Not logged in CLN-619, a MICA/B monoclonal antibody that promotes innate immune cell-mediated antitumor activity Whalen, Kerry A.; Henry, Catherine C.; Mehta, Naveen K.; Rakhra, Kavya; Yalcin, Safak; Meetze, Kristan; Gibson, Neil W.; Baeuerle, Patrick A.; Michaelson, Jennifer S. Share Save
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Safety, tolerability, and antiviral effect of RG-101 in patients with chronic hepatitis C: a phase 1B, double-blind, randomised controlled trial van der Ree, Meike H.; de Vree, J. Marleen; Stelma, Femke; Willemse, Sophie; van der Valk, Marc; Rietdijk, Svend; Molenkamp, Richard; Schinkel, Janke; van Nuenen, Ad C.; Beuers, Ulrich; Hadi, Salah; Harbers, Marten; van der Veer, Eva; Liu, Kai; Grundy, John; Patick, Amy K.; Pavlicek, Adam; Blem, Jacqueline; Huang, Michael; Grint, Paul; Neben, Steven; Gibson, Neil W.; Kootstra, Neeltje A.; Reesink, Hendrik W. Share Save
PHARMACOKINETICS AND PHARMACOLOGY OF RG-101, A NOVEL GalNAc-CONJUGATED OLIGONUCLEOTIDE TARGETING MICRORNA-122, IN HEALTHY VOLUNTEERS Liu, K.; Neben, S.; Gibson, N. W.; Grint, P.; van Vliet, A.; Hadi, S.; de Vree, M.; Van der Ree, M.; Reesink, H. Share Save
PHARMACOKINETICS, PHARMACODYNAMICS, AND TOXICITY PROFILE OF RG-101, A NOVEL GalNAc-CONJUGATED HEPATOCYTE-TARGETNG INHIBITOR OF MICRORNA-122, IN RODENTS AND CYNOMOLGUS MONKEYS Neben, S.; Liu, K.; Berman, C.; Tay, J.; Esau, C.; Kaiser, R.; Wahle, B.; Chau, N.; Bhat, B.; Gibson, N. W. Share Save
A SINGLE SUBCUTANEOUS DOSE OF 2 mg/kg OR 4 mg/kg OF RG-101, A GalNAc-CONJUGATED OLIGONUCLEOTIDE WITH ANTAGONIST ACTIVITY AGAINST MIR-122, RESULTS IN SIGNIFICANT VIRAL LOAD REDUCTIONS IN CHRONIC HEPATITIS C PATIENTS Van der Ree, M.; de Vree, M. L.; Stelma, F.; Willemse, S.; van der Valk, M.; Rietdijk, S.; Molenkamp, R.; Schinkel, J.; Hadi, S.; Harbers, M.; van Vliet, A.; de Haes, J. Udo; Grint, P.; Neben, S.; Gibson, N.; Reesink, H. W. Share Save
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miR-221: A potential therapeutic target for hepatocellular carcinoma Lee, Edmund C.; Xu, Jessica; Vincent, Thomas; Chen, Jie; Nelson, Michael; Huang, Xinqiang; Marcusson, Eric; Androsavich, John; Davis, Scott; Pavlicek, Adam; Gibson, Neil; Zabludoff, Sonya Share Save
Preclinical Characterization of OSI-027, a Potent and Selective Inhibitor of mTORC1 and mTORC2: Distinct from Rapamycin Bhagwat, Shripad V.; Gokhale, Prafulla C.; Crew, Andrew P.; Cooke, Andy; Yao, Yan; Mantis, Christine; Kahler, Jennifer; Workman, Jennifer; Bittner, Mark; Dudkin, Lorina; Epstein, David M.; Gibson, Neil W.; Wild, Robert; Arnold, Lee D.; Houghton, Peter J.; Pachter, Jonathan A. Share Save
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Discovery of OSI-906: a selective and orally efficacious dual inhibitor of the IGF-I receptor and insulin receptor Mulvihill, Mark J.; Cooke, Andrew; Rosenfeld-Franklin, Maryland; Buck, Elizabeth; Foreman, Ken; Landfair, Darla; O'Connor, Matthew; Pirritt, Caroline; Sun, Yingchaun; Yao, Yan; Arnold, Lee D.; Gibson, Neil W.; Ji, Qun-Sheng Share Save
