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LKB1 regulates JNK-dependent stress signaling and apoptotic dependency of KRAS-mutant lung cancers Li, Chendi; Syed, Mohammed Usman; Nimbalkar, Anahita; Shen, Yi; Vieira, Melissa D.; Fraser, Cameron; Inde, Zintis; Qin, Xingping; Ouyang, Jian; Kreuzer, Johannes; Clark, Sarah E.; Kelley, Grace; Hensley, Emily M.; Morris, Robert; Lazaro, Raul; Belmonte, Brian; Oh, Audris; Walcott, Makeba; Nabel, Christopher S.; Caenepeel, Sean; Saiki, Anne Y.; Rex, Karen; Lipford, J. Russell; Heist, Rebecca S.; Lin, Jessica J.; Haas, Wilhelm; Sarosiek, Kristopher; Hughes, Paul E.; Hata, Aaron N. Share Save
SRC inhibition enables formation of a growth suppressive MAGI1-PP2A complex in isocitrate dehydrogenase-mutant cholangiocarcinoma Luk, Iris S.; Bridgwater, Caroline M.; Yu, Angela; Boila, Liberalis D.; Yanez-Bartolome, Mariana; Lampano, Aaron E.; Hulahan, Taylor S.; Boukhali, Myriam; Kathiresan, Meena; Macarulla, Teresa; Kenerson, Heidi L.; Yamamoto, Naomi; Sokolov, David; Engstrom, Ian A.; Sullivan, Lucas B.; Lampe, Paul D.; Cooper, Jonathan A.; Yeung, Raymond S.; Tian, Tian V.; Haas, Wilhelm; Saha, Supriya K.; Kugel, Sita Share Save
FGFR inhibition blocks NF-ĸB-dependent glucose metabolism and confers metabolic vulnerabilities in cholangiocarcinoma Zhen, Yuanli; Liu, Kai; Shi, Lei; Shah, Simran; Xu, Qin; Ellis, Haley; Balasooriya, Eranga R.; Kreuzer, Johannes; Morris, Robert; Baldwin, Albert S.; Juric, Dejan; Haas, Wilhelm; Bardeesy, Nabeel Share Save
APOE2 gene therapy reduces amyloid deposition and improves markers of neuroinflammation and neurodegeneration in a mouse model of Alzheimer disease Jackson, Rosemary J.; Keiser, Megan S.; Meltzer, Jonah C.; Fykstra, Dustin P.; Dierksmeier, Steven E.; Hajizadeh, Soroush; Kreuzer, Johannes; Morris, Robert; Melloni, Alexandra; Nakajima, Tsuneo; Tecedor, Luis; Ranum, Paul T.; Carrell, Ellie; Chen, Yonghong; Nishtar, Maryam A.; Holtzman, David M.; Haas, Wilhelm; Davidson, Beverly L.; Hyman, Bradley T. Share Save
Multiomics analysis unravels tumor metabolic reprogramming and potential resistance mechanism(s) to curative therapy in TNBC Ren, Zuen; Kurmi, Kiran; Morris, Robert; Joshi, Shakchhi; Zaniewski, Eric; Kreuzer, Johannes; Gioia, Gabrielle Elena; Bossuyt, Veerle I.; Dontchos, Brian N.; Wang, Gary X.; Chou, Shinn-Huey S.; Spring, Laura M.; Haas, Wilhelm; Haigis, Marcia C.; Ellisen, Leif W. Share Save
Genetic retargeting of E3 ligases to enhance CAR T cell therapy Lane, Isabel C.; Kembuan, Gabriele; Carreiro, Jeannie; Kann, Michael C.; Lin, William; Bouffard, Amanda A.; Kreuzer, Johannes; Morris, Robert; Schneider, Emily M.; Kim, Joanna Y.; Zou, Charles; Salas-Benito, Diego; Gasser, Jessica A.; Leick, Mark B.; Slabicki, Mikolaj; Haas, Wilhelm; V. Maus, Marcela; Jan, Max Share Save
A non-canonical MiT/TFE-dependent NRF2 program is a druggable vulnerability in multiple cancer types Luo, Xinbo; Lutterbach, Bart; Pancholi, Priya; Choi, Yeon Sook; Liu, Xiao; Munson, Phillip; Faisal, Saqib; Whipple, David A.; Smith, Robert A.; Weiner, Warren S.; Johnson, David K.; Boukhali, Myriam; Persky, Nicole S.; Rees, Matthew G.; Kitajima, Shunsuke; Barbie, David; Roy, Anuradha; Baltezor, Michael; Rajewski, Lian; McGuinness, William; Haslam, John; Sadagopan, Ananthan; Yoon, Charles H.; Johannessen, Cory M.; Lian, Christine G.; Hornick, Jason L.; Viswanathan, Srinivas R.; Liu, David; Nienaber, Vicki; Haas, Wilhelm; Schoenen, Frank J.; Fisher, David E.; Haq, Rizwan Share Save
Multiomics analysis of triple negative breast cancer identifies potential metabolic vulnerability for overcoming the resistance of neoadjuvant therapy Ren, Zuen; Kurmi, Kiran; Morris, Robert; Joshi, Shakchhi; Zaniewski, Eric; Kreuzer, Johannes; Gioia, Gabrielle Elena; Haas, Wilhelm; Haigis, Marcia C.; Ellisen, Leif W. Share Save
