Not logged in Shared Nearest Neighbors Approach and Interactive Browser for Network Analysis of a Comprehensive Non-Small-Cell Lung Cancer Data Set Schmidt, Stephanie T.; Akhave, Neal; Knightly, Ryan E.; Reuben, Alexandre; Vokes, Natalie; Zhang, Jianhua; Li, Jun; Fujimoto, Junya; Byers, Lauren A.; Sanchez-Espiridion, Beatriz; Diao, Lixia; Wang, Jing; Federico, Lorenzo; Forget, Marie-Andree; McGrail, Daniel J.; Weissferdt, Annikka; Lin, Shiaw-Yih; Lee, Younghee; Suzuki, Erika; Kovacs, Jeffrey J.; Behrens, Carmen; Wistuba, Ignacio I.; Futreal, Andrew; Vaporciyan, Ara; Sepesi, Boris; Heymach, John V.; Bernatchez, Chantale; Haymaker, Cara; Cascone, Tina; Zhang, Jianjun; Bristow, Christopher A.; Heffernan, Timothy P.; Negrao, Marcelo V.; Gibbons, Don L. Share Save
Discovery of 6-[(3S,4S)-4-Amino-3-methyl-2-oxa-8-azaspiro[4.5]decan-8-yl]-3-(2,3-dichlorophenyl)-2-methyl-3,4-dihydropyrimidin-4-one (IACS-15414), a Potent and Orally Bioavailable SHP2 Inhibitor Czako, Barbara; Sun, Yuting; McAfoos, Timothy; Cross, Jason B.; Leonard, Paul G.; Burke, Jason P.; Carroll, Christopher L.; Feng, Ningping; Harris, Angela L.; Jiang, Yongying; Kang, Zhijun; Kovacs, Jeffrey J.; Mandal, Pijus; Meyers, Brooke A.; Mseeh, Faika; Parker, Connor A.; Yu, Simon S.; Williams, Christopher C.; Wu, Qi; Di Francesco, Maria Emilia; Draetta, Giulio; Heffernan, Timothy; Marszalek, Joseph R.; Kohl, Nancy E.; Jones, Philip Share Save
PRMT1-dependent regulation of RNA metabolism and DNA damage response sustains pancreatic ductal adenocarcinoma Giuliani, Virginia; Miller, Meredith A.; Liu, Chiu-Yi; Hartono, Stella R.; Class, Caleb A.; Bristow, Christopher A.; Suzuki, Erika; Sanz, Lionel A.; Gao, Guang; Gay, Jason P.; Feng, Ningping; Rose, Johnathon L.; Tomihara, Hideo; Daniele, Joseph R.; Peoples, Michael D.; Bardenhagen, Jennifer P.; Geck Do, Mary K.; Chang, Qing E.; Vangamudi, Bhavatarini; Vellano, Christopher; Ying, Haoqiang; Deem, Angela K.; Do, Kim-Anh; Genovese, Giannicola; Marszalek, Joseph R.; Kovacs, Jeffrey J.; Kim, Michael; Fleming, Jason B.; Guccione, Ernesto; Viale, Andrea; Maitra, Anirban; Emilia Di Francesco, M.; Yap, Timothy A.; Jones, Philip; Draetta, Giulio; Carugo, Alessandro; Chedin, Frederic; Heffernan, Timothy P. Share Save
Dual Inhibition of MEK and AXL Targets Tumor Cell Heterogeneity and Prevents Resistant Outgrowth Mediated by the Epithelial-to-Mesenchymal Transition in NSCLC Konen, Jessica M.; Rodriguez, B. Leticia; Padhye, Aparna; Ochieng, Joshua K.; Gibson, Laura; Diao, Lixia; Fowlkes, Natalie W.; Fradette, Jared J.; Peng, David H.; Cardnell, Robert J.; Kovacs, Jeffrey J.; Wang, Jing; Byers, Lauren A.; Gibbons, Don L. Share Save
Allosteric SHP2 Inhibitor, IACS-13909, Overcomes EGFR-Dependent and EGFR-Independent Resistance Mechanisms toward Osimertinib Sun, Yuting; Meyers, Brooke A.; Czako, Barbara; Leonard, Paul; Mseeh, Faika; Harris, Angela L.; Wu, Qi; Johnson, Sarah; Parker, Connor A.; Cross, Jason B.; Di Francesco, Maria Emilia; Bivona, Benjamin J.; Bristow, Christopher A.; Burke, Jason P.; Carrillo, Caroline C.; Carroll, Christopher L.; Chang, Qing; Feng, Ningping; Gao, Guang; Gera, Sonal; Giuliani, Virginia; Huang, Justin K.; Jiang, Yongying; Kang, Zhijun; Kovacs, Jeffrey J.; Liu, Chiu-Yi; Lopez, Anastasia M.; Ma, Xiaoyan; Mandal, Pijus K.; McAfoos, Timothy; Miller, Meredith A.; Mullinax, Robert A.; Peoples, Michael; Ramamoorthy, Vandhana; Seth, Sahil; Spencer, Nakia D.; Suzuki, Erika; Williams, Christopher C.; Yu, Simon S.; Zuniga, Andy M.; Draetta, Giulio F.; Marszalek, Joseph R.; Heffernan, Timothy P.; Kohl, Nancy E.; Jones, Philip Share Save
