Not logged inDirect and selective pharmacological disruption of the YAP-TEAD interface by IAG933 inhibits Hippo-dependent and RAS-MAPK-altered cancers (Apr, 10.1038/s43018-024-00754-9, 2024)
Chapeau, Emilie A.; Sansregret, Laurent; Galli, Giorgio G.; Chene, Patrick; Wartmann, Markus; Mourikis, Thanos P.; Jaaks, Patricia; Baltschukat, Sabrina; Barbosa, Ines A. M.; Bauer, Daniel; Brachmann, Saskia M.; Delaunay, Clara; Estadieu, Claire; Faris, Jason E.; Furet, Pascal; Harlfinger, Stefanie; Hueber, Andreas; Jimenez Nunez, Eloisa; Kodack, David P.; Mandon, Emeline; Martin, Typhaine; Mesrouze, Yannick; Romanet, Vincent; Scheufler, Clemens; Sellner, Holger; Stamm, Christelle; Sterker, Dario; Tordella, Luca; Hofmann, Francesco; Soldermann, Nicolas; Schmelzle, Tobias .png)
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SaveDirect and selective pharmacological disruption of the YAP-TEAD interface by IAG933 inhibits Hippo-dependent and RAS-MAPK-altered cancersChapeau, Emilie A.; Sansregret, Laurent; Galli, Giorgio G.; Chene, Patrick; Wartmann, Markus; Mourikis, Thanos P.; Jaaks, Patricia; Baltschukat, Sabrina; Barbosa, Ines A. M.; Bauer, Daniel; Brachmann, Saskia M.; Delaunay, Clara; Estadieu, Claire; Faris, Jason E.; Furet, Pascal; Harlfinger, Stefanie; Hueber, Andreas; Jimenez Nunez, Eloisa; Kodack, David P.; Mandon, Emeline; Martin, Typhaine; Mesrouze, Yannick; Romanet, Vincent; Scheufler, Clemens; Sellner, Holger; Stamm, Christelle; Sterker, Dario; Tordella, Luca; Hofmann, Francesco; Soldermann, Nicolas; Schmelzle, Tobias Share Save RNF43 mutations predict response to anti-BRAF/EGFR combinatory therapies in BRAFV600E metastatic colorectal cancerElez, Elena; Ros, Javier; Fernandez, Jose; Villacampa, Guillermo; Moreno-Cardenas, Ana Belen; Arenillas, Carlota; Bernatowicz, Kinga; Comas, Raquel; Li, Shanshan; Kodack, David Philip; Fasani, Roberta; Garcia, Ariadna; Gonzalo-Ruiz, Javier; Piris-Gimenez, Alejandro; Nuciforo, Paolo; Kerr, Grainne; Intini, Rossana; Montagna, Aldo; Germani, Marco Maria; Randon, Giovanni; Vivancos, Ana; Smits, Ron; Graus, Diana; Perez-Lopez, Raquel; Cremolini, Chiara; Lonardi, Sara; Pietrantonio, Filippo; Dienstmann, Rodrigo; Tabernero, Josep; Toledo, Rodrigo A. Share Save Fatty acid synthesis is required for breast cancer brain metastasis (vol 2, pg 414, 2021)Ferraro, Gino B.; Ali, Ahmed; Luengo, Alba; Kodack, David P.; Deik, Amy; Abbott, Keene L.; Bezwada, Divya; Blanc, Landry; Prideaux, Brendan; Jin, Xin; Posada, Jessica M.; Chen, Jiang; Chin, Christopher R.; Amoozgar, Zohreh; Ferreira, Raphael; Chen, Ivy X.; Naxerova, Kamila; Ng, Christopher; Westermark, Anna M.; Duquette, Mark; Roberge, Sylvie; Lindeman, Neal I.; Lyssiotis, Costas A.; Nielsen, Jens; Housman, David E.; Duda, Dan G.; Brachtel, Elena; Golub, Todd R.; Cantley, Lewis C.; Asara, John M.; Davidson, Shawn M.; Fukumura, Dai; Dartois, Veronique A.; Clish, Clary B.; Jain, Rakesh K.; Vander Heiden, Matthew G. Share Save Fatty acid synthesis is