Not logged in A Phase 2 Study of Sitravatinib in Combination with Nivolumab in Patients with Advanced or Metastatic Urothelial Carcinoma Msaouel, Pavlos; Sweis, Randy F.; Bupathi, Manojkumar; Heath, Elisabeth; Goodman Jr, Oscar B.; Hoimes, Christopher J.; Milowsky, Matthew I.; Davis, Nancy; Kalebasty, Arash Rezazadeh; Picus, Joel; Shaffer, David; Mao, Shifeng; Adra, Nabil; Yorio, Jeffrey; Gandhi, Sunil; Grivas, Petros; Siefker-Radtke, Arlene; Yang, Rui; Latven, Lisa; Olson, Peter; Chin, Curtis D.; Der-Torossian, Hirak; Mortazavi, Amir; Iyer, Gopa Share Save
Mechanisms of Resistance to Oncogenic KRAS Inhibition in Pancreatic Cancer Dilly, Julien; Hoffman, Megan T.; Abbassi, Laleh; Li, Ziyue; Paradiso, Francesca; Parent, Brendan D.; Hennessey, Connor J.; Jordan, Alexander C.; Morgado, Micaela; Dasgupta, Shatavisha; Uribe, Giselle A.; Yang, Annan; Kapner, Kevin S.; Hambitzer, Felix P.; Qiang, Li; Feng, Hanrong; Geisberg, Jacob; Wang, Junning; Evans, Kyle E.; Lyu, Hengyu; Schalck, Aislyn; Feng, Ningping; Lopez, Anastasia M.; Bristow, Christopher A.; Kim, Michael P.; Rajapakshe, Kimal I.; Bahrambeigi, Vahid; Roth, Jennifer A.; Garg, Kavita; Guerrero, Paola A.; Stanger, Ben Z.; Cristea, Simona; Lowe, Scott W.; Baslan, Timour; Van Allen, Eliezer M.; Mancias, Joseph D.; Chan, Emily; Anderson, Abraham; Katlinskaya, Yuliya V.; Shalek, Alex K.; Hong, David S.; Pant, Shubham; Hallin, Jill; Anderes, Kenna; Olson, Peter; Heffernan, Timothy P.; Chugh, Seema; Christensen, James G.; Maitra, Anirban; Wolpin, Brian M.; Raghavan, Srivatsan; Nowak, Jonathan A.; Winter, Peter S.; Dougan, Stephanie K.; Aguirre, Andrew J. Share Save
The SOS1 Inhibitor MRTX0902 Blocks KRAS Activation and Demonstrates Antitumor Activity in Cancers Dependent on KRAS Nucleotide Loading Sudhakar, Niranjan; Yan, Larry; Qiryaqos, Fadia; Engstrom, Lars D.; Laguer, Jade; Calinisan, Andrew; Hebbert, Allan; Waters, Laura; Moya, Krystal; Bowcut, Vickie; Vegar, Laura; Ketcham, John M.; Ivetac, Anthony; Smith, Christopher R.; Lawson, J. David; Rahbaek, Lisa; Clarine, Jeffrey; Nguyen, Natalie; Saechao, Barbara; Parker, Cody; Elliott, Adam J.; Vanderpool, Darin; He, Leo; Hover, Laura D.; Fernandez-Banet, Julio; Coma, Silvia; Pachter, Jonathan A.; Hallin, Jill; Marx, Matthew A.; Briere, David M.; Christensen, James G.; Olson, Peter; Haling, Jacob; Khare, Shilpi Share Save
Discovery of ORIC-944, a novel inhibitor of PRC2 with best-in-class properties for the treatment of prostate cancer Marx, Matthew A.; Burns, Aaron C.; Arora, Nidhi; Bobinski, Thomas P.; Briere, David M.; Calinisan, Andrew; Gunn, Robin J.; Ketcham, John M.; Lawson, David; Lee, Matthew; Olson, Peter; Smith, Christopher R.; Sudhakar, Niranjan; Christensen, James G.; Chen, Chelsea X.; Yuen, Natalie; Ulicna, Livia; Duong, Frank; Colas, Christophe; Ramnath, Anjana; Xu, Ron; Maneval, Edna Chow; Multani, Pratik S.; Patel, Rupal; Kumar, Archana; Daemen, Anneleen; Romero, Anthony; Junttila, Melissa R.; Friedman, Lori S. Share Save
The SOS1 inhibitor MRTX0902 demonstrates activity across cancer models with mutations in proximal components of the RAS-MAPK pathway Sudhakar, Niranjan; Yan, Larry; Qiryaqos, Fadia; laguer, Jade; Briere, David; Hebbert, Allan; Calinisan, Andrew; Coma, Silvia; Pachter, Jonathan; Christensen, James G.; Olson, Peter; Khare, Shilpi Share Save
Effects of adagrasib on cholesterol, lipid and glucose gene expression regulation in tumor xenograft models and patient samples Shelton, Fabiola; Hoffman, Natalie; Trinh, David; Helu, Xousaen M.; Calinisan, Andrew; Hebbert, Allan; Yan, Larry; Briere, David M.; Hover, Laura; Fernandez-Benet, Julio; Anderes, Kenna; Christensen, James G.; Hallin, Jill; Olson, Peter Share Save
