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A FAN1 point mutation associated with accelerated Huntington's disease progression alters its PCNA-mediated assembly on DNA Aretz, Jonas; Jeyasankar, Gayathri; Salerno-Kochan, Anna; Thomsen, Maren; Thieulin-Pardo, Gabriel; Haque, Tasir; Monteagudo, Edith; Felsenfeld, Dan; Finley, Michael; Vogt, Thomas F.; Boudet, Julien; Prasad, Brinda C. Share Save
Optimization of Single Relaxin B-Chain Peptide Leads to the Identification of R2R01, a Potent, Long-Acting RXFP1 Agonist for Cardiovascular and Renal Diseases Mallart, Sergio; Ingenito, Raffaele; Magotti, Paola; Bresciani, Alberto; Di Marco, Annalise; Esposito, Simone; Monteagudo, Edith; Caretti, Fulvia; Orsatti, Laura; Santoprete, Alessia; Roversi, Daniela; Tucci, Federica; Veneziano, Maria; Brasseur, Denis; Chenede, Xavier; Corbier, Alain; Gauzy-Lazo, Laurence; Gervat, Vincent; Marguet, Frank; Minoletti, Claire; Pasquier, Olivier; Poirier, Bruno; Azam, Aurelien; Maillere, Bernard; Bianchi, Elisabetta; Janiak, Philip; Duclos, Olivier; Illiano, Stephane Share Save
Identification and Optimization of RNA-Splicing Modulators as Huntingtin Protein-Lowering Agents for the Treatment of Huntington's Disease Liu, Longbin; Malagu, Karine; Haughan, Alan F.; Khetarpal, Vinod; Stott, Andrew J.; Esmieu, William; Vater, Huw D.; Webster, Stephen J.; van de Poel, Amanda J.; Clissold, Cole; Cosgrove, Brett; Sutton, Benjamin; Spencer, Jonathan A.; Breccia, Perla; Gancia, Emanuela; Bonomo, Silvia; Ladduwahetty, Tammy; Lazari, Ovadia; Patel, Hiral; Atton, Helen C.; Clifton, Steve; Mota, Daniel M.; Magnani, Dario; O'Neill, Amy; Stebbeds, Marta; Macabuag, Natsuko; Todd, Daniel; Herva, Maria E.; Mitchell, Philip; Visser, Mijke; Compte Sancerni, Sara; Grand Moursel, Laure; da Silva, Marta; Kritikou, Eva; Heikkinen, Taneli T.; Bolkvadze, Tamuna; Fodale, Valentina; Spadafora, Debora; Daldin, Manuel; Bresciani, Alberto; Mangette, John E.; Doherty, Elizabeth M.; Lee, Matthew R.; Herbst, Todd; Monteagudo, Edith; Macdonald, Douglas; Plotnikov, Nikolay V.; Chambers, Mark; Mcallister, George; Munoz-Sanjuan, Ignacio; Dominguez, Celia Share Save
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Fatty acid acylated peptide therapeutics: discovery of omega-n oxidation of the lipid chain as a novel metabolic pathway in preclinical species Esposito, Simone; Krick, Alain; Pasquier, Olivier; Bonche, Fabrice; Ingenito, Raffaele; Magotti, Paola; Bianchi, Elisabetta; Monteagudo, Edith; Gallo, Mariana; Cicero, Daniel Oscar; Orsatti, Laura; Veneziano, Maria; Caretti, Fulvia; Mele, Riccardo; Roversi, Daniela; Gennari, Nadia; Brasseur, Denis; Gauzy-Lazo, Laurence; Duclos, Olivier; Mauriac, Christine; Illiano, Stephane; Mallart, Sergio Share Save
Design and Evaluation of [18F]CHDI-650 as a Positron Emission Tomography Ligand to Image Mutant Huntingtin Aggregates Liu, Longbin; Johnson, Peter D.; Prime, Michael E.; Khetarpal, Vinod; Brown, Christopher J.; Anzillotti, Luca; Bertoglio, Daniele; Chen, Xuemei; Coe, Samuel; Davis, Randall; Dickie, Anthony P.; Esposito, Simone; Gadouleau, Elise; Giles, Paul R.; Greenaway, Catherine; Haber, James; Halldin, Christer; Haller, Scott; Hayes, Sarah; Herbst, Todd; Herrmann, Frank; Hessmann, Manuela; Hsai, Ming Min; Khani, Yaser; Kotey, Adrian; Lembo, Angelo; Mangette, John E.; Marriner, Gwendolyn A.; Marston, Richard W.; Mills, Matthew R.; Monteagudo, Edith; Forsberg-Moren, Anton; Nag, Sangram; Orsatti, Laura; Sandiego, Christine; Schaertl, Sabine; Sproston, Joanne; Staelens, Steven; Tookey, Jack; Turner, Penelope A.; Vecchi, Andrea; Veneziano, Maria; Munoz-Sanjuan, Ignacio; Bard, Jonathan; Dominguez, Celia Share Save
