Not logged in Sterol 14-alpha demethylase (CYP51) activity in Leishmania donovani is likely dependent upon cytochrome P450 reductase 1 Tulloch, Lindsay B.; Tinti, Michele; Wall, Richard J.; Weidt, Stefan K.; Corpas- Lopez, Victoriano; Dey, Gourav; Smith, Terry K.; Fairlamb, Alan H.; Barrett, Michael P.; Wyllie, Susan Share Save
Tres Cantos Open Lab: celebrating a decade of innovation in collaboration to combat endemic infectious diseases COMMENT Calderon, Felix; Ballell, Lluis; Barros, David; Bilbe, Graeme; Cammack, Nicholas; Gabarro, Raquel; Halsey, Audra; Heaton, Penny M.; Kang, Gagandeep; Mizrahi, Valerie; Nathan, Carl; Strange, Mike E.; Williams, Pauline M.; Winzeler, Elizabeth A.; Fairlamb, Alan H. Share Save
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Monocyclic Nitro-heteroaryl Nitrones with Dual Mechanism of Activation: Synthesis and Antileishmanial Activity Pacheco, Juliana da Silva; Costa, Debora de Souza; Cunha-Junior, Edezio Ferreira; Andrade-Neto, Valter Viana; Fairlamb, Alan H.; Wyllie, Susan; Goulart, Marilia O. F.; Santos, Danyelle C.; Silva, Thaissa L.; Alves, Marina A.; Costa, Paulo R. R.; Dias, Ayres G.; Torres-Santos, Eduardo Caio Share Save
Multiple unbiased approaches identify oxidosqualene cyclase as the molecular target of a promising anti-leishmanial Paradela, Luciana S.; Wall, Richard J.; Carvalho, Sandra; Chemi, Giulia; Corpas-Lopez, Victoriano; Moynihan, Eoin; Bello, Davide; Patterson, Stephen; Guther, Maria Lucia S.; Fairlamb, Alan H.; Ferguson, Michael A. J.; Zuccotto, Fabio; Martin, Julio; Gilbert, Ian H.; Wyllie, Susan Share Save
Antikinetoplastid SAR study in 3-nitroimidazopyridine series: Identification of a novel non-genotoxic and potent anti-T.b. brucei hitcompound with improved pharmacokinetic properties Fersing, Cyril; Boudot, Clotilde; Paoli-Lombardo, Romain; Primas, Nicolas; Pinault, Emilie; Hutter, Sebastien; Castera-Ducros, Caroline; Kabri, Youssef; Pedron, Julien; Bourgeade-Delmas, Sandra; Sournia-Saquet, Alix; Stigliani, Jean-Luc; Valentin, Alexis; Azqueta, Amaya; Muruzabal, Damian; Destere, Alexandre; Wyllie, Susan; Fairlamb, Alan H.; Corvaisier, Sophie; Since, Marc; Malzert-Freon, Aurelie; Di Giorgio, Carole; Rathelot, Pascal; Azas, Nadine; Courtioux, Bertrand; Vanelle, Patrice; Verhaeghe, Pierre Share Save
8-Alkynyl-3-nitroimidazopyridines display potent antitrypanosomal activity against both T. b. brucei and cruzi Fersing, Cyril; Boudot, Clotilde; Castera-Ducros, Caroline; Pinault, Emilie; Hutter, Sebastien; Paoli-Lombardo, Romain; Primas, Nicolas; Pedron, Julien; Seguy, Line; Bourgeade-Delmas, Sandra; Sournia-Saquet, Alix; Stigliani, Jean-Luc; Brossas, Jean-Yves; Paris, Luc; Valentin, Alexis; Wyllie, Susan; Fairlamb, Alan H.; Boutet-Robinet, Elisa; Corvaisier, Sophie; Since, Marc; Malzert-Freon, Aurelie; Destere, Alexandre; Mazier, Dominique; Rathelot, Pascal; Courtioux, Bertrand; Azas, Nadine; Verhaeghe, Pierre; Vanelle, Patrice Share Save
Discovery of an Allosteric Binding Site in Kinetoplastid Methionyl-tRNA Synthetase Torrie, Leah S.; Robinson, David A.; Thomas, Michael G.; Hobrath, Judith, V; Shepherd, Sharon M.; Post, John M.; Ko, Eun-Jung; Ferreira, Rafael Alves; Mackenzie, Claire J.; Wrobel, Karolina; Edwards, Darren P.; Gilbert, Ian H.; Gray, David W.; Fairlamb, Alan H.; De Rycker, Manu Share Save
