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J

James E. Bradner

Novartis

114H-index
746Paper Count
5.4WCitation Count
Published Papers 192
Publication Date
Discovery of EGT710; an Oral Nonpeptidomimetic Reversible Covalent SARS-CoV-2 Main Protease Inhibitor
err2026-02-09
err0
PREAI
errJulien P. N. Papillon; Jun Yuan; Matthew J. Hesse; Lei Zhang; Richard I. Robinson; Nathaniel F. Ware; Viktor Hornak; Rajeshri G. Karki; Tom Kirrane; Keira Garland; Sajan Joseph; Stephanie A. Moquin; Suresh B. Lakshminarayana; Laura Tandeske; Dustin Dovala; Mark Knapp; Elizabeth Ornelas; Daniel Fuller; Pei-i Ho; Xuping Xie; Katarina Vulic; Suzanne M. Skolnik; Jinhai Gao; Mark Zambrowski; Meike Spiess; José S. Duca; Scott A. Busby; Markus Schirle; Michael Robinson; Pei-Yong Shi; Heinz E. Moser; Christopher Sarko; James E. Bradner; Thierry T. Diagana; John A. Tallarico
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An oncogenic Ezh2 mutation induces tumors through global redistribution of histone 3 lysine 27 trimethylation (vol 22, pg 632, 2016)
err2024-02-21
err2
errOAAI
errSouroullas, George. P.; Jeck, William. R.; Parker, Joel. S.; Simon, Jeremy. M.; Liu, Jie-Yu; Paulk, Joshiawa; Xiong, Jessie; Clark, Kelly. S.; Fedoriw, Yuri; Qi, Jun; Burd, Christin. E.; Bradner, James. E.; Sharpless, Norman. E.
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Diversity-oriented synthesis encoded by deoxyoligonucleotides (vol 14, 4930, 2023)
err2023-11-21
err0
errOAAI
errHudson, Liam; Mason, Jeremy W.; Westphal, Matthias V.; Richter, Matthieu J. R.; Thielman, Jonathan R.; Hua, Bruce K.; Gerry, Christopher J.; Xia, Guoqin; Osswald, Heather L.; Knapp, John M.; Tan, Zher Yin; Kokkonda, Praveen; Tresco, Ben I. C.; Liu, Shuang; Reidenbach, Andrew G.; Lim, Katherine S.; Poirier, Jennifer; Capece, John; Bonazzi, Simone; Gampe, Christian M.; Smith, Nichola J.; Bradner, James E.; Coley, Connor W.; Clemons, Paul A.; Melillo, Bruno; Hon, C. Suk-Yee; Ottl, Johannes; Dumelin, Christoph E.; Schaefer, Jonas V.; Faust, Ann Marie E.; Berst, Frederic; Schreiber, Stuart L.; Zecri, Frederic J.; Briner, Karin
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Diversity-oriented synthesis encoded by deoxyoligonucleotides
err2023-08-15
err7
errOAAI
errHudson, Liam; Mason, Jeremy W.; Westphal, Matthias V.; Richter, Matthieu J. R.; Thielman, Jonathan R.; Hua, Bruce K.; Gerry, Christopher J.; Xia, Guoqin; Osswald, Heather L.; Knapp, John M.; Tan, Zher Yin; Kokkonda, Praveen; Tresco, Ben I. C.; Liu, Shuang; Reidenbach, Andrew G.; Lim, Katherine S.; Poirier, Jennifer; Capece, John; Bonazzi, Simone; Gampe, Christian M.; Smith, Nichola J.; Bradner, James E.; Coley, Connor W.; Clemons, Paul A.; Melillo, Bruno; Hon, C. Suk-Yee; Ottl, Johannes; Dumelin, Christoph E.; Schaefer, Jonas V.; Faust, Ann Marie E.; Berst, Frederic; Schreiber, Stuart L.; Zecri, Frederic J.; Briner, Karin
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Genome-scale functional genomics identify genes preferentially essential for multiple myeloma cells compared to other neoplasias
err2023-05-26
err15
PREAI
errSimoes, Ricardo de Matos; Shirasaki, Ryosuke; Downey-Kopyscinski, Sondra L.; Matthews, Geoffrey M.; Barwick, Benjamin G.; Gupta, Vikas A.; Dupere-Richer, Daphne; Yamano, Shizuka; Hu, Yiguo; Sheffer, Michal; Dhimolea, Eugen; Dashevsky, Olga; Gandolfi, Sara; Ishiguro, Kazuya; Meyers, Robin M.; Bryan, Jordan G.; Dharia, Neekesh V.; Hengeveld, Paul J.; Bruggenthies, Johanna B.; Tang, Huihui; Aguirre, Andrew J.; Sievers, Quinlan L.; Ebert, Benjamin L.; Glassner, Brian J.; Ott, Christopher J.; Bradner, James E.; Kwiatkowski, Nicholas P.; Auclair, Daniel; Levy, Joan; Keats, Jonathan J.; Groen, Richard W. J.; Gray, Nathanael S.; Culhane, Aedin C.; McFarland, James M.; Dempster, Joshua M.; Licht, Jonathan D.; Boise, Lawrence H.; Hahn, William C.; Vazquez, Francisca; Tsherniak, Aviad; Mitsiades, Constantine S.