SULT1A1-dependent sulfonation of alkylators is a lineage-dependent vulnerability of liver cancers Shi, Lei; Shen, William; Davis, Mindy I.; Kong, Ke; Vu, Phuong; Saha, Supriya K.; Adil, Ramzi; Kreuzer, Johannes; Egan, Regina; Lee, Tobie D.; Greninger, Patricia; Shrimp, Jonathan H.; Zhao, Wei; Wei, Ting-Yu; Zhou, Mi; Eccleston, Jason; Sussman, Jonathan; Manocha, Ujjawal; Weerasekara, Vajira; Kondo, Hiroshi; Vijay, Vindhya; Wu, Meng-Ju; Kearney, Sara E.; Ho, Jeffrey; McClanaghan, Joseph; Murchie, Ellen; Crowther, Giovanna S.; Patnaik, Samarjit; Boxer, Matthew B.; Shen, Min; Ting, David T.; Kim, William Y.; Stanger, Ben Z.; Deshpande, Vikram; Ferrone, Cristina R.; Benes, Cyril H.; Haas, Wilhelm; Hall, Matthew D.; Bardeesy, Nabeel Share Save
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Neutrophil profiles of pediatric COVID-19 and multisystem inflammatory syndrome in children Boribong, Brittany P.; LaSalle, Thomas J.; Bartsch, Yannic C.; Ellett, Felix; Loiselle, Maggie E.; Davis, Jameson P.; Gonye, Anna L. K.; Sykes, David B.; Hajizadeh, Soroush; Kreuzer, Johannes; Pillai, Shiv; Haas, Wilhelm; Edlow, Andrea G.; Fasano, Alessio; Alter, Galit; Irimia, Daniel; Sade-Feldman, Moshe; Yonker, Lael M. Share Save
Ribosome changes reprogram translation for chemosurvival in G0 leukemic cells Datta, Chandreyee; Truesdell, Samuel S.; Wu, Keith Q.; Bukhari, Syed I. A.; Ngue, Harrison; Buchanan, Brienna; Le Tonqueze, Olivier; Lee, Sooncheol; Kollu, Swapna; Granovetter, Madeleine A.; Boukhali, Myriam; Kreuzer, Johannes; Batool, Maheen S.; Balaj, Leonora; Haas, Wilhelm; Vasudevan, Shobha Share Save
CD4+ T helper 2 cells suppress breast cancer by inducing terminal differentiation Boieri, Margherita; Malishkevich, Anna; Guennoun, Ranya; Marchese, Emanuela; Kroon, Sanne; Trerice, Kathryn E. E.; Awad, Mary; Park, Jong Ho; Iyer, Sowmya; Kreuzer, Johannes; Haas, Wilhelm; Rivera, Miguel N. N.; Demehri, Shadmehr Share Save
Global characterization of macrophage polarization mechanisms and identification of M2-type polarization inhibitors He, Lizhi; Jhong, Jhih-Hua; Chen, Qi; Huang, Kai-Yao; Strittmatter, Karin; Kreuzer, Johannes; DeRan, Michael; Wu, Xu; Lee, Tzong-Yi; Slavov, Nikolai; Haas, Wilhelm; Marneros, Alexander G. Share Save
Integrated multi-omics analysis of RB-loss identifies widespread cellular programming and synthetic weaknesses (vol 4, 977, 2021) Rajasekaran, Swetha; Siddiqui, Jalal; Rakijas, Jessica; Nicolay, Brandon; Lin, Chenyu; Khan, Eshan; Patel, Rahi; Morris, Robert; Wyler, Emanuel; Boukhali, Myriam; Balasubramanyam, Jayashree; Ranjith Kumar, R.; Van Rechem, Capucine; Vogel, Christine; Elchuri, Sailaja V.; Landthaler, Markus; Obermayer, Benedikt; Haas, Wilhelm; Dyson, Nicholas; Miles, Wayne Share Save
Synaptic proteins associated with cognitive performance and neuropathology in older humans revealed by multiplexed fractionated proteomics Carlyle, Becky C.; Kandigian, Savannah E.; Kreuzer, Johannes; Das, Sudeshna; Trombetta, Bianca A.; Kuo, Yikai; Bennett, David A.; Schneider, Julie A.; Petyuk, Vladislav A.; Kitchen, Robert R.; Morris, Robert; Nairn, Angus C.; Hyman, Bradley T.; Haas, Wilhelm; Arnold, Steven E. Share Save
Integrated multi-omics analysis of RB-loss identifies widespread cellular programming and synthetic weaknesses Rajasekaran, Swetha; Siddiqui, Jalal; Rakijas, Jessica; Nicolay, Brandon; Lin, Chenyu; Khan, Eshan; Patel, Rahi; Morris, Robert; Wyler, Emanuel; Boukhali, Myriam; Balasubramanyam, Jayashree; Ranjith Kumar, R.; Van Rechem, Capucine; Vogel, Christine; Elchuri, Sailaja V.; Landthaler, Markus; Obermayer, Benedikt; Haas, Wilhelm; Dyson, Nicholas; Miles, Wayne Share Save
Multisystem inflammatory syndrome in children is driven by zonulin-dependent loss of gut mucosal barrier Yonker, Lael M.; Gilboa, Tal; Ogata, Alana F.; Senussi, Yasmeen; Lazarovits, Roey; Boribong, Brittany P.; Bartsch, Yannic C.; Loiselle, Maggie; Noval Rivas, Magali; Porritt, Rebecca A.; Lima, Rosiane; Davis, Jameson P.; Farkas, Eva J.; Burns, Madeleine D.; Young, Nicola; Mahajan, Vinay S.; Hajizadeh, Soroush; Lopez, Xcanda I. Herrera; Kreuzer, Johannes; Morris, Robert; Martinez, Enid E.; Han, Isaac; Griswold, Kettner, Jr.; Barry, Nicholas C.; Thompson, David B.; Church, George; Edlow, Andrea G.; Haas, Wilhelm; Pillai, Shiv; Arditi, Moshe; Alter, Galit; Walt, David R.; Fasano, Alessio Share Save
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