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Boudrioua, Abdelhakim; Baetz, Benjamin; Desmadril, Solenn; Goulard, Christophe; Groo, Anne-Claire; Lombard, Carine; Gueulle, Sabrina; Marugan, Marie; Malzert-Freon, Aurelie; Hartke, Axel; Li, Yanyan; Giraud, Caroline .png)
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SaveEvidence from a mouse model supports repurposing an anti-asthmatic drug, bambuterol, against Alzheimer's disease by administration through an intranasal routeGroo, Anne-Claire; Curel, Thomas; Malzert-Freon, Aurelie; Seguy, Line; Bento, Ophelie; Corvaisier, Sophie; Culerier, Thomas; Legrand, Romain; Callizot, Noelle; Henriques, Alexandre; Culley, Georgia; Claeysen, Sylvie; Rochais, Christophe; Dallemagne, Patrick Share Save MRI-based microthrombi detection in stroke with polydopamine iron oxideJacqmarcq, Charlene; Picot, Audrey; Flon, Jules; Lebrun, Florent; Martinez de Lizarrondo, Sara; Naveau, Mikael; Bernay, Benoit; Goux, Didier; Rubio, Marina; Malzert-Freon, Aurelie; Michel, Anita; Proamer, Fabienne; Mangin, Pierre; Gauberti, Maxime; Vivien, Denis; Bonnard, Thomas Share Save Share Save Novel thienopyrimidones targeting hepatic and erythrocytic stages of Plasmodium parasites with increased microsomal stabilityLagardere, Prisca; Mustiere, Romain; Amanzougaghene, Nadia; Hutter, Sebastien; Casanova, Marion; Franetich, Jean-Francois; Tajeri, Shahin; Malzert-Freon, Aurelie; Corvaisier, Sophie; Since, Marc; Azas, Nadine; Vanelle, Patrice; Verhaeghe, Pierre; Primas, Nicolas; Mazier, Dominique; Masurier, Nicolas; Lisowski, Vincent Share Save New antiplasmodial 4-amino-thieno[3,2-d]pyrimidines with improved intestinal permeability and microsomal stabilityLagardere, Prisca; Mustiere, Romain; Amanzougaghene, Nadia; Hutter, Sebastien; Casanova, Marion; Franetich, Jean-Francois; Tajeri, Shahin; Malzert-Freon, Aurelie; Corvaisier, Sophie; Azas, Nadine; Vanelle, Patrice; Verhaeghe, Pierre; Primas, Nicolas; Mazier, Dominique; Masurier, Nicolas; Lisowski, Vincent Share Save In vitro evaluation of NA1-115-7-loaded nanoemulsions, an MCL-1-specific inhibitor of natural origin, intended to treat B-cell lymphoproliferative disorders after oral administrationSeguy, Line; Daressy, Florian; Lahlil, Sophia; Corvaisier, Sophie; Dumontet, Vincent; Litaudon, Marc; Apel, Cecile; Roussi, Fanny; Wiels, Joelle; Robert, Aude; Groo, Anne-Claire; Malzert-Freon, Aurelie Share Save Synthesis of antiplasmodial 2-aminothieno[3,2-d]pyrimidin-4(3H)-one analogues using the scaffold hopping strategyMustiere, Romain; Lagardere, Prisca; Hutter, Sebastien; Dell'Orco, Viviana; Amanzougaghene, Nadia; Tajeri, Shahin; Franetich, Jean-Francois; Corvaisier, Sophie; Since, Marc; Malzert-Freon, Aurelie; Masurier, Nicolas; Lisowski, Vincent; Verhaeghe, Pierre; Mazier, Dominique; Azas, Nadine; Vanelle, Patrice; Primas, Nicolas Share Save NA1-115-7, from Zygogynum pancheri, is a new selective MCL-1 inhibitor inducing the apoptosis of hematological cancer cells but non-toxic to normal blood cells or cardiomyocytesDaressy, Florian; Seguy, Line; Favre, Loetitia; Corvaisier, Sophie; Apel, Cecile; Groo, Anne-Claire; Litaudon, Marc; Dumontet, Vincent; Malzert-Freon, Aurelie; Desrat, Sandy; Roussi, Fanny; Robert, Aude; Wiels, Joelle Share Save Improving Aqueous Solubility and In Vitro Pharmacokinetic Properties of the 3-Nitroimidazo[1,2-a]pyridine Antileishmanial PharmacophorePaoli-Lombardo, Romain; Primas, Nicolas; Bourgeade-Delmas, Sandra; Hutter, Sebastien; Sournia-Saquet, Alix; Boudot, Clotilde; Brenot, Emilie; Castera-Ducros, Caroline; Corvaisier, Sophie; Since, Marc; Malzert-Freon, Aurelie; Courtioux, Bertrand; Valentin, Alexis; Verhaeghe, Pierre; Azas, Nadine; Rathelot, Pascal; Vanelle, Patrice