Not logged in Acquired resistance to temozolomide in the Th-MYCN mouse as a clinically-relevant platform to evaluate novel therapeutic strategies against high-risk neuroblastoma Poon, Evon; Liang, Tong; Barone, Giuseppe; Costa, Barbara M.; Heuss, Sara; Robinson, Simon P.; Lin, Charles; Workman, Paul; Jamin, Yann; Chesler, Louis Share Save
MYC Induces Oncogenic Stress through RNA Decay and Ribonucleotide Catabolism in Breast Cancer Meena, Jitendra K.; Wang, Jarey H.; Neill, Nicholas J.; Keough, Dianne; Putluri, Nagireddy; Katsonis, Panagiotis; Koire, Amanda M.; Lee, Hyemin; Bowling, Elizabeth A.; Tyagi, Siddhartha; Orellana, Mayra; Dominguez-Vidana, Rocio; Li, Heyuan; Eagle, Kenneth; Danan, Charles; Chung, Hsiang-Ching; Yang, Andrew D.; Wu, William; Kurley, Sarah J.; Ho, Brian M.; Zoeller, Joseph R.; Olson, Calla M.; Meerbrey, Kristen L.; Lichtarge, Olivier; Sreekumar, Arun; Dacso, Clifford C.; Guddat, Luke W.; Rejman, Dominik; Hockova, Dana; Janeba, Zlatko; Simon, Lukas M.; Lin, Charles Y.; Pillon, Monica C.; Westbrook, Thomas F. Share Save
A dose escalation and cohort expansion study of the CDK9 inhibitor KB-0742 in triple negative breast cancer and transcriptionally addicted relapsed or refractory solid tumors Mita, Monica; Mita, Alain; Villalona-Calero, Miguel; Federman, Noah; Rasco, Drew; Spigel, David; Luo, Jia; Cote, Gregory; Cutler, Richard; Kumar, Pavan; MacKenzie, Crystal; Lin, Charles; DiMartino, Jorge; Olek, Elizabeth; Van Tine, Brian Share Save
A dose escalation and cohort expansion study of the CDK9 inhibitor KB0742 in relapsed, refractory and transcriptionally addicted solid tumors Calero, Miguel Villalona; Agulnik, Mark; Mita, Monica; Mita, Alain; Federman, Noah; Rasco, Drew; Spigel, David; Luo, Jia; Hanna, Glenn; Cote, Gregory; Salkeni, Mohamad A.; Chugh, Rashmi; Ammakkanavar, Natraj R.; Shah, Satish A.; Rao, Amol; Sankhala, Kamalesh Kumar; Cutler, Richard E.; Hood, Tressa; Carvajal, Luis; MacKenzie, Crystal; Lin, Charles; DiMartino, Jorge; Olek, Elizabeth A.; Van Tine, Brian Share Save
KB-0742, an oral highly selective CDK9 inhibitor, demonstrates preclinical activity in transcription factor fusion driven adenoid cystic carcinoma patient-derived models McKeown, Michael R.; Carvajal, Luis A.; Hood, Tressa R.; Burr, Nicole S.; Kaufman, Jeffrey; Boynton, Adam; Mori, Kameron; DesRochers, Tessa; Wick, Michael; Lin, Charles Y.; DiMartino, Jorge F. Share Save
p300 catalytic inhibition selectively targets IRF4 oncogenic activity in multiple myeloma McKeown, Michael R.; Giorgetti, Giulia; Lenoir, Walter F.; Kobylarz, Marek J.; Hopkins, Tamara D.; Glore, Wayne L.; Shum, Michelle G.; Calderon, Yare; Mori, Kameron R.; Gao, Hua; Carvajal, Luis A.; Obholzer, Nikolaus D.; Trotter, Benjamin W.; Dinsmore, Christopher D.; Munshi, Nikhil C.; Rahl, Peter B.; Fulciniti, Mariateresa; Lin, Charles Y. Share Save
A dose escalation and cohort expansion study of the CDK9 inhibitor KB0742 in relapsed, refractory ovarian cancer and transcriptionally addicted relapsed or refractory solid tumors Villalona-Calero, Miguel; Mita, Monica; Mita, Alain; Federman, Noah; Rasco, Drew; Spigel, David; Luo, Jia; Cote, Gregory M.; Cutler, Richard E.; Kumar, Pavan; MacKenzie, Crystal J.; Lin, Charles; DiMartino, Jorge F.; Olek, Elizabeth A.; Van Tine, Brian Share Save
Discovery of KB-0742, a Potent, Selective, Orally Bioavailable Small Molecule Inhibitor of CDK9 for MYC-Dependent Cancers Freeman, David B.; Hopkins, Tamara D.; Mikochik, Peter J.; Vacca, Joseph P.; Gao, Hua; Naylor-Olsen, Adel; Rudra, Sonali; Li, Huixu; Pop, Marius S.; Villagomez, Rosa A.; Lee, Christina; Li, Heng; Zhou, Minyun; Saffran, Douglas C.; Rioux, Nathalie; Hood, Tressa R.; Day, Melinda A. L.; Mckeown, Michael R.; Lin, Charles Y.; Bischofberger, Norbert; Trotter, B. Wesley Share Save