required for breast cancer brain metastasisFerraro, Gino B.; Ali, Ahmed; Luengo, Alba; Kodack, David P.; Deik, Amy; Abbott, Keene L.; Bezwada, Divya; Blanc, Landry; Prideaux, Brendan; Jin, Xin; Possada, Jessica M.; Chen, Jiang; Chin, Christopher R.; Amoozgar, Zohreh; Ferreira, Raphael; Chen, Ivy X.; Naxerova, Kamila; Ng, Christopher; Westermark, Anna M.; Duquette, Mark; Roberge, Sylvie; Lindeman, Neal I.; Lyssiotis, Costas A.; Nielsen, Jens; Housman, David E.; Duda, Dan G.; Brachtel, Elena; Golub, Todd R.; Cantley, Lewis C.; Asara, John M.; Davidson, Shawn M.; Fukumura, Dai; Dartois, Veronique A.; Clish, Clary B.; Jain, Rakesh K.; Vander Heiden, Matthew G. Share Save In vivo shRNA screens under treatment pressure by BRAF and MEK inhibitors to identify novel combination treatment strategies for BRAF-mutant colorectal cancerBhang, Hyo-eun C.; DiMare, Matthew T.; Kodack, David P.; Tan, Lujian; Kerr, Grainne; Radhakrishna, Viveksagar Krishnamurthy; Golji, Javad; Ruddy, David A.; Yuan, Tina; Niederst, Matthew J.; Korn, Joshua M.; Porta, Diana Graus; Hammerman, Peter S.; Engelman, Jeffrey A.; Abrams, Tinya; Williams, Juliet Share Save Dual endothelin receptor inhibition enhances T-DM1 efficacy in brain metastases from HER2-positive breast cancerAskoxylakis, Vasileios; Ferraro, Gino B.; Badeaux, Mark; Kodack, David P.; Kirst, Isabelle; Shankaraiah, Ram C.; Wong, Christina S. F.; Duda, Dan G.; Fukumura, Dai; Jain, Rakesh K. Share Save Share Save Primary Patient-Derived Cancer Cells and Their Potential for Personalized Cancer Patient CareKodack, David P.; Farago, Anna F.; Dastur, Anahita; Held, Matthew A.; Dardaei, Leila; Friboulet, Luc; von Flotow, Friedrich; Damon, Leah J.; Lee, Dana; Parks, Melissa; Dicecca, Richard; Greenberg, Max; Kattermann, Krystina E.; Riley, Amanda K.; Fintelmann, Florian J.; Rizzo, Coleen; Piotrowska, Zofia; Shaw, Alice T.; Gainor, Justin F.; Sequist, Lecia V.; Niederst, Matthew J.; Engelman, Jeffrey A.; Benes, Cyril H. Share Save The brain microenvironment mediates resistance in luminal breast cancer to PI3K inhibition through HER3 activationFerraro, Gino B.; Kodack, David P.; Askoxylakis, Vasileios; Sheng, Qing; Badeaux, Mark; Goel, Shom; Qi, Xiaolong; Shankaraiah, Ram; Cao, Alexander Z.; Ramjiawan, Rakesh R.; Bezwada, Divya; Patel, Bhushankumar; Song, Youngchul; Costa, Carlotta; Naxerova, Kamila; Wong, Christina; Kloepper, Jonas; Das, Rita; Tam, Angela; Tanboon, Jantima; Duda, Dan G.; Miller, Ryan C.; Siegel, Marni B.; Anders, Carey K.; Sanders, Melinda; Estrada, Valeria M.; Schlegel, Robert; Arteaga, Carlos L.; Brachtel, Elena; Huang, Alan; Fukumura, Dai; Engelman, Jeffrey A.; Jain, Rakesh K. Share Save Share Save The brain microenvironment mediates resistance in luminal breast cancer to PI3K inhibition through HER3 activationKodack, David P.; Askoxylakis, Vasileios; Ferraro, Gino B.; Sheng, Qing; Badeaux, Mark; Goel, Shom; Qi, Xiaolong; Shankaraiah, Ram; Cao, Z. Alexander; Ramjiawan, Rakesh