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Highly potent quinoxalinediones inhibit a-hemolysin and ameliorate Staphylococcus aureus lung infections Shekhar, Aditya; Di Lucrezia, Raffaella; Jerye, Karoline; Korotkov, Vadim S.; Harmrolfs, Kirsten; Rox, Katharina; Weich, Herbert A.; Ghai, Ishan; Delhommel, Florent; Becher, Isabelle; Degenhart, Carsten; Fansa, Eyad; Unger, Anke; Habenberger, Peter; Klebl, Bert; Lukat, Peer; Schmelz, Stefan; Henke, Steffi; Borgert, Sebastian; Lang, Julia C.; Sasse, Florenz; Diestel, Randi; Richter, Clementine; Schneider-Daum, Nicole; Hinkelmann, Bettina; Niemz, Jana; Lehr, Claus-Michael; Jaensch, Lothar; Huehn, Jochen; Alm, Richard; Savitski, Mikhail; Welte, Tobias; Hesterkamp, Thomas; Sattler, Michael; Winterhalter, Mathias; Blankenfeldt, Wulf; Medina, Eva; Bilitewski, Ursula; Dinkel, Klaus; Broenstrup, Mark Share Save
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Exquisite selectivity of griselimycin extends to beta subunit of DNA polymerases from Gram-negative bacterial pathogens Fenwick, Michael K.; Pierce, Phillip G.; Abendroth, Jan; Barrett, Kayleigh F.; Barrett, Lynn K.; Bowatte, Kalinga; Choi, Ryan; Chun, Ian; Conrady, Deborah G.; Craig, Justin K.; Dranow, David M.; Hammerson, Bradley; Higgins, Tate; Lorimer, Donald D.; Lukat, Peer; Mayclin, Stephen J.; Hewitt, Stephen Nakazawa; Peng, Ying Po; Shanbhogue, Ashwini; Smutney, Hayden; Stigliano, Matthew Z. Z.; Tillery, Logan M.; Udell, Hannah S.; Wallace, Ellen G.; Derocher, Amy E.; Phan, Isabelle Q.; Staker, Bart L.; Subramanian, Sandhya; Van Voorhis, Wesley C.; Blankenfeldt, Wulf; Mueller, Rolf; Edwards, Thomas E.; Myler, Peter J. Share Save
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Biocatalytic Ether Lipid Synthesis by an Archaeal Glycerolprenylase Kaspar, Felix; Eilert, Lea; Staar, Sophie; Oung, Sangwar Wadtey; Wolter, Mario; Ganskow, Charity S. G.; Kemper, Sebastian; Klahn, Philipp; Jacob, Christoph R.; Blankenfeldt, Wulf; Schallmey, Anett Share Save
Discovery and optimization of thiazole-based quorum sensing inhibitors as potent blockers of Pseudomonas aeruginosa pathogenicity Abdelsamie, Ahmed S.; Hamed, Mostafa M.; Schuetz, Christian; Roehrig, Teresa; Kany, Andreas M.; Schmelz, Stefan; Blankenfeldt, Wulf; Hirsch, Anna K. H.; Hartmann, Rolf W.; Empting, Martin Share Save
Target-Directed Dynamic Combinatorial Chemistry Affords Binders of Mycobacterium tuberculosis IspE Braun-Cornejo, Maria; Ornago, Camilla; Sonawane, Vidhisha; Haupenthal, Joerg; Kany, Andreas M.; Diamanti, Eleonora; Jezequel, Gwenaelle; Reiling, Norbert; Blankenfeldt, Wulf; Maas, Peter; Hirsch, Anna K. H. Share Save
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The alternative coproporphyrinogen III oxidase (CgoN) catalyzes the oxygen-independent conversion of coproporphyrinogen III into coproporphyrin III Mingers, Toni; Barthels, Stefan; Mass, Violetta; Acuna, Jose Manuel Borrero-de; Biedendieck, Rebekka; Cooke, Ana; Dailey, Tamara A.; Gerdes, Svetlana; Blankenfeldt, Wulf; Dailey, Harry A.; Warren, Martin J.; Jahn, Martina; Jahn, Dieter Share Save
Elucidation of unusual biosynthesis and DnaN-targeting mode of action of potent anti-tuberculosis antibiotics Mycoplanecins Fu, Chengzhang; Liu, Yunkun; Walt, Christine; Rasheed, Sari; Bader, Chantal D.; Lukat, Peer; Neuber, Markus; Haeckl, F. P. Jake; Blankenfeldt, Wulf; Kalinina, Olga V.; Mueller, Rolf Share Save
The Cytomegalovirus M35 Protein Directly Binds to the Interferon-β Enhancer and Modulates Transcription of Ifnb1 and Other IRF3-Driven Genes Schwanke, Hella; Goncalves Magalhaes, Vladimir; Schmelz, Stefan; Wyler, Emanuel; Hennig, Thomas; Guenther, Thomas; Grundhoff, Adam; Doelken, Lars; Landthaler, Markus; van Ham, Marco; Jaensch, Lothar; Buessow, Konrad; van den Heuvel, Joop; Blankenfeldt, Wulf; Friedel, Caroline C.; Erhard, Florian; Brinkmann, Melanie M. Share Save
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Towards Translation of PqsR Inverse Agonists: From In Vitro Efficacy Optimization to In Vivo Proof-of-Principle Hamed, Mostafa M.; Abdelsamie, Ahmed S.; Rox, Katharina; Schuetz, Christian; Kany, Andreas M.; Roehrig, Teresa; Schmelz, Stefan; Blankenfeldt, Wulf; Arce-Rodriguez, Alejandro; Borrero-de Acuna, Jose Manuel; Jahn, Dieter; Rademacher, Jessica; Ringshausen, Felix C.; Cramer, Nina; Tuemmler, Burkhard; Hirsch, Anna K. H.; Hartmann, Rolf W.; Empting, Martin Share Save
Moonlighting chaperone activity of the enzyme PqsE contributes to RhlR-controlled virulence of Pseudomonas aeruginosa Borgert, Sebastian Roman; Henke, Steffi; Witzgall, Florian; Schmelz, Stefan; Lage, Susanne zur; Hotop, Sven-Kevin; Stephen, Steffi; Luebken, Dennis; Krueger, Jonas; Gomez, Nicolas Oswaldo; van Ham, Marco; Jaensch, Lothar; Kalesse, Markus; Pich, Andreas; Broenstrup, Mark; Haeussler, Susanne; Blankenfeldt, Wulf Share Save
Citraconate inhibits ACOD1 (IRG1) catalysis, reduces interferon responses and oxidative stress, and modulates inflammation and cell metabolism Chen, F.; Elgaher, W. A. M.; Winterhoff, M.; Buessow, K.; Waqas, F. H.; Graner, E.; Pires-Afonso, Y.; Perez, L. Casares; de la Vega, L.; Sahini, N.; Czichon, L.; Zobl, W.; Zillinger, T.; Shehata, M.; Pleschka, S.; Baehre, H.; Falk, C.; Michelucci, A.; Schuchardt, S.; Blankenfeldt, W.; Hirsch, A. K. H.; Pessler, F. Share Save
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