Discovery and characterization of potential drivers of resistance to the KRAS G12D inhibitor, MRTX1133, in cancer cell line models Helu, Xousaen M.; Griffiths, Ellie; Calinisan, Andrew; Hebbert, Allan; Yan, Larry; Hoffman, Natalie; Trinh, David; Hover, Laura; Fernandez-Banet, Julio; Briere, David M.; Lifset, Ella; Olson, Peter; Christensen, James G.; Hallin, Jill Share Save
Impact of KEAP1/STK11 co-mutations and NRF2 signaling on resistance to adagrasib in advanced NSCLC Negrao, Marcelo V.; Molkentine, David; Paula, Alvaro G.; Hover, Laura; Nilsson, Monique; Vokes, Natalie; Engstrom, Lars; Calinisan, Andrew; Waters, Laura; Briere, David M.; Hallin, Jill; Blumenschein, George R.; Skoulidis, Ferdinandos; Kopetz, Scott E.; Hong, David S.; Gibbons, Don L.; Olson, Peter; Christensen, James; Heymach, John V. Share Save
Discovery of Five SOS2 Fragment Hits with Binding Modes Determined by SOS2 X-Ray Cocrystallography Smith, Christopher R.; Chen, Dan; Christensen, James G.; Coulombe, Rene; Fethiere, James; Gunn, Robin J.; Hollander, Johan; Jones, Benjamin; Ketcham, John M.; Khare, Shilpi; Kuehler, Jon; Lawson, J. David; Marx, Matthew A.; Olson, Peter; Pearson, Kelly E.; Ren, Cynthia; Tsagris, Denise; Ulaganathan, Thirumalaiselvi; Van't Veer, Inge; Wang, Xiaolun; Ivetac, Anthony Share Save
TEAD Inhibition Overcomes YAP1/TAZ-Driven Primary and Acquired Resistance to KRASG12C Inhibitors Edwards, A. Cole; Stalnecker, Clint A.; Morales, Alexis Jean; Taylor, Khalilah E.; Klomp, Jennifer E.; Klomp, Jeffrey A.; Waters, Andrew M.; Sudhakar, Niranjan; Hallin, Jill; Tang, Tracy T.; Olson, Peter; Post, Leonard; Christensen, James G.; Cox, Adrienne D.; Der, Channing J. Share Save
Phase II trial of neoadjuvant sitravatinib plus nivolumab in patients undergoing nephrectomy for locally advanced clear cell renal cell carcinoma Karam, Jose A.; Msaouel, Pavlos; Haymaker, Cara L.; Matin, Surena F.; Campbell, Matthew T.; Zurita, Amado J.; Shah, Amishi Y.; Wistuba, Ignacio I.; Marmonti, Enrica; Duose, Dzifa Y.; Parra, Edwin R.; Soto, Luisa Maren Solis; Laberiano-Fernandez, Caddie; Lozano, Marisa; Abraham, Alice; Hallin, Max; Chin, Curtis D.; Olson, Peter; Der-Torossian, Hirak; Yan, Xiaohong; Tannir, Nizar M.; Wood, Christopher G. Share Save
Inhibition of SOS1 by MRTX0902 augments the antitumor response of the targeted EGFR inhibitor osimertinib in NSCLC Khare, Shilpi; Sudhakar, Niranjan; laguer, JaDe; Briere, David M.; Yan, Larry; Hebbert, Allan; Calinisan, Andrew; Engstrom, Lars D.; Qiryaqos, Fadia; Olson, Peter; Christensen, James G.; Haling, Jacob R. Share Save
Anti-tumor efficacy of a potent and selective non-covalent KRASG12D inhibitor Hallin, Jill; Bowcut, Vickie; Calinisan, Andrew; Briere, David M.; Hargis, Lauren; Engstrom, Lars D.; Laguer, Jade; Medwid, James; Vanderpool, Darin; Lifset, Ella; Trinh, David; Hoffman, Natalie; Wang, Xiaolun; Lawson, J. David; Gunn, Robin J.; Smith, Christopher R.; Thomas, Nicole C.; Martinson, Matthew; Bergstrom, Alex; Sullivan, Francis; Bouhana, Karyn; Winski, Shannon; He, Leo; Fernandez-Banet, Julio; Pavlicek, Adam; Haling, Jacob R.; Rahbaek, Lisa; Marx, Matthew A.; Olson, Peter; Christensen, James G. Share Save
