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Zongertinib (BI1810631), an irreversible HER2 TKI spares EGFR signaling and improves therapeutic response in preclinical models and patients with HER2-driven cancers Neumueller, R.; Wilding, B.; Augsten, M.; Baum, A.; Chylinski, K.; Waizenegger, I.; Woelflingseder, L.; Solca, F.; Kraut, N. Share Save
SOS1 inhibition in combination with HER2 inhibition in models of HER2driven cancer Schenk, Robyn L.; Kostyrko, Kaja; Popow, Johannes; Gewinner, Christina; Baum, Anke; Albrecht, Christoph; Hinkel, Melanie; Jacob, Robin; Madensky, Tom; Ruzicka, Regina; Strauss, Eva; Lyu, Hengyu; Lopez, Anastasia M.; Feng, Ningping; Vellano, Christopher P.; Marszalek, Joseph R.; Heffernan, Timothy P.; Pearson, Mark; Hofmann, Marco H. Share Save
SOS1 inhibition is an effective therapeutic strategy in SOS1-mutant cancer Sale, Matthew J.; Mukherjee, Neal; Koch, Martin; Ruzicka, Regina; Jacob, Robin; Albrecht, Christoph; Zanin, Teresa; Madensky, Thomas; Schenk, Robyn L.; Baum, Anke; Kostyrko, Kaja; Gerlach, Daniel; Hofmann, Marco H.; McCormick, Frank Share Save
SOS1 inhibition is an effective therapeutic strategy in SOS1-mutant cancer Sale, Matthew J.; Mukherjee, Neal; Ruzicka, Regina; Jacob, Robin; Albrecht, Christoph; Zanin, Teresa; Madensky, Tom; Kostyrko, Kaja; Schenk, Robyn L.; Baum, Anke; Gerlach, Daniel; Hofmann, Marco H.; McCormick, Frank Share Save
BI-732, a novel fourth-generation EGFR-TKI, demonstrates promising activities against the C797S-mediated EGFRTKI resistance Lee, Eun Ji; Lee, Jiyun; Oh, Seung Yeon; Lee, You Won; Kim, Ju Young; Choi, Su-Jin; Park, Sewon; Yu, Mi Ra; Kim, Jae Hwan; Pyo, Kyoung-Ho; Lee, Jii Bum; Hong, Min Hee; Lim, Sun Min; Baum, Anke; Woelflingseder, Lydia; Engelhardt, Harald; Petronczki, Mark; Solca, Flavio; Yun, Mi Ran; Cho, Byoung Chul Share Save
Pharmacodynamic and Antitumor Activity of BI 836880, a Dual Vascular Endothelial Growth Factor and Angiopoietin 2 Inhibitor, Alone and Combined with Programmed Cell Death Protein-1 Inhibition Hofmann, Irmgard; Baum, Anke; Hofmann, Marco H.; Trapani, Francesca; Reichel-Voda, Claudia; Ehrensperger, Diane; Aichinger, Martin; Ebner, Florian; Budano, Nicole; Schweifer, Norbert; Sykora, Martina; Depla, Erik; Boucneau, Joachim; Gschwind, Andreas; Kraut, Norbert; Hilberg, Frank; Kunkele, Klaus-Peter Share Save
Discovery of potent and selective HER2 inhibitors with efficacy against HER2 exon 20 insertion-driven tumors, which preserve wild-type EGFR signaling Wilding, Birgit; Scharn, Dirk; Boese, Dietrich; Baum, Anke; Santoro, Valeria; Chetta, Paolo; Schnitzer, Renate; Botesteanu, Dana A.; Reiser, Christoph; Kornigg, Stefan; Knesl, Petr; Hoermann, Alexandra; Koeferle, Anna; Corcokovic, Maja; Lieb, Simone; Scholz, Guido; Bruchhaus, Jens; Spina, Markus; Balla, Josef; Peric-Simov, Biljana; Zimmer, Jasmin; Mitzner, Sophie; Fett, Thomas N.; Beran, Alexandra; Lamarre, Lyne; Gerstberger, Thomas; Gerlach, Daniel; Bauer, Markus; Bergner, Andreas; Schlattl, Andreas; Bader, Gerd; Treu, Matthias; Engelhardt, Harald; Zahn, Stephan; Fuchs, Julian E.; Zuber, Johannes; Ettmayer, Peter; Pearson, Mark; Petronczki, Mark; Kraut, Norbert; McConnell, Darryl B.; Solca, Flavio; Neumuller, Ralph A. Share Save