Share Save Share Save A New Thienopyrimidinone Chemotype Shows Multistage Activity against Plasmodium falciparum, Including Artemisinin-Resistant ParasitesBosson-Vanga, Henriette; Primas, Nicolas; Franetich, Jean-Francois; Lavazec, Catherine; Gomez, Lina; Ashraf, Kutub; Tefit, Maurel; Soulard, Valerie; Dereuddre-Bosquet, Nathalie; Le Grand, Roger; Donnette, Melanie; Mustiere, Romain; Amanzougaghene, Nadia; Tajeri, Shahin; Suzanne, Peggy; Malzert-Freon, Aurelie; Rault, Sylvain; Vanelle, Patrice; Hutter, Sebastien; Cohen, Anita; Snounou, Georges; Roques, Pierre; Azas, Nadine; Lagardere, Prisca; Lisowski, Vincent; Masurier, Nicolas; Nguyen, Michel; Paloque, Lucie; Benoit-Vical, Francoise; Verhaeghe, Pierre; Mazier, Dominique Share Save Active Targeted Nanoemulsions for Repurposing of Tegaserod in Alzheimer's Disease TreatmentSeguy, Line; Guyon, Lena; Maurel, Manon; Verdie, Pascal; Davis, Audrey; Corvaisier, Sophie; Lisowski, Vincent; Dallemagne, Patrick; Groo, Anne-Claire; Malzert-Freon, Aurelie Share Save Share Save Drimane Derivatives as the First Examples of Covalent BH3 Mimetics that Target MCL-1Daressy, Florian; Malard, Florian; Seguy, Line; Guerineau, Vincent; Apel, Cecile; Dumontet, Vincent; Robert, Aude; Groo, Anne-Claire; Litaudon, Marc; Bignon, Jerome; Desrat, Sandy; Malzert-Freon, Aurelie; Wiels, Joelle; Lescop, Ewen; Roussi, Fanny Share Save Share Save Antikinetoplastid SAR study in 3-nitroimidazopyridine series: Identification of a novel non-genotoxic and potent anti-T.b. brucei hitcompound with improved pharmacokinetic propertiesFersing, Cyril; Boudot, Clotilde; Paoli-Lombardo, Romain; Primas, Nicolas; Pinault, Emilie; Hutter, Sebastien; Castera-Ducros, Caroline; Kabri, Youssef; Pedron, Julien; Bourgeade-Delmas, Sandra; Sournia-Saquet, Alix; Stigliani, Jean-Luc; Valentin, Alexis; Azqueta, Amaya; Muruzabal, Damian; Destere, Alexandre; Wyllie, Susan; Fairlamb, Alan H.; Corvaisier, Sophie; Since, Marc; Malzert-Freon, Aurelie; Di Giorgio, Carole; Rathelot, Pascal; Azas, Nadine; Courtioux, Bertrand; Vanelle, Patrice; Verhaeghe, Pierre Share Save Pyridoclax-loaded nanoemulsion for enhanced anticancer effect on ovarian cancerGroo, A. C.; Hedir, S.; Since, M.; Brotin, E.; Weiswald, L. -B.; Paysant, H.; Nee, G.; Coolzaet, M.; Goux, D.; Delepee, R.; Freret, T.; Poulain, L.; Voisin-Chiret, A. S.; Malzert-Freon, A. Share Save 8-Alkynyl-3-nitroimidazopyridines display potent antitrypanosomal activity against both T. b. brucei and cruziFersing, Cyril; Boudot, Clotilde; Castera-Ducros, Caroline; Pinault, Emilie; Hutter, Sebastien; Paoli-Lombardo, Romain; Primas, Nicolas; Pedron, Julien; Seguy, Line; Bourgeade-Delmas, Sandra; Sournia-Saquet, Alix; Stigliani, Jean-Luc; Brossas, Jean-Yves; Paris, Luc; Valentin, Alexis; Wyllie, Susan; Fairlamb, Alan H.; Boutet-Robinet, Elisa; Corvaisier, Sophie; Since, Marc; Malzert-Freon, Aurelie; Destere, Alexandre; Mazier, Dominique; Rathelot, Pascal; Courtioux, Bertrand; Azas, Nadine; Verhaeghe, Pierre; Vanelle, Patrice Share Save Pharmacotechnical Development of a Nasal Drug Delivery Composite Nanosystem Intended for Alzheimer's Disease TreatmentAdnet, Thomas; Groo, Anne-Claire; Picard, Celine; Davis, Audrey; Corvaisier, Sophie; Since, Marc; Bounoure, Frederic; Rochais, Christophe; Le Pluart, Loic; Dallemagne, Patrick; Malzert-Freon, Aurelie Share Save 
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