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Regulation of NO Synthesis, Local Inflammation, and Innate Immunity to Pathogens by BET Family Proteins
err2023-03-20
err66
errOAAI
errWienerroither, Sebastian; Rauch, Isabella; Rosebrock, Felix; Jamieson, Amanda M.; Bradner, James; Muhar, Matthias; Zuber, Johannes; Mueller, Mathias; Decker, Thomas
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Discovery and characterization of a selective IKZF2 glue degrader for cancer immunotherapy
err2023-03-01
err59
errOAAI
errBonazzi, Simone; d'Hennezel, Eva; Beckwith, Rohan E. J.; Xu, Lei; Fazal, Aleem; Magracheva, Anna; Ramesh, Radha; Cernijenko, Artiom; Antonakos, Brandon; Bhang, Hyo-eun C.; Caro, Roxana Garcia; Cobb, Jennifer S.; Ornelas, Elizabeth; Ma, Xiaolei; Wartchow, Charles A.; Clifton, Matthew C.; Forseth, Ry R.; Fortnam, Bethany Hughes; Lu, Hongbo; Csibi, Alfredo; Tullai, Jennifer; Carbonneau, Seth; Thomsen, Noel M.; Larrow, Jay; Chie-Leon, Barbara; Hainzl, Dominik; Gu, Yi; Lu, Darlene; Meyer, Matthew J.; Alexander, Dylan; Kinyamu-Akunda, Jacqueline; Sabatos-Peyton, Catherine A.; Dales, Natalie A.; Zecri, Frederic J.; Jain, Rishi K.; Shulok, Janine; Wang, Y. Karen; Briner, Karin; Porter, Jeffery A.; Tallarico, John A.; Engelman, Jeffrey A.; Dranoff, Glenn; Bradner, James E.; Visser, Michael; Solomon, Jonathan M.
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Inhibition of EZH2 transactivation function sensitizes solid tumors to stress
err2022-01-14
err28
errOAAI
errLiao, Yiji; Chen, Chen-Hao; Xiao, Tengfei; Avalos, Barbara de la Pena; Dray, Eloise, V; Cai, Changmeng; Gao, Shuai; Shah, Neel; Zhang, Zhao; Feit, Avery; Xue, Pengya; Liu, Zhijie; Yang, Mei; Lee, Ji Hoon; Xu, Han; Li, Wei; Mei, Shenglin; Pierre, Roodolph S.; Shu, Shaokun; Fei, Teng; Duarte, Melissa; Zhao, Jin; Bradner, James E.; Polyak, Kornelia; Kantoff, Philip W.; Long, Henry; Balk, Steven P.; Liu, X. Shirley; Brown, Myles; Xu, Kexin
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Selective targeting of MYC mRNA by stabilized antisense oligonucleotides
err2021-10-14
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errOAAI
errGill, Taylor; Wang, Haichuan; Bandaru, Raj; Lawlor, Matthew; Lu, Chenyue; Nieman, Linda T.; Tao, Junyan; Zhang, Yixian; Anderson, Daniel G.; Ting, David T.; Chen, Xin; Bradner, James E.; Ott, Christopher J.
