Not logged in Activity-Based DNA-Encoded Library Screening for Selective Inhibitors of Eukaryotic Translation Barhoosh, Huda; Dixit, Anjali; Cochrane, Wesley G.; Cavett, Valerie; Prince, Robin N.; Blair, Brooke O.; Ward, Fred R.; Mcclure, Kim F.; Patten, Phillip A.; Paulick, Margot G.; Paegel, Brian M. Share Save
Preclinical characterization and IND-enabling safety studies for PNT001, an antibody that recognizes cis-pT231 tau Foster, Kelly; Manca, Matteo; McClure, Kim; Koivula, Pyry; Trojanowski, John Q.; Havas, Daniel; Chancellor, Sarah; Goldstein, Lee; Brunden, Kurt R.; Kraus, Allison; Ahlijanian, Michael K. Share Save
PF-07059013: A Noncovalent Modulator of Hemoglobin for Treatment of Sickle Cell Disease Gopalsamy, Ariamala; Aulabaugh, Ann E.; Barakat, Amey; Beaumont, Kevin C.; Cabral, Shawn; Canterbury, Daniel P.; Casimiro-Garcia, Agustin; Chang, Jeanne S.; Chen, Ming Z.; Choi, Chulho; Dow, Robert L.; Fadeyi, Olugbeminiyi O.; Feng, Xidong; France, Scott P.; Howard, Roger M.; Janz, Jay M.; Jasti, Jayasankar; Jasuja, Reema; Jones, Lyn H.; King-Ahmad, Amanda; Knee, Kelly M.; Kohrt, Jeffrey T.; Limberakis, Chris; Liras, Spiros; Martinez, Carlos A.; McClure, Kim F.; Narayanan, Arjun; Narula, Jatin; Novak, Jonathan J.; O'Connell, Thomas N.; Parikh, Mihir D.; Piotrowski, David W.; Plotnikova, Olga; Robinson, Ralph P.; Sahasrabudhe, Parag, V; Sharma, Raman; Thuma, Benjamin A.; Vasa, Dipy; Wei, Liuqing; Wenzel, A. Zane; Withka, Jane M.; Xiao, Jun; Yayla, Hatice G. Share Save
Structure-function relationships of the soluble form of the antiaging protein Klotho have therapeutic implications for managing kidney disease Zhong, Xiaotian; Jagarlapudi, Srinath; Weng, Yan; Ly, Mellisa; Rouse, Jason C.; McClure, Kim; Ishino, Tetsuya; Zhang, Yan; Sousa, Eric; Cohen, Justin; Tzvetkova, Boriana; Cote, Kaffa; Scarcelli, John J.; Johnson, Keith; Palandra, Joe; Apgar, James R.; Yaddanapudi, Suma; Gonzalez-Villalobos, Romer A.; Opsahl, Alan C.; Lam, Khetemenee; Yao, Qing; Duan, Weili; Sievers, Annette; Zhou, Jing; Ferguson, Darren; D'Antona, Aaron; Zollner, Richard; Zhu, Hongli L.; Kriz, Ron; Lin, Laura; Clerin, Valerie Share Save
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Small Molecule Proprotein Convertase Subtilisin/Kexin Type 9 (PCSK9) Inhibitors: Hit to Lead Optimization of Systemic Agents Londregan, Allyn T.; Wei, Liuqing; Xiao, Jun; Lintner, Nathanael G.; Petersen, Donna; Dullea, Robert G.; McClure, Kim F.; Bolt, Michael W.; Warmus, Joseph S.; Coffey, Steven B.; Limberakis, Chris; Genovino, Julien; Thuma, Benjamin A.; Hesp, Kevin D.; Aspnes, Gary E.; Reidich, Benjamin; Salatto, Christopher T.; Chabot, Jeffrey R.; Cate, Jamie H. D.; Liras, Spiros; Piotrowski, David W. Share Save
Receptor-Mediated Delivery of CRISPR-Cas9 Endonuclease for Cell-Type-Specific Gene Editing Rouet, Romain; Thuma, Benjamin A.; Roy, Marc D.; Lintner, Nathanael G.; Rubitski, David M.; Finley, James E.; Wisniewska, Hanna M.; Mendonsa, Rima; Hirsh, Ariana; de Onate, Lorena; Barron, Joan Compte; McLellan, Thomas J.; Bellenger, Justin; Feng, Xidong; Varghese, Alison; Chrunyk, Boris A.; Borzilleri, Kris; Hesp, Kevin D.; Zhou, Kaihong; Ma, Nannan; Tu, Meihua; Dullea, Robert; McClure, Kim F.; Wilson, Ross C.; Liras, Spiros; Mascitti, Vincent; Doudna, Jennifer A. Share Save
Liver-Targeted Small-Molecule Inhibitors of Proprotein Convertase Subtilisin/Kexin Type 9 Synthesis McClure, Kim F.; Piotrowski, David W.; Petersen, Donna; Wei, Liuqing; Xiao, Jun; Londregan, Allyn T.; Kamlet, Adam S.; Dechert-Schmitt, Anne-Marie; Raymer, Brian; Ruggeri, Roger B.; Canterbury, Daniel; Limberakis, Chris; Liras, Spiros; DaSilva-Jardine, Paul; Dullea, Robert G.; Loria, Paula M.; Reidich, Benjamin; Salatto, Christopher T.; Eng, Heather; Kimoto, Emi; Atkinson, Karen; King-Ahmad, Amanda; Scott, Dennis; Beaumont, Kevin; Chabot, Jeffrey R.; Bolt, Michael W.; Maresca, Kevin; Dahl, Kenneth; Arakawa, Ryosuke; Takano, Akihiro; Halldin, Christer Share Save