New 8-Nitroquinolinone Derivative Displaying Submicromolar in Vitro Activities against Both Trypanosoma brucei and cruzi Pedron, Julien; Boudot, Clotilde; Brossas, Jean-Yves; Pinault, Emilie; Bourgeade-Delmas, Sandra; Sournia-Saquet, Alix; Boutet-Robinet, Elisa; Destere, Alexandre; Tronnet, Antoine; Berge, Justine; Bonduelle, Colin; Deraeve, Celine; Pratviel, Genevieve; Stigliani, Jean-Luc; Paris, Luc; Mazier, Dominique; Corvaisier, Sophie; Since, Marc; Malzert-Freon, Aureprimelie; Wyllie, Susan; Milne, Rachel; Fairlamb, Alan H.; Valentin, Alexis; Courtioux, Bertrand; Verhaeghe, Pierre Share Save
The Qi Site of Cytochrome b is a Promiscuous Drug Target in Trypanosoma cruzi and Leishmania donovani Wall, Richard J.; Carvalho, Sandra; Milne, Rachel; Bueren-Calabuig, Juan A.; Moniz, Sonia; Cantizani-Perez, Juan; MacLean, Lorna; Kessler, Albane; Cotillo, Ignacio; Sastry, Lalitha; Manthri, Sujatha; Patterson, Stephen; Zuccotto, Fabio; Thompson, Stephen; Martin, Julio; Marco, Maria; Miles, Timothy J.; De Rycker, Manu; Thomas, Michael G.; Fairlamb, Alan H.; Gilbert, Ian H.; Wyllie, Susan Share Save
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Substituted Aminoacetamides as Novel Leads for Malaria Treatment Norcross, Neil R.; Wilson, Caroline; Baragana, Beatriz; Hallyburton, Irene; Osuna-Cabello, Maria; Norval, Suzanne; Riley, Jennifer; Fletcher, Daniel; Sinden, Robert; Delves, Michael; Ruecker, Andrea; Duffy, Sandra; Meister, Stephan; Antonova-Koch, Yevgeniya; Crespo, Benigno; de Cozar, Cristina; Sanz, Laura M.; Javier Gamo, Francisco; Avery, Vicky M.; Frearson, Julie A.; Gray, David W.; Fairlamb, Alan H.; Winzeler, Elizabeth A.; Waterson, David; Campbell, Simon F.; Willis, Paul A.; Read, Kevin D.; Gilbert, Ian H. Share Save
Preclinical candidate for the treatment of visceral leishmaniasis that acts through proteasome inhibition Wyllie, Susan; Brand, Stephen; Thomas, Michael; De Rycker, Manu; Chung, Chun-wa; Pena, Imanol; Bingham, Ryan P.; Bueren-Calabuig, Juan A.; Cantizani, Juan; Cebrian, David; Craggs, Peter D.; Ferguson, Liam; Goswami, Panchali; Hobrath, Judith; Howe, Jonathan; Jeacock, Laura; Ko, Eun-Jung; Korczynska, Justyna; MacLean, Lorna; Manthri, Sujatha; Martinez, Maria S.; Mata-Cantero, Lydia; Moniz, Sonia; Nuhs, Andrea; Osuna-Cabello, Maria; Pinto, Erika; Riley, Jennifer; Robinson, Sharon; Rowland, Paul; Simeons, Frederick R. C.; Shishikura, Yoko; Spinks, Daniel; Stojanovski, Laste; Thomas, John; Thompson, Stephen; Gaza, Elisabet Viayna; Wall, Richard J.; Zuccotto, Fabio; Horn, David; Ferguson, Michael A. J.; Fairlamb, Alan H.; Fiandor, Jose M.; Martin, Julio; Gray, David W.; Miles, Timothy J.; Gilbert, Ian H.; Read, Kevin D.; Marco, Maria; Wyatt, Paul G. Share Save
Lysyl-tRNA synthetase as a drug target in malaria and cryptosporidiosis Baragana, Beatriz; Forte, Barbara; Choi, Ryan; Hewitt, Stephen Nakazawa; Bueren-Calabuig, Juan A.; Pisco, Joao Pedro; Peet, Caroline; Dranow, David M.; Robinson, David A.; Jansen, Chimed; Norcross, Neil R.; Vinayak, Sumiti; Anderson, Mark; Brooks, Carrie F.; Cooper, Caitlin A.; Damerow, Sebastian; Delves, Michael; Dowers, Karen; Duffy, James; Edwards, Thomas E.; Hallyburton, Irene; Horst, BenjaminG.; Hulverson, Matthew A.; Ferguson, Liam; Belen Jimenez-Diaz, Maria; Jumani, Rajiv S.; Lorimer, Donald D.; Love, Melissa S.; Maher, Steven; Matthews, Holly; McNamara, Casew.; Miller, Peter; O'Neill, Sandra; Ojo, Kayode K.; Osuna-Cabello, Maria; Pinto, Erika; Post, John; Riley, Jennifer; Rottmann, Matthias; Sanz, Laura