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The synergy of BET inhibitors with aurora A kinase inhibitors in MYCN-amplified neuroblastoma is heightened with functional TP53
err2021-06-01
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errOAAI
errYi, Joanna S.; Sias-Garcia, Oscar; Nasholm, Nicole; Hu, Xiaoyu; Iniguez, Amanda Balboni; Hall, Matthew D.; Davis, Mindy; Guha, Rajarshi; Moreno-Smith, Myrthala; Barbieri, Eveline; Duong, Kevin; Koach, Jessica; Qi, Jun; Bradner, James E.; Stegmaier, Kimberly; Weiss, William A.; Gustafson, W. Clay
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An IMiD-inducible degron provides reversible regulation for chimeric antigen receptor expression and activity (Dec, 10.1016/j.chembiol.2020.11.012, 2020)
err2021-04-01
err3
PREAI
errCarbonneau, Seth; Sharma, Sujata; Peng, Liaomin; Rajan, Vaisakh; Hainzl, Dominik; Henault, Martin; Yang, Chian; Hale, Jacob; Shulok, Janine; Tallarico, John; Porter, Jeff; Brogdon, Jennifer L.; Dranoff, Glenn; Bradner, James E.; Hild, Marc; Guimaraes, Carla P.
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Functional Genomics Identify Distinct and Overlapping Genes Mediating Resistance to Different Classes of Heterobifunctional Degraders of Oncoproteins
err2021-01-01
err68
errOAAI
errShirasaki, Ryosuke; Matthews, Geoffrey M.; Gandolfi, Sara; Simoes, Ricardo de Matos; Buckley, Dennis L.; Vora, Joseline Raja; Sievers, Quinlan L.; Bruggenthies, Johanna B.; Dashevsky, Olga; Poarch, Haley; Tang, Huihui; Bariteau, Megan A.; Sheffer, Michal; Hu, Yiguo; Downey-Kopyscinski, Sondra L.; Hengeveld, Paul J.; Glassner, Brian J.; Dhimolea, Eugen; Ott, Christopher J.; Zhang, Tinghu; Kwiatkowski, Nicholas P.; Laubach, Jacob P.; Schlossman, Robert L.; Richardson, Paul G.; Culhane, Aedin C.; Groen, Richard W. J.; Fischer, Eric S.; Vazquez, Francisca; Tsherniak, Aviad; Hahn, William C.; Levy, Joan; Auclair, Daniel; Licht, Jonathan D.; Keats, Jonathan J.; Boise, Lawrence H.; Ebert, Benjamin L.; Bradner, James E.; Gray, Nathanael S.; Mitsiades, Constantine S.
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Rapid and direct control of target protein levels with VHL-recruiting dTAG molecules
err2020-09-18
err152
errOAAI
errNabet, Behnam; Ferguson, Fleur M.; Seong, Bo Kyung A.; Kuljanin, Miljan; Leggett, Alan L.; Mohardt, Mikaela L.; Robichaud, Amanda; Conway, Amy S.; Buckley, Dennis L.; Mancias, Joseph D.; Bradner, James E.; Stegmaier, Kimberly; Gray, Nathanael S.
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Synthetic Lethal and Resistance Interactions with BET Bromodomain Inhibitors in Triple-Negative Breast Cancer
err2020-06-01
err134
errOAAI
errShu, Shaokun; Wu, Hua-Jun; Ge, Jennifer Y.; Zeid, Rhamy; Harris, Isaac S.; Jovanovic, Bojana; Murphy, Katherine; Wang, Binbin; Qiu, Xintao; Endress, Jennifer E.; Reyes, Jaime; Lim, Klothilda; Font-Tello, Alba; Syamala, Sudeepa; Xiao, Tengfei; Chilamakuri, Chandra Sekhar Reddy; Papachristou, Evangelia K.; D'Santos, Clive; Anand, Jayati; Hinohara, Kunihiko; Li, Wei; McDonald, Thomas O.; Luoma, Adrienne; Modiste, Rebecca J.; Quang-De Nguyen; Michel, Brittany; Cejas, Paloma; Kadoch, Cigall; Jaffe, Jacob D.; Wucherpfennig, Kai W.; Qi, Jun; Liu, X. Shirley; Long, Henry; Brown, Myles; Carroll, Jason S.; Brugge, Joan S.; Bradner, James; Michor, Franziska; Polyak, Kornelia
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Selective Mediator dependence of cell-type-specifying transcription
err2020-06-01
err88
errOAAI
errJaeger, Martin G.; Schwalb, Bjoern; Mackowiak, Sebastian D.; Velychko, Taras; Hanzl, Alexander; Imrichova, Hana; Brand, Matthias; Agerer, Benedikt; Chorn, Someth; Nabet, Behnam; Ferguson, Fleur M.; Mueller, Andre C.; Bergthaler, Andreas; Gray, Nathanael S.; Bradner, James E.; Bock, Christoph; Hnisz, Denes; Cramer, Patrick; Winter, Georg E.