Knockdown of Ron Kinase Inhibits Mutant Phosphatidylinositol 3-Kinase and Reduces Metastasis in Human Colon Carcinoma Wang, Jing; Rajput, Ashwani; Kan, Julie L. C.; Rose, Rebecca; Liu, Xiao-Qiong; Kuropatwinski, Karen; Hauser, Jennie; Beko, Alexander; Dominquez, Ivan; Sharratt, Elizabeth A.; Brattain, Lisa; LeVea, Charles; Sun, Feng-Lei; Keane, David M.; Gibson, Neil W.; Brattain, Michael G. Share Save
Feedback Mechanisms Promote Cooperativity for Small Molecule Inhibitors of Epidermal and Insulin-Like Growth Factor Receptors Buck, Elizabeth; Eyzaguirre, Alexandra; Rosenfeld-Franklin, Maryland; Thomson, Stuart; Mulvihill, Mark; Barr, Sharon; Brown, Eric; O'Connor, Mathew; Yao, Yan; Pachter, Jonathan; Miglarese, Mark; Epstein, David; Iwata, Kenneth K.; Haley, John D.; Gibson, Neil W.; Ji, Qun-Sheng Share Save
Bypassing cellular EGF receptor dependence through epithelial-to-mesenchymal-like transitions Barr, Sharon; Thomson, Stuart; Buck, Elizabeth; Russo, Suzanne; Petti, Filippo; Sujka-Kwok, Izabela; Eyzaguirre, Alexandra; Rosenfeld-Franklin, Maryland; Gibson, Neil W.; Miglarese, Mark; Epstein, David; Iwata, Kenneth K.; Haley, John D. Share Save
A novel, potent, and selective insulin-like growth factor-I receptor kinase inhibitor blocks insulin-like growth factor-I receptor signaling in vitro and inhibits insulin-like growth factor-I receptor-dependent tumor growth in vivo Ji, Qun-Sheng; Mulvihill, Mark J.; Rosenfeld-Franklin, Maryland; Cooke, Andrew; Feng, Lixin; Mak, Gilda; O'Connor, Matthew; Yao, Yan; Pirritt, Caroline; Buck, Elizabeth; Eyzaguirre, Alexandra; Arnold, Lee D.; Gibson, Neil W.; Pachter, Jonathan A. Share Save
Colon carcinoma cells harboring PIK3CA mutations display resistance to growth factor deprivation induced apoptosis Wang, Jing; Kuropatwinski, Karen; Hauser, Jennie; Rossi, Michael R.; Zhou, Yunfei; Conway, Alexis; Kan, Julie L. C.; Gibson, Neil W.; Willson, James K. V.; Cowell, John K.; Brattain, Michael G. Share Save
Loss of homotypic cell adhesion by epithelial-mesenchymal transition or mutation limits sensitivity to epidermal growth factor receptor inhibition Buck, Elizabeth; Eyzaguirre, Alexandra; Barr, Sharon; Thompson, Stuart; Sennello, Regina; Young, David; Iwata, Kenneth K.; Gibson, Neil W.; Cagnoni, Pablo; Haley, John D. Share Save
Rapamycin synergizes with the epidermal growth factor receptor inhibitor erlotinib in non-small-cell lung, pancreatic, colon, and breast tumors Buck, Elizabeth; Eyzaguirre, Alexandra; Brown, Eric; Petti, Filippo; McCormack, Siobhan; Haley, John D.; Iwata, Kenneth K.; Gibson, Neil W.; Griffin, Graeme Share Save
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