Pharmacological characterization of the first in class clinical candidate PF-05190457: a selective ghrelin receptor competitive antagonist with inverse agonism that increases vagal afferent firing and glucose-dependent insulin secretion ex vivo Kong, J.; Chuddy, J.; Stock, I. A.; Loria, P. M.; Straub, S. V.; Vage, C.; Cameron, K. O.; Bhattacharya, S. K.; Lapham, K.; McClure, K. F.; Zhang, Y.; Jackson, V. M. Share Save
Evaluation and Synthesis of Polar Aryl- and Heteroaryl Spiroazetidine-Piperidine Acetamides as Ghrelin Inverse Agonists Orr, Suvi T. M.; Beveridge, Ramsay; Bhattacharya, Samit K.; Cameron, Kimberly O.; Coffey, Steven; Fernando, Dilinie; Hepworth, David; Jackson, Margaret V.; Khot, Vishal; Kosa, Rachel; Lapham, Kimberly; Loria, Paula M.; McClure, Kim F.; Patel, Jigna; Rose, Colin; Saenz, James; Stock, Ingrid A.; Storer, Gregory; von Volkenburg, Maria; Vrieze, Derek; Wang, Guoqiang; Xiao, Jun; Zhang, Yingxin Share Save
Discovery of PF-5190457, a Potent, Selective, and Orally Bioavailable Ghrelin Receptor Inverse Agonist Clinical Candidate Bhattacharya, Samit K.; Andrews, Kim; Beveridge, Ramsay; Cameron, Kimberly O.; Chen, Chiliu; Dunn, Matthew; Fernando, Dilinie; Gao, Hua; Hepworth, David; Jackson, V. Margaret; Khot, Vishal; Kong, Jimmy; Kosa, Rachel E.; Lapham, Kimberly; Loria, Paula M.; Londregan, Allyn T.; McClure, Kim F.; Orr, Suvi T. M.; Patel, Jigna; Rose, Colin; Saenz, James; Stock, Ingrid A.; Storer, Gregory; VanVolkenburg, Maria; Vrieze, Derek; Wang, Guoqiang; Xiao, Jun; Zhang, Yingxin Share Save
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Design and Synthesis of Diazatricyclodecane Agonists of the G-Protein-Coupled Receptor 119 Darout, Etzer; Robinson, Ralph P.; McClure, Kim F.; Corbett, Matthew; Li, Bryan; Shavnya, Andrei; Andrews, Melissa P.; Jones, Christopher S.; Li, Qifang; Minich, Martha L.; Mascitti, Vincent; Guimaraes, Cristiano R. W.; Munchhof, Michael J.; Bahnck, Kevin B.; Cai, Cuiman; Price, David A.; Liras, Spiros; Bonin, Paul D.; Cornelius, Peter; Wang, Ruduan; Bagdasarian, Victoria; Sobota, Colleen P.; Hornby, Sam; Masterson, Victoria M.; Joseph, Reena M.; Kalgutkar, Amit S.; Chen, Yue Share Save
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Oxidative Metabolism of a Quinoxaline Derivative by Xanthine Oxidase in Rodent Plasma Sharma, Raman; Eng, Heather; Walker, Gregory S.; Barreiro, Gabriela; Stepan, Antonia F.; McClure, Kim F.; Wolford, Angela; Bonin, Paul D.; Cornelius, Peter; Kalgutkar, Amit S. Share Save
Activation of the G-Protein-Coupled Receptor 119: A Conformation-Based Hypothesis for Understanding Agonist Response McClure, Kim F.; Darout, Etzer; Guimaraes, Cristiano R. W.; DeNinno, Michael P.; Mascitti, Vincent; Munchhof, Michael J.; Robinson, Ralph P.; Kohrt, Jeffrey; Harris, Anthony R.; Moore, Dianna E.; Li, Bryan; Samp, Lacey; Lefker, Bruce A.; Futatsugi, Kentaro; Kung, Daniel; Bonin, Paul D.; Cornelius, Peter; Wang, Ruduan; Salter, Eben; Hornby, Sam; Kalgutkar, Amit S.; Chen, Yue Share Save
Intrinsic Electrophilicity of a 4-Substituted-5-cyano-6-(2-methylpyridin-3-yloxy)pyrinnidine Derivative: Structural Characterization of Glutathione Conjugates in Vitro Kalgutkar, Amit S.; Mascitti, Vincent; Sharma, Raman; Walker, Gregory W.; Ryder, Tim; McDonald, Thomas S.; Chen, Yue; Preville, Cathy; Basak, Arindrajit; McClure, Kim F.; Kohrt, Jeffrey T.; Robinson, Ralph P.; Munchhof, Michael J.; Cornelius, Peter Share Save
Theoretical and experimental design of atypical kinase inhibitors: Application to p38 MAP kinase McClure, KF; Abramov, YA; Laird, ER; Barberia, JT; Cai, WL; Carty, TJ; Cortina, SR; Danley, DE; Dipesa, AJ; Donahue, KM; Dombroski, MA; Elliott, NC; Gabel, CA; Han, SG; Hynes, TR; LeMotte, PK; Mansour, MN; Marr, ES; Letavic, MA; Pandit, J; Ripin, DB; Sweeney, FJ; Tan, D; Tao, Y Share Save
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