Characterization of a new potent and long-lasting single chain peptide agonist of RXFP1 in cells and in vivo translational models Illiano, Stephane; Poirier, Bruno; Minoletti, Claire; Pasquier, Olivier; Riva, Laurence; Chenede, Xavier; Menguy, Isabelle; Guillotel, Michel; Prigent, Philippe; Le Claire, Stephane; Gillot, Florence; Thill, Gilbert; Lo Presti, Francois; Corbier, Alain; Le Bail, Jean-Christophe; Grailhe, Patrick; Monteagudo, Edith; Ingenito, Raffaele; Bianchi, Elisabetta; Philippo, Christophe; Duclos, Olivier; Mallart, Sergio; Bathgate, Ross; Janiak, Philip Share Save
Oligomerization, albumin binding and catabolism of therapeutic peptides in the subcutaneous compartment: An investigation on lipidated GLP-1 analogs Gallo, Mariana; Vanni, Domitilla; Esposito, Simone; Alaimo, Nadine; Orvieto, Federica; Rulli, Federica; Missineo, Antonino; Caretti, Fulvia; Bonelli, Fabio; Veneziano, Maria; Orsatti, Laura; Monteagudo, Edith Share Save
Kynurenine pathway activation and deviation to anthranilic and kynurenic acid in fibrosing chronic graft-versus-host disease Orsatti, Laura; Stiehl, Thomas; Dischinger, Katharina; Speziale, Roberto; Di Pasquale, Pamela; Monteagudo, Edith; Mueller-Tidow, Carsten; Radujkovic, Aleksandar; Dreger, Peter; Luft, Thomas Share Save
[11C]CHDI-626, a PET Tracer Candidate for Imaging Mutant Huntingtin Aggregates with Reduced Binding to AD Pathological Proteins Liu, Longbin; Johnson, Peter D.; Prime, Michael E.; Khetarpal, Vinod; Lee, Matthew R.; Brown, Christopher J.; Chen, Xuemei; Clark-Frew, Daniel; Coe, Samuel; Conlon, Mike; Davis, Randall; Ensor, Samantha; Esposito, Simone; Moren, Anton Forsberg; Gai, Xinjie; Green, Samantha; Greenaway, Catherine; Haber, James; Halldin, Christer; Hayes, Sarah; Herbst, Todd; Herrmann, Frank; He-mann, Manuela; Hsai, Ming Min; Kotey, Adrian; Mangette, John E.; Mills, Matthew R.; Monteagudo, Edith; Nag, Sangram; Nibbio, Martina; Orsatti, Laura; Schaertl, Sabine; Scheich, Christoph; Sproston, Joanne; Stepanov, Vladimir; Varnas, Katarina; Varrone, Andrea; Wityak, John; Mrzljak, Ladislav; Munoz-Sanjuan, Ignacio; Bard, Jonathan A.; Dominguez, Celia Share Save
Personalized Metabolic Profile by Synergic Use of NMR and HRMS Petrella, Greta; Montesano, Camilla; Lentini, Sara; Ciufolini, Giorgia; Vanni, Domitilla; Speziale, Roberto; Salonia, Andrea; Montorsi, Francesco; Summa, Vincenzo; Vago, Riccardo; Orsatti, Laura; Monteagudo, Edith; Cicero, Daniel Oscar Share Save
Identification of Potent and Long-Acting Single-Chain Peptide Mimetics of Human Relaxin-2 for Cardiovascular Diseases Mallart, Sergio; Ingenito, Raffaele; Bianchi, Elisabetta; Bresciani, Alberto; Esposito, Simone; Gallo, Mariana; Magotti, Paola; Monteagudo, Edith; Orsatti, Laura; Roversi, Daniela; Santoprete, Alessia; Tucci, Federica; Veneziano, Maria; Bartsch, Regine; Boehm, Claudius; Brasseur, Denis; Bruneau, Patricia; Corbier, Alain; Froissant, Jacques; Gauzy-Lazo, Laurence; Gervat, Vincent; Marguet, Frank; Menguy, Isabelle; Minoletti, Claire; Nicolas, Marie-Francoise; Pasquier, Olivier; Poirier, Bruno; Raux, Alexandre; Riva, Laurence; Janiak, Philip; Strobel, Hartmut; Duclos, Olivier; Illiano, Stephane Share Save