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Evolutionary conserved NSL complex/BRD4 axis controls transcription activation via histone acetylation
err2020-05-07
err19
errOAAI
errGaub, Aline; Sheikh, Bilal N.; Basilicata, M. Felicia; Vincent, Marie; Nizon, Mathilde; Colson, Cindy; Bird, Matthew J.; Bradner, James E.; Thevenon, Julien; Boutros, Michael; Akhtar, Asifa
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High-fat diet fuels prostate cancer progression by rewiring the metabolome and amplifying the MYC program
err2019-09-25
err126
errOAAI
errLabbe, David P.; Zadra, Giorgia; Yang, Meng; Reyes, Jaime M.; Lin, Charles Y.; Cacciatore, Stefano; Ebot, Ericka M.; Creech, Amanda L.; Giunchi, Francesca; Fiorentino, Michelangelo; Elfandy, Habiba; Syamala, Sudeepa; Karoly, Edward D.; Alshalalfa, Mohammed; Erho, Nicholas; Ross, Ashley; Schaeffer, Edward M.; Gibb, Ewan A.; Takhar, Mandeep; Den, Robert B.; Lehrer, Jonathan; Karnes, R. Jeffrey; Freedland, Stephen J.; Davicioni, Elai; Spratt, Daniel E.; Ellis, Leigh; Jaffe, Jacob D.; Amico, Anthony V. D.; Kantoff, Philip W.; Bradner, James E.; Mucci, Lorelei A.; Chavarro, Jorge E.; Loda, Massimo; Brown, Myles
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PAX8 activates metabolic genes via enhancer elements in Renal Cell Carcinoma
err2019-08-20
err46
errOAAI
errBleu, Melusine; Gaulis, Swann; Lopes, Rui; Sprouffske, Kathleen; Apfel, Verena; Holwerda, Sjoerd; Pregnolato, Marco; Yildiz, Umut; Cordo, Valentina; Dost, Antonella F. M.; Knehr, Judith; Carbone, Walter; Lohmann, Felix; Lin, Charles Y.; Bradner, James E.; Kauffmann, Audrey; Tordella, Luca; Roma, Guglielmo; Galli, Giorgio G.
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Neuronal differentiation and cell-cycle programs mediate response to BET-bromodomain inhibition in MYC-driven medulloblastoma
err2019-06-03
err38
errOAAI
errBandopadhayay, Pratiti; Piccioni, Federica; O'Rourke, Ryan; Ho, Patricia; Gonzalez, Elizabeth M.; Buchan, Graham; Qian, Kenin; Gionet, Gabrielle; Girard, Emily; Coxon, Margo; Rees, Matthew G.; Brenan, Lisa; Dubois, Frank; Shapira, Ofer; Greenwald, Noah F.; Pages, Melanie; Iniguez, Amanda Balboni; Paolella, Brenton R.; Meng, Alice; Sinai, Claire; Roti, Giovanni; Dharia, Neekesh V.; Creech, Amanda; Tanenbaum, Benjamin; Khadka, Prasidda; Tracy, Adam; Tiv, Hong L.; Hong, Andrew L.; Coy, Shannon; Rashid, Rumana; Lin, Jia-Ren; Cowley, Glenn S.; Lam, Fred C.; Goodale, Amy; Lee, Yenarae; Schoolcraft, Kathleen; Vazquez, Francisca; Hahn, William C.; Tsherniak, Aviad; Bradner, James E.; Yaffe, Michael B.; Milde, Till; Pfister, Stefan M.; Qi, Jun; Schenone, Monica; Carr, Steven A.; Ligon, Keith L.; Kieran, Mark W.; Santagata, Sandro; Olson, James M.; Gokhale, Prafulla C.; Jaffe, Jacob D.; Root, David E.; Stegmaier, Kimberly; Johannessen, Cory M.; Beroukhim, Rameen
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