Discovery of IPN60090, a Clinical Stage Selective Glutaminase-1 (GLS-1) Inhibitor with Excellent Pharmacokinetic and Physicochemical Properties Soth, Michael J.; Le, Kang; Di Francesco, Maria Emilia; Hamilton, Matthew M.; Liu, Gang; Burke, Jason P.; Carroll, Chris L.; Kovacs, Jeffrey J.; Bardenhagen, Jennifer P.; Bristow, Christopher A.; Cardozo, Mario; Czako, Barbara; de Stanchina, Elisa; Feng, Ningping; Garvey, Jill R.; Gay, Jason P.; Do, Mary K. Geck; Greer, Jennifer; Han, Michelle; Harris, Angela; Herrera, Zachary; Huang, Sha; Giuliani, Virginia; Jiang, Yongying; Johnson, Sarah B.; Johnson, Troy A.; Kang, Zhijun; Leonard, Paul G.; Liu, Zhen; McAfoos, Timothy; Miller, Meredith; Morlacchi, Pietro; Mullinax, Robert A.; Palmer, Wylie S.; Pang, Jihai; Rogers, Norma; Rudin, Charles M.; Shepard, Hannah E.; Spencer, Nakia D.; Theroff, Jay; Wu, Qi; Xu, Alan; Yau, Ju Anne; Draetta, Giulio; Toniatti, Carlo; Heffernan, Timothy P.; Jones, Philip Share Save
Discovery of IACS-9439, a Potent, Exquisitely Selective, and Orally Bioavailable Inhibitor of CSF1R Czako, Barbara; Marszalek, Joseph. R.; Burke, Jason P.; Mandal, Pijus; Leonard, Paul G.; Cross, Jason B.; Mseeh, Faika; Jiang, Yongying; Chang, Edward Q.; Suzuki, Erika; Kovacs, Jeffrey J.; Feng, Ningping; Gera, Sonal; Harris, Angela L.; Liu, Zhen; Mullinax, Robert A.; Pang, Jihai; Parker, Connor A.; Spencer, Nakia D.; Yu, Simon S.; Wu, Qi; Tremblay, Martin R.; Mikule, Keith; Wilcoxen, Keith; Heffernan, Timothy P.; Draetta, Giulio F.; Jones, Philip Share Save
Discovery of IACS-13909, an allosteric SHP2 inhibitor that overcomes multiple mechanisms underlying osimertinib resistance Sun, Yuting; Meyers, Brooke A.; Johnson, Sarah B.; Harris, Angela L.; Czako, Barbara; Cross, Jason B.; Leonard, Paul G.; Mseeh, Faika; Di Francesco, Maria E.; Parker, Connor A.; Wu, Qi; Bristow, Christopher A.; Burke, Jason P.; Carrillo, Caroline C.; Carroll, Christopher L.; Chang, Qing; Feng, Ningping; Gera, Sonal; Guang, Gao; Huang, Justin Kwang-Lay; Jiang, Yongying; Kang, Zhijun; Kovacs, Jeffrey J.; Ma, Xiaoyan; Mandal, Pijus K.; McAfoos, Timothy; Mullinax, Robert A.; Peoples, Michael D.; Ramamoorthy, Vandhana; Seth, Sahil; Suzuki, Erika; Williams, Christopher Conrad; Yu, Simon S.; Zuniga, Andy M.; Draetta, Giulio F.; Marszalek, Joseph R.; Heffernan, Timothy P.; Kohl, Nancy E.; Jones, Philip Share Save
ZEB1/NuRD complex suppresses TBC1D2b to stimulate E-cadherin internalization and promote metastasis in lung cancer Manshouri, Roxsan; Coyaud, Etienne; Kundu, Samrat T.; Peng, David H.; Stratton, Sabrina A.; Alton, Kendra; Bajaj, Rakhee; Fradette, Jared J.; Minelli, Rosalba; Peoples, Michael D.; Carugo, Alessandro; Chen, Fengju; Bristow, Christopher; Kovacs, Jeffrey J.; Barton, Michelle C.; Heffernan, Tim; Creighton, Chad J.; Raught, Brian; Gibbons, Don L. Share Save
Inhibition of protein arginine methylation alters RNA metabolism and DNA damage response providing a new therapeutic strategy in pancreatic ductal adenocarcinoma Giuliani, Virginia; Carugo, Alessandro; Miller, Meredith; Sanz, Lionel; Liu, Chiu-Yi; Bristow, Christopher A.; Suzuki, Erika; Class, Caleb A.; Hartono, Stella R.; Gao, Guang; Feng, Ningping; Gay, Jason P.; Vangamudi, Bhavatarini; Marszalek, Joseph R.; Kovacs, Jeffrey; Di Francesco, Maria Emilia; Chedin, Frederic; Jones, Philip; Draetta, Giulio; Heffernan, Timothy Share Save