M.; Scullion, Paul; Sharma, Arvind; Shepherd, Sharon M.; Shishikura, Yoko; Simeons, Frederick R. C.; Stebbins, Erin E.; Stojanovski, Laste; Straschil, Ursula; Tamaki, Fabio K.; Tamjar, Jevgenia; Torrie, Leah S.; Vantaux, Amelie; Witkowski, Benoit; Wittlin, Sergio; Yogavel, Manickam; Zuccotto, Fabio; Angulo-Barturen, Inigo; Sinden, Robert; Baum, Jake; Gamo, Francisco-Javier; Maser, Pascal; Kyle, Dennis E.; Winzeler, Elizabeth A.; Myler, Peter J.; Wyatt, Paul G.; Floyd, David; Matthews, David; Sharmao, Amit; Striepen, Boris; Huston, Christopher D.; Gray, David W.; Fairlamb, Alan H.; Pisliakov, Andrei V.; Walpole, Chris; Read, Kevin D.; Van Voorhis, Wesley C.; Gilbert, Ian H. Share Save
Nongenotoxic 3-Nitroimidazo[1,2-a]pyridines Are NTR1 Substrates That Display Potent in Vitro Antileishmanial Activity Fersing, Cyril; Basmaciyan, Louise; Boudot, Clotilde; Pedron, Julien; Hatter, Sebastien; Cohen, Anita; Castera-Ducros, Caroline; Primas, Nicolas; Laget, Michele; Casanova, Magali; Bourgeade-Delmas, Sandra; Piednoel, Melanie; Sournia-Saquet, Alix; Mbou, Valere Belle; Courtioux, Bertrand; Boutet-Robinet, Elisa; Since, Marc; Milne, Rachel; Wyllie, Susan; Fairlamb, Alan H.; Valentin, Alexis; Rathelot, Pascal; Verhaeghe, Pierre; Vanelle, Patrice; Azas, Nadine Share Save
Pharmacological Validation of N-Myristoyltransferase as a Drug Target in Leishmania donovani Corpas-Lopez, Victoriano; Moniz, Sonia; Thomas, Michael; Wall, Richard J.; Torrie, Leah S.; Zander-Dinse, Dorothea; Tinti, Michele; Brand, Stephen; Stojanovski, Laste; Manthri, Sujatha; Hallyburton, Irene; Zuccotto, Fabio; Wyatt, Paul G.; De Rycker, Manu; Horn, David; Ferguson, Michael A. J.; Clos, Joachim; Read, Kevin D.; Fairlamb, Alan H.; Gilbert, Ian H.; Wyllie, Susan Share Save
Development of Chemical Proteomics for the Folateome and Analysis of the Kinetoplastid Folateome Webster, Lauren A.; Thomas, Michael; Urbaniak, Michael; Wyllie, Susan; Ong, Han; Tinti, Michele; Fairlamb, Alan H.; Boesche, Markus; Ghidelli-Disse, Sonja; Drewes, Gerard; Gilbert, Ian H. Share Save
Antitrypanosomatid Pharmacomodulation at Position 3 of the 8-Nitroquinolin-2(1H)-one Scaffold Using Palladium-Catalysed Cross-Coupling Reactions Pedron, Julien; Boudot, Clotilde; Bourgeade-Delmas, Sandra; Sournia-Saquet, Alix; Paloque, Lucie; Rastegari, Maryam; Abdoulaye, Mansour; El-Kashef, Hussein; Bonduelle, Colin; Pratviel, Genevieve; Wyllie, Susan; Fairlamb, Alan H.; Courtioux, Bertrand; Verhaeghe, Pierre; Valentin, Alexis Share Save
Anti-trypanosomatid drug discovery: an ongoing challenge and a continuing need (vol 15, pg 217, 2017) Field, Mark C.; Horn, David; Fairlamb, Alan H.; Ferguson, Michael A. J.; Gray, David W.; Read, Kevin D.; De Rycker, Manu; Torrie, Leah S.; Wyatt, Paul G.; Wyllie, Susan; Gilbert, Ian H. Share Save
8-Aryl-6-chloro-3-nitro-2-(phenylsulfonylmethyl)imidazo[1,2-a] pyridines as potent antitrypanosomatid molecules bioactivated by type 1 nitroreductases Fersing, Cyril; Boudot, Clotilde; Pedron, Julien; Hutter, Sebastien; Primas, Nicolas; Castera-Ducros, Caroline; Bourgeade-Delmas, Sandra; Sournia-Saquet, Alix; Moreau, Alain; Cohen, Anita; Stigliani, Jean-Luc; Pratviel, Genevieve; Crozet, Maxime D.; Wyllie, Susan; Fairlamb, Alan; Valentin, Alexis; Rathelot, Pascal; Azas, Nadine; Courtioux, Bertrand; Verhaeghe, Pierre; Vanelle, Patrice Share Save
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