R.; Bezwada, Divya; Patel, Bhushankumar; Song, Yongchul; Costa, Carlotta; Naxerova, Kamila; Wong, Christina S. F.; Kloepper, Jonas; Das, Rita; Tam, Angela; Tanboon, Jantima; Duda, Dan G.; Miller, C. Ryan; Siegel, Marni B.; Anders, Carey K.; Sanders, Melinda; Estrada, Monica V.; Schlegel, Robert; Arteaga, Carlos L.; Brachtel, Elena; Huang, Alan; Fukumura, Dai; Engelman, Jeffrey A.; Jain, Rakesh K. Share Save Share Save Share Save Share Save Preclinical Efficacy of Ado-trastuzumab Emtansine in the Brain MicroenvironmentAskoxylakis, Vasileios; Ferraro, Gino B.; Kodack, David P.; Badeaux, Mark; Shankaraiah, Ram C.; Seano, Giorgio; Kloepper, Jonas; Vardam, Trupti; Martin, John D.; Naxerova, Kamila; Bezwada, Divya; Qi, Xiaolong; Selig, Martin K.; Brachtel, Elena; Duda, Dan G.; Huang, Peigen; Fukumura, Dai; Engelman, Jeffrey A.; Jain, Rakesh K. Share Save PF-06463922, a novel next generation ALK/ROS1 inhibitor, overcomes resistance to 1st and 2nd generation ALK inhibitors in pre-clinical modelsFriboulet, Luc; Zou, Helen; Kodack, David P.; Engstrom, Lars D.; Li, Qiuhua; West, Melissa; Tang, Ruth W.; Wang, Hui; Tsaparikos, Konstantinos; Wang, Jinwei; Timofeevski, Sergei; Dinh, Dac M.; Hieu Lam; Lam, Justine L.; Yamazaki, Shinji; Hu, Wenyue; Patel, Bhushankumar; Bezwada, Divya; Mahmood, Sidra; Lifshits, Eugene; Affolter, Timothy; Lappin, Patrick B.; Gukasyan, Hovhannes; Lee, Nathan; Deng, Shibing; Jain, Rakesh K.; Johnson, Ted W.; Shaw, Alice T.; Fantin, Valeria R.; Smeal, Tod Share Save Blockade of MMP14 Activity in Murine Breast Carcinomas: Implications for Macrophages, Vessels, and RadiotherapyAger, Eleanor I.; Kozin, Sergey V.; Kirkpatrick, Nathaniel D.; Seano, Giorgio; Kodack, David P.; Askoxylakis, Vasileios; Huang, Yuhui; Goel, Shom; Snuderl, Matija; Muzikansky, Alona; Finkelstein, Dianne M.; Dransfield, Daniel T.; Devy, Laetitia; Boucher, Yves; Fukumura, Dai; Jain, Rakesh K. Share Save mTOR Inhibition Specifically Sensitizes Colorectal Cancers with KRAS or BRAF Mutations to BCL-2/BCL-XL Inhibition by Suppressing MCL-1Faber, Anthony C.; Coffee, Erin M.; Costa, Carlotta; Dastur, Anahita; Ebi, Hiromichi; Hata, Aaron N.; Yeo, Alan T.; Edelman, Elena J.; Song, Youngchul; Tam, Ah Ting; Boisvert, Jessica L.; Milano, Randy J.; Roper, Jatin; Kodack, David P.; Jain, Rakesh K.; Corcoran, Ryan B.; Rivera, Miguel N.; Ramaswamy, Sridhar; Hung, Kenneth E.; Benes, Cyril H.; Engelman, Jeffrey A. Share Save mTOR inhibition specifically sensitizes colorectal cancers with KRAS or BRAF mutations to BCL-2/BCL-XL inhibition by suppressing MCL-1Coffee, Erin M.; Faber, Anthony C.; Costa, Carlotta; Dastur, Anahita; Ebi, Hiromichi; Hata, Aaron N.; Yeo, Alan T.; Elena, J.; Song, Youngchul; Tam, Ah Ting; Boisvert, Jessica L.; Milano, Randy J.; Roper, Jatin; Kodack, David P.; Jain, Rakesh K.; Corcoran, Ryan B.; Rivera, Miguel N.; Ramaswamy, Sridhar; Hung, Kenneth E.; Benes, Cyril H.; Engelman, Jeffrey A. Share Save 
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