Not logged in Greedy reduction of Bacillus subtilis genome yields emergent phenotypes of high resistance to a DNA damaging agent and low evolvability Dervyn, Etienne; Planson, Anne-Gaelle; Tanaka, Kosei; Chubukov, Victor; Guerin, Cyprien; Derozier, Sandra; Lecointe, Francois; Sauer, Uwe; Yoshida, Ken-Ichi; Nicolas, Pierre; Noirot, Philippe; Jules, Matthieu Share Save
Itaconate confers tolerance to late NLRP3 inflammasome activation Bambouskova, Monika; Potuckova, Lucie; Paulenda, Tomas; Kerndl, Martina; Mogilenko, Denis A.; Lizotte, Kate; Swain, Amanda; Hayes, Sebastian; Sheldon, Ryan D.; Kim, Hyeryun; Kapadnis, Unnati; Ellis, Abigail E.; Isaguirre, Christine; Burdess, Samantha; Laha, Anwesha; Amarasinghe, Gaya K.; Chubukov, Victor; Roddy, Thomas P.; Diamond, Michael S.; Jones, Russell G.; Simons, Donald M.; Artyomov, Maxim N. Share Save
Selective Vulnerability to Pyrimidine Starvation in Hematologic Malignancies Revealed by AG-636, a Novel Clinical-Stage Inhibitor of Dihydroorotate Dehydrogenase McDonald, Gabrielle; Chubukov, Victor; Coco, John; Truskowski, Kevin; Narayanaswamy, Rohini; Choe, Sung; Steadman, Mya; Artin, Erin; Padyana, Anil K.; Jin, Lei; Ronseaux, Sebastien; Locuson, Charles; Fan, Zi-Peng; Erdmann, Tabea; Mann, Alan; Hayes, Sebastian; Fletcher, Mark; Nellore, Kavitha; Rao, Siva Sanjeeva; Subramanya, Hosahalli; Reddy, K. Satish; Panigrahi, Sunil K.; Antony, Thomas; Gopinath, Sreevalsam; Sui, Zhihua; Nagaraja, Nelamangala; Dang, Lenny; Lenz, Georg; Hurov, Jonathan; Biller, Scott A.; Murtie, Josh; Marks, Kevin M.; Ulanet, Danielle B. Share Save
Comparative evaluation of itaconate and its derivatives reveals divergent inflammasome and type I interferon regulation in macrophages Swain, Amanda; Bambouskova, Monika; Kim, Hyeryun; Andhey, Prabhakar Sairam; Duncan, Dustin; Auclair, Karine; Chubukov, Victor; Simons, Donald M.; Roddy, Thomas P.; Stewart, Kelly M.; Artyomov, Maxim N. Share Save
Methionine Metabolism Shapes T Helper Cell Responses through Regulation of Epigenetic Reprogramming Roy, Dominic G.; Chen, Jocelyn; Mamane, Victoria; Ma, Eric H.; Muhire, Brejnev M.; Sheldon, Ryan D.; Shorstova, Tatiana; Koning, Rutger; Johnson, Radia M.; Esaulova, Ekaterina; Williams, Kelsey S.; Hayes, Sebastian; Steadman, Mya; Samborska, Bozena; Swain, Amanda; Daigneault, Audrey; Chubukov, Victor; Roddy, Thomas P.; Foulkes, William; Pospisilik, J. Andrew; Bourgeois-Daigneault, Marie-Claude; Artyomov, Maxim N.; Witcher, Michael; Krawczyk, Connie M.; Larochelle, Catherine; Jones, Russell G. Share Save
AG-348 (mitapivat), an allosteric activator of red blood cell pyruvate kinase, increases enzymatic activity, protein stability, and adenosine triphosphate levels over a broad range of PKLR genotypes Rab, Minke A. E.; van Oirschot, Brigitte A.; Kosinski, Penelope A.; Hixon, Jeffrey; Johnson, Kendall; Chubukov, Victor; Dang, Lenny; Pasterkamp, Gerard; van Straaten, Stephanie; van Solinge, Wouter W.; van Beers, Eduard J.; Kung, Charles; van Wijk, Richard Share Save
Metabolic Profiling Using Stable Isotope Tracing Reveals Distinct Patterns of Glucose Utilization by Physiologically Activated CD8+ T Cells Ma, Eric H.; Verway, Mark J.; Johnson, Radia M.; Roy, Dominic G.; Steadman, Mya; Hayes, Sebastian; Williams, Kelsey S.; Sheldon, Ryan D.; Samborska, Bozena; Kosinski, Penelope A.; Kim, Hyeryun; Griss, Takla; Faubert, Brandon; Condotta, Stephanie A.; Krawczyk, Connie M.; DeBerardinis, Ralph J.; Stewart, Kelly M.; Richer, Martin J.; Chubukov, Victor; Roddy, Thomas P.; Jones, Russell G. Share Save
A chemical biology screen identifies a vulnerability of neuroendocrine cancer cells to SQLE inhibition Mahoney, Christopher E.; Pirman, David; Chubukov, Victor; Sleger, Taryn; Hayes, Sebastian; Fan, Zi Peng; Allen, Eric L.; Chen, Ying; Huang, Lingling; Liu, Meina; Zhang, Yingjia; McDonald, Gabrielle; Narayanaswamy, Rohini; Choe, Sung; Chen, Yue; Gross, Stefan; Cianchetta, Giovanni; Padyana, Anil K.; Murray, Stuart; Liu, Wei; Marks, Kevin M.; Murtie, Joshua; Dorsch, Marion; Jin, Shengfang; Nagaraja, Nelamangala; Biller, Scott A.; Roddy, Thomas; Popovici-Muller, Janeta; Smolen, Gromoslaw A. Share Save
A chemical biology screen identifies a unique vulnerability of neuroendocrine cancer cells to SQLE inhibition Mahoney, Christopher; Pirman, David; Chubukov, Victor; Sleger, Taryn; Padyana, Anil; Gross, Stefan; Hayes, Sebastian; Fan, Zi Peng; McDonald, Gabrielle; Chen, Yu; Murtie, Joshua; Cianchetta, Giovanni; Nagaraja, Raj; Narayanaswamy, Rohini; Choe, Sung; Murray, Stuart; Jin, Shengfang; Biller, Scott; Roddy, Thomas; Smolen, Gromoslaw A. Share Save
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Quantitative prediction of genome-wide resource allocation in bacteria Goelzer, Anne; Muntel, Jan; Chubukov, Victor; Jules, Matthieu; Prestel, Eric; Noelker, Rolf; Mariadassou, Mahendra; Aymerich, Stephane; Hecker, Michael; Noirot, Philippe; Becher, Doerte; Fromion, Vincent Share Save
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