Design and Discovery of MRTX0902, a Potent, Selective, Brain- Penetrant, and Orally Bioavailable Inhibitor of the SOS1:KRAS Protein-Protein Interaction Ketcham, John M.; Haling, Jacob; Khare, Shilpi; Bowcut, Vickie; Briere, David M.; Burns, Aaron C.; Gunn, Robin J.; Ivetac, Anthony; Kuehler, Jon; Kulyk, Svitlana; Laguer, Jade; Lawson, J. David; Moya, Krystal; Nguyen, Natalie; Rahbaek, Lisa; Saechao, Barbara; Smith, Christopher R.; Sudhakar, Niranjan; Thomas, Nicole C.; Vegar, Laura; Vanderpool, Darin; Wang, Xiaolun; Yan, Larry; Olson, Peter; Christensen, James G.; Marx, Matthew A. Share Save
Fragment-Based Discovery of MRTX1719, a Synthetic Lethal Inhibitor of the PRMT5•MTA Complex for the Treatment of MTAP-Deleted Cancers Smith, Christopher R.; Aranda, Ruth; Bobinski, Thomas P.; Briere, David M.; Burns, Aaron C.; Christensen, James G.; Clarine, Jeffery; Engstrom, Lars D.; Gunn, Robin J.; Ivetac, Anthony; Jean-Baptiste, Ronald; Ketcham, John M.; Kobayashi, Masakazu; Kuehler, Jon; Kulyk, Svitlana; Lawson, J. David; Moya, Krystal; Olson, Peter; Rahbaek, Lisa; Thomas, Nicole C.; Wang, Xiaolun; Waters, Laura M.; Marx, Matthew A. Share Save
Identification of MRTX1133, a Noncovalent, Potent, and Selective KRASG12D Inhibitor Wang, Xiaolun; Allen, Shelley; Blake, James F.; Bowcut, Vickie; Briere, David M.; Calinisan, Andrew; Dahlke, Joshua R.; Fell, Jay B.; Fischer, John P.; Gunn, Robin J.; Hallin, Jill; Laguer, Jade; Lawson, J. David; Medwid, James; Newhouse, Brad; Phong Nguyen; O'Leary, Jacob M.; Olson, Peter; Pajk, Spencer; Rahbaek, Lisa; Rodriguez, Mareli; Smith, Christopher R.; Tang, Tony P.; Thomas, Nicole C.; Vanderpool, Darin; Vigers, Guy P.; Christensen, James G.; Marx, Matthew A. Share Save
Detection of KRAS amplification on extrachromosomal DNA (ecDNA) upon acquired resistance to KRASG12C inhibitors Hansen, Ryan J.; Horton, Steven; Wiese, Julie; Bibay, BellJohn; Mora-Blanco, E. Lorena; Nguyen, Nam-Phuong; Engstrom, Lars D.; Briere, David M.; Calinisan, Andres; Olson, Peter; Awad, Mark M.; Aguirre, Andrew J.; Christiansen, Jason; Hassig, Christian; Kasibhatla, Shailaja Share Save
MRTX1719: A first-in-class MTA-cooperative PRMT5 inhibitor that selectively elicits antitumor activity in MTAP/CDKN2A deleted cancer models Smith, Christopher R.; Engstrom, Lars D.; Kulyk, Svitlana; Aranda, Ruth; Waters, Laura; Moya, Krystal; Bowcut, Victoria; Hebbert, Allan; Trinh, David; Briere, David M.; Lawson, J. David; Clarine, Jeff; Rahbaek, Lisa; Christensen, James G.; Marx, Matthew A.; Olson, Peter Share Save
Antitumor immune effects of preoperative sitravatinib and nivolumab in oral cavity cancer: SNOW window-of-opportunity study Oliva, Marc; Chepeha, Douglas; Araujo, Daniel, V; Diaz-Mejia, J. Javier; Olson, Peter; Prawira, Amy; Spreafico, Anna; Bratman, Scott, V; Shek, Tina; de Almeida, John; Hansen, Aaron; Hope, Andrew; Goldstein, David; Weinreb, Ilan; Smith, Stephen; Perez-Ordonez, Bayardo; Irish, Jonathan; Torti, Dax; Bruce, Jeffrey P.; Wang, Ben X.; Fortuna, Anthony; Pugh, Trevor J.; Der-Torossian, Hirak; Shazer, Ronald; Attanasio, Nickolas; Au, Qingyan; Tin, Antony; Feeney, Jordan; Sethi, Himanshu; Aleshin, Alexey; Chen, Isan; Siu, Lillian Share Save
The KRASG12C Inhibitor MRTX849 Reconditions the Tumor Immune Microenvironment and Sensitizes Tumors to Checkpoint Inhibitor Therapy Briere, David M.; Li, Shuai; Calinisan, Andrew; Sudhakar, Niranjan; Aranda, Ruth; Hargis, Lauren; Peng, David H.; Deng, Jiehui; Engstrom, Lars D.; Hallin, Jill; Gatto, Sole; Fernandez-Banet, Julio; Pavlicek, Adam; Wong, Kwok-Kin; Christensen, James G.; Olson, Peter Share Save
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