Cyclic Phosphopantothenic Acid Prodrugs for Treatment of Pantothenate Kinase-Associated Neurodegeneration Auciello, Giulio; Di Marco, Annalise; Paz, Odalys Gonzalez; Malancona, Savina; Harper, Steven; Beconi, Maria; Rossetti, Ilaria; Ciammaichella, Alina; Fezzardi, Paola; Vecchi, Andrea; Bracacel, Elena; Cicero, Daniel; Monteagudo, Edith; Elbaum, Daniel Share Save
Imaging Mutant Huntingtin Aggregates: Development of a Potential PET Ligand Liu, Longbin; Prime, Michael E.; Lee, Matt R.; Khetarpal, Vinod; Brown, Christopher J.; Johnson, Peter D.; Miranda-Azpiazu, Patricia; Chen, Xuemei; Clark-Frew, Daniel; Coe, Samuel; Davis, Randall; Dickie, Anthony; Ebneth, Andreas; Esposito, Simone; Gadouleau, Elise; Gai, Xinjie; Galan, Sebastien; Green, Samantha; Greenaway, Catherine; Giles, Paul; Halldin, Christer; Hayes, Sarah; Herbst, Todd; Herrmann, Frank; Hessmann, Manuela; Jia, Zhisheng; Kiselyov, Alexander; Kotey, Adrian; Krulle, Thomas; Mangette, John E.; Marston, Richard W.; Menta, Sergio; Mills, Matthew R.; Monteagudo, Edith; Nag, Sangram; Nibbio, Martina; Orsatti, Laura; Schaertl, Sabine; Scheich, Christoph; Sproston, Joanne; Stepanov, Vladimir; Svedberg, Marie; Takano, Akihiro; Taylor, Malcolm; Thomas, Wayne; Toth, Miklos; Vaidya, Darshan; Vanras, Katarina; Weddell, Derek; Wigginton, Ian; Wityak, John; Mrzljak, Ladislav; Munoz-Sanjuan, Ignacio; Bard, Jonathan A.; Dominguez, Celia Share Save
Establishment of an in Vitro Human Blood-Brain Barrier Model Derived from Induced Pluripotent Stem Cells and Comparison to a Porcine Cell-Based System Di Marco, Annalise; Vignone, Domenico; Paz, Odalys Gonzalez; Fini, Ivan; Battista, Maria Rosaria; Cellucci, Antonella; Bracacel, Elena; Auciello, Giulio; Veneziano, Maria; Khetarpal, Vinod; Rose, Mark; Rosa, Alessandro; Gloaguen, Isabelle; Monteagudo, Edith; Herbst, Todd; Dominguez, Celia; Munoz-Sanjuan, Ignacio Share Save
5,6-Dihydroxypyrimidine Scaffold to Target HIV-1 Nucleocapsid Protein Malancona, Savina; Mori, Mattia; Fezzardi, Paola; Santoriello, Marisabella; Basta, Andreina; Nibbio, Martina; Kovalenko, Lesia; Speziale, Roberto; Battista, Maria Rosaria; Cellucci, Antonella; Gennari, Nadia; Monteagudo, Edith; Di Marco, Annalise; Giannini, Alessia; Sharma, Rajhans; Pires, Manuel; Real, Eleonore; Zazzi, Maurizio; Lang, Maria Chiara Dasso; De Forni, Davide; Saladini, Francesco; Mely, Yves; Summa, Vincenzo; Harper, Steven; Botta, Maurizio Share Save
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Synthesis and Biological Evaluation of RGD-Cryptophycin Conjugates for Targeted Drug Delivery Borbely, Adina; Figueras, Eduard; Martins, Ana; Esposito, Simone; Auciello, Giulio; Monteagudo, Edith; Di Marco, Annalise; Summa, Vincenzo; Cordella, Paola; Perego, Raffaella; Kemker, Isabell; Frese, Marcel; Gallinari, Paola; Steinkuehler, Christian; Sewald, Norbert Share Save
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