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Start Selective and Rigidify: The Discovery Path toward a Next Generation of EGFR Tyrosine Kinase Inhibitors Engelhardt, Harald; Boese, Dietrich; Petronczki, Mark; Scharn, Dirk; Bader, Gerd; Baum, Anke; Bergner, Andreas; Chong, Eugene; Doebel, Sandra; Egger, Georg; Engelhardt, Christian; Ettmayer, Peter; Fuchs, Julian E.; Gerstberger, Thomas; Gonnella, Nina; Grimm, Andreas; Grondal, Elisabeth; Haddad, Nizar; Hopfgartner, Barbara; Kousek, Roland; Krawiec, Mariusz; Kriz, Monika; Lamarre, Lyne; Leung, Joyce; Mayer, Moriz; Patel, Nitinchandra D.; Simov, Biljana Peric; Reeves, Jonathan T.; Schnitzer, Renate; Schrenk, Andreas; Sharps, Bernadette; Solca, Flavio; Stadtmueller, Heinz; Tan, Zhulin; Wunberg, Tobias; Zoephel, Andreas; McConnell, Darryl B. Share Save
Synergistic activity of BET inhibitor BI 894999 with PLK inhibitor volasertib in AML in vitro and in vivo Tontsch-Grunt, Ulrike; Rudolph, Dorothea; Waizenegger, Irene; Baum, Anke; Gerlach, Daniel; Engelhardt, Harald; Wurm, Melanie; Savarese, Fabio; Schweifer, Norbert; Kraut, Norbert Share Save
Triple Angiokinase Inhibitor Nintedanib Directly Inhibits Tumor Cell Growth and Induces Tumor Shrinkage via Blocking Oncogenic Receptor Tyrosine Kinases Hilberg, Frank; Tontsch-Grunt, Ulrike; Baum, Anke; Le, Anh T.; Doebele, Robert C.; Lieb, Simone; Gianni, Davide; Voss, Tilman; Garin-Chesa, Pilar; Haslinger, Christian; Kraut, Norbert Share Save
The novel BET bromodomain inhibitor BI 894999 represses super-enhancer-associated transcription and synergizes with CDK9 inhibition in AML Gerlach, Daniel; Tontsch-Grunt, Ulrike; Baum, Anke; Popow, Johannes; Scharn, Dirk; Hofmann, Marco H.; Engelhardt, Harald; Kaya, Onur; Beck, Janina; Schweifer, Norbert; Gerstberger, Thomas; Zuber, Johannes; Savarese, Fabio; Kraut, Norbert Share Save
Efficacy of the highly selective focal adhesion kinase inhibitor BI 853520 in adenocarcinoma xenograft models is linked to a mesenchymal tumor phenotype Hirt, Ulrich A.; Waizenegger, Irene C.; Schweifer, Norbert; Haslinger, Christian; Gerlach, Daniel; Braunger, Juergen; Weyer-Czernilofsky, Ulrike; Stadtmueller, Heinz; Sapountzis, Ioannis; Bader, Gerd; Zoephel, Andreas; Bister, Bojan; Baum, Anke; Quant, Jens; Kraut, Norbert; Garin-Chesa, Pilar; Adolf, Guenther R. Share Save
Combination of the novel BET inhibitor BI 894999 with CDK9 inhibition suggests a promising regimen for the treatment of AML Tontsch-Grunt, U.; Savarese, F.; Baum, A.; Scharn, D.; Gerlach, D.; Hofmann, M. H.; Popow, J.; Schweifer, N.; Engelhardt, H.; Musa, H.; Lee, C. P.; Munzert, G. M.; Kraut, N. Share Save
A Novel RAF Kinase Inhibitor with DFG-Out-Binding Mode: High Efficacy in BRAF-Mutant Tumor Xenograft Models in the Absence of Normal Tissue Hyperproliferation Waizenegger, Irene C.; Baum, Anke; Steurer, Steffen; Stadtmueller, Heinz; Bader, Gerd; Schaaf, Otmar; Garin-Chesa, Pilar; Schlattl, Andreas; Schweifer, Norbert; Haslinger, Christian; Colbatzky, Florian; Mousa, Sien; Kalkuhl, Arno; Kraut, Norbert; Adolf, Guenther R. Share Save
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BIBW2992, an irreversible EGFR/HER2 inhibitor highly effective in preclinical lung cancer models Li, D.; Ambrogio, L.; Shimamura, T.; Kubo, S.; Takahashi, M.; Chirieac, L. R.; Padera, R. F.; Shapiro, G. I.; Baum, A.; Himmelsbach, F.; Rettig, W. J.; Meyerson, M.; Solca, F.; Greulich, H.; Wong, K-K Share Save
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BI 2536, a potent and selective inhibitor of polo-like kinase 1, inhibits tumor growth in vivo Steegmaier, Martin; Hoffmann, Matthias; Baum, Anke; Lenart, Peter; Petronczki, Mark; Krssak, Martin; Guertler, Ulrich; Garin-Chesa, Pilar; Lieb, Simone; Quant, Jens; Grauert, Matthias; Adolf, Guenther R.; Kraut, Norbert; Peters, Jan-Michael; Rettig, Wolfgang J. Share Save
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