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PPM1D Mutations Drive Clonal Hematopoiesis in Response to Cytotoxic Chemotherapy Hsu, Joanne, I; Dayaram, Tajhal; Tovy, Ayala; De Braekeleer, Etienne; Jeong, Mira; Wang, Feng; Zhang, Jianhua; Heffernan, Timothy P.; Gera, Sonal; Kovacs, Jeffrey J.; Marszalek, Joseph R.; Bristow, Christopher; Yan, Yuanqing; Garcia-Manero, Guillermo; Kantarjian, Hagop; Vassiliou, George; Futreal, P. Andrew; Donehower, Lawrence A.; Takahashi, Koichi; Goodell, Margaret A. Share Save
LKB1 and KEAP1/NRF2 pathways cooperatively promote glutamine dependence and vulnerability to glutaminase inhibitors in KRAS-mutant lung adenocarcinoma Galan-Cobo, Ana; Sitthideatphaiboon, Piyada; Qu, Xiao; Kovacs, Jeffrey J.; Poteete, Alissa; Tong, Pan; Cho, Sungnam; Gandhi, Varsha V.; Skoulidis, Ferdinandos; Wang, Jing; Heffernan, Timothy P.; Heymach, John V. Share Save
Promoting an anti-tumor immune environment with a novel, exquisitely selective CSF1R inhibitor Suzuki, Erika; Kovacs, Jeffrey J.; Spencer, Nakia D.; Sonal, Sonal; Feng, Ningping; Harris, Angela L.; Mullinax, Robert A.; Zuniga, Andy M.; Johnson, Sarah B.; Mahendra, Mikhila; Khor, Tin Oo; Mseeh, Faika; Liu, Zhen; Burke, Jason P.; Mikule, Keith; Tremblay, Martin; Heffernan, Timothy P.; Jones, Philip; Czako, Barbara; Marszalek, Joseph R. Share Save
Identification of protein arginine methyltransferase 1 as novel epigenetic vulnerability in KRAS/p53 mutant PDAC primary patient models Giuliani, Virginia; Vangamudi, Bhavatarini; Suzuki, Erika; Miller, Meredith; Liu, Chiu-Yi; Carugo, Alessandro; Bristow, Christopher; Gao, Guang; Han, Jing; Sun, Yuting; Feng, Ningping; Chang, Edward; Marszalek, Joseph; Kovacs, Jeffrey; Di Francesco, Maria Emilia; Toniatti, Carlo; Heffernan, Timothy; Jones, Philip; Draetta, Giulio Share Save
β-Arrestin2 mediates the initiation and progression of myeloid leukemia Fereshteha, Mark; Ito, Takahiro; Kovacs, Jeffrey J.; Zhao, Chen; Kwon, Hyog Young; Tornini, Valerie; Konuma, Takaaki; Chen, Minyong; Lefkowitz, Robert J.; Reya, Tannishtha Share Save
β-Arrestin Deficiency Protects Against Pulmonary Fibrosis in Mice and Prevents Fibroblast Invasion of Extracellular Matrix Lovgren, Alysia Kern; Kovacs, Jeffrey J.; Xie, Ting; Potts, Erin N.; Li, Yuejuan; Foster, Michael; Liang, Jiurong; Meltzer, Eric B.; Jiang, Dianhua; Lefkowitz, Robert J.; Noble, Paul W. Share Save
Global phosphorylation analysis of β-arrestin-mediated signaling downstream of a seven transmembrane receptor (7TMR) Xiao, Kunhong; Sun, Jinpeng; Kim, Jihee; Rajagopal, Sudarshan; Zhai, Bo; Villen, Judit; Haas, Wilhelm; Kovacs, Jeffrey J.; Shukla, Arun K.; Hara, Makoto R.; Hernandez, Marylens; Lachmann, Alexander; Zhao, Shan; Lin, Yuan; Cheng, Yishan; Mizuno, Kensaku; Ma'ayan, Avi; Gygi, Steven P.; Lefkowitz, Robert J. Share Save
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β-Arrestin1 mediates nicotinic acid-induced flushing, but not its antilipolytic effect, in mice Walters, Robert W.; Shukla, Arun K.; Kovacs, Jeffrey J.; Violin, Jonathan D.; DeWire, Scott M.; Lam, Christopher M.; Chen, J. Ruthie; Muehlbauer, Michael J.; Whalen, Erin J.; Lefkowitz, Robert J. Share Save
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