Targeting transcription in heart failure via CDK7/12/13 inhibition Hsu, Austin; Duan, Qiming; Day, Daniel S.; Luo, Xin; McMahon, Sarah; Huang, Yu; Feldman, Zachary B.; Jiang, Zhen; Zhang, Tinghu; Liang, Yanke; Alexanian, Michael; Padmanabhan, Arun; Brown, Jonathan D.; Lin, Charles Y.; Gray, Nathanael S.; Young, Richard A.; Bruneau, Benoit G.; Haldar, Saptarsi M. Share Save
Transcriptional Plasticity Drives Leukemia Immune Escape Eagle, Kenneth; Harada, Taku; Kalfon, Jeremie; Perez, Monika W.; Heshmati, Yaser; Ewers, Jazmin; Koren, Jost Vrabic; Dempster, Joshua M.; Kugener, Guillaume; Paralkar, Vikram R.; Lin, Charles Y.; V. Dharia, Neekesh; Stegmaier, Kimberly; Orkin, Stuart H.; Pimkin, Maxim Share Save
An oncogenic enhancer encodes selective selenium dependency (vol 29, 386.e1, 2022) Eagle, Kenneth; Jiang, Yajian; Shi, Xiangguo; Li, Minhua; Obholzer, Nikolaus P.; Hu, Tianyuan; Perez, Monika W.; Koren, Jost Vrabic; Kitano, Ayumi; Yi, Joanna S.; Lin, Charles Y.; Nakada, Daisuke Share Save
KLF15 cistromes reveal a hepatocyte pathway governing plasma corticosteroid transport and systemic inflammation Jiang, Zhen; Elsarrag, Selma Z.; Duan, Qiming; LaGory, Edward L.; Wang, Zhe; Alexanian, Michael; McMahon, Sarah; Rulifson, Ingrid C.; Winchester, Sarah; Wang, Yi; Vaisse, Christian; Brown, Jonathan D.; Quattrocelli, Mattia; Lin, Charles Y.; Haldar, Saptarsi M. Share Save
An oncogenic enhancer encodes selective selenium dependency in AML Eagle, Kenneth; Jiang, Yajian; Shi, Xiangguo; Li, Minhua; Obholzer, Nikolaus P.; Hu, Tianyuan; Perez, Monika W.; Koren, Jost Vrabic; Kitano, Ayumi; Yi, Joanna S.; Lin, Charles Y.; Nakada, Daisuke Share Save
Preclinical activity of KB-0742, an oral, highly selective, CDK9 inhibitor, in cell lines and in MYC-high expressing, patient-derived models of multiple breast cancer subtypes Saffran, Douglas C.; Day, Melinda A. L.; Rioux, Nathalie; Chen, Tom; Lee, Christina; Amara, Suha Naffar-Abu; Freeman, David B.; Hood, Tressa; Lin, Charles Y.; Kumar, Pavan; DiMartino, Jorge Share Save
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Defining the transcriptional control of pediatric AML highlights RARA as a superenhancer-regulated druggable dependency Perez, Monika W.; Sias-Garcia, Oscar; Daramola, Alfred; Wei, Helen; Terrell, Maci; Rashid, Raushan; Park, Woojun D.; Duong, Kevin; Horton, Terzah M.; Li, Feng; Cherayil, Nikitha; Koren, Jost Vrabic; Gant, Vincent U.; Junco, Jacob J.; Curry, Choladda, V; Stevens, Alexandra M.; Lin, Charles Y.; Yi, Joanna S. Share Save
Spinal Anesthesia with Targeted Sedation based on Bispectral Index Values Compared with General Anesthesia with Masked Bispectral Index Values to Reduce Delirium: The SHARP Randomized Controlled Trial Brown, Charles H.; Edwards, Charles; Lin, Charles; Jones, Emily Ledford; Yanek, Lisa R.; Esmaili, Melody; Gorashi, Yara; Skelton, Richard; Kaganov, Daniel; Curto, Ryan; Lessing, Noah L.; Cha, Stephanie; Colantuoni, Elizabeth; Neufeld, Karin; Sieber, Frederick; Dean, Clayton L.; Hogue, Charles W. Share Save
HDAC Inhibition Reverses Preexisting Diastolic Dysfunction and Blocks Covert Extracellular Matrix Remodeling Travers, Joshua G.; Wennersten, Sara A.; Pena, Brisa; Bagchi, Rushita A.; Smith, Harrison E.; Hirsch, Rachel A.; Vanderlinden, Lauren A.; Lin, Ying-Hsi; Dobrinskikh, Evgenia; Demos-Davies, Kimberly M.; Cavasin, Maria A.; Mestroni, Luisa; Steinkuhler, Christian; Lin, Charles Y.; Houser, Steven R.; Woulfe, Kathleen C.; Lam, Maggie P. Y.; McKinsey, Timothy A. Share Save
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