni, Rohit N.; Wagner, Bridget K. Share Save
Correlating chemical sensitivity and basal gene expression reveals mechanism of action Rees, Matthew G.; Seashore-Ludlow, Brinton; Cheah, Jaime H.; Adams, Drew J.; Price, Edmund V.; Gill, Shubhroz; Javaid, Sarah; Coletti, Matthew E.; Jones, Victor L.; Bodycombe, Nicole E.; Soule, Christian K.; Alexander, Benjamin; Li, Ava; Montgomery, Philip; Kotz, Joanne D.; Hon, C. Suk-Yee; Munoz, Benito; Liefeld, Ted; Dancik, Vlado; Haber, Daniel A.; Clish, Clary B.; Bittker, Joshua A.; Palmer, Michelle; Wagner, Bridget K.; Clemons, Paul A.; Shamji, Alykhan F.; Schreiber, Stuart L. Share Save
Harnessing Connectivity in a Large-Scale Small-Molecule Sensitivity Dataset Seashore-Ludlow, Brinton; Rees, Matthew G.; Cheah, Jaime H.; Cokol, Murat; Price, Edmund V.; Coletti, Matthew E.; Jones, Victor; Bodycombe, Nicole E.; Soule, Christian K.; Gould, Joshua; Alexander, Benjamin; Li, Ava; Montgomery, Philip; Wawer, Mathias J.; Kuru, Nurdan; Kotz, Joanne D.; Hon, C. Suk-Yee; Munoz, Benito; Liefeld, Ted; Dancik, Vlado; Bittker, Joshua A.; Palmer, Michelle; Bradner, James E.; Shamji, Alykhan F.; Clemons, Paul A.; Schreiber, Stuart L. Share Save
Small-molecule enhancers of autophagy modulate cellular disease phenotypes suggested by human genetics Kuoa, Szu-Yu; Castoreno, Adam B.; Aldrich, Leslie N.; Lassen, Kara G.; Goel, Gautam; Dancik, Vlado; Kuballa, Petric; Latorre, Isabel; Conway, Kara L.; Sarkar, Sovan; Maetzel, Dorothea; Jaenisch, Rudolf; Clemons, Paul A.; Schreiber, Stuart L.; Shamji, Alykhan F.; Xavier, Ramnik J. Share Save
Kinase-Independent Small-Molecule Inhibition of JAK-STAT Signaling Chou, Danny Hung-Chieh; Vetere, Amedeo; Choudhary, Amit; Scully, Stephen S.; Schenone, Monica; Tang, Alicia; Gomez, Rachel; Burns, Sean M.; Lundh, Morten; Vital, Tamara; Comer, Eamon; Faloon, Patrick W.; Dancik, Vlado; Ciarlo, Christie; Paulk, Joshiawa; Dai, Mingji; Reddy, Clark; Sun, Hanshi; Young, Matthew; Donato, Nicholas; Jaffe, Jacob; Clemons, Paul A.; Palmer, Michelle; Carr, Steven A.; Schreiber, Stuart L.; Wagner, Bridget K. Share Save
Niche-Based Screening in Multiple Myeloma Identifies a Kinesin-5 Inhibitor with Improved Selectivity over Hematopoietic Progenitors Chattopadhyay, Shrikanta; Stewart, Alison L.; Mukherjee, Siddhartha; Huang, Cherrie; Hartwell, Kimberly A.; Miller, Peter G.; Subramanian, Radhika; Carmody, Leigh C.; Yusuf, Rushdia Z.; Sykes, David B.; Paulk, Joshiawa; Vetere, Amedeo; Vallet, Sonia; Santo, Loredana; Cirstea, Diana D.; Hideshima, Teru; Dancik, Vlado; Majireck, Max M.; Hussain, Mahmud M.; Singh, Shambhavi; Quiroz, Ryan; Iaconelli, Jonathan; Karmacharya, Rakesh; Tolliday, Nicola J.; Clemons, Paul A.; Moore, Malcolm A. S.; Stern, Andrew M.; Shamji, Alykhan F.; Ebert, Benjamin L.; Golub, Todd R.; Raje, Noopur S.; Scadden, David T.; Schreiber, Stuart L. Share Save
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Small-molecule screening identifies inhibition of salt-inducible kinases as a therapeutic strategy to enhance immunoregulatory functions of dendritic cells Sundberg, Thomas B.; Choi, Hwan Geun; Song, Joo-Hye; Russell, Caitlin N.; Hussain, Mahmud M.; Graham, Daniel B.; Khor, Bernard; Gagnon, John; O'Connell, Daniel J.; Narayan, Kavitha; Dancik, Vlado; Perez, Jose R.; Reinecker, Hans-Christian; Gray, Nathanael S.; Schreiber, Stuart L.; Xavier, Ramnik J.; Shamji, Alykhan F. Share Save
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